A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

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Check prices for these dates

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Jul 31 - Aug 2
Next weekend
Aug 7 - Aug 9

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Our top choices for Defiance hotels

Breakfast included
Exterior

1. Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (953 reviews)
"Staff was very helpful and welcoming. The complimentary breakfast was fresh and very good."
United States
Sheria
The price is ļæ„15,705
ļæ„18,524 total
includes taxes & fees
Aug 3 - Aug 4
Holiday Inn Express St. Louis West - O'Fallon by IHG
Premium bedding, desk, iron/ironing board, WiFi (free)

2. Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,061 reviews)
"This is a gem of a hotel. The check in was smooth, staff was friendly, everything was clean, and the entire place smelled fresh. The bed was very comfortable and good water pressure in the shower."
United States
Kirsten
The price is ļæ„13,058
ļæ„15,403 total
includes taxes & fees
Aug 30 - Aug 31
Sleep Inn & Suites O'Fallon MO - Technology Drive
Property entrance

3. The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,667 reviews)
"Great location, very nice place to stay."
United States
Hailey
The price is ļæ„12,529
ļæ„14,596 total
includes taxes & fees
Aug 31 - Sep 1
The Wildwood Hotel
Property amenity

4. TownePlace Suites by Marriott St. Louis Chesterfield

TownePlace Suites by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (318 reviews)
"It's a nice place to stay."
United States
Cindy
The price is ļæ„20,430
ļæ„23,978 total
includes taxes & fees
Aug 14 - Aug 15
TownePlace Suites by Marriott St. Louis Chesterfield
Bar (on property)

5. Hyatt Place St. Louis/Chesterfield

Hyatt Place St. Louis/Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (1,000 reviews)
"Clean and nice hotel for our family stay! Kids loved the pool and the rooms were clean!"
United States
Taylor
The price is ļæ„20,686
ļæ„23,993 total
includes taxes & fees
Aug 30 - Aug 31
Hyatt Place St. Louis/Chesterfield
Standard Room, 2 Queen Beds, Non Smoking | Hypo-allergenic bedding available, desk, laptop workspace

6. Comfort Inn & Suites Chesterfield - St. Louis

Comfort Inn & Suites Chesterfield - St. Louis
2.5 star property
Chesterfield
7.8 out of 10, Good, (1,007 reviews)
"It was a great stay for the money. Would stay again. Our room was spacious and the beds were comfortable."
United States
Jessica
The price is ļæ„13,075
ļæ„15,773 total
includes taxes & fees
Aug 30 - Aug 31
Comfort Inn & Suites Chesterfield - St. Louis
Lobby lounge

7. Residence Inn by Marriott O'Fallon

Residence Inn by Marriott O'Fallon
3.0 star property
O'Fallon
8.4 out of 10, Very Good, (486 reviews)
"Breakfast was great"
United States
Gerald
The price is ļæ„20,909
ļæ„24,661 total
includes taxes & fees
Aug 14 - Aug 15
Residence Inn by Marriott O'Fallon
Lobby sitting area

8. Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO
3.0 star property
O'Fallon
8.8 out of 10, Excellent, (750 reviews)
"Great stay! Nice hotel with nice restaurant next door."
United States
Kassie
The price is ļæ„22,119
ļæ„26,226 total
includes taxes & fees
Aug 13 - Aug 14
Hilton Garden Inn St. Louis/O'Fallon MO
Exterior

9. Staybridge Suites O'Fallon Chesterfield by IHG

Staybridge Suites O'Fallon Chesterfield by IHG
3.0 star property
O'Fallon
8.6 out of 10, Excellent, (463 reviews)
"Wonderful place. Its beautiful and clean. Great place to stay. The staff was very welcoming."
United States
Nadia
The price is ļæ„17,992
ļæ„21,222 total
includes taxes & fees
Aug 3 - Aug 4
Staybridge Suites O'Fallon Chesterfield by IHG
BBQ/picnic area

10. Courtyard by Marriott St. Louis Chesterfield

Courtyard by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (651 reviews)
"Wish there was a way to walk to the factory from the hotel."
United States
Mark
The price is ļæ„16,145
ļæ„18,786 total
includes taxes & fees
Aug 14 - Aug 15
Courtyard by Marriott St. Louis Chesterfield
Exterior

11. Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
2.5 star property
St. Peters
9.4 out of 10, Exceptional, (434 reviews)
"Wonderful stay from start to finish!"
United States
Brittany
The price is ļæ„18,355
ļæ„22,080 total
includes taxes & fees
Aug 30 - Aug 31
Holiday Inn Express & Suites St Peters by IHG
Lobby

12. Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (1,209 reviews)
"Had a great stay"
United States
Madeleine
The price is ļæ„20,748
ļæ„24,066 total
includes taxes & fees
Aug 16 - Aug 17
Drury Plaza Hotel St. Louis Chesterfield
Lobby

13. Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,000 reviews)
"Front desk was very helpful and friendly. Breakfast was very good and staff was extremely friendly!"
United States
DANA
The price is ļæ„17,556
ļæ„20,180 total
includes taxes & fees
Aug 30 - Aug 31
Drury Inn & Suites St. Louis St. Peters
Room, Accessible | Desk, iron/ironing board, WiFi (free), bed sheets

14. Super 8 by Wyndham O'Fallon MO/St. Louis Area

Super 8 by Wyndham O'Fallon MO/St. Louis Area
2.0 star property
O'Fallon
7.0 out of 10, Good, (1,008 reviews)
"Clean room, friendly staff"
United States
Shelly
The price is ļæ„10,989
ļæ„12,962 total
includes taxes & fees
Aug 16 - Aug 17
Super 8 by Wyndham O'Fallon MO/St. Louis Area
Indoor pool

15. Holiday Inn St. Louis West Six Flags by IHG

Holiday Inn St. Louis West Six Flags by IHG
3.0 star property
Eureka
9.0 out of 10, Wonderful, (1,000 reviews)
"Great place to stay with kids!"
United States
Samantha
The price is ļæ„18,994
ļæ„22,125 total
includes taxes & fees
Aug 30 - Aug 31
Holiday Inn St. Louis West Six Flags by IHG
Lobby

16. Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville
3.0 star property
Wentzville
9.0 out of 10, Wonderful, (694 reviews)
"Very clean and spacious rooms"
United States
Alexandria
The price is ļæ„21,145
ļæ„24,200 total
includes taxes & fees
Aug 26 - Aug 27
Fairfield Inn & Suites Wentzville
Lobby

17. Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very Good, (1,005 reviews)
"Nice place, good location and comfortable bed"
United States
Alice
The price is ļæ„13,359
ļæ„15,088 total
includes taxes & fees
Aug 12 - Aug 13
Quality Inn Foristell
Lobby

18. Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (713 reviews)
"Large spacious room, clean conditions, wonderful breakfast selection!"
United States
Zackariah
The price is ļæ„20,590
ļæ„23,441 total
includes taxes & fees
Aug 10 - Aug 11
Best Western Plus Washington Hotel
Property amenity

19. Residence Inn by Marriott St. Louis Chesterfield

Residence Inn by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (240 reviews)
"Our stay here was wonderful. The rooms are comfortable, the staff is friendly and the location is convenient with nearby shopping and restaurants."
United States
Tenisha
The price is ļæ„30,166
ļæ„35,291 total
includes taxes & fees
Aug 6 - Aug 7
Residence Inn by Marriott St. Louis Chesterfield
Courtyard

20. Hampton Inn & Suites St. Louis/Chesterfield

Hampton Inn & Suites St. Louis/Chesterfield
3.5 star property
Chesterfield
8.8 out of 10, Excellent, (895 reviews)
"breakfast was great"
United States
Karen E
The price is ļæ„17,538
ļæ„20,408 total
includes taxes & fees
Aug 30 - Aug 31
Hampton Inn & Suites St. Louis/Chesterfield
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)
This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.
See properties

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Top Defiance Hotel Reviews

Best Western Plus Fenton

Best Western Plus Fenton

8/10 Good
"Good hotel for the money"
Michael 4-night trip
Posted 5 hours ago
Best Western Plus Fenton

More cheap stays in Defiance

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

1970 Craig Rd Maryland Heights MO
The price is ļæ„10,853 per night from Aug 30 to Aug 31
ļæ„10,853
ļæ„12,589 total
Aug 30 - Aug 31
includes taxes & fees
4.4/10 (1,000 reviews)

Frequently asked questions

What's the best place to stay in Defiance?
Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and The Wildwood Hotel. See all available top hotels, or vacation rentals in Defiance.
What's the top vacation rental in Defiance?
St. Charles 1860's Gem - Sleeps 6!: Visitors like this Defiance vacation home rental. It is located on a river and has a garden, a selection of books, and air-conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
Where can I learn more about changing or cancelling my trip to Defiance?
For more information about changing or cancelling your trip to Defiance, head over to our customer service page.
Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?
Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.
What about the best place to stay near Chandler Hill Vineyards?
One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.
What are some accommodations with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Offers an indoor pool, an outdoor pool, and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.
What's the best place to stay near Lambert-St. Louis International Airport (STL)?
Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.
What's it like to stay in Defiance?
Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium, and Dome at America's Center. In Defiance, there are 19 hotels and other accommodations to choose from. Find out more about Defiance.
What is there to see in Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River, and Matson Hill Park Trailhead. A couple of additional sights to add to your agenda are Chandler Hill Vineyards and Sugar Creek Winery. Check out what more to see and do in Expedia's Defiance guide.
What's the seasonal weather like in Defiance?
The hottest months are usually July and August with an average temp of 76Ā°F, while the coldest months are January and February with an average of 38Ā°F. Average annual precipitation for Defiance is 48 inches.

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