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Find hotels in Defiance, MO from ¥8,979

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Compare 830 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Drury Plaza Hotel St. Louis Chesterfield

3.0 star property
9.6 out of 10, Exceptional, (1008)
"Hotel was great "
The price is ¥19,101
¥22,154 total
includes taxes & fees
Aug 29 - Aug 30
Drury Plaza Hotel St. Louis Chesterfield

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
8.4 out of 10, Very Good, (1005)
"Very good hotel for the price"
The price is ¥13,114
¥15,146 total
includes taxes & fees
Aug 31 - Sep 1
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Quality Inn Near Six Flags St. Louis

2.5 star property
8.4 out of 10, Very Good, (333)
"Pool was small. Staff was great. Room was very clean and well maintained. Overall very nice stay. "
The price is ¥14,547
¥16,652 total
includes taxes & fees
Sep 1 - Sep 2
Quality Inn Near Six Flags St. Louis

Super 8 by Wyndham St. Clair MO

2.0 star property
7.2 out of 10, Good, (896)
"Nice location amd staff were very nice would go there again!"
The price is ¥10,874
¥11,904 total
includes taxes & fees
Aug 26 - Aug 27
Super 8 by Wyndham St. Clair MO

Hampton Inn & Suites St. Louis/Chesterfield

3.5 star property
8.8 out of 10, Excellent, (806)
"Everything was wonderful!"
The price is ¥14,863
¥17,294 total
includes taxes & fees
Aug 31 - Sep 1
Hampton Inn & Suites St. Louis/Chesterfield

Comfort Inn St. Louis Airport

3.0 star property
8.6 out of 10, Excellent, (894)
"Good experience during our stay. "
The price is ¥13,092
¥15,659 total
includes taxes & fees
Aug 26 - Aug 27
Comfort Inn St. Louis Airport

Wingate by Wyndham St. Louis/Fenton Route 66

3.0 star property
8.2 out of 10, Very Good, (1006)
"Good hotel! "
The price is ¥12,365
¥14,283 total
includes taxes & fees
Aug 31 - Sep 1
Wingate by Wyndham St. Louis/Fenton Route 66

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

3.0 star property
7.4 out of 10, Good, (1011)
"It's a beautiful place to stay "
The price is ¥11,892
¥13,794 total
includes taxes & fees
Sep 25 - Sep 26
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
8.6 out of 10, Excellent, (769)
"Friendly staff and clean, fresh smelling rooms."
The price is ¥15,429
¥18,200 total
includes taxes & fees
Aug 28 - Aug 29
Holiday Inn Express St. Louis West - O'Fallon by IHG

Super 8 by Wyndham St Charles

2.0 star property
8.0 out of 10, Very Good, (1000)
"Great breakfast and awesome staff"
The price is ¥11,491
¥13,205 total
includes taxes & fees
Sep 1 - Sep 2
Super 8 by Wyndham St Charles

Super 8 by Wyndham Warrenton

2.0 star property
7.4 out of 10, Good, (583)
"Staff was extremely accommodating and friendly."
The price is ¥10,492
¥12,011 total
includes taxes & fees
Sep 1 - Sep 2
Super 8 by Wyndham Warrenton

Quality Inn

2.5 star property
8.2 out of 10, Very Good, (837)
"Lovely clean room and comfortable bed, quiet area , nice breakfast … all the things i need."
The price is ¥13,864
¥15,659 total
includes taxes & fees
Sep 24 - Sep 25
Quality Inn

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
8.8 out of 10, Excellent, (1006)
"Perfect place to stay, very clean and quiet."
The price is ¥13,820
¥16,301 total
includes taxes & fees
Sep 1 - Sep 2
Sleep Inn & Suites O'Fallon MO - Technology Drive

Super 8 by Wyndham Washington

2.0 star property
8.4 out of 10, Very Good, (667)
"It was clean and quaint for the price and was also close to where I was going the next morning. "
The price is ¥12,703
¥14,462 total
includes taxes & fees
Sep 1 - Sep 2
Super 8 by Wyndham Washington

The Wildwood Hotel

3.5 star property
9.2 out of 10, Wonderful, (1560)
"Great place to stay."
The Wildwood Hotel

Comfort Inn & Suites St. Louis - O'Fallon

2.5 star property
7.6 out of 10, Good, (1001)
"And nice hotel at a nice price "
The price is ¥12,541
¥14,791 total
includes taxes & fees
Sep 7 - Sep 8
Comfort Inn & Suites St. Louis - O'Fallon

Holiday Inn Express & Suites St Peters by IHG

2.5 star property
9.2 out of 10, Wonderful, (341)
"Very nice place. Clean... quiet and very friendly staff!! We will definitely stay here again!!"
The price is ¥12,490
¥15,217 total
includes taxes & fees
Sep 1 - Sep 2
Holiday Inn Express & Suites St Peters by IHG

Drury Plaza Hotel St. Louis Creve Coeur

3.0 star property
9.2 out of 10, Wonderful, (1005)
"The staff and hotel were great. The provided hot breakfast and diner buffet was great!"
The price is ¥16,860
¥19,597 total
includes taxes & fees
Aug 31 - Sep 1
Drury Plaza Hotel St. Louis Creve Coeur

Hampton Inn St. Louis Southwest

2.5 star property
9.0 out of 10, Wonderful, (940)
"The hotel was nice and clean. The staff were friendly and helpful. The breakfast was great. I highly recommend the hotel."
The price is ¥16,362
¥19,141 total
includes taxes & fees
Sep 4 - Sep 5
Hampton Inn St. Louis Southwest

Comfort Suites St Charles - St Louis

2.5 star property
8.4 out of 10, Very Good, (1008)
"Everything was great, clean, close to the places we were going too. "
The price is ¥14,741
¥16,941 total
includes taxes & fees
Aug 31 - Sep 1
Comfort Suites St Charles - St Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

Top Defiance Hotel Reviews

Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West. See all available top hotels, or vacation rentals in Defiance.

What's the top vacation rental in Defiance?

St. Charles 1860's Gem - Sleeps 6!: Visitors like this Defiance vacation home rental. It is located on a river and has a garden, a selection of books, and air-conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. See all vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

Where can I learn more about changing or cancelling my trip to Defiance?

For more information about changing or cancelling your trip to Defiance, head over to our customer service page.

Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?

Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.

What about the best place to stay near Chandler Hill Vineyards?

One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.

What are some accommodations with pools in Defiance?
What's the best place to stay near Lambert-St. Louis International Airport (STL)?

Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.

What's it like to stay in Defiance?

Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium, and Gateway Arch. In Defiance, there are 20 hotels and other accommodations to choose from. Find out more about Defiance.

What is there to see in Defiance?

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River, and Matson Hill Park Trailhead. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.

What's the seasonal weather like in Defiance?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.