Find hotels in Defiance, MO from ￥10,743

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Dec 13 - Dec 14
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Dec 14 - Dec 15
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Dec 19 - Dec 21
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Dec 26 - Dec 28

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Our top choices for Defiance hotels

Ballroom
The Wildwood Hotel

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1608)
"Great place!"
United States
Biju
The Wildwood Hotel
Lobby sitting area
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very Good, (1039)
"Everything was clean and friendly staff overall good experience "
United States
dennis
The price is ￥13,217
￥15,266 total
includes taxes & fees
Dec 28 - Dec 29
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Exterior
WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.8 out of 10, Exceptional, (17)
"The room was super clean and tidy. The staff was very friendly and overall a great experience. "
United States
Fred
The price is ￥11,506
￥13,226 total
includes taxes & fees
Jan 12 - Jan 13, 2026
WoodSpring Suites St Peters-OFallon
Lobby
Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport
2.5 star property
Maryland Heights
8.0 out of 10, Very Good, (1029)
"The room was great and the bed was very comfortable "
United States
Joyce
The price is ￥13,084
￥15,177 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Best Western Plus St. Louis West-Westport
Lobby
AC Hotel by Marriott St. Louis Chesterfield

AC Hotel by Marriott St. Louis Chesterfield

AC Hotel by Marriott St. Louis Chesterfield
3.5 star property
Chesterfield
9.2 out of 10, Wonderful, (237)
"Newer hotel, very clean, up to date and in nice area. "
United States
Johnny
The price is ￥18,541
￥21,505 total
includes taxes & fees
Dec 21 - Dec 22
AC Hotel by Marriott St. Louis Chesterfield
Property amenity
Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.4 out of 10, Good, (1000)
"Room very clean, most of staff helpful"
United States
Ranata
The price is ￥12,199
￥13,995 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Baymont by Wyndham Warrenton
Front of property
Sonesta ES Suites St. Louis - Chesterfield

Sonesta ES Suites St. Louis - Chesterfield

Sonesta ES Suites St. Louis - Chesterfield
3.0 star property
Chesterfield
8.0 out of 10, Very Good, (1029)
"Clean room,Friendly staff, Good location and Good Breakfast options"
United States
Micheal
The price is ￥13,528
￥15,691 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Sonesta ES Suites St. Louis - Chesterfield
Exterior
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very Good, (1007)
"Great staff, clean room. "
United States
Amanda
The price is ￥13,558
￥15,582 total
includes taxes & fees
Dec 28 - Dec 29
Hampton Inn St. Charles St. Peters
Lobby
Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
8.8 out of 10, Excellent, (1001)
"Nice breakfast, friendly staff"
United States
Damon
The price is ￥12,200
￥14,390 total
includes taxes & fees
Dec 15 - Dec 16
Sleep Inn & Suites O'Fallon MO - Technology Drive
Exterior
Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (833)
"The staff was so friendly and helpful! The hotel was exceptionally clean. Breakfast was very good with lots of variety!"
United States
Millie
The price is ￥12,932
￥15,253 total
includes taxes & fees
Dec 15 - Dec 16
Holiday Inn Express St. Louis West - O'Fallon by IHG
Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG
2.5 star property
Wentzville
9.4 out of 10, Exceptional, (836)
"Excellent location, very clean and comfortable, great hot breakfast, and amazing staff!"
United States
Shannon
The price is ￥17,139
￥20,565 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Lobby
Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles
2.0 star property
St. Peters
6.4 out of 10, (1000)
"Staff was very friendly. Room was kept clean."
United States
Sandra
The price is ￥9,933
￥11,419 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Days Inn by Wyndham St Peters/St Charles
Lobby
Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1002)
"The stay was perfect. Very clean, quiet and comfortable. The staff were very friendly and helpful. I will stay again. "
United States
holly
The price is ￥17,880
￥20,727 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Drury Plaza Hotel St. Louis St. Charles
Front of property - evening/night
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis
3.5 star property
Maryland Heights
8.4 out of 10, Very Good, (2218)
"Front staff was very friendly and very helpful. Check-in and check out was smooth and very easy. "
United States
James
The price is ￥16,325
￥21,305 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Hollywood Casino & Hotel St. Louis
Egyptian cotton sheets, premium bedding, pillowtop beds, desk
Best Western Plus Washington Hotel

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (635)
"One of our favorites! This hotel is very clean, breakfast is very good and the kids love the indoor pool."
United States
Debra
The price is ￥20,058
￥22,836 total
includes taxes & fees
Dec 21 - Dec 22
Best Western Plus Washington Hotel
Interior entrance
Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn
2.5 star property
St. Charles
5.8 out of 10, (1002)
"Nice staff, respectful."
United States
LaurenRenee
The price is ￥9,267
￥10,743 total
includes taxes & fees
Dec 21 - Dec 22
Americas Best Value Inn & Suites St. Louis, St. Charles Inn
Desk, blackout drapes, iron/ironing board, free cribs/infant beds
Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1111)
"The young lady that checked us in was very friendly and helpful."
United States
Wenona
The price is ￥12,291
￥14,196 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Wingate by Wyndham St. Louis/Fenton Route 66
In-room safe, desk, laptop workspace, blackout drapes
Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (621)
"Room was clean. Staff very helpful, accommodating. "
United States
Ranata
The price is ￥9,271
￥10,635 total
includes taxes & fees
Dec 22 - Dec 23
Super 8 by Wyndham Warrenton
Double Room, 2 Double Beds | In-room safe, laptop workspace, blackout drapes, iron/ironing board
Super 8 by Wyndham St. Clair MO

Super 8 by Wyndham St. Clair MO

Super 8 by Wyndham St. Clair MO
2.0 star property
St. Clair
7.2 out of 10, Good, (943)
"Was what I needed after a long drive."
United States
Michael
The price is ￥10,377
￥11,360 total
includes taxes & fees
Dec 19 - Dec 20
Super 8 by Wyndham St. Clair MO
Daily buffet breakfast (USD 12.95 per person)
Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield
3.0 star property
Chesterfield
8.2 out of 10, Very Good, (783)
"Just a really nice hotel tucked away from everything, but still close to get whereevre you need to go!"
United States
Roy
The price is ￥15,207
￥17,696 total
includes taxes & fees
Dec 21 - Dec 22
Hilton Garden Inn Chesterfield
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

You can enjoy a tasting or tour at Chandler Hill Vineyards during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.
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Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

Explore the great outdoors at August A. Busch Memorial Conservation Area, a lovely green space in Defiance. While in this family-friendly area, you can savor the top-notch restaurants.
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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent
"My friend and I stayed here for our annual Christmas shopping event in St. Charles. I would definitely stay here again. The staff was nice, and it is a really nice hotel."
Sara 1-night trip
Posted 2 days ago
Country Inn & Suites by Radisson, St. Charles Historic District

More cheap stays in Defiance

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

1310 Bass Pro Drive St. Charles MO
The price is ￥9,267 per night from Dec 21 to Dec 22
￥9,267
￥10,743 total
Dec 21 - Dec 22
includes taxes & fees
5.6/10 (1,003 reviews)

Frequently asked questions

What's the best place to stay in Defiance?
Ameristar Casino Resort and Spa, located 18.3 mi (29.5 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are The Wildwood Hotel and Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham. See all available top hotels, or vacation rentals in Defiance.
What's the top vacation rental in Defiance?
Stunning 1890's Home - Sleeps 8!: Visitors like this Defiance vacation home rental. It is equipped with a barbecue grill, air-conditioning, and laundry facilities to help you feel comfortable during your stay. It has 4 bedrooms as well as a kitchen with a dishwasher, a stovetop, and a microwave, so you can cook with friends or family. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
Where can I learn more about changing or cancelling my trip to Defiance?
For more information about changing or cancelling your trip to Defiance, head over to our customer service page.
Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?
Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.
What about the best place to stay near Chandler Hill Vineyards?
One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.
What are some accommodations with pools in Defiance?
Ameristar Casino Resort and Spa: Hotel steps from Ameristar Casino St. Charles. Features 6 restaurants, a seasonal outdoor pool, and a full-service spa. The Wildwood Hotel and Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.
What's the best place to stay near Lambert-St. Louis International Airport (STL)?
Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.
What's it like to stay in Defiance?
Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station and Gateway Arch. In Defiance, there are 20 hotels and other accommodations to choose from. Find out more about Defiance.
What is there to see in Defiance?
Natural beauty is on display at Matson Hill Park Trailhead, August A. Busch Memorial Conservation Area, and Missouri River. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.
What's the seasonal weather like in Defiance?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.

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