A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

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Oct 30 - Nov 1
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Nov 6 - Nov 8

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Our top choices for Defiance hotels

A hotel room with a bed, a sofa, a coffee table, and wall art.

1. Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,153 reviews)
"Rooms are very clean, the staff is friendly and the location is great. We enjoyed are stay."
United States
Matthew
The price is ļæ„13,196
ļæ„15,564 total
includes taxes & fees
Nov 1 - Nov 2
Sleep Inn & Suites O'Fallon MO - Technology Drive
A multi-story hotel with a mix of brick and siding exteriors, multiple windows, and a well-maintained lawn.

2. Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.4 out of 10, Very good, (1,000 reviews)
"This was a clean, safe and convenient place to stay while traveling through St. Louis."
United States
Greg
The price is ļæ„14,607
ļæ„17,230 total
includes taxes & fees
Nov 1 - Nov 2
Holiday Inn Express St. Louis West - O'Fallon by IHG
An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

3. TownePlace Suites by Marriott St. Louis Chesterfield

TownePlace Suites by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (335 reviews)
"Excellent 1 night stay. Clean and comfortable"
United States
Thomas
The price is ļæ„19,235
ļæ„22,577 total
includes taxes & fees
Nov 13 - Nov 14
TownePlace Suites by Marriott St. Louis Chesterfield
A hotel entrance with a stone facade, a wooden archway, and a paved walkway.

4. Staybridge Suites O'Fallon Chesterfield by IHG

Staybridge Suites O'Fallon Chesterfield by IHG
3.0 star property
O'Fallon
8.4 out of 10, Very good, (488 reviews)
"Everything was great. Rooms were clean, bedding comfortable, breakfast really good."
United States
Cheri
The price is ļæ„18,628
ļæ„21,972 total
includes taxes & fees
Nov 1 - Nov 2
Staybridge Suites O'Fallon Chesterfield by IHG
A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

5. The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,679 reviews)
"Clean, quiet, great continental breakfast, and close to several places to eat."
United States
Lori
The price is ļæ„12,928
ļæ„15,060 total
includes taxes & fees
Nov 16 - Nov 17
The Wildwood Hotel
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

6. Comfort Inn & Suites Chesterfield - St. Louis

Comfort Inn & Suites Chesterfield - St. Louis
2.5 star property
Chesterfield
7.8 out of 10, Good, (1,003 reviews)
"Mindy was very nice. Bed not so much, please keep a smoke detector in the room instead of taking it apart."
United States
Charissa
The price is ļæ„12,865
ļæ„15,521 total
includes taxes & fees
Nov 29 - Nov 30
Comfort Inn & Suites Chesterfield - St. Louis
A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

7. Residence Inn by Marriott O'Fallon

Residence Inn by Marriott O'Fallon
3.0 star property
O'Fallon
8.4 out of 10, Very good, (507 reviews)
"Beautiful room, very clean with nice staff"
United States
Rianna
The price is ļæ„19,235
ļæ„22,687 total
includes taxes & fees
Nov 21 - Nov 22
Residence Inn by Marriott O'Fallon
A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

8. Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO
3.0 star property
O'Fallon
8.8 out of 10, Excellent, (764 reviews)
"Everything you could need for an overnight or extended stay. Staff was extremely helpful, and the property is well-maintained."
United States
Duane
The price is ļæ„19,263
ļæ„22,841 total
includes taxes & fees
Nov 26 - Nov 27
Hilton Garden Inn St. Louis/O'Fallon MO
A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.

9. Hampton Inn & Suites St. Louis/Chesterfield

Hampton Inn & Suites St. Louis/Chesterfield
3.5 star property
Chesterfield
8.8 out of 10, Excellent, (917 reviews)
"Breakfast selection was good and staff was very helpful"
United States
Vijay
The price is ļæ„17,287
ļæ„20,116 total
includes taxes & fees
Nov 29 - Nov 30
Hampton Inn & Suites St. Louis/Chesterfield
A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

10. Hyatt Place St. Louis/Chesterfield

Hyatt Place St. Louis/Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (1,001 reviews)
"Very clean hotel."
United States
Debbie
The price is ļæ„21,915
ļæ„25,418 total
includes taxes & fees
Nov 1 - Nov 2
Hyatt Place St. Louis/Chesterfield
An outdoor patio area with wicker furniture and a central fire feature.

11. Courtyard by Marriott St. Louis Chesterfield

Courtyard by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.0 out of 10, Wonderful, (679 reviews)
"Love the location and most of the staff were very nice! The cafe/Starbucks was a little disappointing."
United States
Kelly
The price is ļæ„17,287
ļæ„20,115 total
includes taxes & fees
Nov 19 - Nov 20
Courtyard by Marriott St. Louis Chesterfield
A modern dining area with a long table and chairs, a flat-screen TV mounted on the wall, and a wooden ceiling.

12. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
2.5 star property
Chesterfield
9.0 out of 10, Wonderful, (1,000 reviews)
"Clean room and very helpful staff!"
United States
Keith
The price is ļæ„16,870
ļæ„19,631 total
includes taxes & fees
Nov 29 - Nov 30
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.

13. Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (412 reviews)
"Great hotel and Breakfast is nothing special but it makes sense for the price you pay."
United States
Chantelle
The price is ļæ„13,339
ļæ„15,269 total
includes taxes & fees
Nov 10 - Nov 11
Quality Inn Near Six Flags St. Louis
A spacious lobby with a central round table, two sofas, and a chandelier.

14. Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
3.0 star property
Chesterfield
9.6 out of 10, Exceptional, (1,307 reviews)
"Great stay. Food was great. Location is great. Will stay again."
United States
Sara
The price is ļæ„20,494
ļæ„23,771 total
includes taxes & fees
Nov 9 - Nov 10
Drury Plaza Hotel St. Louis Chesterfield
A spacious lobby with a grand staircase, a fireplace, and comfortable seating areas.

15. Holiday Inn St. Louis West Six Flags by IHG

Holiday Inn St. Louis West Six Flags by IHG
3.0 star property
Eureka
9.0 out of 10, Wonderful, (1,000 reviews)
"Great hotel!"
United States
Rob
The price is ļæ„19,865
ļæ„23,139 total
includes taxes & fees
Nov 30 - Dec 1
Holiday Inn St. Louis West Six Flags by IHG
An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

16. Comfort Inn Near Six Flags St. Louis

Comfort Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very good, (1,010 reviews)
"The breakfast was mediocre and there was road noise but other than that, it was a nice stay."
United States
Scott
The price is ļæ„14,018
ļæ„16,047 total
includes taxes & fees
Nov 30 - Dec 1
Comfort Inn Near Six Flags St. Louis
An outdoor patio with a built-in grill, seating area, and stone walls.

17. Residence Inn by Marriott St. Louis Chesterfield

Residence Inn by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.8 out of 10, Exceptional, (258 reviews)
"Would stay here again!"
United States
Chelsea
The price is ļæ„29,798
ļæ„34,859 total
includes taxes & fees
Nov 10 - Nov 11
Residence Inn by Marriott St. Louis Chesterfield
A modern living room with a stone fireplace, a large window, and a seating area with a coffee table.

18. Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville
3.0 star property
Wentzville
9.0 out of 10, Wonderful, (725 reviews)
"Very nice place to stay"
United States
Lindsey
The price is ļæ„20,887
ļæ„23,906 total
includes taxes & fees
Nov 29 - Nov 30
Fairfield Inn & Suites Wentzville
A spacious hotel lobby with a long reception desk, multiple seating areas, and large windows allowing natural light.

19. Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (742 reviews)
"Great hotel!"
United States
Jill
The price is ļæ„22,653
ļæ„25,699 total
includes taxes & fees
Nov 29 - Nov 30
Hampton Inn St. Louis Wentzville
A large hotel with a prominent tower and multiple parking areas.

20. Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis
3.5 star property
Riverport
8.6 out of 10, Excellent, (2,243 reviews)
"The stay was great."
United States
Nicole
The price is ļæ„14,894
ļæ„19,812 total
includes taxes & fees
Nov 18 - Nov 19
Hollywood Casino & Hotel St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

A glass of red wine on a wooden table with a vineyard in the background.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

7.8/10 (7 reviews)
This elegant Missouri winery showcases local and California wines from its hillside setting. Savor varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
See properties

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Top Defiance Hotel Reviews

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent
"Wonderful place to stay & within walking distance to Main Street"
Sue 1-night trip
Posted 10 hours ago
Country Inn & Suites by Radisson, St. Charles Historic District

More cheap stays in Defiance

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

1970 Craig Rd Maryland Heights MO
The price is ļæ„9,381 per night from Nov 4 to Nov 5
ļæ„9,381
ļæ„10,880 total
Nov 4 - Nov 5
includes taxes & fees

Frequently asked questions

What's the best place to stay in Defiance?
Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Sonesta ES Suites St. Louis - Chesterfield and Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham. See all available top hotels, or vacation rentals in Defiance.
What's the top vacation rental in Defiance?
HotTub-2br2b-near Historic Main Street: Visitors like this Defiance vacation home rental. It offers a patio, a garden, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. Make the most of the hot tub in this rental home to help you unwind. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
Where can I learn more about changing or cancelling my trip to Defiance?
For more information about changing or cancelling your trip to Defiance, head over to our customer service page.
Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?
Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.
What about the best place to stay near Chandler Hill Vineyards?
One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.
What are some accommodations with pools in Defiance?
Sonesta ES Suites St. Louis - Chesterfield: Offers daily, a seasonal outdoor pool, and free self parking. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Ameristar Casino Resort and Spa are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.
What's the best place to stay near Lambert-St. Louis International Airport (STL)?
Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.
What's it like to stay in Defiance?
Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station and St. Louis Zoo. In Defiance, there are 19 hotels and other accommodations to choose from. Find out more about Defiance.
What is there to see in Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River, and Matson Hill Park Trailhead. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.
What's the seasonal weather like in Defiance?
The hottest months are usually July and August with an average temp of 76Ā°F, while the coldest months are January and February with an average of 38Ā°F. Average annual precipitation for Defiance is 48 inches.

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