Defiance Vacations
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ￥109,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Find the Best Defiance Vacation Packages
Defiance Hotel Deals
Hollywood Casino & Hotel St. Louis
777 Casino Center Drive Maryland Heights MO
Fully refundableReserve now, pay when you stay
￥14,566
￥21,717 total
Aug 27 - Aug 28
includes taxes & fees
8.6/10 Excellent! (2,249 reviews)
"Stayed at the property for a concert. The shuttle service from the hotel to the venue was convenient. Casino was large and not very crowded for a Sunday night. Room was clean and functional. We would stay here for another concert/casino overnight."
Reviewed on Aug 24, 2026
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
￥14,996
￥17,319 total
Aug 26 - Aug 27
includes taxes & fees
Ameristar Casino Resort and Spa
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay
￥25,305
￥32,210 total
Sep 7 - Sep 8
includes taxes & fees
8.6/10 Excellent! (1,043 reviews)
"Great location and atmosphere! Rooms are so spacious and nice. Will definitely stay again!"
Reviewed on Aug 23, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Defiance attractions
August A. Busch Memorial Conservation Area
8.6/10 (7 reviews)
This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.
Photo by Pages of Travel
Chandler Hill Vineyards
7.8/10 (7 reviews)
This elegant Missouri winery showcases local and California wines from its hillside setting. Savor varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
Historic Daniel Boone Home and Heritage Center
9.6/10 (4 reviews)
Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life.
Sugar Creek Winery
8.0/10 (1 review)
Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views.
Yellow Farmhouse Winery
This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views.
Matson Hill Park Trailhead
Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendor.
Broemmelsiek Park
This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience.
Hamburg Trail Trailhead
This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields.
What to do in Defiance
Private Tour of St. Louis's Iconic BBQ Joints & Breweries
￥20,590
per adult
StL's Signature "Sights and Bites" - Private Tour in St. Louis
￥27,932
per adult
St. Louis Ghost Tour: Sinister Sins & Shadows
￥3,831
per adult
100% of travellers recommend
Frequently asked questions
How much does a Defiance vacation package cost?
You can grab a vacation package to this popular destination on Expedia. However, how much your vacation to Defiance costs will depend on factors like the season, hotel choice and length of stay.
What are the cheapest months to go to Defiance?
Plan your getaway for the shoulder or low season and you're likely to find cheap Defiance vacation packages. Remember that public holidays and major local events can have an impact on prices, so do a little research before booking.
How many days is enough for Defiance?
With a well-planned schedule, you can easily tick off the main Defiance attractions in a few days. But if you want to explore off the beaten track or go on day trips, consider booking your Defiance vacation for longer.
How to find the best Defiance package deals?
Use Expedia's filters to find some terrific Defiance package deals. When you begin your search, simply set your maximum budget and then sort the results by "Price: low to high." If you're looking to save, plan your trip for midweek, or search for Defiance package deals in the off-season. Switch up your travel dates and you may land even bigger discounts. As a rule of thumb, it's typically best to book your vacation package well in advance.
Is it cheaper to book a Defiance vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your hotel, car rental and flight into one great-value price and you could save hundreds of dollars. You'll usually land a better deal than booking each component separately. And you'll still enjoy the flexibility to create a customized Defiance vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Defiance?
If you have your Defiance vacation dates locked in, book as soon as you can to snap up some awesome deals. With Expedia, you can generally reserve some flights up to one year ahead of time. Prefer spontaneous getaways? Our last-minute deals are perfect for quick escapes.
How to plan a trip to Defiance?
- Choose your dates: The things you'd like to do in Defiance and your favorite season can help you decide when to get away.
- Plan your budget wisely: In addition to the cost of your hotel, you'll need to factor in other expenses too. These include transportation, food and flights. Also, set aside some extra funds for unexpected costs that could crop up during your trip to Defiance.
- Decide how long to go away for: Now that you know more about Defiance, you can figure out the perfect length of your vacation. Create a draft itinerary and allocate enough time for all the things you want to do.
- Combine your airfare and accommodations: Once you've nailed down your travel dates and duration, lock in the right Defiance vacation package for you.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
