A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Defiance Vacation Rentals

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Check prices for these dates

In two weeks
Sep 18 - Sep 20
In two months
Oct 30 - Nov 1
In three months
Nov 27 - Nov 29
In four months
Dec 25 - Dec 27

Our top choices for Defiance vacation rentals

Dining

1. Lots of Space! Central to St Charles and STL. Newly Remodeled. Large Backyard!

Lots of Space! Central to St Charles and STL. Newly Remodeled. Large Backyard!
Pinehurst
8.6 out of 10, Excellent, (36 reviews)
"Great place with lots of space great area host is great!"
United States
Jacob L.
The price is ￥39,190
￥122,328 total
includes taxes & fees
Sep 10 - Sep 11
Lots of Space! Central to St Charles and STL. Newly Remodeled. Large Backyard!
Room

2. 1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed

1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed
Westport
9.6 out of 10, Exceptional, (41 reviews)
"Great spot!"
United States
Anonymous traveler
The price is ￥9,855
￥11,430 total
includes taxes & fees
Sep 14 - Sep 15
1 Queen Bed | Non-Smoking, Kitchen, Sofa-Bed
Dining

3. Great for Business Travelers! Comfortable Suite in St. Louis | BBQ Area

Great for Business Travelers! Comfortable Suite in St. Louis | BBQ Area
Westport
10.0 out of 10, Exceptional, (5 reviews)
"Everything from the staff to the amenities to the rooms were amazing! Definitely recommend staying here! "
Canada
Lashon C.
The price is ￥33,607
￥44,136 total
includes taxes & fees
Sep 13 - Sep 14
Great for Business Travelers! Comfortable Suite in St. Louis | BBQ Area
Living area

4. Historic Main St 2BR | Steps to Shops

Historic Main St 2BR | Steps to Shops
St. Charles Historic District
9.4 out of 10, Exceptional, (42 reviews)
"This property has a nice renovation while keeping a lot of its original character. Very clean and comfortable beds as well. The location couldn’t be better! We really enjoyed our stay."
United States
William O.
The price is ￥17,214
￥59,103 total
includes taxes & fees
Sep 9 - Sep 10
Historic Main St 2BR | Steps to Shops
Living area

5. Prime Loft of Main Street

Prime Loft of Main Street
St. Charles Historic District
9.8 out of 10, Exceptional, (116 reviews)
"Host was great. The cutest place in the perfect spot! "
United States
Anonymous traveler
The price is ￥19,548
￥40,659 total
includes taxes & fees
Sep 8 - Sep 9
Prime Loft of Main Street
Interior

6. The Lofts of North Main Street

The Lofts of North Main Street
St. Charles Historic District
9.6 out of 10, Exceptional, (189 reviews)
"It was great! Clean and great communication with host."
United States
Natalie H.
The price is ￥19,548
￥40,659 total
includes taxes & fees
Sep 8 - Sep 9
The Lofts of North Main Street
Interior

7. Amazing Renovated Historic Loft on Main Street

Amazing Renovated Historic Loft on Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (68 reviews)
"Lovely accommodations, very clean, well equipped, great location. "
United States
Emily B.
The price is ￥19,548
￥40,659 total
includes taxes & fees
Sep 8 - Sep 9
Amazing Renovated Historic Loft on Main Street
Exterior

8. Historic Main Street Studio | Dog-Friendly

Historic Main Street Studio | Dog-Friendly
St. Charles Historic District
9.2 out of 10, Wonderful, (37 reviews)
"Had a wonderful stay. It was a Monday night so parking was very easy and the room was clean and comfortable. I would recommend this place 100% "
United States
Sarah C.
The price is ￥13,501
￥32,244 total
includes taxes & fees
Sep 13 - Sep 14
Historic Main Street Studio | Dog-Friendly
Living area

9. Main Street 2BR Apartment with Garage and Deck

Main Street 2BR Apartment with Garage and Deck
St. Charles Historic District
9.4 out of 10, Exceptional, (21 reviews)
"We loved our stay for Memorial Day weekend! It was the perfect space to unwind after a day of walking around historic Saint Charles. Our favorite spot was the back deck. Having the garage was so convenient and the space itself is really beautiful. The only thing we wish we had prepared for was a lack of basic kitchen cooking items. We bought breakfast food to cook but did not think to bring cooking oil/s&p. Would love to stay again sometime! We had a great weekend."
United States
Jennifer M.
The price is ￥21,095
￥47,486 total
includes taxes & fees
Sep 15 - Sep 16
Main Street 2BR Apartment with Garage and Deck
Private kitchen

10. Historic 1908 Frenchtown Home

Historic 1908 Frenchtown Home
St. Charles Historic District
8.8 out of 10, Excellent, (26 reviews)
"Kitchen has a Kurig so be sure to get pods.The house is functional as a historic property but we really only used it as a place to sleep while in town for work. Getting ready with 3 people and one bath was slightly difficult as the bedroom didn't have a mirror so everyone required the bathroom, but the beds were comfy.It is a nice part of town, near the college and on a quiet one way street."
United States
Megan B.
The price is ￥21,095
￥49,572 total
includes taxes & fees
Sep 9 - Sep 10
Historic 1908 Frenchtown Home
Property grounds

11. Driftwood Den | Boho 2BR | Dog-Friendly

Driftwood Den | Boho 2BR | Dog-Friendly
St. Charles Historic District
10.0 out of 10, Exceptional, (6 reviews)
"Loved our stay here. Clean, comfortable, convenient. Couldn’t have been easier, in all aspects. Already plan to stay there again!!!"
United States
Kourtney S.
The price is ￥21,564
￥52,455 total
includes taxes & fees
Sep 9 - Sep 10
Driftwood Den | Boho 2BR | Dog-Friendly
Exterior

12. HotTub-2br2b-near Historic Main Street

HotTub-2br2b-near Historic Main Street
St. Charles Historic District
10.0 out of 10, Exceptional, (19 reviews)
"Comfy beds, great location!"
United States
Jessie W.
The price is ￥23,064
￥46,766 total
includes taxes & fees
Sep 8 - Sep 9
HotTub-2br2b-near Historic Main Street
Private kitchen

13. Historic 1805 Main Street 2BR

Historic 1805 Main Street 2BR
St. Charles Historic District
9.6 out of 10, Exceptional, (42 reviews)
"The location is excellent. "
United States
McRay H.
The price is ￥23,439
￥59,293 total
includes taxes & fees
Sep 20 - Sep 21
Historic 1805 Main Street 2BR
Private kitchen

14. Historic Main St. Customs House Upstairs Apartment

Historic Main St. Customs House Upstairs Apartment
St. Charles Historic District
9.6 out of 10, Exceptional, (39 reviews)
"Lovely place to stay!"
United States
Margaret A.
The price is ￥21,095
￥56,280 total
includes taxes & fees
Sep 9 - Sep 10
Historic Main St. Customs House Upstairs Apartment
Private kitchen

15. Home Near Main Street-Covered Patio-Hot Tub!

Home Near Main Street-Covered Patio-Hot Tub!
Saint Charles
9.6 out of 10, Exceptional, (39 reviews)
"Great house and great location"
United States
Mike L.
The price is ￥30,080
￥105,555 total
includes taxes & fees
Sep 8 - Sep 9
Home Near Main Street-Covered Patio-Hot Tub!
Room

16. Walk to Main | Pet-Friendly Yard & Workspace

Walk to Main | Pet-Friendly Yard & Workspace
St. Charles Historic District
10.0 out of 10, Exceptional, (11 reviews)
"I will stay here again. It was a great location for my visit. Lots of room and amenities. Highly recommend this location if you are visiting the St Louis area. Barely a mile to get to Hwy 70, so easy access to St Louis, St Peter's, Wentzville etc. Maybe two blocks from Historic St Charles and Ameristar Casino."
United States
Karen M.
The price is ￥19,914
￥43,190 total
includes taxes & fees
Sep 9 - Sep 10
Walk to Main | Pet-Friendly Yard & Workspace
Private kitchen

17. Pet-Friendly Duplex | Historic Main

Pet-Friendly Duplex | Historic Main
St. Charles Historic District
10.0 out of 10, Exceptional, (25 reviews)
"Great location"
United States
todd p.
The price is ￥21,095
￥43,148 total
includes taxes & fees
Sep 9 - Sep 10
Pet-Friendly Duplex | Historic Main
Living area

18. Cottage on Historic Main Street- Low Cleaning fee

Cottage on Historic Main Street- Low Cleaning fee
St. Charles Historic District
10.0 out of 10, Exceptional, (23 reviews)
"Great location to Main Street. "
United States
Daneen H.
The price is ￥20,783
￥48,677 total
includes taxes & fees
Sep 8 - Sep 9
Cottage on Historic Main Street- Low Cleaning fee
Interior

19. Cottage on Main st- Low Cleaning Fee

Cottage on Main st- Low Cleaning Fee
St. Charles Historic District
10.0 out of 10, Exceptional, (10 reviews)
"Good location. Decorated very nicely. "
United States
Debbie A.
The price is ￥20,040
￥47,876 total
includes taxes & fees
Sep 20 - Sep 21
Cottage on Main st- Low Cleaning Fee
Living area

20. Music House · Music House on Main Street at The Wine Garden

Music House · Music House on Main Street at The Wine Garden
Saint Charles
9.4 out of 10, Exceptional, (18 reviews)
"Nice area nice place and communication"
United States
Zack P.
The price is ￥46,722
￥99,360 total
includes taxes & fees
Sep 13 - Sep 14
Music House · Music House on Main Street at The Wine Garden
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

10/10 Excellent
"Good stay, will book there again!"
Cathy 1-night trip
Posted 4 hours ago
Sleep Inn & Suites O'Fallon MO - Technology Drive

Find out more about Defiance

Search for holiday rentals in Defiance on Expedia! You can easily find your home rentals, villas, holiday apartments in Defiance using one of the methods below:

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Look no further and take a look at our great range of rental properties in Defiance!

Frequently asked questions

Can I find vacation rentals in Defiance?

Yes, there are vacation rentals close to popular sights in Defiance, or you can choose a more secluded option if you're looking for relaxation. Defiance is known for its wineries and parks.

What are some of the best vacation home rentals that Defiance has to offer?

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!: This vacation home rental outside of Defiance is equipped with a barbecue grill, air-conditioning, and laundry facilities to help you feel comfortable during your stay. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

How many vacation rentals will I find in Defiance?

With 3 Expedia vacation rentals, you're sure to find just the right place for your Defiance stay.

What’s there to see and do in Defiance?

August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Chandler Hill Vineyards and Sugar Creek Winery.

What’s a vacation rental in Defiance like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Defiance. Vacation rentals feature amenities like laundry facilities and kitchens so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of security away from shared hotel elevators and busy front desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great option for families.