Defiance Vacation Rentals

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Check prices for these dates

Tonight
Dec 2 - Dec 3
Tomorrow
Dec 3 - Dec 4
This weekend
Dec 5 - Dec 7
Next weekend
Dec 12 - Dec 14

Vacation Rentals in Defiance

Microwave, oven, stovetop, dishwasher
Stunning 1890's Home - Sleeps 8!

Vacation Home in St. Charles Historic District

10.0 out of 10, Exceptional, (95)
"Check-in was easy and the house was lovely "
United States
Delfino A.
The price is ￥15,712
￥44,809 total
includes taxes & fees
Dec 3 - Dec 4
Stunning 1890's Home - Sleeps 8!
Outdoor dining
The St. Charles Guest House, lovely historic home, fun for families and groups

Vacation Home in St. Charles Historic District

10.0 out of 10, Exceptional, (136)
"We loved staying here in this adorable clean house that was only 1 block off of downtown Main Street shopping. "
United States
Lisa S.
The St. Charles Guest House, lovely historic home, fun for families and groups
Exterior
Cozy Cottage, we're told it's heavenly!

Cabin in Marthasville

10.0 out of 10, Exceptional, (209)
"Wonderful as always….i come every few months and it is like my home away from home"
United States
Melissa F.
Cozy Cottage, we're told it's heavenly!
Studio Suite, 1 King Bed | Desk, laptop workspace, blackout drapes, WiFi
Value Suites Extended Stay - St Louis

Aparthotel in Maryland Heights

3.0 star property
7.0 out of 10, Good, (1110)
"We’ve stayed here twice before and have always been pleased with everything. Very good hotel close to what we need."
United States
Timothy
The price is ￥59,464
￥81,724 total
includes taxes & fees
Dec 3 - Dec 4
Value Suites Extended Stay - St Louis
Outdoor dining
Honky Tonk Hideaway

Vacation Home in St. Charles Historic District

8.8 out of 10, Excellent, (12)
"Great location close to historic district."
United States
Hugh S.
The price is ￥19,289
￥52,062 total
includes taxes & fees
Dec 25 - Dec 26
Honky Tonk Hideaway
Fridge, microwave, oven, stovetop
St. Charles 1860's Gem - Sleeps 6!

Vacation Home in St. Charles Historic District

9.8 out of 10, Exceptional, (132)
"This was such a cute historical home and was perfect for our weekend in St Charles!"
United States
Isabelle C.
The price is ￥19,445
￥39,512 total
includes taxes & fees
Dec 3 - Dec 4
St. Charles 1860's Gem - Sleeps 6!
Smart TV
Cozy Clark Suite in Frenchtown Saint Charles

Apartment in St. Charles Historic District

9.6 out of 10, Exceptional, (13)
"Awesome place to stay"
United States
paul
Cozy Clark Suite in Frenchtown Saint Charles
Exterior
Authentic Log cabin with something for everyone!

Cabin in Marthasville

9.6 out of 10, Exceptional, (377)
"Very beautiful place to stay. We really enjoyed the lake. "
United States
Kristi W.
Authentic Log cabin with something for everyone!
Outdoor dining
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!

Cottage in St. Charles Historic District

10.0 out of 10, Exceptional, (210)
"Nice view of the Mississippi in the morning. Just off of the main street in old town St Charles, this place was perfect for our needs."
United States
Ralph
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
Fridge, microwave, oven, stovetop
New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!

Vacation Home in St. Charles Historic District

9.8 out of 10, Exceptional, (60)
"We had a great weekend and enjoyed the house very much! We had everything we needed!"
United States
Laurie S.
The price is ￥25,667
￥65,374 total
includes taxes & fees
Dec 3 - Dec 4
New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!
2 bedrooms, desk, iron/ironing board, free WiFi
The Otter Suite at Divine Otter

Aparthotel in St. Charles Historic District

9.0 out of 10, Wonderful, (6)
"We absolutely loved this place! I would recommend this place. We had one issue but it was resolved. If you have children, I would probably stay somewhere else. There are bars all around and gets loud at night but it does get really quiet after 1:30 a.m. The property manager was absolutely amazing and is very quick to respond to your needs. "
United States
kim F.
The Otter Suite at Divine Otter
Fridge, microwave, oven, stovetop
Home Near Main Street-Covered Patio-Hot Tub!

Vacation Home in Saint Charles

9.8 out of 10, Exceptional, (26)
"The place was great! "
United States
Melissa I.
The price is ￥33,368
￥74,394 total
includes taxes & fees
Dec 3 - Dec 4
Home Near Main Street-Covered Patio-Hot Tub!
Property grounds
The Hare Suite at Divine Otter

Aparthotel in St. Charles Historic District

9.6 out of 10, Exceptional, (14)
"We really enjoyed our stay! The Hare was an amazing suite & the location was great!"
United States
Angela R.
The Hare Suite at Divine Otter
Interior
Charming open 4bd and screen-in porch! Sleeps 10!

Vacation Home in Saint Charles

9.2 out of 10, Wonderful, (31)
"House and yard were great! Loved the location."
United States
Jennifer P.
Charming open 4bd and screen-in porch! Sleeps 10!
Interior
Residence on the Roundabout

Vacation Home in St Charles

9.4 out of 10, Exceptional, (143)
"House was very nice. Pictures were good and we knew what to expect. Location was great for where we wanted to go.Owner was punctual when we had any questions!"
United States
Anne L.
Residence on the Roundabout
2 bedrooms, desk, iron/ironing board, travel crib
Madison House 1 -Walk to Main St

Vacation Home in St. Charles Historic District

8.6 out of 10, Excellent, (14)
"The house was clean and well stocked, location was great, and plenty of street parking. "
United States
Brad K.
The price is ￥15,400
￥39,334 total
includes taxes & fees
Dec 14 - Dec 15
Madison House 1 -Walk to Main St
Outdoor dining
Cowboy Cabin, come sit under the trees

Cabin in Marthasville

10.0 out of 10, Exceptional, (208)
"We loved our stay"
United States
Kinya R.
Cowboy Cabin, come sit under the trees
Smart TV
Prime Loft of Main Street

Apartment in St. Charles Historic District

9.8 out of 10, Exceptional, (100)
"The loft was very nice, very clean, well appointed, and in a perfect location. I highly recommend this property!"
United States
Mary ann S.
The price is ￥19,461
￥40,505 total
includes taxes & fees
Dec 7 - Dec 8
Prime Loft of Main Street
Fridge, microwave, oven, stovetop
Peaceful chalet - *new* private beach, WIFI, kayaks

Chalet in Innsbrook

10.0 out of 10, Exceptional, (77)
"Exceeded expectations, beautiful home and very clean. The outdoor property did not disappoint. We will book again in the near future! "
United States
Paul L.
Peaceful chalet - *new* private beach, WIFI, kayaks
Property grounds
Charming 4-bedroom chalet with lake access in enchanting Innsbrook.

Chalet in Innsbrook

10.0 out of 10, Exceptional, (11)
"The property was beautiful. Loved taking my morning coffee down to the dock each morning. "
United States
Andy Y.
Charming 4-bedroom chalet with lake access in enchanting Innsbrook.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

The Wildwood Hotel

The Wildwood Hotel

10/10 Excellent
"The hotel was amazing from the staff to the rooms. Great location as well. Definitely recommend this place if traveling! "
Brandi 1-night trip
Posted 16 hours ago
The Wildwood Hotel

Find out more about Defiance

Search for holiday rentals in Defiance on Expedia! You can easily find your home rentals, villas, holiday apartments in Defiance using one of the methods below:

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Look no further and take a look at our great range of rental properties in Defiance!

Frequently asked questions

Can I find vacation rentals in Defiance?

Yes, there are vacation rentals close to popular sights in Defiance, or you can choose a more secluded option if you're looking for relaxation. Defiance is known for its wineries and parks.

What are some of the best vacation home rentals that Defiance has to offer?

Stunning 1890's Home - Sleeps 8! : This vacation home rental outside of Defiance is equipped with a barbecue grill, air-conditioning, and laundry facilities to help you feel comfortable during your stay. It has 4 bedrooms as well as a kitchen with a dishwasher, a stovetop, and a microwave, so you can cook with friends or family.

How many vacation rentals will I find in Defiance?

With 4 Expedia vacation rentals, you're sure to find just the right place for your Defiance stay.

What’s there to see and do in Defiance?

Matson Hill Park Trailhead and August A. Busch Memorial Conservation Area are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Yellow Farmhouse Winery and Chandler Hill Vineyards.

What’s a vacation rental in Defiance like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Defiance. Vacation rentals feature amenities like laundry facilities and kitchens so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of security away from shared hotel elevators and busy front desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great option for families.