Defiance Vacation Rentals

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Check prices for these dates

Tonight
Oct 9 - Oct 10
Tomorrow
Oct 10 - Oct 11
This weekend
Oct 10 - Oct 12
Next weekend
Oct 17 - Oct 19

Vacation Rentals in Defiance

St. Charles 1860's Gem - Sleeps 6!
Fridge, microwave, oven, stovetop

St. Charles 1860's Gem - Sleeps 6!

9.8 out of 10, Exceptional, (126)
"Perfect place to stay while we were in town for a show! "
The price is ￥19,066
￥38,742 total
includes taxes & fees
Oct 12 - Oct 13
St. Charles 1860's Gem - Sleeps 6!
Residence on the Roundabout
Interior

Residence on the Roundabout

9.4 out of 10, Exceptional, (138)
"Very clean. Comfortable couch/beds"
Residence on the Roundabout
The St. Charles Guest House, lovely historic home, fun for families and groups
Outdoor dining

The St. Charles Guest House, lovely historic home, fun for families and groups

10.0 out of 10, Exceptional, (133)
"We loved staying here in this adorable clean house that was only 1 block off of downtown Main Street shopping. "
The St. Charles Guest House, lovely historic home, fun for families and groups
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway
Dining

Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

9.6 out of 10, Exceptional, (51)
"This place was perfect for our visit to St Charles. We'll definitely book it again the next time we come to visit family"
The price is ￥21,827
￥52,180 total
includes taxes & fees
Oct 12 - Oct 13
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway
Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!
Terrace/patio

Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!

10.0 out of 10, Exceptional, (39)
"The perfect place for our family reunion. Something for everyone….pool, basketball hoop, swing set, hot tub, fire pit and a huge yard for the kiddos to run around. "
The price is ￥78,705
￥137,177 total
includes taxes & fees
Oct 13 - Oct 14
Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!
Madison House 1 -Walk to Main St
2 bedrooms, desk, iron/ironing board, travel crib

Madison House 1 -Walk to Main St

8.8 out of 10, Excellent, (13)
"Comfortable place to stay easy to find location close to everything in St Charles"
The price is ￥13,575
￥35,915 total
includes taxes & fees
Oct 12 - Oct 13
Madison House 1 -Walk to Main St
Cozy Clark Suite in Frenchtown Saint Charles
Smart TV

Cozy Clark Suite in Frenchtown Saint Charles

9.4 out of 10, Exceptional, (9)
"Perfect for a couple. Well maintained. "
Cozy Clark Suite in Frenchtown Saint Charles
St. Charles, MO house with Private Patio
Fridge, microwave, oven, stovetop

St. Charles, MO house with Private Patio

8.8 out of 10, Excellent, (17)
"The responsive of our host was incredible!!We anticipate staying here again!! The location is great. And the neighbors are great.!"
The price is ￥23,063
￥53,828 total
includes taxes & fees
Oct 13 - Oct 14
St. Charles, MO house with Private Patio
Prime Loft of Main Street
Smart TV

Prime Loft of Main Street

9.8 out of 10, Exceptional, (99)
"This is a great property located in wiyhin walking distance to shops restaurants and interesting things to see"
The price is ￥17,709
￥37,695 total
includes taxes & fees
Oct 19 - Oct 20
Prime Loft of Main Street
Stunning 1890's Home - Sleeps 8!
Microwave, oven, stovetop, dishwasher

Stunning 1890's Home - Sleeps 8!

10.0 out of 10, Exceptional, (82)
"We loved this beautiful property. The host was great at communicating with us and took care of everything we needed to accommodate my family. We will be booking this property for our next stay!"
The price is ￥29,743
￥61,431 total
includes taxes & fees
Oct 15 - Oct 16
Stunning 1890's Home - Sleeps 8!
Victorian Gem Steps from Main St – Sleeps 9 & Pets
Fridge, microwave, oven, stovetop

Victorian Gem Steps from Main St – Sleeps 9 & Pets

9.8 out of 10, Exceptional, (17)
"Great location and accommodation for a business trip with some colleagues. Easy to check in and find everything we needed! Super cute and cozy!"
The price is ￥32,641
￥101,545 total
includes taxes & fees
Oct 19 - Oct 20
Victorian Gem Steps from Main St – Sleeps 9 & Pets
Cozy vacation home just 20 minutes from Six Flags St. Louis
Interior

Cozy vacation home just 20 minutes from Six Flags St. Louis

8.2 out of 10, Very Good, (48)
"Very cool house with unique designs! The road right before the house was a little washed out so our small car was a little tricky but a truck or SUV would be fine! "
Cozy vacation home just 20 minutes from Six Flags St. Louis
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
Outdoor dining

1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!

10.0 out of 10, Exceptional, (209)
"The riverside guest house was a perfect find for our two day getaway. Would definitely stay again. Perfect location. "
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
Cozy Cottage, we're told it's heavenly!
Exterior

Cozy Cottage, we're told it's heavenly!

10.0 out of 10, Exceptional, (204)
"The cabin was so cute and the grounds are beautiful! Very peaceful and charming. Enjoyed our day at a nearby winery. Would definitely stay again! "
Cozy Cottage, we're told it's heavenly!
Honky Tonk Hideaway
Outdoor dining

Honky Tonk Hideaway

9.4 out of 10, Exceptional, (8)
"Great place to stay"
Honky Tonk Hideaway
New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!
Fridge, microwave, oven, stovetop

New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!

9.8 out of 10, Exceptional, (59)
"We enjoyed the roomy house and proximity to riverfront area."
The price is ￥27,852
￥67,835 total
includes taxes & fees
Oct 14 - Oct 15
New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!
Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!
3 bedrooms, WiFi, bed sheets

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

9.6 out of 10, Exceptional, (68)
"Comfy beds, plenty of towels, good location."
Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!
Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort
Outdoor spa tub

Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort

10.0 out of 10, Exceptional, (66)
"We had a lovely lake weekend getaway - Mandy (the owner) was so responsive and helpful. The chalet is lovely and perfectly situated on a private small lake. Our girls loved every moment of water activities."
Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort
Escape the city to quiet and picturesque Golden Eagle, IL..
Dining

Escape the city to quiet and picturesque Golden Eagle, IL..

10.0 out of 10, Exceptional, (358)
"Loved the property. It was beautiful and peaceful. A great place for total relaxation. Hosts respond quickly to messages."
Escape the city to quiet and picturesque Golden Eagle, IL..
Historic 4‑BR Farmhouse • Steps to Main Street
Fridge, microwave, oven, stovetop

Historic 4‑BR Farmhouse • Steps to Main Street

10.0 out of 10, Exceptional, (15)
"Absolutely loved the home and it truly is right in the middle of everything.. "
The price is ￥22,880
￥83,334 total
includes taxes & fees
Oct 12 - Oct 13
Historic 4‑BR Farmhouse • Steps to Main Street
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

10/10 Excellent
"Friendly staff, clean facility!"
Kelly 1-night trip
Posted 22 hours ago
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Find out more about Defiance

Find out more about Defiance

Search for holiday rentals in Defiance on Expedia! You can easily find your home rentals, villas, holiday apartments in Defiance using one of the methods below:

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Look no further and take a look at our great range of rental properties in Defiance!

Frequently asked questions

Can I find vacation rentals in Defiance?

Yes, there are vacation rentals close to popular sights in Defiance, or you can choose a more secluded option if you're looking for relaxation. Defiance is known for its wineries and parks.

What are some of the best vacation home rentals that Defiance has to offer?

St. Charles 1860's Gem - Sleeps 6!: This vacation home rental outside of Defiance is located on a river and has a garden, a selection of books, and air-conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop.

How many vacation rentals will I find in Defiance?

With 4 Expedia vacation rentals, you're sure to find just the right place for your Defiance stay.

What’s there to see and do in Defiance?

August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Yellow Farmhouse Winery and Chandler Hill Vineyards.

What’s a vacation rental in Defiance like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Defiance. Vacation rentals feature amenities like laundry facilities and kitchens so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of security away from shared hotel elevators and busy front desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great option for families.