Defiance Vacation Rentals

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Check prices for these dates

In two weeks
Oct 10 - Oct 12
In one month
Oct 24 - Oct 26
In two months
Nov 21 - Nov 23
In three months
Dec 19 - Dec 21

Vacation Rentals in Defiance

Our top choices for Defiance vacation rentals

St. Charles 1860's Gem - Sleeps 6!
Fridge, microwave, oven, stovetop

St. Charles 1860's Gem - Sleeps 6!

9.8 out of 10, Exceptional, (121)
"Perfect place to stay while we were in town for a show! "
The price is ￥18,451
￥37,788 total
includes taxes & fees
Sep 28 - Sep 29
St. Charles 1860's Gem - Sleeps 6!
Residence on the Roundabout
Interior

Residence on the Roundabout

9.6 out of 10, Exceptional, (137)
"Very clean. Comfortable couch/beds"
Residence on the Roundabout
Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!
Terrace/patio

Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!

10.0 out of 10, Exceptional, (38)
"Home was very nice, had a great location and manager was fantastic to work with. "
The price is ￥73,517
￥128,259 total
includes taxes & fees
Oct 6 - Oct 7
Beautiful Sunrise, Rural, close to town, near wineries, next to Sunset Bluffs!
The St. Charles Guest House, lovely historic home, fun for families and groups
Outdoor dining

The St. Charles Guest House, lovely historic home, fun for families and groups

10.0 out of 10, Exceptional, (133)
"We loved staying here in this adorable clean house that was only 1 block off of downtown Main Street shopping. "
The St. Charles Guest House, lovely historic home, fun for families and groups
Honky Tonk Hideaway
Outdoor dining

Honky Tonk Hideaway

9.2 out of 10, Wonderful, (7)
"Great place to stay"
Honky Tonk Hideaway
Prime Loft of Main Street
Smart TV

Prime Loft of Main Street

9.8 out of 10, Exceptional, (99)
"This is a great property located in wiyhin walking distance to shops restaurants and interesting things to see"
The price is ￥17,138
￥36,775 total
includes taxes & fees
Sep 29 - Sep 30
Prime Loft of Main Street
Cozy Clark Suite in Frenchtown Saint Charles
Smart TV

Cozy Clark Suite in Frenchtown Saint Charles

9.4 out of 10, Exceptional, (8)
"Perfect for a couple. Well maintained. "
Cozy Clark Suite in Frenchtown Saint Charles
Madison House 1 -Walk to Main St
2 bedrooms, desk, iron/ironing board, travel crib

Madison House 1 -Walk to Main St

8.8 out of 10, Excellent, (13)
"Comfortable place to stay easy to find location close to everything in St Charles"
The price is ￥13,137
￥34,904 total
includes taxes & fees
Sep 28 - Sep 29
Madison House 1 -Walk to Main St
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway
Dining

Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway

9.6 out of 10, Exceptional, (49)
"This place was perfect for our visit to St Charles. We'll definitely book it again the next time we come to visit family"
The price is ￥18,466
￥47,840 total
includes taxes & fees
Sep 28 - Sep 29
Historic*Unique*Downtown*Quiet*Bright*Cheerful*Getaway
Stunning 1890's Home - Sleeps 8!
Microwave, oven, stovetop, dishwasher

Stunning 1890's Home - Sleeps 8!

10.0 out of 10, Exceptional, (78)
"The house is beautiful, in a great location, and has all the amenities of home. Definitely glad we stayed here instead of a nearby hotel."
The price is ￥29,020
￥60,086 total
includes taxes & fees
Oct 12 - Oct 13
Stunning 1890's Home - Sleeps 8!
Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!
3 bedrooms, WiFi, bed sheets

Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!

9.6 out of 10, Exceptional, (66)
"Comfy beds, plenty of towels, good location."
Aunt Doodle’s House 8 blocks from Historic Main Street.. Convenient location!
Newly Updated Charming and Cozy Home near Historic Main Street in Frenchtown.
Smart TV

Newly Updated Charming and Cozy Home near Historic Main Street in Frenchtown.

10.0 out of 10, Exceptional, (39)
"The house was very cute and cozy. The host was very responsive and even let us check n a little early. We would definitely stay here again."
Newly Updated Charming and Cozy Home near Historic Main Street in Frenchtown.
Escape the city to quiet and picturesque Golden Eagle, IL..
Dining

Escape the city to quiet and picturesque Golden Eagle, IL..

10.0 out of 10, Exceptional, (357)
"Loved the property. It was beautiful and peaceful. A great place for total relaxation. Hosts respond quickly to messages."
Escape the city to quiet and picturesque Golden Eagle, IL..
Cozy Cottage, we're told it's heavenly!
Exterior

Cozy Cottage, we're told it's heavenly!

10.0 out of 10, Exceptional, (203)
"Small but very cozy cabin in a very private spot. Still had all the conveniences and close to town. "
Cozy Cottage, we're told it's heavenly!
Rustic Augusta Cabin by StayLage
TV

Rustic Augusta Cabin by StayLage

10.0 out of 10, Exceptional, (3)
"I booked this place wit spend some homely time with my kids and it was amazing, the place was clean they even dropped off some extra towels without us having to ask, it was truly amazing. Will definitely stay there again. "
The price is ￥19,927
￥49,176 total
includes taxes & fees
Sep 28 - Sep 29
Rustic Augusta Cabin by StayLage
Historic 4‑BR Farmhouse • Steps to Main Street
Fridge, microwave, oven, stovetop

Historic 4‑BR Farmhouse • Steps to Main Street

10.0 out of 10, Exceptional, (13)
"Absolutely loved the home and it truly is right in the middle of everything.. "
The price is ￥29,817
￥90,938 total
includes taxes & fees
Sep 28 - Sep 29
Historic 4‑BR Farmhouse • Steps to Main Street
Cowboy Cabin, come sit under the trees
Outdoor dining

Cowboy Cabin, come sit under the trees

10.0 out of 10, Exceptional, (203)
"We had a fantastic stay here. Loved the cozy quiet vibe. My favorite part was all the fire flies that come out at night while sitting on the porch in the trees. "
Cowboy Cabin, come sit under the trees
New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!
Fridge, microwave, oven, stovetop

New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!

9.8 out of 10, Exceptional, (58)
"We enjoyed the roomy house and proximity to riverfront area."
The price is ￥24,356
￥62,033 total
includes taxes & fees
Sep 29 - Sep 30
New Remodel in St. Charles - Sleeps 10! New patio! Large Fenced-in backyard!
🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟
Fridge, microwave, oven, stovetop

🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟

9.8 out of 10, Exceptional, (68)
"Pleasant and a great location."
🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟
Victorian Gem Steps from Main St – Sleeps 9 & Pets
Fridge, microwave, oven, stovetop

Victorian Gem Steps from Main St – Sleeps 9 & Pets

9.8 out of 10, Exceptional, (17)
"Great location and accommodation for a business trip with some colleagues. Easy to check in and find everything we needed! Super cute and cozy!"
The price is ￥29,817
￥95,973 total
includes taxes & fees
Sep 28 - Sep 29
Victorian Gem Steps from Main St – Sleeps 9 & Pets
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

10/10 Excellent
"For a pretty good price it was a very nice stay, no bad smells motels have come to be known for."
Shane 1-night trip
Posted 10 hours ago
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Find out more about Defiance

Find out more about Defiance

Search for holiday rentals in Defiance on Expedia! You can easily find your home rentals, villas, holiday apartments in Defiance using one of the methods below:

  • View our selection of featured holiday rentals in Defiance
  • Use the map to find apartments and other holiday homes in the Defiance neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Defiance while they last

Look no further and take a look at our great range of rental properties in Defiance!

Frequently asked questions

Can I find vacation rentals in Defiance?

Yes, there are vacation rentals close to popular sights in Defiance, or you can choose a more secluded option if you're looking for relaxation. Defiance is known for its wineries and parks.

What are some of the best vacation home rentals that Defiance has to offer?

St. Charles 1860's Gem - Sleeps 6!: This vacation home rental outside of Defiance is located on a river and has a garden, a selection of books, and air-conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop.

How many vacation rentals will I find in Defiance?

With 4 Expedia vacation rentals, you're sure to find just the right place for your Defiance stay.

What’s there to see and do in Defiance?

August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Yellow Farmhouse Winery and Chandler Hill Vineyards.

What’s a vacation rental in Defiance like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Defiance. Vacation rentals feature amenities like laundry facilities and kitchens so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of security away from shared hotel elevators and busy front desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great option for families.