Defiance Vacation Rentals

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Check prices for these dates

In two weeks
Nov 21 - Nov 23
In two months
Jan 2 - Jan 4
In three months
Jan 30 - Feb 1
In four months
Feb 27 - Mar 1

Vacation Rentals in Defiance

Outdoor dining
The St. Charles Guest House, lovely historic home, fun for families and groups

The St. Charles Guest House, lovely historic home, fun for families and groups

St. Charles Historic District
10.0 out of 10, Exceptional, (135)
"House is so charming and a home away from home! The historical home and town were literally the vacation I will cherish! Game room was a hit!I highly recommend for any family that plans to visit St. Charles, MO!"
United States
Schererville A.
The St. Charles Guest House, lovely historic home, fun for families and groups
Bar (on property)
Studio Condo on the Water @ Innsbrook

Studio Condo on the Water @ Innsbrook

Wright City
9.8 out of 10, Exceptional, (39)
"Had a good golf day wonderful place to stay "
United States
david c.
The price is ￥11,046
￥28,039 total
includes taxes & fees
Nov 11 - Nov 12
Studio Condo on the Water @ Innsbrook
2 bedrooms, desk, iron/ironing board, travel crib
Madison House 2 -Walk to Main St

Madison House 2 -Walk to Main St

St. Charles Historic District
8.8 out of 10, Excellent, (6)
"Poor communication with property owner we told him of issues including two ceiling fans not working missing lightbulbs broken coffee maker unusable backyard due to negligence old stove and broken chair in backyard dirty back porch he responded on the first day he would bring lightbulbs and never came even though he said he lived one block away "
United States
Tom B.
The price is ￥15,189
￥38,487 total
includes taxes & fees
Nov 11 - Nov 12
Madison House 2 -Walk to Main St
Smart TV
Cozy Clark Suite in Frenchtown Saint Charles

Cozy Clark Suite in Frenchtown Saint Charles

St. Charles Historic District
9.6 out of 10, Exceptional, (11)
"Awesome place to stay"
United States
paul
Cozy Clark Suite in Frenchtown Saint Charles
Exterior
Authentic Log cabin with something for everyone!

Authentic Log cabin with something for everyone!

Marthasville
9.6 out of 10, Exceptional, (375)
"Very beautiful place to stay. We really enjoyed the lake. "
United States
Kristi W.
Authentic Log cabin with something for everyone!
Microwave, oven, stovetop, dishwasher
Stunning 1890's Home - Sleeps 8!

Stunning 1890's Home - Sleeps 8!

St. Charles Historic District
10.0 out of 10, Exceptional, (86)
"The house is beautiful, in a great location, and has all the amenities of home. Definitely glad we stayed here instead of a nearby hotel."
United States
Emily D.
The price is ￥31,451
￥63,094 total
includes taxes & fees
Nov 11 - Nov 12
Stunning 1890's Home - Sleeps 8!
Fridge, microwave, oven, stovetop
Historic Main Street Heritage Retreat

Historic Main Street Heritage Retreat

4.0 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (36)
"No complaints here, would definitely stay here again! "
United States
Adrienne R.
Historic Main Street Heritage Retreat
Outdoor dining
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!

1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!

St. Charles Historic District
10.0 out of 10, Exceptional, (209)
"Nice view of the Mississippi in the morning. Just off of the main street in old town St Charles, this place was perfect for our needs."
United States
Ralph
1830's Luxury Brick Cottage, Cozy Fireplace, right off the Cobblestone Streets!
Exterior
Cozy Cottage, we're told it's heavenly!

Cozy Cottage, we're told it's heavenly!

Marthasville
10.0 out of 10, Exceptional, (208)
"Small but very cozy cabin in a very private spot. Still had all the conveniences and close to town. "
United States
Kathie H.
Cozy Cottage, we're told it's heavenly!
Property grounds
The Hare Suite at Divine Otter

The Hare Suite at Divine Otter

St. Charles Historic District
9.4 out of 10, Exceptional, (12)
"This is such a cute place. Highly recommend. Very relaxing while also all kinds of shopping and dining options. There was a water main break our first few hrs into the stay. Host was great responded fast to any questions we had. "
United States
Pam
The Hare Suite at Divine Otter
Interior
5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1

St. Charles Historic District
9.2 out of 10, Wonderful, (11)
"Comfortable home in a convenient location."
United States
Troy B.
The price is ￥18,257
￥42,599 total
includes taxes & fees
Nov 11 - Nov 12
5th Street #1 · Historic 5th Street House - Fully Rehabbed # 1
Fridge, microwave, oven, stovetop
St. Charles 1860's Gem - Sleeps 6!

St. Charles 1860's Gem - Sleeps 6!

St. Charles Historic District
9.8 out of 10, Exceptional, (129)
"Great location to historic St. Charles! Lots of room and it was a great stay!"
United States
brooke c.
The price is ￥20,116
￥40,061 total
includes taxes & fees
Nov 20 - Nov 21
St. Charles 1860's Gem - Sleeps 6!
Outdoor dining
Honky Tonk Hideaway

Honky Tonk Hideaway

St. Charles Historic District
9.2 out of 10, Wonderful, (10)
"We were in town for a concert and loved our stay here. Great location very close to restaurants and bars. Very safe area. Had a very private back patio next to a creek which made morning coffee even better. Place was clean and had all the necessities. We will stay here again."
United States
LAURIE P.
Honky Tonk Hideaway
Fridge, microwave, oven, stovetop
The Lewis & Clark Hangout

The Lewis & Clark Hangout

St. Charles Historic District
9.0 out of 10, Wonderful, (19)
"Close to down town and easy to get to. Communicate with home owner was very good! "
United States
Michelle L.
The price is ￥24,394
￥59,328 total
includes taxes & fees
Nov 11 - Nov 12
The Lewis & Clark Hangout
2 bedrooms, desk, iron/ironing board, free WiFi
The Otter Suite at Divine Otter

The Otter Suite at Divine Otter

St. Charles Historic District
9.0 out of 10, Wonderful, (6)
"We absolutely loved this place! I would recommend this place. We had one issue but it was resolved. If you have children, I would probably stay somewhere else. There are bars all around and gets loud at night but it does get really quiet after 1:30 a.m. The property manager was absolutely amazing and is very quick to respond to your needs. "
United States
kim F.
The Otter Suite at Divine Otter
Fridge, microwave, oven, stovetop
Home Near Main Street-Covered Patio-Hot Tub!

Home Near Main Street-Covered Patio-Hot Tub!

Saint Charles
9.8 out of 10, Exceptional, (25)
"The interior is super clean, showers all very nice, and beds seemed like they have never been slept in. I highly recommend this place, the kitchen is well suited for cooking anything! "
United States
Sam R.
The price is ￥32,909
￥73,370 total
includes taxes & fees
Nov 11 - Nov 12
Home Near Main Street-Covered Patio-Hot Tub!
Fridge, microwave, oven, stovetop
Victorian Gem Steps from Main St - Sleeps 9 & Pets

Victorian Gem Steps from Main St - Sleeps 9 & Pets

St. Charles Historic District
9.8 out of 10, Exceptional, (18)
"Excellent home, lots of room for a big family gathering. One block From Main Street. Parking in alley and garage makes easy access. Would stay here again."
United States
Ardith B.
The price is ￥37,741
￥107,449 total
includes taxes & fees
Nov 30 - Dec 1
Victorian Gem Steps from Main St - Sleeps 9 & Pets
Outdoor spa tub
Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort

Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort

Innsbrook
10.0 out of 10, Exceptional, (69)
"This Chalet was Great, Beautiful clear lake, Peaceful. Has everything you could possibly need. We Highly recommend this cozy Chalet."
United States
Tammy S.
Cozy 2 bedroom waterfront chalet with private beach, hot tub at Innsbrook Resort
Studio Suite, 1 King Bed | 1 bedroom, desk, laptop workspace, blackout drapes
Value Suites Extended Stay - St Louis

Value Suites Extended Stay - St Louis

3.0 star property
Maryland Heights
7.0 out of 10, Good, (1110)
"Close to the city, very comfortable and has a full kitchen which is nice."
United States
Anonymous traveler
The price is ￥58,646
￥80,599 total
includes taxes & fees
Nov 11 - Nov 12
Value Suites Extended Stay - St Louis
Outdoor dining
Cowboy Cabin, come sit under the trees

Cowboy Cabin, come sit under the trees

Marthasville
10.0 out of 10, Exceptional, (207)
"It was amazing! The dogs were so sweet and just so welcoming. The place was very neat and awesome!!! It’s so quiet and peaceful."
United States
Caden W.
Cowboy Cabin, come sit under the trees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Hilton St. Louis Frontenac

Hilton St. Louis Frontenac

10/10 Excellent
"Great staff.. very clean room , bed was comfortable. Only stayed one night, but I would come back."
Rhonda 1-night trip
Posted 2 days ago
Hilton St. Louis Frontenac

Find out more about Defiance

Search for holiday rentals in Defiance on Expedia! You can easily find your home rentals, villas, holiday apartments in Defiance using one of the methods below:

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Look no further and take a look at our great range of rental properties in Defiance!

Frequently asked questions

Can I find vacation rentals in Defiance?

Yes, there are vacation rentals close to popular sights in Defiance, or you can choose a more secluded option if you're looking for relaxation. Defiance is known for its wineries and parks.

What are some of the best vacation home rentals that Defiance has to offer?

The St. Charles Guest House, lovely historic home, fun for families and groups: This vacation home rental outside of Defiance is located on a river and has a fireplace, a selection of games, and air-conditioning to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

How many vacation rentals will I find in Defiance?

With 4 Expedia vacation rentals, you're sure to find just the right place for your Defiance stay.

What’s there to see and do in Defiance?

August A. Busch Memorial Conservation Area and Missouri River are a couple of scenic spots to enjoy the outdoors, whereas Historic Daniel Boone Home and Heritage Center is one of the cultural attractions. Other places in town to visit include Yellow Farmhouse Winery and Chandler Hill Vineyards.

What’s a vacation rental in Defiance like?

A vacation rental is a private property where you can stay for a few weeks or just a few days in Defiance. Vacation rentals feature amenities like laundry facilities and kitchens so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of security away from shared hotel elevators and busy front desks while still allowing you a great travel experience. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a great option for families.