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Check prices for these dates

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May 11 - May 12
Tomorrow
May 12 - May 13
This weekend
May 15 - May 17
Next weekend
May 22 - May 24

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Our top choices for Defiance hotels

Reception

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very Good, (1,268 reviews)
"Had a great experience with this hotel for 3dys, the rooms were clean, the indoor pool was nice with the jaccuzzi and breakfast was good!"
United States
Rhonda
The price is ￥15,582
￥17,995 total
includes taxes & fees
May 14 - May 15
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Lobby

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very Good, (982 reviews)
"Clean and comfortable. Just what you need for an affordable place to sleep, when you're on the road."
United States
Amy
The price is ￥13,819
￥15,609 total
includes taxes & fees
May 17 - May 18
Quality Inn Foristell
Indoor pool

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.6 out of 10, Good, (1,006 reviews)
"Excellent place to stay!"
United States
Steven
The price is ￥11,588
￥13,235 total
includes taxes & fees
May 26 - May 27
Baymont by Wyndham Warrenton
Lobby

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (681 reviews)
"Very clean and staff were friendly. Breakfast was good and will definitely stay here again. "
United States
Rod
The price is ￥20,212
￥23,012 total
includes taxes & fees
May 14 - May 15
Best Western Plus Washington Hotel
Reception

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (702 reviews)
"Good location, clean and friendly staff. "
United States
Michelle
The price is ￥21,183
￥24,244 total
includes taxes & fees
May 25 - May 26
Hampton Inn St. Louis Wentzville
Standard Room, 2 Queen Beds | In-room safe, desk, laptop workspace, blackout drapes

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (646 reviews)
"The parking was easy, the room was verry clean."
United States
Gary
The price is ￥8,523
￥9,735 total
includes taxes & fees
May 19 - May 20
Super 8 by Wyndham Warrenton
Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free cribs/infant beds

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1,213 reviews)
"Clean and a safe place to stay"
United States
Cindy
The price is ￥13,318
￥15,381 total
includes taxes & fees
May 12 - May 13
Wingate by Wyndham St. Louis/Fenton Route 66
Exterior

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
8.6 out of 10, Excellent, (107 reviews)
"It was very clean, spacious and quiet. I like that it was non smoking and the staff was friendly"
United States
Kimbra
The price is ￥12,184
￥14,425 total
includes taxes & fees
May 25 - May 26
WoodSpring Suites St Peters-OFallon
Lobby

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
Valley Park
9.6 out of 10, Exceptional, (1,015 reviews)
"The room was very nice and clean. A lot of choices for hot breakfast. Will definitely stay again in the future."
United States
Amanda
The price is ￥20,053
￥23,459 total
includes taxes & fees
May 18 - May 19
Drury Inn & Suites Southwest St. Louis
Exterior

Holiday Inn Express & Suites St Peters by IHG

Holiday Inn Express & Suites St Peters by IHG
2.5 star property
St. Peters
9.2 out of 10, Wonderful, (407 reviews)
"Great stay. Easy and quick check in."
United States
John
The price is ￥17,548
￥21,129 total
includes taxes & fees
May 31 - Jun 1
Holiday Inn Express & Suites St Peters by IHG
Premium bedding, desk, iron/ironing board, free WiFi

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,011 reviews)
"Everything was excellent, location amenities, food.."
United States
FERNANDO
The price is ￥12,860
￥15,170 total
includes taxes & fees
May 19 - May 20
Sleep Inn & Suites O'Fallon MO - Technology Drive
Indoor pool

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very Good, (1,009 reviews)
"Breakfast was really good. It was getting close to closing time and they were still restocking food because people were still eating."
United States
Danielle
The price is ￥16,574
￥19,047 total
includes taxes & fees
May 25 - May 26
Hampton Inn St. Charles St. Peters
Free daily buffet breakfast

SpringHill Suites by Marriott St. Louis Chesterfield

SpringHill Suites by Marriott St. Louis Chesterfield
3.0 star property
Chesterfield
9.8 out of 10, Exceptional, (14 reviews)
"Very clean and nice rooms, friendly staff, and great location close to restaurants and shopping. "
United States
Kenny
The price is ￥18,512
￥21,471 total
includes taxes & fees
May 17 - May 18
SpringHill Suites by Marriott St. Louis Chesterfield
Free daily buffet breakfast

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (282 reviews)
"Staff and breakfast were amazing!"
United States
Shilo
The price is ￥15,540
￥17,946 total
includes taxes & fees
May 17 - May 18
Best Western Plus Fenton
Lobby

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1,008 reviews)
"Everything about this hotel was great "
United States
Delovin Choice
The price is ￥22,717
￥26,336 total
includes taxes & fees
May 25 - May 26
Drury Plaza Hotel St. Louis St. Charles
Room, 2 Queen Beds, Non Smoking | In-room safe, desk, blackout drapes, iron/ironing board

Super 8 by Wyndham Washington

Super 8 by Wyndham Washington
2.0 star property
Washington
8.4 out of 10, Very Good, (722 reviews)
"Very nice motel for the price. Breakfast was average, minimal choices."
United States
James
The price is ￥13,537
￥15,411 total
includes taxes & fees
May 24 - May 25
Super 8 by Wyndham Washington
Exterior

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very Good, (1,010 reviews)
"Room was clean breakfast was wonderful. "
United States
Eileen
The price is ￥14,665
￥16,854 total
includes taxes & fees
May 25 - May 26
Comfort Suites St Charles - St Louis
Lobby lounge

Fairfield Inn & Suites Wentzville

Fairfield Inn & Suites Wentzville
3.0 star property
Wentzville
9.0 out of 10, Wonderful, (674 reviews)
"Property was nice, easy check-in, nice breakfast, room was clean."
United States
Doris
The price is ￥20,757
￥23,757 total
includes taxes & fees
May 24 - May 25
Fairfield Inn & Suites Wentzville
Lobby

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,009 reviews)
"Great location and clean hotel!"
United States
Admir
The price is ￥18,643
￥21,430 total
includes taxes & fees
May 25 - May 26
Drury Inn & Suites St. Louis St. Peters
Exterior

Holiday Inn Express Warrenton by IHG

Holiday Inn Express Warrenton by IHG
2.5 star property
Warrenton
9.0 out of 10, Wonderful, (538 reviews)
"Very good breakfast, especially good coffee, clean rooms, friendly staff, comfortable beds"
United States
Tom
The price is ￥20,995
￥23,983 total
includes taxes & fees
Jun 7 - Jun 8
Holiday Inn Express Warrenton by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

3.9/5 (7 reviews)
This elegant Missouri winery showcases local and California wines from its hillside setting. Savor varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
See properties

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

10/10 Excellent
"Large, comfortable room, very convenient location, right off Hwy 44. Plenty of restaurants nearby."
keith 2-night trip
Posted 2 hours ago
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

More cheap stays in Defiance

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

Days Inn and Suites by Wyndham St. Louis/Westport Plaza

1970 Craig Rd Maryland Heights MO
The price is ￥10,654 per night from May 18 to May 19
￥10,654
￥12,359 total
May 18 - May 19
includes taxes & fees
4.6/10 (1,006 reviews)

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Hollywood Casino & Hotel St. Louis and Ameristar Casino Resort and Spa. See all available top hotels, or vacation rentals in Defiance.
What's the top vacation rental in Defiance?
🌟 Adorable Historic 🏠 in the ❤️ of St. Charles 🌟: Visitors like this Defiance vacation home rental. It offers a patio, a garden, and air-conditioning to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
Where can I learn more about changing or cancelling my trip to Defiance?
For more information about changing or cancelling your trip to Defiance, head over to our customer service page.
Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?
Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.
What about the best place to stay near Chandler Hill Vineyards?
One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.
What are some accommodations with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool, and buffet. Ameristar Casino Resort and Spa and The Wildwood Hotel are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.
What's the best place to stay near Lambert-St. Louis International Airport (STL)?
Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.
What's it like to stay in Defiance?
Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium, and Gateway Arch. In Defiance, there are 19 hotels and other accommodations to choose from. Find out more about Defiance.
What is there to see in Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River, and Matson Hill Park Trailhead. A couple of additional sights to add to your agenda are Chandler Hill Vineyards and Sugar Creek Winery. Check out what more to see and do in Expedia's Defiance guide.
What's the seasonal weather like in Defiance?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.

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