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Find hotels in Defiance, MO from ￥10,580

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Nov 10 - Nov 11
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Nov 11 - Nov 12
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Nov 14 - Nov 16
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Nov 21 - Nov 23

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Compare 789 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Lobby sitting area
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
Fenton
8.0 out of 10, Very Good, (1009)
"Good hotel"
United States
Kelly
The price is ￥13,041
￥15,063 total
includes taxes & fees
Nov 23 - Nov 24
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Ballroom
The Wildwood Hotel

The Wildwood Hotel

3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1601)
"Great hotel in a great neighborhood "
United States
Linda
The Wildwood Hotel
Front of property
Sonesta ES Suites St. Louis - Chesterfield

Sonesta ES Suites St. Louis - Chesterfield

3.0 star property
Chesterfield
8.0 out of 10, Very Good, (1018)
"This was a very nice place to stay. Centrally located, very clean and quiet with a great breakfast!"
United States
Kirsti
The price is ￥14,238
￥16,515 total
includes taxes & fees
Nov 18 - Nov 19
Sonesta ES Suites St. Louis - Chesterfield
Property amenity
Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton

2.5 star property
Warrenton
7.4 out of 10, Good, (1006)
"The room was amazing the jacuzzi tub worked great we love our stay at Baymont "
United States
Christopher
The price is ￥13,117
￥15,049 total
includes taxes & fees
Nov 17 - Nov 18
Baymont by Wyndham Warrenton
Front of property
Super 8 by Wyndham Eureka/Six Flags Nearby

Super 8 by Wyndham Eureka/Six Flags Nearby

2.0 star property
Eureka
7.0 out of 10, Good, (1002)
"A much needed comfortable bed and hot shower, staff was lovely. "
United States
Rachel
The price is ￥9,205
￥10,724 total
includes taxes & fees
Dec 1 - Dec 2
Super 8 by Wyndham Eureka/Six Flags Nearby
Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
Wentzville
9.4 out of 10, Exceptional, (820)
"Comfortable beds good shower "
United States
Chad
The price is ￥20,712
￥24,679 total
includes taxes & fees
Nov 16 - Nov 17
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Lobby
Best Western Plus St. Louis West-Westport

Best Western Plus St. Louis West-Westport

2.5 star property
Maryland Heights
8.0 out of 10, Very Good, (1013)
"Room was clean and staff were welcoming! "
United States
Kayla
The price is ￥15,189
￥17,619 total
includes taxes & fees
Nov 11 - Nov 12
Best Western Plus St. Louis West-Westport
1 bedroom, Egyptian cotton sheets, premium bedding, pillowtop beds
Best Western Plus Washington Hotel

Best Western Plus Washington Hotel

2.5 star property
Washington
9.2 out of 10, Wonderful, (624)
"Great breakfast, comfortable room, and wonderful staff, all for a reasonable price. We stay here every time we are in Washington."
United States
Kimberly
The price is ￥19,791
￥22,532 total
includes taxes & fees
Nov 11 - Nov 12
Best Western Plus Washington Hotel
Lobby
Days Inn by Wyndham St Peters/St Charles

Days Inn by Wyndham St Peters/St Charles

2.0 star property
St. Peters
6.4 out of 10, (1001)
"Decent for the price"
United States
Kathie
The price is ￥10,302
￥11,841 total
includes taxes & fees
Nov 23 - Nov 24
Days Inn by Wyndham St Peters/St Charles
Lobby
Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
O'Fallon
8.8 out of 10, Excellent, (1007)
"Nice breakfast, friendly staff"
United States
Damon
The price is ￥13,409
￥15,815 total
includes taxes & fees
Nov 11 - Nov 12
Sleep Inn & Suites O'Fallon MO - Technology Drive
Exterior
Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
O'Fallon
8.6 out of 10, Excellent, (814)
"Clean, well maintained hotel. Friendly staff, great breakfast. Close to shopping and restaurants."
United States
Theresa
The price is ￥14,575
￥17,191 total
includes taxes & fees
Nov 16 - Nov 17
Holiday Inn Express St. Louis West - O'Fallon by IHG
Daily buffet breakfast (USD 12.95 per person)
Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

3.0 star property
Chesterfield
8.2 out of 10, Very Good, (779)
"Staff was courteous. "
United States
John
The price is ￥14,974
￥17,424 total
includes taxes & fees
Nov 30 - Dec 1
Hilton Garden Inn Chesterfield
Desk, blackout drapes, iron/ironing board, free cribs/infant beds
Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

3.0 star property
Fenton
7.8 out of 10, Good, (1084)
"Nice clean rooms."
United States
Chrysta
The price is ￥12,128
￥14,007 total
includes taxes & fees
Nov 16 - Nov 17
Wingate by Wyndham St. Louis/Fenton Route 66
In-room safe, desk, laptop workspace, blackout drapes
Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton

2.0 star property
Warrenton
7.4 out of 10, Good, (609)
"Ample free parking for our large RV. Staff was indifferent and acted like they were doing us a favor by letting us stay. Had to wait quite a while to be greeted for check in. Very limited lodging choices in the area, so??"
United States
Gary
The price is ￥9,389
￥10,771 total
includes taxes & fees
Nov 18 - Nov 19
Super 8 by Wyndham Warrenton
Double Room, 2 Double Beds | In-room safe, laptop workspace, blackout drapes, iron/ironing board
Super 8 by Wyndham St. Clair MO

Super 8 by Wyndham St. Clair MO

2.0 star property
St. Clair
7.2 out of 10, Good, (931)
"Was what I needed after a long drive."
United States
Michael
The price is ￥10,218
￥11,187 total
includes taxes & fees
Nov 16 - Nov 17
Super 8 by Wyndham St. Clair MO
Front of property - evening/night
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 star property
Maryland Heights
8.4 out of 10, Very Good, (2189)
"We had a pleasant stay."
United States
Larry
The price is ￥11,812
￥15,993 total
includes taxes & fees
Nov 23 - Nov 24
Hollywood Casino & Hotel St. Louis
Exterior
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

2.5 star property
St. Charles
8.0 out of 10, Very Good, (1004)
"polite staff, great service, nice breakfast, clean room "
United States
John
The price is ￥14,606
￥16,787 total
includes taxes & fees
Nov 16 - Nov 17
Hampton Inn St. Charles St. Peters
Exterior
Holiday Inn Express & Suites St. Louis West - Fenton by IHG

Holiday Inn Express & Suites St. Louis West - Fenton by IHG

3.0 star property
Fenton
8.8 out of 10, Excellent, (1003)
"Spotless room great mattress and pillows and super friendly staff"
United States
judith
The price is ￥16,876
￥19,490 total
includes taxes & fees
Nov 13 - Nov 14
Holiday Inn Express & Suites St. Louis West - Fenton by IHG
Lobby
Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles

3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1007)
"Hotel was very clean."
United States
christine
The price is ￥16,875
￥19,563 total
includes taxes & fees
Nov 16 - Nov 17
Drury Plaza Hotel St. Louis St. Charles
Lobby
AC Hotel by Marriott St. Louis Chesterfield

AC Hotel by Marriott St. Louis Chesterfield

3.5 star property
Chesterfield
9.2 out of 10, Wonderful, (220)
"Newer hotel, very clean, up to date and in nice area. "
United States
Johnny
The price is ￥19,484
￥22,599 total
includes taxes & fees
Nov 21 - Nov 22
AC Hotel by Marriott St. Louis Chesterfield
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Wetlands landscape with a bird blind and cloudy sky reflected in a lake at the August A. Busch Memorial Conservation Area in St. Charles County Missouri

August A. Busch Memorial Conservation Area

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.
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Missouri wineries have some of the most superb wine we've ever tasted! We recommend sipping on some chambourcin while basking in the sunshine.
Photo by Pages of Travel
Open Photo by Pages of Travel

Chandler Hill Vineyards

This elegant Missouri winery showcases local and California wines from its hillside setting. Savor varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.
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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
Bucsh Wildlife lakes are beautiful spots for sunrise or sunset.
Photo by Michael True
Open Photo by Michael True

Top Defiance Hotel Reviews

Hilton St. Louis Frontenac

Hilton St. Louis Frontenac

10/10 Excellent
"Great staff.. very clean room , bed was comfortable. Only stayed one night, but I would come back."
Rhonda 1-night trip
Posted 2 days ago
Hilton St. Louis Frontenac

More cheap stays in Defiance

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

1310 Bass Pro Drive, St. Charles, MO
The price is ￥9,127 per night from Nov 11 to Nov 12
￥9,127
￥10,580 total
Nov 11 - Nov 12
includes taxes & fees
5.6/10 (1,003 reviews)

Frequently asked questions

What's the best place to stay in Defiance?
Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Hilton St. Louis Frontenac. See all available top hotels, or vacation rentals in Defiance.
What's the top vacation rental in Defiance?
The St. Charles Guest House, lovely historic home, fun for families and groups: Visitors like this Defiance vacation home rental. It is located on a river and has a fireplace, a selection of games, and air-conditioning to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. See all vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
Where can I learn more about changing or cancelling my trip to Defiance?
For more information about changing or cancelling your trip to Defiance, head over to our customer service page.
Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?
Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.
What about the best place to stay near Chandler Hill Vineyards?
One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.
What are some accommodations with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Offers an indoor pool, an outdoor pool, and buffet. Hilton St. Louis Frontenac and La Quinta Inn & Suites by Wyndham St. Louis Westport are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.
What's the best place to stay near Lambert-St. Louis International Airport (STL)?
Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.
What's it like to stay in Defiance?
Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium, and Gateway Arch. In Defiance, there are 20 hotels and other accommodations to choose from. Find out more about Defiance.
What is there to see in Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River, and Matson Hill Park Trailhead. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.
What's the seasonal weather like in Defiance?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.

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