Top 10 Hotels in Defiance, MO from ￥12,302 - Competitive Prices

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Defiance

Pet friendly

Apartment

Pool

Hot tub

Condo

Family friendly

Waterpark

Chalet

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Defiance hotels

A hotel room with a bed, a sofa, a coffee table, and wall art.

A hotel lobby with a reception desk, seating area, and a large potted plant.

A restaurant with wooden tables and chairs, a blue wall with white floral patterns, and a counter with a coffee machine.

An indoor swimming pool with a clear view of the outside, a metal ladder, and a ceiling with recessed lighting.

1. Sleep Inn & Suites O'Fallon MO - Technology Drive

O'Fallon

Tim

￥12,457

￥14,693 total

includes taxes & fees

Sep 27 - Sep 28

A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

A hotel room with two beds, a blue sofa, a small table, and a kitchenette.

A coffee station with two coffee machines and a display of coffee pods and cups.

A Holiday Inn Express & Suites building with a brick facade, a covered entrance, and a numbered address.

2. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Chesterfield

Steven

￥17,246

￥20,068 total

includes taxes & fees

Sep 27 - Sep 28

A modern kitchen with a bar area, wooden cabinets, and pendant lighting.

A modern hotel entrance with a glass canopy, large windows, and a brick facade.

A hotel room with three computer workstations, each with a monitor, keyboard, and a lamp.

A hotel room with two beds, a sofa, a small table, a lamp, and a framed abstract painting on the wall.

3. Hyatt Place St. Louis/Chesterfield

Chesterfield

Chelsea

￥20,383

￥23,642 total

includes taxes & fees

Sep 29 - Sep 30

A modern dining area with a brick fireplace, yellow and blue chairs, and a blue sofa.

An indoor swimming pool with a blue interior, surrounded by white chairs and tables, and a blue ceiling.

4. Comfort Inn & Suites Chesterfield - St. Louis

Chesterfield

Donna

￥12,760

￥15,398 total

includes taxes & fees

Oct 4 - Oct 5

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

A hotel room with a large bed, a bedside lamp, a telephone, a mirror, and a bathroom with a sink and towel rack.

A spacious living area with a staircase, a large painting, and a chandelier.

A formal dining table set for six with a vase of white flowers, candles, and a view of buildings through large windows.

5. The Wildwood Hotel

Wildwood

Ramona

￥14,334

￥16,698 total

includes taxes & fees

Oct 21 - Oct 22

A spacious lobby with a staircase, a blue sofa, and a wooden table.

A hotel reception desk with a blue water feature design, a sign reading "Quality by Choice Hotels," and a digital screen.

A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

A gym with treadmills, weight machines, and a large potted plant.

6. Quality Inn Foristell

Foristell

Adrian

￥13,447

￥15,189 total

includes taxes & fees

Sep 27 - Sep 28

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

A swimming pool with tiled edges and a hot tub area, surrounded by windows and chairs.

An outdoor patio with a beige sofa set, two armchairs, and a table.

A hotel room with a dining area, a fireplace, and a view of the outdoors.

7. Best Western Plus Washington Hotel

Washington

Michael Macumber

￥20,289

￥23,100 total

includes taxes & fees

Sep 27 - Sep 28

A multi-story hotel with a central entrance featuring a covered patio area.

A hotel room with a sofa, armchair, bedside table, lamp, TV, and a bed with patterned bedding.

A hotel room with a desk, chair, sofa, and a window with curtains.

A hotel lobby with a sectional sofa, a fireplace, a flat-screen TV, and framed artwork on the walls.

8. Staybridge Suites O'Fallon Chesterfield by IHG

O'Fallon

Norman

￥17,458

￥20,592 total

includes taxes & fees

Oct 4 - Oct 5

A multi-story hotel with a stone facade and a covered entrance.

A modern living room with a blue accent wall, a gray sofa, a dining table with chairs, and a coffee table.

A compact hotel room with two beds, a desk with a chair, a television, a microwave, and a refrigerator.

A modern living room with a wooden dining table, grey chairs, a sofa, and a coffee machine.

9. WoodSpring Suites St Peters-OFallon

St. Peters

Thomas

￥12,826

￥15,187 total

includes taxes & fees

Sep 28 - Sep 29

A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

A shop with a variety of snacks and beverages, including a refrigerated section with drinks and a display of packaged snacks.

A spacious lobby with a sofa, a coffee station, and a reception desk.

A spacious lobby with a fireplace, comfortable seating, a large painting, and a view of the kitchen area.

10. Hilton Garden Inn St. Louis/O'Fallon MO

O'Fallon

Kassie

￥17,024

￥20,185 total

includes taxes & fees

Oct 4 - Oct 5

A hotel named Sonesta ES Suites with a staircase leading to the entrance, surrounded by well-maintained greenery and red flowers.

A hotel room with a living area, kitchenette, and a bed.

A compact kitchen with a refrigerator, microwave, stove, and a small dining table with two stools.

A modern living room with a fireplace, a flat-screen TV, a sofa, and a dining area with a table and chairs.

11. Sonesta ES Suites St. Louis - Chesterfield

Chesterfield

Dennis

￥17,112

￥19,849 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

A hotel lobby with a seating area, a reception desk, and a flat-screen TV mounted on the wall.

A Holiday Inn Express hotel with a brick facade, a covered entrance, and a clear sky.

A reception desk with a modern design, featuring a blue geometric wall and a wooden finish.

12. Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

Greg

￥13,998

￥16,511 total

includes taxes & fees

Sep 30 - Oct 1

An outdoor patio with a built-in grill, seating area, and stone walls.

A spacious lounge area with a stone fireplace, comfortable seating, and a large TV screen.

An indoor swimming pool with clear glass walls, sunlit seating area, and lifeguard station.

A modern lobby with a stone accent wall, a flat-screen TV, a reception desk, seating area with sofas and ottomans, and a patterned rug.

13. Residence Inn by Marriott St. Louis Chesterfield

Chesterfield

Brandon

￥29,726

￥34,776 total

includes taxes & fees

Oct 3 - Oct 4

A hotel room with a large bed, a sofa, a desk, and two framed pictures on the wall.

A gym with cardio machines, weightlifting equipment, and mirrors.

A hotel lobby with a fireplace, seating area, and a patterned carpet.

A reception area with a granite counter, red chairs, and framed artwork on the wall.

14. Comfort Inn & Suites St. Louis - O'Fallon

O'Fallon

Hollie Charlene

￥13,001

￥15,334 total

includes taxes & fees

Oct 6 - Oct 7

A modern interior with hanging pendant lights, large windows, and a view of the outside.

A modern hotel with a covered entrance, brick facade, and a parking area.

A modern hotel lobby with a high ceiling, multiple hanging pendant lights, a reception desk with a Missouri US 66 sign, and large windows allowing natural light.

A hotel indoor pool area with a hot tub, seating, and a view of the outdoors.

15. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Fenton

Dashaun

￥14,839

￥17,137 total

includes taxes & fees

Sep 27 - Sep 28

An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

A modern kitchen with wooden cabinets, a stainless steel countertop, and various appliances including a coffee maker and a rice cooker.

A multi-story hotel with a brick facade, a covered outdoor seating area with a fire feature, and a sign indicating it is a Marriott property.

A hotel room with a large bed, bedside lamps, a TV, a desk, and a bathroom.

16. TownePlace Suites by Marriott St. Louis Chesterfield

Chesterfield

Bobbi jo

￥20,132

￥23,628 total

includes taxes & fees

Oct 5 - Oct 6

A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.

A modern hotel room with a large window, a desk with a flat-screen TV, a comfortable seating area, and a decorative wall piece.

A modern dining area with a long table, multiple chairs, and pendant lighting.

A reception desk with a "WELCOME TO THE SHOW ME STATE" sign, a wooden counter, and a Hilton Honors sign.

17. Hampton Inn & Suites St. Louis/Chesterfield

Chesterfield

Vijay

￥20,836

￥24,246 total

includes taxes & fees

Oct 4 - Oct 5

An outdoor patio area with wicker furniture and a central fire feature.

A Courtyard Marriott hotel with a parking lot and a green shuttle service.

A hotel room with a bed, a sofa, a desk, and a chair.

A modern hotel lobby with a bar area, seating arrangements, and a reception desk.

18. Courtyard by Marriott St. Louis Chesterfield

Chesterfield

Kelly

￥18,968

￥22,071 total

includes taxes & fees

Oct 4 - Oct 5

A Days Inn lobby with a reception desk, a clock, a small coffee table, and a sofa.

A bathroom with a granite countertop sink, a mirror, and a shower with a glass door.

A gym with stationary bikes and a treadmill, a mirror reflecting the room, and a ceiling fan.

A Days Inn with a brick facade, a covered entrance, and a parking lot.

19. Days Inn by Wyndham St Peters/St Charles

St. Peters

Jeremy

￥10,695

￥12,295 total

includes taxes & fees

Sep 29 - Sep 30

A spacious lobby with a central round table, two sofas, and a chandelier.

An indoor swimming pool area with clear signage indicating a depth of 3 feet and a no diving warning.

A Drury Plaza hotel with a modern design, featuring a curved facade, large windows, and a Drury Plaza sign on the top.

A buffet setup with various food items and a decorative vase of flowers.

20. Drury Plaza Hotel St. Louis Chesterfield

Chesterfield

Cassandra

￥20,445

￥23,714 total

includes taxes & fees

Oct 25 - Oct 26

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Defiance attractions

A glass of red wine on a wooden table with a vineyard in the background.

Chandler Hill Vineyards

7.8/10 (7 reviews)

This elegant Missouri winery showcases local and California wines from its hillside setting. Savor varietals on the expansive terrace while enjoying vineyard views and seasonal cuisine from their full-service kitchen.

See properties

A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)

This sprawling conservation area features over 30 lakes and historic WWII bunkers amid diverse habitats. Explore well-maintained trails while watching for migratory birds and wildlife in their natural environment.

See properties

Sugar Creek Winery

8.0/10 (1 review)

Sip award-winning Missouri wines at this hillside vineyard along the scenic Katy Trail. Relax on covered decks with your own picnic while enjoying live weekend music and panoramic countryside views.

See properties

Historic Daniel Boone Home and Heritage Center

9.6/10 (4 reviews)

Step into the limestone home where Daniel Boone's son Nathan crafted a frontier masterpiece with seven fireplaces. Explore the surrounding historic village for an authentic glimpse into 19th-century pioneer life.

See properties

Yellow Farmhouse Winery

This boutique winery in Defiance, Missouri was known for its distinctive unfiltered wines and relaxed atmosphere. Visitors could enjoy tastings with live music while picnicking on scenic grounds with vineyard views.

See properties

Broemmelsiek Park

This 494-acre natural playground offers nine miles of trails through forests and around serene lakes. Attend a monthly stargazing event at the astronomy viewing area for a uniquely celestial park experience.

See properties

Matson Hill Park Trailhead

Wander through 475 acres of rugged forest terrain with challenging hiking paths and gravity-flow mountain bike trails. The historic 1830s Hays Home offers a glimpse into pioneer life amid the natural splendor.

See properties

Hamburg Trail Trailhead

This moderate 6.9-mile loop winds through the scenic Weldon Spring Conservation Area, connecting to the Katy Trail State Park. Spot native wildlife while traversing diverse landscapes of shaded woodlands and open fields.

See properties

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance

Top Defiance Hotel Reviews

Hyatt Place St. Louis/Chesterfield

10/10 Excellent

"The room was very clean, comfortable & roomy. Parking was plentiful & breakfast was excellent. My only criticism is that there wasn’t an ice machine on every floor"

Sonesta ES Suites St. Louis - Chesterfield

10/10 Excellent

"It’s a nice place for extended stay. There are good and hot breakfast, only thing they didn’t change menu often. It’s a good value for the price and it’s in good location. I highly recommend this hotel for someone who wants longer stay."

Elimwood Hotel, a Ramada by Wyndham

8/10 Good

"The shower was kinda gross but other than that the place was really nice. It smelled nice in the whole place and staff were very friendly at check in and check out. We stayed for a concert and they had a free shuttle to the venue which was great too!"

Hollywood Casino & Hotel St. Louis

10/10 Excellent

"Staff was helpful. Clean rooms. Very accommodating."

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

8/10 Good

"Staff was excellent, rooms are clean, bed and bedding excellent and comfortable, hallways showing a little wear, breakfast choices could offer more variety. Overall the stay was nice for our concert trip"

Wingate by Wyndham St. Louis/Fenton Route 66

8/10 Good

"The hotel and room were what you expect for the price. The enterance was not clearly marked and getting into the property could have had better signage."

Hampton Inn St. Charles St. Peters

10/10 Excellent

"Friendly and helpful staff. Very good breakfast and coffee. Clean rooms."

Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent

"Staff was welcoming and very helpful with a situation that occurred with our booking!"

Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

10/10 Excellent

"Muy bien"

More cheap stays in Defiance

Sleep Inn & Suites O'Fallon MO - Technology Drive

1147 Technology Drive O'Fallon MO

￥12,457

￥14,693 total

Sep 27 - Sep 28

includes taxes & fees

Quality Inn Foristell

12 Highway W Foristell MO

￥13,447

￥15,189 total

Sep 27 - Sep 28

includes taxes & fees

Country Inn & Suites by Radisson, St. Peters, MO

3877 Veterans Memorial Pkwy St. Charles MO

￥13,356

￥15,352 total

Oct 27 - Oct 28

includes taxes & fees

8/10 Very Good! (1,000 reviews)

Comfort Suites St Charles - St Louis

1400 S 5th St St. Charles MO

￥13,734

￥15,784 total

Oct 18 - Oct 19

includes taxes & fees

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO

￥18,188

￥20,903 total

Oct 18 - Oct 19

includes taxes & fees

8.2/10 Very Good! (1,004 reviews)

Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO

￥23,115

￥26,564 total

Oct 18 - Oct 19

includes taxes & fees

9.4/10 Exceptional! (1,097 reviews)

Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Sonesta ES Suites St. Louis - Chesterfield and Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham. See all available top hotels, or vacation rentals in Defiance.

What's the top vacation rental in Defiance?

HotTub-2br2b-near Historic Main Street: Visitors like this Defiance vacation home rental. It offers a patio, a garden, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. Make the most of the hot tub in this rental home to help you unwind. See all vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

Where can I learn more about changing or cancelling my trip to Defiance?

For more information about changing or cancelling your trip to Defiance, head over to our customer service page.

Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?

Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.

What about the best place to stay near Chandler Hill Vineyards?

One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.

What are some accommodations with pools in Defiance?

Sonesta ES Suites St. Louis - Chesterfield: Offers daily, a seasonal outdoor pool, and free self parking. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Ameristar Casino Resort and Spa are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.

What's the best place to stay near Lambert-St. Louis International Airport (STL)?

Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.

What's it like to stay in Defiance?

Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station, Enterprise Center, and St. Louis Zoo. In Defiance, there are 19 hotels and other accommodations to choose from. Find out more about Defiance.

What is there to see in Defiance?

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River, and Matson Hill Park Trailhead. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.

What's the seasonal weather like in Defiance?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.

Explore a world of travel with Expedia

Pacific Vacations

Rental cars Lambert-St. Louis Intl. airport

Book Hotels in Defiance on Expedia.com

Find hotels in Defiance, MO from ￥12,302

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Defiance

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Defiance hotels

1. Sleep Inn & Suites O'Fallon MO - Technology Drive

2. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

3. Hyatt Place St. Louis/Chesterfield

4. Comfort Inn & Suites Chesterfield - St. Louis

5. The Wildwood Hotel

6. Quality Inn Foristell

7. Best Western Plus Washington Hotel

8. Staybridge Suites O'Fallon Chesterfield by IHG

9. WoodSpring Suites St Peters-OFallon

10. Hilton Garden Inn St. Louis/O'Fallon MO

11. Sonesta ES Suites St. Louis - Chesterfield

12. Holiday Inn Express St. Louis West - O'Fallon by IHG

13. Residence Inn by Marriott St. Louis Chesterfield

14. Comfort Inn & Suites St. Louis - O'Fallon

15. Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

16. TownePlace Suites by Marriott St. Louis Chesterfield

17. Hampton Inn & Suites St. Louis/Chesterfield

18. Courtyard by Marriott St. Louis Chesterfield

19. Days Inn by Wyndham St Peters/St Charles

20. Drury Plaza Hotel St. Louis Chesterfield

Stay near popular Defiance attractions

Chandler Hill Vineyards

August A. Busch Memorial Conservation Area

Sugar Creek Winery

Historic Daniel Boone Home and Heritage Center

Yellow Farmhouse Winery

Broemmelsiek Park

Matson Hill Park Trailhead

Hamburg Trail Trailhead

Learn more about Defiance

Top Defiance Hotel Reviews

Hyatt Place St. Louis/Chesterfield

Sonesta ES Suites St. Louis - Chesterfield

Elimwood Hotel, a Ramada by Wyndham

Hollywood Casino & Hotel St. Louis

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Wingate by Wyndham St. Louis/Fenton Route 66

Hampton Inn St. Charles St. Peters

Country Inn & Suites by Radisson, St. Charles Historic District

Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

More cheap stays in Defiance

Sleep Inn & Suites O'Fallon MO - Technology Drive

Quality Inn Foristell

Country Inn & Suites by Radisson, St. Peters, MO

Comfort Suites St Charles - St Louis

Hampton Inn St. Charles St. Peters

Country Inn & Suites by Radisson, St. Charles Historic District

Frequently asked questions

Explore a world of travel with Expedia

Go further with the Expedia app