Photo by Michael True
Find hotels in Defiance, MO from ¥10,580
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Compare 789 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Fenton
8.0 out of 10, Very Good, (1009)
The price is ¥13,041
¥15,063 total
includes taxes & fees
Nov 23 - Nov 24

The Wildwood Hotel
Wildwood
9.2 out of 10, Wonderful, (1601)

Sonesta ES Suites St. Louis - Chesterfield
Chesterfield
8.0 out of 10, Very Good, (1018)
The price is ¥14,238
¥16,515 total
includes taxes & fees
Nov 18 - Nov 19

Baymont by Wyndham Warrenton
Warrenton
7.4 out of 10, Good, (1006)
The price is ¥13,117
¥15,049 total
includes taxes & fees
Nov 17 - Nov 18

Super 8 by Wyndham Eureka/Six Flags Nearby
Eureka
7.0 out of 10, Good, (1002)
The price is ¥9,205
¥10,724 total
includes taxes & fees
Dec 1 - Dec 2

Holiday Inn Express & Suites Wentzville St Louis West by IHG
Wentzville
9.4 out of 10, Exceptional, (820)
The price is ¥20,712
¥24,679 total
includes taxes & fees
Nov 16 - Nov 17
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions
Learn more about Defiance
Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

Photo by Michael True
Open Photo by Michael True
More cheap stays in Defiance

Americas Best Value Inn & Suites St. Louis, St. Charles Inn
1310 Bass Pro Drive, St. Charles, MO
The price is ¥9,127 per night from Nov 11 to Nov 12
¥9,127
¥10,580 total
Nov 11 - Nov 12
includes taxes & fees
5.6/10 (1,003 reviews)
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Stay near popular Defiance attractions
- Hotels near Mississippi River
- Hotels near Hollywood Casino Amphitheatre
- Hotels near Ameristar Casino St. Charles
- Hotels near Six Flags St. Louis
- Hotels near Westport Plaza
- Hotels near St Charles Convention Center
- Hotels near Hidden Valley Ski Resort
- Hotels near Magic House - St. Louis Children's Museum
- Hotels near Route 66 State Park
- Hotels near Purina Farms
Hotels near Defiance Airports
Other Hotels near Defiance, St. Louis
- St. Charles Hotels
- Chesterfield Hotels
- Maryland Heights Hotels
- St. Peters Hotels
- O'Fallon Hotels
- Innsbrook Hotels
- Wentzville Hotels
- Fenton Hotels
- Eureka Hotels
- Washington Hotels
- Kirkwood Hotels
- Bridgeton Hotels
- Ozarks Hotels
- Hazelwood Hotels
- Wildwood Hotels
- Ballwin Hotels
- Florissant Hotels
- Valley Park Hotels
- Warrenton Hotels
- Troy Hotels
Explore more hotels
- Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
- Americas Best Value Inn & Suites St. Louis, St. Charles Inn
- Courtyard by Marriott St Louis Westport Plaza
- Hyatt Place St. Louis/Chesterfield
- Sonesta ES Suites St. Louis - Chesterfield
- Elimwood Hotel, a Ramada by Wyndham
- Country Inn & Suites by Radisson, St. Charles Historic District
- Drury Plaza Hotel St. Louis Chesterfield
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