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Find hotels in Defiance, MO from ¥10,452

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Compare 827 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
8.2 out of 10, Very Good, (1034)
"The staff was nice, breakfast was good, the location was convenient. "
The price is ¥13,282
¥15,340 total
includes taxes & fees
Sep 28 - Sep 29
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

The Wildwood Hotel

3.5 star property
9.2 out of 10, Wonderful, (1599)
"We enjoyed our stay!"
The Wildwood Hotel

Baymont by Wyndham Warrenton

2.5 star property
7.4 out of 10, Good, (1001)
"Very friendly staff. Nice place to stay"
The price is ¥13,261
¥15,180 total
includes taxes & fees
Oct 12 - Oct 13
Baymont by Wyndham Warrenton

Sonesta ES Suites St. Louis - Chesterfield

3.0 star property
8.0 out of 10, Very Good, (1017)
"Very nice place"
The price is ¥12,947
¥15,017 total
includes taxes & fees
Oct 1 - Oct 2
Sonesta ES Suites St. Louis - Chesterfield

Best Western Plus St. Louis West-Westport

2.5 star property
8.0 out of 10, Very Good, (1015)
"It was a very nice place"
The price is ¥13,126
¥15,224 total
includes taxes & fees
Oct 19 - Oct 20
Best Western Plus St. Louis West-Westport

Super 8 by Wyndham Eureka/Six Flags Nearby

2.0 star property
7.0 out of 10, Good, (1005)
"It did us for the night but i wouldnt book this if it was optional. Two of the few great things was some of the staff was super nice and the close proximity to six flags. "
The price is ¥8,929
¥10,403 total
includes taxes & fees
Oct 8 - Oct 9
Super 8 by Wyndham Eureka/Six Flags Nearby

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
8.8 out of 10, Excellent, (1011)
"Perfect place to stay, very clean and quiet."
The price is ¥13,260
¥15,641 total
includes taxes & fees
Sep 28 - Sep 29
Sleep Inn & Suites O'Fallon MO - Technology Drive

Hollywood Casino & Hotel St. Louis

3.5 star property
8.4 out of 10, Very Good, (2165)
"Great stay!"
The price is ¥13,095
¥17,432 total
includes taxes & fees
Oct 19 - Oct 20
Hollywood Casino & Hotel St. Louis

Best Western Plus Washington Hotel

2.5 star property
9.0 out of 10, Wonderful, (598)
"Great breakfast, comfortable room, and wonderful staff, all for a reasonable price. We stay here every time we are in Washington."
The price is ¥19,042
¥21,680 total
includes taxes & fees
Oct 7 - Oct 8
Best Western Plus Washington Hotel

AC Hotel by Marriott St. Louis Chesterfield

3.5 star property
9.2 out of 10, Wonderful, (206)
"Loved my stay here "
The price is ¥23,216
¥26,928 total
includes taxes & fees
Oct 12 - Oct 13
AC Hotel by Marriott St. Louis Chesterfield

Days Inn by Wyndham St Peters/St Charles

2.0 star property
6.2 out of 10, (988)
"Staff was very friendly. Room was kept clean."
The price is ¥10,752
¥12,359 total
includes taxes & fees
Oct 19 - Oct 20
Days Inn by Wyndham St Peters/St Charles

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
8.6 out of 10, Excellent, (789)
"The staff were very nice & the breakfast was enjoyable. The hotel was clean."
The price is ¥15,031
¥17,730 total
includes taxes & fees
Sep 28 - Sep 29
Holiday Inn Express St. Louis West - O'Fallon by IHG

Drury Plaza Hotel St. Louis St. Charles

3.0 star property
9.6 out of 10, Exceptional, (1012)
"Its a great place to stay to enjoy the City."
The price is ¥16,369
¥18,976 total
includes taxes & fees
Oct 5 - Oct 6
Drury Plaza Hotel St. Louis St. Charles

Elimwood Hotel, a Ramada by Wyndham

3.0 star property
7.4 out of 10, Good, (1014)
"Clean room friendly staff very helpful would definitely stay again "
The price is ¥12,993
¥15,071 total
includes taxes & fees
Oct 26 - Oct 27
Elimwood Hotel, a Ramada by Wyndham

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
9.4 out of 10, Exceptional, (800)
"Everyone and everything was great. Friendly staff, clean facilities, and good breakfast. "
The price is ¥21,281
¥25,312 total
includes taxes & fees
Sep 28 - Sep 29
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Comfort Inn & Suites St. Louis - O'Fallon

2.5 star property
7.6 out of 10, Good, (1008)
"And nice hotel at a nice price "
The price is ¥11,322
¥13,355 total
includes taxes & fees
Oct 26 - Oct 27
Comfort Inn & Suites St. Louis - O'Fallon

Wingate by Wyndham St. Louis/Fenton Route 66

3.0 star property
8.0 out of 10, Very Good, (1034)
"The hotel is old but the staff is friendly"
The price is ¥12,523
¥14,463 total
includes taxes & fees
Sep 28 - Sep 29
Wingate by Wyndham St. Louis/Fenton Route 66

La Quinta Inn & Suites by Wyndham St. Louis Westport

3.0 star property
7.2 out of 10, Good, (1054)
"Great stay"
The price is ¥13,126
¥15,224 total
includes taxes & fees
Sep 28 - Sep 29
La Quinta Inn & Suites by Wyndham St. Louis Westport

Super 8 by Wyndham Union

2.0 star property
8.2 out of 10, Very Good, (616)
"Good room for a reasonable price "
The price is ¥12,054
¥13,318 total
includes taxes & fees
Oct 26 - Oct 27
Super 8 by Wyndham Union

Best Western Plus The Charles Hotel

3.0 star property
8.0 out of 10, Very Good, (1021)
"This is a great place to stay! Room great, breakfast great! All around it is the best place we stayed in the last two weeks!"
The price is ¥13,788
¥15,982 total
includes taxes & fees
Oct 12 - Oct 13
Best Western Plus The Charles Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

Top Defiance Hotel Reviews

More cheap stays in Defiance

More cheap stays in Defiance

Frequently asked questions

What's the best place to stay in Defiance?

Hollywood Casino & Hotel St. Louis, located 18.1 mi (29.2 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham and Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West. See all available top hotels, or vacation rentals in Defiance.

What's the top vacation rental in Defiance?

St. Charles 1860's Gem - Sleeps 6!: Visitors like this Defiance vacation home rental. It is located on a river and has a garden, a selection of books, and air-conditioning to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. See all vacation rentals in Defiance.

If I need to cancel my hotel reservation in Defiance, will I receive a refund?

Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.

Where can I learn more about changing or cancelling my trip to Defiance?

For more information about changing or cancelling your trip to Defiance, head over to our customer service page.

Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?

Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.

What about the best place to stay near Chandler Hill Vineyards?

One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.

What are some accommodations with pools in Defiance?
What's the best place to stay near Lambert-St. Louis International Airport (STL)?

Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.

What's it like to stay in Defiance?

Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station, Busch Stadium, and Gateway Arch. In Defiance, there are 20 hotels and other accommodations to choose from. Find out more about Defiance.

What is there to see in Defiance?

Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River, and Matson Hill Park Trailhead. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.

What's the seasonal weather like in Defiance?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.

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