Find hotels in Clayton, St. Louis

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Clayton hotels

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay
3.5 star property
Clayton
8.8 out of 10, Excellent, (3048)
"Clean room, good breakfast and good location "
United States
Martin
The price is ¥14,750
¥17,219 total
includes taxes & fees
Jan 30 - Jan 31, 2026
Clayton Plaza Hotel & Extended Stay

AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton
3.0 star property
Clayton
9.0 out of 10, Wonderful, (230)
"Staff was amazing "
Canada
Sham
The price is ¥20,276
¥23,670 total
includes taxes & fees
Jan 18 - Jan 19, 2026
AC Hotel St. Louis Clayton

Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton
4.0 star property
Clayton
8.8 out of 10, Excellent, (681)
"The gym was amazing! "
United States
Hannah
The price is ¥21,087
¥24,829 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Le Méridien St. Louis Clayton

The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (554)
"The stay was ok even though nothing was explained to be. The hours of restaurant, where the gym is located about the bar in the room nothing. "
United States
Shemelle
The price is ¥77,829
¥90,856 total
includes taxes & fees
Jan 1 - Jan 2, 2026
The Ritz-Carlton, St. Louis

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Hampton Inn & Suites Clayton/St. Louis-Galleria Area
3.0 star property
Clayton
9.0 out of 10, Wonderful, (921)
"Clean room, friendly staff."
United States
Patrick George
The price is ¥17,777
¥20,930 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Residence Inn By Marriott St. Louis Clayton

Residence Inn By Marriott St. Louis Clayton
3.0 star property
Clayton
9.2 out of 10, Wonderful, (195)
"Clean rooms. Great location. Get a room facing the park. "
United States
Gerhardt
The price is ¥25,111
¥30,193 total
includes taxes & fees
Jan 23 - Jan 24, 2026
Residence Inn By Marriott St. Louis Clayton

Seven Gables, St. Louis West, a Tribute Portfolio Hotel

Seven Gables, St. Louis West, a Tribute Portfolio Hotel
3.5 star property
Clayton
8.4 out of 10, Very Good, (577)
"Love this place."
United States
Robert
The price is ¥20,432
¥25,336 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Seven Gables, St. Louis West, a Tribute Portfolio Hotel

Homewood Suites by Hilton St Louis - Galleria

Homewood Suites by Hilton St Louis - Galleria
3.0 star property
Clayton
8.0 out of 10, Very Good, (1005)
"The room was clean, the accommodations were, great, and the staff was extremely professional and friendly, in particular, Barbara. She was very helpful and professional and we will definitely stay here again when visiting St. Louis."
United States
Russell
The price is ¥15,987
¥18,984 total
includes taxes & fees
Jan 23 - Jan 24, 2026
Homewood Suites by Hilton St Louis - Galleria

Drury Plaza Hotel St. Louis Creve Coeur

Drury Plaza Hotel St. Louis Creve Coeur
3.0 star property
Creve Coeur, 11.2 km from Clayton
9.2 out of 10, Wonderful, (1001)
"Excellent hotel! "
United States
Sara
The price is ¥17,896
¥20,802 total
includes taxes & fees
Jan 22 - Jan 23, 2026
Drury Plaza Hotel St. Louis Creve Coeur

River City Casino & Hotel

River City Casino & Hotel
4.0 star property
13.6 km from Clayton
9.0 out of 10, Wonderful, (1455)
"Everything was absolutely wonderfull"
United States
Suada
The price is ¥13,741
¥18,259 total
includes taxes & fees
Jan 8 - Jan 9, 2026
River City Casino & Hotel

Moonrise Hotel

Moonrise Hotel
4.0 star property
2.6 km from Clayton
9.0 out of 10, Wonderful, (1923)
"Great place"
United States
Edward
The price is ¥20,259
¥24,094 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Moonrise Hotel

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
20.1 km from Clayton
9.4 out of 10, Exceptional, (1006)
"Everything was great!"
United States
Rita
The price is ¥16,439
¥18,893 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Country Inn & Suites by Radisson, St. Charles Historic District

Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel
3.0 star property
20.5 km from Clayton
8.2 out of 10, Very Good, (1007)
"Clean room, great stay"
United States
Becky
The price is ¥14,274
¥16,550 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Best Western Plus The Charles Hotel

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
20 km from Clayton
9.6 out of 10, Exceptional, (1002)
"Staff and hotel were amazing"
United States
Allison
The price is ¥17,935
¥20,791 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Drury Plaza Hotel St. Louis St. Charles

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch
4.0 star property
Downtown St. Louis, 12 km from Clayton
8.4 out of 10, Very Good, (4043)
"Staff was supper nice and it all went so smooth."
United States
Brayden
The price is ¥20,120
¥23,728 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hyatt Regency St. Louis at The Arch

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
3.0 star property
17.2 km from Clayton
7.4 out of 10, Good, (1005)
"Spacious suite, friendly staff. Check in was easy and everything looked clean"
United States
Jonathan
The price is ¥9,760
¥11,322 total
includes taxes & fees
Jan 15 - Jan 16, 2026
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Forest Park Hotel by MDR

Forest Park Hotel by MDR
3.0 star property
The Hill, 4.3 km from Clayton
7.6 out of 10, Good, (1280)
"location attentive staff large king room"
United States
Stephen
Forest Park Hotel by MDR

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
19.8 km from Clayton
8.4 out of 10, Very Good, (1011)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
The price is ¥27,934
¥35,237 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Ameristar Casino Resort and Spa

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
20.3 km from Clayton
8.4 out of 10, Very Good, (1001)
"Nice staff at reception. "
United States
Denise
The price is ¥12,333
¥14,173 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Comfort Suites St Charles - St Louis

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis
3.5 star property
18.3 km from Clayton
8.4 out of 10, Very Good, (2222)
"Fun place to stay"
Canada
James
The price is ¥18,247
¥23,558 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Hollywood Casino & Hotel St. Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Clayton

Find the best Clayton areas and neighborhoods for the activities you enjoy most.

Downtown St. Louis

Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Busch Stadium or Gateway Arch National Park might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

Berkeley

Visitors highly recommend Berkeley for its abundant dining options, and you can make a stop by James S. McDonnell Prologue Room while you're in town.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

Downtown West

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Saint Louis Abbey while you're in town.

Top Clayton Hotel Reviews

Frequently asked questions

What's it like in Clayton?
Clayton is a welcoming neighborhood known for its array of dining options and sporting events. Be sure to check out Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center as part of your Clayton travel plans.
Where is the best hotel for a stay in Clayton?
Based on Expedia customer reviews, AC Hotel St. Louis Clayton is the highest ranked property in Clayton. This hotel offers 2 restaurants and 2 bars. Other top choices in the neighborhood include Residence Inn By Marriott St. Louis Clayton and The Ritz-Carlton, St. Louis.
How many hotels can I expect to find in Clayton?
Expedia has 9 Clayton hotels and other accommodations, and one might make a good home base for venturing out into the greater St. Louis area.
If I need to cancel my hotel reservation in Clayton, will I receive a refund?
Yes, you'll find most room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to view the best options available in Clayton.
Where can I learn more about changing or cancelling my trip to Clayton?
To find more details about rescheduling or cancelling your trip to Clayton, click here.
What are the top things to see and do in Clayton?
A few attractions you might want to check out while you're in Clayton are Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. When you're sightseeing in St. Louis, Tao Tennis Center and Center of Creative Arts are also worth a stop.
How can I get around Clayton and the greater St. Louis area?
Ready to get out and explore the city? Clayton Station is the closest metro station.

Explore a world of travel with Expedia