Find Luxury Hotels in Clayton, MO

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Our top choices for Clayton luxury hotels

Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton
4.0 star property
Clayton
8.8 out of 10, Excellent, (681)
"The gym was amazing! "
United States
Hannah
The price is ¥18,663
¥21,973 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Le Méridien St. Louis Clayton

The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (554)
"The stay was ok even though nothing was explained to be. The hours of restaurant, where the gym is located about the bar in the room nothing. "
United States
Shemelle
The price is ¥78,128
¥91,204 total
includes taxes & fees
Dec 29 - Dec 30
The Ritz-Carlton, St. Louis

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4.0 star property
Downtown St. Louis
8.8 out of 10, Excellent, (1169)
"Staff was helpful at suggesting places to eat and shop"
United States
Ann Marie
The price is ¥15,187
¥18,060 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

River City Casino & Hotel

River City Casino & Hotel
4.0 star property
St. Louis
9.0 out of 10, Wonderful, (1454)
"Everything was absolutely wonderfull"
United States
Suada
The price is ¥14,725
¥19,415 total
includes taxes & fees
Jan 1 - Jan 2, 2026
River City Casino & Hotel

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch
4.0 star property
Downtown St. Louis
8.4 out of 10, Very Good, (4031)
"Staff was supper nice and it all went so smooth."
United States
Brayden
The price is ¥15,500
¥18,280 total
includes taxes & fees
Dec 30 - Dec 31
Hyatt Regency St. Louis at The Arch

White House at Grand Central

White House at Grand Central
4.0 star property
Grand Center
8.6 out of 10, Excellent, (125)
"Very clean and very friendly people "
United States
Mary
The price is ¥10,180
¥21,974 total
includes taxes & fees
Jan 6 - Jan 7, 2026
White House at Grand Central

Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown
4.0 star property
Downtown St. Louis
8.8 out of 10, Excellent, (1254)
"Very cool hotel, rooms were clean and nice design, the food at the bar/restaurant was fantastic!!!"
United States
Cullin
The price is ¥17,204
¥20,462 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Embassy Suites by Hilton St. Louis Downtown

The Westin St. Louis

The Westin St. Louis
4.5 star property
Downtown St. Louis
8.6 out of 10, Excellent, (1003)
"Great location "
United States
Gregory
The price is ¥22,491
¥26,298 total
includes taxes & fees
Jan 15 - Jan 16, 2026
The Westin St. Louis

Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel
4.0 star property
Berkeley
8.4 out of 10, Very Good, (1064)
"I loved the service, room cleanliness, club lounge offered a nice variety of food and treats. The property is noticeably old but well maintained. "
United States
Ingrid I
The price is ¥19,102
¥22,346 total
includes taxes & fees
Jan 16 - Jan 17, 2026
Renaissance St. Louis Airport Hotel

Hilton Pennywell St. Louis at the Arch

Hilton Pennywell St. Louis at the Arch
4.0 star property
Downtown St. Louis
8.8 out of 10, Excellent, (1020)
"My second time staying there as always it was lovely "
United States
Nina
The price is ¥16,784
¥19,794 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hilton Pennywell St. Louis at the Arch
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Clayton Hotel Reviews

Frequently asked questions

Are you looking for a luxury hotel for your stay in Clayton?
While you're visiting, you might want to think about enjoying the museums and sporting events, which Clayton is known for.
What's the best luxury place to stay in Clayton?
The Ritz-Carlton, St. Louis is a luxury hotel with 2 restaurants and 3 bars, and it's a popular choice for Expedia travelers looking for an elegant place to stay.
What's there to see and do in Clayton?
Experience Clayton with a stop at Chapel of St. Timothy And St. Titus, Concordia Seminary, St. Louis Union Station, and Busch Stadium. If you have extra time while you're in the area, you might want to see Saint Louis Galleria Mall and St. Louis Art Museum.
How can I get around Clayton?
It's easier to get around town comfortably when you know your options. Head to Clayton Station for metro transit.

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