Santo Spirito

Florence

A grand church interior with high vaulted ceilings, large columns, and a central altar.
A stone bridge over a calm river, with historic buildings on either side.
A bustling outdoor market with white tents and various stalls.
A church with a bell tower, a circular window, and a weather vane.
A cityscape with a river, a bridge, and mountains in the background.

Stay near popular Santo Spirito attractions

A town square with historic buildings, a church, and a bell tower.

Piazza Santo Spirito

9.6/10 (8 reviews)
Learn about the local history of Florence with a stop at Piazza Santo Spirito. Discover the acclaimed art scene and notable monuments in this vibrant area.
See properties

Things to do

City Sightseeing Florence Hop-on Hop-off

City Sightseeing Florence Hop-on Hop-off Bus Tour

ļæ„4,536
per adult
76% of travellers recommend
City Sightseeing Florence Hop-on Hop-off Bus Tour
Best of Florence Tour with Fast Track Accademia & Duomo

Best of Florence Tour with David at Accademia & Duomo (with VIP option)

ļæ„15,275
per adult
96% of travellers recommend
Best of Florence Tour with David at Accademia & Duomo (with VIP option)
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour

ļæ„3,322
per adult
80% of travellers recommend
Skip-the-Line Florence Duomo: Priority-Access Express Guided Tour
Michaelangelo's David

Accademia timed-entry Ticket with Instant Delivery & Priority Access

ļæ„7,545
per adult
94% of travellers recommend
Accademia timed-entry Ticket with Instant Delivery & Priority Access
People riding scooters in Tuscany

Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine

ļæ„21,532
per adult
100% of travellers recommend
Florence Vespa Tour: Tuscan Hills, Food and Chianti Wine
Best of Florence Walking Tour

Best of Florence Walking Tour

ļæ„3,681
per adult
92% of travellers recommend
Best of Florence Walking Tour
See all activities in Florence

Santo Spirito Hotel Deals

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
The price is ļæ„23,595 per night from Aug 31 to Sep 1
ļæ„23,595
ļæ„28,554 total
Aug 31 - Sep 1
includes taxes & fees
Stay at this hotel in Florence. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
9.8/10 Exceptional! (713 reviews)
"Good location, close to main attractions."

Reviewed on Aug 21, 2026

Hotel Horto Convento
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
The price is ļæ„12,544 per night from Aug 26 to Aug 27
ļæ„12,544
ļæ„16,398 total
Aug 26 - Aug 27
includes taxes & fees
Stay at this residence in Florence. Enjoy free WiFi, valet parking (surcharge), and daily housekeeping. Popular attractions Ponte Vecchio and Piazza del Duomo ...
9.2/10 Wonderful! (296 reviews)
"The location and staff is amazing! The room was huge, great AC!!"

Reviewed on Aug 22, 2026

La Torre Del Cestello
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59 Florence FI
The price is ļæ„14,580 per night from Aug 30 to Aug 31
ļæ„14,580
ļæ„18,637 total
Aug 30 - Aug 31
includes taxes & fees
Book a stay at this boutique hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
8.4/10 Very Good! (1,006 reviews)
"Very clean, nice rooms, staff and great breakfast / evening food in the restaurant. Location 20min walk to main Santa Maria Station."

Reviewed on Aug 16, 2026

UNA Hotels Vittoria Firenze
Foresteria Valdese di Firenze - Casa per Ferie

Foresteria Valdese di Firenze - Casa per Ferie

Via dei Serragli 49 Florence FI
The price is ļæ„13,178 per night from Aug 31 to Sep 1
ļæ„13,178
ļæ„16,722 total
Aug 31 - Sep 1
includes taxes & fees
Stay at this guesthouse in Florence. Enjoy free WiFi, 2 meeting rooms, and satellite TV channels. Our guests praise the helpful staff and the clean rooms in ...
8.8/10 Excellent! (235 reviews)
"There was a fridge and AC in the room which was nice. Check-in desk was friendly, we actually checked in like an hour early and when checking out we checked out 15 minutes late, not charged and were able to drop our bags with a bathroom available in the lobby. The area felt safe at night and there ..."

Reviewed on Aug 14, 2026

Foresteria Valdese di Firenze - Casa per Ferie
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
The price is ļæ„19,598 per night from Aug 25 to Aug 26
ļæ„19,598
ļæ„24,157 total
Aug 25 - Aug 26
includes taxes & fees
Stay at this residence in Florence. Enjoy free WiFi, concierge services, and premium bedding. Our guests praise the helpful staff in our reviews. Popular attractions ...
Palazzo Mannaioni Suites
Hostel Santa Monaca

Hostel Santa Monaca

Via Santa Monaca 6 Florence FI
Stay at this hostel in Florence. Enjoy free WiFi, daily housekeeping, and dry cleaning or laundry services. Popular attractions Ponte Vecchio and Cathedral of ...
7.8/10 Good! (64 reviews)
"No"

Reviewed on Jul 30, 2026

Get rates
Hostel Santa Monaca
See all 500 properties in Santo Spirito
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Learn more about Santo Spirito
A river with buildings on the right bank.

Historic Centre of Florence

Known for its fascinating museums, stunning cathedral, and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Piazza del Duomo and Piazza di Santa Maria Novella are major draws. Catch the metro at UnitĆ  Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

A historic building with intricate architectural details, including a dome and ornate facades.

Duomo

Piazza del Duomo and Piazza di Santa Maria Novella are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.

A historic bridge with arches over a river, surrounded by yellow buildings and a crowd of people.

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

A historic church with intricate architecture and a large open plaza with people.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

An ornate building with intricate architectural details and a clear blue sky in the background.

Santa Croce

Travelers come to Santa Croce for its interesting museums, and you can see top attractions like Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Santo Spirito

Explore a world of travel with Expedia