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Jan 31 - Feb 1
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Our top choices for Santo Spirito hotels

Panoramic Double Room, 1 Bedroom, Air conditioning, City View | Hypo-allergenic bedding, minibar, blackout drapes, soundproofing

SPIRIT OF FLORENCE Boutique Rooms

SPIRIT OF FLORENCE Boutique Rooms
Santo Spirito
10.0 out of 10, Exceptional, (25 reviews)
"My husband and I enjoyed our stay here! Large rooms and bathrooms, wonderful location, and great staff! "
United States
Christina
The price is ￥22,653
￥27,118 total
includes taxes & fees
Feb 22 - Feb 23
SPIRIT OF FLORENCE Boutique Rooms
Double Room, Garden View | Pillowtop beds, minibar, in-room safe, desk

La Fonderia Firenze

La Fonderia Firenze
Santo Spirito
9.6 out of 10, Exceptional, (172 reviews)
"The room was beautiful and clean, the staff was pleasant, breakfast was fantastic, 10/10"
United States
Dan
The price is ￥15,115
￥18,826 total
includes taxes & fees
Feb 2 - Feb 3
La Fonderia Firenze
Royal Double Room | Minibar, in-room safe, soundproofing, free WiFi

Oltrarno Splendid

Oltrarno Splendid
Santo Spirito
10.0 out of 10, Exceptional, (104 reviews)
"It was a great stay. The renovation style is very tasteful. "
Singapore
Maoying
The price is ￥23,146
￥28,029 total
includes taxes & fees
Feb 25 - Feb 26
Oltrarno Splendid
Property entrance

Residenza D'Epoca Al Numero 8

Residenza D'Epoca Al Numero 8
Santo Spirito
8.8 out of 10, Excellent, (139 reviews)
"Our stay was wonderful! Roxy was so welcoming and helpful! The room and view was beautiful as well! Great location with amazing food and sights nearby! "
United States
Jacqueline
Residenza D'Epoca Al Numero 8
Property entrance

Foresteria Valdese di Firenze - Casa per Ferie

Foresteria Valdese di Firenze - Casa per Ferie
Santo Spirito
8.8 out of 10, Excellent, (196 reviews)
"The room was clean a d comfortable, and the staff was very courteous and helpful. The location was also good with most attractions being a 30 to 40 minute walk or less."
United States
Roger
Foresteria Valdese di Firenze - Casa per Ferie
Lobby sitting area

AdAstra Suites

AdAstra Suites
Santo Spirito
9.8 out of 10, Exceptional, (222 reviews)
"Loved my stay at this Hotel. Everything about it was wonderful. The staff was warm and welcoming, the location was in what is now the more interesting and authentic part of Florence. The Terrace overlooking the Gardens where you can eat breakfast was dazzling. In this age of ultra modern hotels, this one stood out because of its preservation of history and yet the room and the bathroom were large and roomy yet warm and cozy. "
United States
monica
The price is ￥27,775
￥33,119 total
includes taxes & fees
Feb 2 - Feb 3
AdAstra Suites
Rooftop terrace

Hotel Palazzo Guadagni

Hotel Palazzo Guadagni
Santo Spirito
9.0 out of 10, Wonderful, (201 reviews)
"Absolutely amazing stay! Great location to all major attractions, great restaurants nearby, beautiful rooms, certain room has Duomo view, incredibly helpful staff! Definitely recommend it and we are planning to come back! "
United States
Ann
The price is ￥35,794
￥41,574 total
includes taxes & fees
Feb 1 - Feb 2
Hotel Palazzo Guadagni
Superior Double Room, 1 King Bed | Premium bedding, down comforters, in-room safe, desk

La Torre Del Cestello

La Torre Del Cestello
Santo Spirito
9.0 out of 10, Wonderful, (233 reviews)
"The Torre del Cestello had the "Room with a View" (complete with garden below) that I had been dreaming of for my first visit to Florence. The desk staff were all pleasant, helpful, and set me up with a map and suggestions when I checked in. There was easy access in and out of the room. Quiet but incredibly convenient location. "
United States
Tanya
The price is ￥9,976
￥13,540 total
includes taxes & fees
Feb 1 - Feb 2
La Torre Del Cestello
Fireplace

Ottantotto Firenze

Ottantotto Firenze
Santo Spirito
9.6 out of 10, Exceptional, (169 reviews)
"Great location and extremely charming!"
United States
Brook
The price is ￥29,837
￥35,389 total
includes taxes & fees
Feb 8 - Feb 9
Ottantotto Firenze
Front of property

Palazzo D'Oltrarno - Residenza D'Epoca

Palazzo D'Oltrarno - Residenza D'Epoca
Santo Spirito
9.4 out of 10, Exceptional, (46 reviews)
"Excellent place to stay!"
United States
Diane
The price is ￥15,563
￥19,320 total
includes taxes & fees
Feb 10 - Feb 11
Palazzo D'Oltrarno - Residenza D'Epoca
Lobby

Hotel Horto Convento

Hotel Horto Convento
4.0 star property
Santo Spirito
9.8 out of 10, Exceptional, (615 reviews)
"Wonderful place, super clean, very nice staff and wonderful breakfast. Also great location for beautiful walks not too close to areas overcrowded by tourists!"
United States
Gianmaria
The price is ￥17,363
￥21,666 total
includes taxes & fees
Feb 5 - Feb 6
Hotel Horto Convento
Standard Double or Twin Room, 1 Double or 2 Twin Beds, Private Bathroom | Down comforters, individually decorated, individually furnished, desk

1900 Artevita

1900 Artevita
Santo Spirito
8.8 out of 10, Excellent, (178 reviews)
"Our stay here was wonderful! The host was so pleasant and the view from the terrace was beautiful. The location was in a great spot for enjoying the Florentine neighborhoods, and close to many of the restaurants recommended to us. We would stay here again in a heartbeat."
United States
Bianca
1900 Artevita
Suite | Premium bedding, in-room safe, desk, laptop workspace

Palazzo Mannaioni Suites

Palazzo Mannaioni Suites
4.0 star property
Santo Spirito
9.2 out of 10, Wonderful, (1,080 reviews)
"Everything great. A+ Looking forward to stay again. "
United States
Rafael
Palazzo Mannaioni Suites
Front of property

Hotel Firenze 2000

Hotel Firenze 2000
2.0 star property
Santo Spirito
7.2 out of 10, Good, (189 reviews)
"The staff was wonderful and very helpful; 24 hr service ! The room was very clean and breakfast was plentiful. Great location if you don’t mind a short walk to the historic town center ; would definitely recommend."
Canada
Josee
The price is ￥9,461
￥12,057 total
includes taxes & fees
Feb 24 - Feb 25
Hotel Firenze 2000
Hallway

Soggiorno Alessandra

Soggiorno Alessandra
Santo Spirito
8.6 out of 10, Excellent, (86 reviews)
"Alessandra is an amazing host, we had a perfect stay! The apartment is in excellent condition and very clean! "
United States
Elias
Soggiorno Alessandra
Interior

Casa Santo Nome di Gesù

Casa Santo Nome di Gesù
Santo Spirito
8.8 out of 10, Excellent, (343 reviews)
"Really a nice place, like the room style and good for family stay!"
United States
Ning
Casa Santo Nome di Gesù
Exterior

Santo Spirito Venti

Santo Spirito Venti
Santo Spirito
8.8 out of 10, Excellent, (60 reviews)
"Great location, friendly staff, I definitely recommend it."
Canada
Pedro
Santo Spirito Venti
Suite | Room amenity

Torre di Bellosguardo

Torre di Bellosguardo
4.0 star property
Santo Spirito
9.0 out of 10, Wonderful, (103 reviews)
"Beautiful property and wonderful staff."
United States
Brad
The price is ￥58,951
￥67,411 total
includes taxes & fees
Feb 2 - Feb 3
Torre di Bellosguardo
Room, River View (Attic) | Minibar, in-room safe, desk, free WiFi

B&B Mia Palace

B&B Mia Palace
Santo Spirito
8.4 out of 10, Very Good, (113 reviews)
"Extremely helpful and friendly staff."
United States
Julie
The price is ￥8,838
￥11,921 total
includes taxes & fees
Feb 3 - Feb 4
B&B Mia Palace
Family Apartment | Living area | 40-inch flat-screen TV with digital channels, TV

Appartamenti degli Artisti by Mmega

Appartamenti degli Artisti by Mmega
Santo Spirito
8.6 out of 10, Excellent, (29 reviews)
"We stayed here in November and had a wonderful experience. The location worked perfectly for my husband and I, close enough to the center to get everywhere easily, yet set in a quiet residential part of Florence where we could feel the local rhythm of the city. The staff who look after the house were all very easy to communicate with. The whole stay was smooth and comfortable. We truly enjoyed our time here!"
United States
Ray
The price is ￥12,229
￥30,314 total
includes taxes & fees
Feb 1 - Feb 2
Appartamenti degli Artisti by Mmega
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Learn more about Santo Spirito
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Duomo featuring heritage architecture and street scenes as well as a small group of people

Duomo

Piazza di Santa Maria Novella and Via de' Calzaiuoli are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.

Santa Maria Novella which includes heritage architecture, a church or cathedral and street scenes

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Uffizi Gallery which includes street scenes as well as a large group of people

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

Piazza Santa Croce showing a city and street scenes

Santa Croce

Travelers come to Santa Croce for its interesting museums, and you can see top attractions like Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Top Santo Spirito Hotel Reviews

Casa Santo Nome di Gesù

Casa Santo Nome di Gesù

10/10 Excellent
"Pretty neat place. Run by nuns. Great building. Friendly staff Breakfast included. Rooms simple clean. Beautiful location. Would definitely go back. "
David 4-night trip
Posted 2 days ago
Casa Santo Nome di Gesù

Frequently asked questions

What is Santo Spirito like?
Santo Spirito is a trendy neighborhood known for its beautiful river views. Be sure to check out Porta Romana and Piazza Santo Spirito as part of your Santo Spirito travel plans.
What's the best accommodation in Santo Spirito?
Based on Expedia customer reviews, Oltrarno Splendid is the highest ranked property in Santo Spirito. This B&B is a short 7-minute walk from Piazza di Santa Maria Novella, and it offers free breakfast and free WiFi. Other favorite options in the area include AdAstra Suites and SPIRIT OF FLORENCE Boutique Rooms.
How many hotels can I expect to find in the Santo Spirito area?
Expedia has 480 hotels and other accommodations in Santo Spirito to choose from, making this an ideal home base for exploring the greater Florence area.
If I need to cancel my hotel reservation in Santo Spirito, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals in Santo Spirito.
Where can I learn more about changing or cancelling my trip to Santo Spirito?
To find more details about updating your trip to Santo Spirito or cancelling it, head over to our customer service page.
What can I see and do in this Florence neighborhood?
Spend some time exploring the natural setting of Santo Spirito with a visit to Arno River and Torrigiani Garden. As you're discovering the neighborhood, Porta Romana and Piazza Santo Spirito are some other places worth a visit. A few places to visit in the area around Santo Spirito include Piazza di Santa Maria Novella, Piazza del Carmine, and Santa Maria della Carmine. When you're sightseeing in Florence, Brancacci Chapel and Il Nabucco di Matteo Gabellini are also worth a stop.

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