Find hotels in Murphy, MO from ￥10,963

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Dec 24 - Dec 25
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Dec 25 - Dec 26
This weekend
Dec 26 - Dec 28
Next weekend
Jan 2 - Jan 4

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Our top choices for Murphy hotels

Exterior
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.0 out of 10, Very Good, (1001)
"Clean room and friendly staff "
United States
Summer Dawn
The price is ￥13,954
￥16,036 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hampton Inn St. Charles St. Peters
Lobby
Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1000)
"Wonderful stay. Checkin was easy and host was very accommodating. "
United States
Teresa
The price is ￥12,285
￥14,491 total
includes taxes & fees
Jan 15 - Jan 16, 2026
Sleep Inn & Suites O'Fallon MO - Technology Drive
Ballroom
The Wildwood Hotel

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1606)
"Great place!"
United States
Biju
The Wildwood Hotel
Exterior
Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (844)
"A very nice stay with very pleasant staff"
United States
Clifford
The price is ￥14,207
￥16,756 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Holiday Inn Express St. Louis West - O'Fallon by IHG
Lobby sitting area
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South
2.5 star property
Festus
7.8 out of 10, Good, (911)
"Vary clean"
United States
George
The price is ￥11,810
￥13,799 total
includes taxes & fees
Dec 26 - Dec 27
Comfort Inn Festus - St Louis South
Lobby
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
8.0 out of 10, Very Good, (892)
"Breakfast was great! Location right off interstate was perfect. The property is a little old."
United States
Mindy
The price is ￥14,464
￥16,540 total
includes taxes & fees
Dec 25 - Dec 26
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Bar (on property)
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4.0 star property
Downtown St. Louis
8.8 out of 10, Excellent, (1169)
"Staff was helpful at suggesting places to eat and shop"
United States
Ann Marie
The price is ￥13,964
￥16,607 total
includes taxes & fees
Dec 28 - Dec 29
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Daily cooked-to-order breakfast for a fee
River City Casino & Hotel

River City Casino & Hotel

River City Casino & Hotel
4.0 star property
St. Louis
9.0 out of 10, Wonderful, (1451)
"Awesome place to stay!!"
United States
Kaitlyn
The price is ￥14,992
￥19,721 total
includes taxes & fees
Jan 4 - Jan 5, 2026
River City Casino & Hotel
Courtyard
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
3.0 star property
Maryland Heights
7.4 out of 10, Good, (1000)
"Spacious suite, friendly staff. Check in was easy and everything looked clean"
United States
Jonathan
The price is ￥10,483
￥12,159 total
includes taxes & fees
Dec 30 - Dec 31
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Lobby sitting area
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very Good, (1051)
"Everything was clean and friendly staff overall good experience "
United States
dennis
The price is ￥13,270
￥15,328 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Terrace/patio
Hampton Inn St. Louis - Columbia

Hampton Inn St. Louis - Columbia

Hampton Inn St. Louis - Columbia
2.5 star property
Columbia
8.6 out of 10, Excellent, (476)
"Breakfast was great and a very good atten"
United States
John
The price is ￥15,348
￥17,033 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Hampton Inn St. Louis - Columbia
Terrace/patio
Courtyard by Marriott St. Louis Brentwood

Courtyard by Marriott St. Louis Brentwood

Courtyard by Marriott St. Louis Brentwood
3.0 star property
Richmond Heights
9.4 out of 10, Exceptional, (839)
"Clean, would stay again."
United States
Eryka
The price is ￥15,792
￥19,374 total
includes taxes & fees
Dec 25 - Dec 26
Courtyard by Marriott St. Louis Brentwood
Lobby
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport
2.5 star property
St. Ann
9.4 out of 10, Exceptional, (2751)
"Great place to stay before your early morning flight. "
United States
Henry
The price is ￥14,049
￥16,539 total
includes taxes & fees
Dec 29 - Dec 30
Pear Tree Inn St. Louis Airport
Free buffet breakfast
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
2.5 star property
Festus
9.4 out of 10, Exceptional, (702)
"Clean, spotless, great room, front desk staff was excellent! Parking great!"
United States
Rick
The price is ￥20,452
￥23,386 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Lobby
Comfort Inn Near Six Flags St. Louis

Comfort Inn Near Six Flags St. Louis

Comfort Inn Near Six Flags St. Louis
2.5 star property
Pacific
8.4 out of 10, Very Good, (877)
"Everything was great"
United States
Sarah
The price is ￥14,379
￥16,460 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Comfort Inn Near Six Flags St. Louis
Exterior
The Principal Hotel

The Principal Hotel

The Principal Hotel
3.5 star property
Columbia
9.8 out of 10, Exceptional, (193)
"Great place. Very nice rooms, new and clean."
United States
Jeff
The price is ￥15,677
￥17,399 total
includes taxes & fees
Dec 28 - Dec 29
The Principal Hotel
Terrace/patio
Hampton Inn By Hilton St Louis Airport

Hampton Inn By Hilton St Louis Airport

Hampton Inn By Hilton St Louis Airport
2.5 star property
Woodson Terrace
8.8 out of 10, Excellent, (104)
"Great stay for the night before our trip"
United States
April
The price is ￥19,075
￥22,764 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hampton Inn By Hilton St Louis Airport
Desk, blackout drapes, iron/ironing board, free cribs/infant beds
Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
7.8 out of 10, Good, (1123)
"Room was clean, air worked good, staff was super nice."
United States
Jessica
The price is ￥12,341
￥14,253 total
includes taxes & fees
Dec 28 - Dec 29
Wingate by Wyndham St. Louis/Fenton Route 66
Free daily buffet breakfast
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1001)
"Everything was great!"
United States
Rita
The price is ￥18,232
￥20,954 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Country Inn & Suites by Radisson, St. Charles Historic District
Exterior
Best Western Plus Fenton

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (182)
"Clean room, nice staff, great food, and great service "
United States
Thuy
The price is ￥15,824
￥18,275 total
includes taxes & fees
Dec 27 - Dec 28
Best Western Plus Fenton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Murphy Hotel Reviews

St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton

10/10 Excellent
"Gorgeous property, clean and updated room!"
Cori 1-night trip
Posted 1 day ago
St. Louis Union Station Hotel, Curio Collection by Hilton

More cheap stays in Murphy

Relax Inn Saint Charles

Relax Inn Saint Charles

3800 Harry S Truman Blvd St. Charles MO
The price is ￥9,540 per night from Dec 28 to Dec 29
￥9,540
￥10,963 total
Dec 28 - Dec 29
includes taxes & fees
6.4/10 (1,001 reviews)

Frequently asked questions

Where is the best place to stay in Murphy?
Located 20 mi (32.1 km) from the heart of Murphy, Magnolia Hotel St. Louis, a Tribute Portfolio Hotel is a top choice for your stay based on our traveler data. Other good options for your trip to the area are Hilton St. Louis Airport and Clayton Plaza Hotel & Extended Stay. See all available top hotels, or vacation rentals in Murphy.
What are some of the best vacation home rentals in Murphy?
Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!: This vacation home rental near Murphy is located in the city center and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. You and your friends and family can relax into your vacation with amenities like a selection of games. See all vacation rentals in Murphy.
If I need to cancel my hotel reservation in Murphy, will I receive a refund?
Yes! Most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might be able to cancel it and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Murphy.
Where can I learn more about changing or cancelling my trip to Murphy?
For additional details about changing or cancelling your trip to Murphy, go to https://www.expedia.com/service/.
What is staying in Murphy like?
Travelers to Murphy will find plenty to explore and enjoy. There are 1732 hotels and other accommodations in the surrounding area. Find out more about Murphy.
What is there to see in Murphy?
A favorite place to visit is Lone Elk Park. You'll also find Castlewood State Park and Route 66 State Park in the area. Check out what more to see and do in Expedia's Murphy guide.
What's the seasonal weather like in Murphy?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Murphy is 52 inches.

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