Find hotels in Illinois Medical District, Chicago from ￥13,681
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Illinois Medical District
Apart hotel
Check prices for these dates
Our top choices for Illinois Medical District hotels
Hyatt House Chicago Medical/University District
Hyatt House Chicago Medical/University DistrictIllinois Medical District
9.0 out of 10, Wonderful, (1252)
"Good staff and excellent room."
Mario Alberto Cervera
The price is ￥14,490
￥17,010 total
includes taxes & fees
Dec 22 - Dec 23
Hyatt Place Chicago Medical/University District
Hyatt Place Chicago Medical/University DistrictIllinois Medical District
9.0 out of 10, Wonderful, (1415)
"The food was delicious "
Frank
The price is ￥13,711
￥16,096 total
includes taxes & fees
Dec 22 - Dec 23
Hampton Inn & Suites Chicago Medical District UIC
Hampton Inn & Suites Chicago Medical District UICIllinois Medical District
9.6 out of 10, Exceptional, (366)
"Room was immaculate, breakfast was very good and there was plenty of shops and eats near by "
Surayah
The price is ￥13,586
￥15,949 total
includes taxes & fees
Dec 21 - Dec 22
Aloft Chicago Downtown River North
Aloft Chicago Downtown River NorthRiver North, 4.4 km from Illinois Medical District
9.4 out of 10, Exceptional, (1165)
"Clean room, friendly staff, perfect location"
Matt
The price is ￥16,360
￥19,207 total
includes taxes & fees
Dec 21 - Dec 22
LondonHouse Chicago, Curio Collection by Hilton
LondonHouse Chicago, Curio Collection by HiltonThe Loop, 4.6 km from Illinois Medical District
9.4 out of 10, Exceptional, (3437)
"Loved the location and view!"
Erica
The price is ￥20,315
￥23,845 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Godfrey Hotel Chicago
The Godfrey Hotel ChicagoRiver North, 4.6 km from Illinois Medical District
8.6 out of 10, Excellent, (1925)
"Good value, great cleaning staff "
farzana
The price is ￥15,575
￥21,944 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Illinois Medical District
Find the best Illinois Medical District areas and neighborhoods for the activities you enjoy most.
Downtown Chicago
The heart of the Midwest’s glittering metropolis has many offerings, from shopping and dining to parks, museums and exciting contemporary public art.
Magnificent Mile
Upscale shopping district with luxury department stores, boutiques, and acclaimed restaurants, featuring landmarks like the Wrigley Building and Chicago Water Tower. The Magnificent Mile is easily accessible by public transit and seasonal trolley service.
The Loop
Chicago's central business district boasts numerous global businesses, retail establishments, and theaters. Explore the Loop Retail Historic District, Chicago Landmark Historic Michigan Boulevard District, and visit iconic attractions like the Art Institute of Chicago.
River North
Artistic spirit thrives here, with art galleries and a design district featuring luxury interior furnishings. Explore Kingsbury Park, enjoy vibrant nightlife on Hubbard Street, and visit the iconic Contemporaine Building.
Theatre District
While you're in Theatre District, take in top sights like Michigan Avenue or State Street, and hop on the metro to see more the city at Washington Station or Monroe Station (Blue Line).
Top Illinois Medical District Hotel Reviews
Crowne Plaza Chicago West Loop by IHG
10/10 Excellent
Explore a world of travel with Expedia
Frequently asked questions
Hotels in top Chicago neighborhoods
- Hotels in Downtown Chicago
- Hotels in Magnificent Mile
- Hotels in The Loop
- Hotels in River North
- Hotels in Theatre District
- Hotels in Lincoln Park
- Hotels in Streeterville
- Hotels in West Loop
- Hotels in O'Hare
- Hotels in Lakeview
- Hotels in Near North Side
- Hotels in Wrigleyville
- Hotels in West Town
- Hotels in Near South Side
- Hotels in Near West Side
- Hotels in South Loop
- Hotels in Old Town Chicago
- Hotels in Wicker Park
- Hotels in Gold Coast
- Hotels in Fulton Market
Hotels near popular Chicago Attractions
More Accommodation Types in Illinois Medical District
Explore more hotels
- The Royal Sonesta Chicago Downtown
- Swissotel - Chicago
- Hyatt Regency Chicago
- Pendry Chicago
- Crowne Plaza Chicago West Loop by IHG
- River Hotel
- Homewood Suites by Hilton Chicago Downtown South Loop
- InterContinental Chicago Magnificent Mile by IHG
- Sable at Navy Pier Chicago, Curio Collection by Hilton
- LondonHouse Chicago, Curio Collection by Hilton
- citizenM Chicago Downtown
- Club Quarters Hotel, Central Loop, Chicago
More ways to book
Expedia's Latest Trends
Hotels
- Hotels in Kasukabe
- Hyatt Regency Paris Etoile
- Noboribetsu Grand Hotel
- FourSeasons Hotels in Savannah
- Toyoko Inn Tokyo Uguisudani Ekimae
- Hotels in Hong Kong Island
- Rembrandt Hotel Bangkok
- La Mamounia
- The Continent Hotel Sukhumvit - Asok BTS Bangkok
- Tokyo Bay Ariake Washington Hotel
- Hotels in Downtown Chicago
- Hotel Wing International Select Nagoya Sakae
Flights
Packages