Find hotels in Illinois Medical District, Chicago from ￥14,855

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Discover 4,808 Illinois Medical District hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Exterior
Hyatt House Chicago Medical/University District

Hyatt House Chicago Medical/University District

3.5 star property
Illinois Medical District
9.0 out of 10, Wonderful, (1224)
"Good place to stay "
United States
Matthew
The price is ￥14,368
￥16,868 total
includes taxes & fees
Dec 22 - Dec 23
Hyatt House Chicago Medical/University District
Lobby
Hyatt Place Chicago Medical/University District

Hyatt Place Chicago Medical/University District

3.0 star property
Illinois Medical District
9.0 out of 10, Wonderful, (1406)
"We definitely enjoyed our stay. Very nice clean room comfortable bed we didn’t want to get out of and excellent customer service at check in and out. Definitely recommend staying here 10/10 "
United States
Brenden
The price is ￥13,709
￥16,093 total
includes taxes & fees
Dec 22 - Dec 23
Hyatt Place Chicago Medical/University District
Business center
Hampton Inn & Suites Chicago Medical District UIC

Hampton Inn & Suites Chicago Medical District UIC

2.5 star property
Illinois Medical District
9.6 out of 10, Exceptional, (353)
"Would stay there again...loved it!"
United States
Deborah
The price is ￥13,523
￥15,876 total
includes taxes & fees
Dec 14 - Dec 15
Hampton Inn & Suites Chicago Medical District UIC
Bar (on property)
Hilton Garden Inn Chicago Downtown/Magnificent Mile

Hilton Garden Inn Chicago Downtown/Magnificent Mile

3.0 star property
River North, 4.7 km from Illinois Medical District
8.4 out of 10, Very Good, (4214)
"Great location. "
United States
Rodger
The price is ￥12,654
￥14,855 total
includes taxes & fees
Dec 21 - Dec 22
Hilton Garden Inn Chicago Downtown/Magnificent Mile
Ballroom
Hilton Chicago/Magnificent Mile Suites

Hilton Chicago/Magnificent Mile Suites

3.5 star property
Streeterville, 5.6 km from Illinois Medical District
9.0 out of 10, Wonderful, (3430)
"Great hotel located in nice area."
United States
Robert
The price is ￥12,918
￥15,164 total
includes taxes & fees
Dec 7 - Dec 8
Hilton Chicago/Magnificent Mile Suites
2 bars/lounges
Hyatt Regency Chicago

Hyatt Regency Chicago

4.0 star property
The Loop, 4.8 km from Illinois Medical District
9.4 out of 10, Exceptional, (3375)
"Nice hotel"
United States
Dick
The price is ￥21,091
￥29,310 total
includes taxes & fees
Dec 22 - Dec 23
Hyatt Regency Chicago
Exterior
Embassy Suites by Hilton Chicago Downtown Magnificent Mile

Embassy Suites by Hilton Chicago Downtown Magnificent Mile

4.0 star property
Streeterville, 5.2 km from Illinois Medical District
8.4 out of 10, Very Good, (2737)
"Great food clean room friendly staff"
United States
MARINA
The price is ￥13,523
￥20,426 total
includes taxes & fees
Dec 23 - Dec 24
Embassy Suites by Hilton Chicago Downtown Magnificent Mile
Cocktail bar
Aloft Chicago Mag Mile

Aloft Chicago Mag Mile

3.0 star property
Streeterville, 5.2 km from Illinois Medical District
8.6 out of 10, Excellent, (2943)
"Great location and great staff!!"
United States
lynne
The price is ￥13,802
￥16,201 total
includes taxes & fees
Dec 7 - Dec 8
Aloft Chicago Mag Mile
Premium bedding, down comforters, pillowtop beds, in-room safe
The Wade

The Wade

4.5 star property
Streeterville, 5.6 km from Illinois Medical District
8.4 out of 10, Very Good, (1501)
"Great location, walkable to so many area attractions. Would definitely stay here again. "
United States
Debbie
The price is ￥14,733
￥17,296 total
includes taxes & fees
Dec 8 - Dec 9
The Wade
Reception
Swissotel - Chicago

Swissotel - Chicago

4.5 star property
5 km from Illinois Medical District
9.0 out of 10, Wonderful, (2987)
"Great stay"
Canada
Lorrington Ashford
The price is ￥11,373
￥17,921 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Swissotel - Chicago
Lobby
Silversmith Hotel Chicago Downtown

Silversmith Hotel Chicago Downtown

4.0 star property
Theatre District, 4.3 km from Illinois Medical District
9.2 out of 10, Wonderful, (2097)
"Lovely hotel in a great spot!"
United States
Natasha
The price is ￥9,454
￥15,852 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Silversmith Hotel Chicago Downtown
American cuisine, alfresco dining
The Godfrey Hotel Chicago

The Godfrey Hotel Chicago

4.5 star property
River North, 4.6 km from Illinois Medical District
8.6 out of 10, Excellent, (1909)
"Awesome staff and great location "
United States
Luis C
The price is ￥12,918
￥18,805 total
includes taxes & fees
Dec 7 - Dec 8
The Godfrey Hotel Chicago
Lobby sitting area
Club Quarters Hotel Wacker at Michigan, Chicago

Club Quarters Hotel Wacker at Michigan, Chicago

4.0 star property
The Loop, 4.6 km from Illinois Medical District
8.8 out of 10, Excellent, (1964)
"A good place for stay "
United States
Julio
The price is ￥14,030
￥16,469 total
includes taxes & fees
Dec 21 - Dec 22
Club Quarters Hotel Wacker at Michigan, Chicago
Exterior
Hyatt Centric Chicago Magnificent Mile

Hyatt Centric Chicago Magnificent Mile

4.0 star property
Streeterville, 5.1 km from Illinois Medical District
9.0 out of 10, Wonderful, (1045)
"Great Hotel!"
United States
Wendy
The price is ￥15,159
￥22,347 total
includes taxes & fees
Dec 7 - Dec 8
Hyatt Centric Chicago Magnificent Mile
Ballroom
Palmer House a Hilton Hotel

Palmer House a Hilton Hotel

4.0 star property
Theatre District, 4.2 km from Illinois Medical District
8.4 out of 10, Very Good, (2129)
"Loved and enjoyed our stay"
United States
Luis
The price is ￥15,896
￥22,538 total
includes taxes & fees
Dec 28 - Dec 29
Palmer House a Hilton Hotel
Terrace/patio
DoubleTree by Hilton Chicago - Magnificent Mile

DoubleTree by Hilton Chicago - Magnificent Mile

4.0 star property
Streeterville, 5.2 km from Illinois Medical District
8.8 out of 10, Excellent, (2173)
"Great stay "
United States
Melinda
The price is ￥13,861
￥16,273 total
includes taxes & fees
Dec 10 - Dec 11
DoubleTree by Hilton Chicago - Magnificent Mile
Lobby
Embassy Suites by Hilton Chicago Downtown River North

Embassy Suites by Hilton Chicago Downtown River North

4.0 star property
River North, 4.7 km from Illinois Medical District
8.6 out of 10, Excellent, (5353)
"excellent hotel "
United States
Myounghee
The price is ￥14,624
￥17,168 total
includes taxes & fees
Dec 18 - Dec 19
Embassy Suites by Hilton Chicago Downtown River North
Lobby sitting area
Warwick Allerton - Chicago

Warwick Allerton - Chicago

4.0 star property
Magnificent Mile, 5.1 km from Illinois Medical District
8.4 out of 10, Very Good, (2994)
"Beautiful hotel, very well situated near restaurants shopping and mass transit "
United States
Joan
The price is ￥10,545
￥16,932 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Warwick Allerton - Chicago
Property amenity
citizenM Chicago Downtown

citizenM Chicago Downtown

4.0 star property
Theatre District, 4.6 km from Illinois Medical District
9.4 out of 10, Exceptional, (4121)
"I enjoyed my stay with this hotel and would stay here again"
United States
Kim Leticia Terrelle
The price is ￥16,594
￥19,481 total
includes taxes & fees
Dec 14 - Dec 15
citizenM Chicago Downtown
Bar (on property)
voco Chicago Downtown - Riverwalk by IHG

voco Chicago Downtown - Riverwalk by IHG

3.5 star property
River North, 3.7 km from Illinois Medical District
8.8 out of 10, Excellent, (3430)
"Great hotel"
United States
Clara
The price is ￥16,004
￥18,786 total
includes taxes & fees
Dec 14 - Dec 15
voco Chicago Downtown - Riverwalk by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Illinois Medical District

Find the best Illinois Medical District areas and neighborhoods for the activities you enjoy most.
Downtown Chicago showing a city

Downtown Chicago

The heart of the Midwest’s glittering metropolis has many offerings, from shopping and dining to parks, museums and exciting contemporary public art.

Magnificent Mile - River North

Magnificent Mile

Upscale shopping district with luxury department stores, boutiques, and acclaimed restaurants, featuring landmarks like the Wrigley Building and Chicago Water Tower. The Magnificent Mile is easily accessible by public transit and seasonal trolley service.

The Loop - Downtown which includes a river or creek

The Loop

Chicago's central business district boasts numerous global businesses, retail establishments, and theaters. Explore the Loop Retail Historic District, Chicago Landmark Historic Michigan Boulevard District, and visit iconic attractions like the Art Institute of Chicago.

River North showing railway items, street scenes and a city

River North

Artistic spirit thrives here, with art galleries and a design district featuring luxury interior furnishings. Explore Kingsbury Park, enjoy vibrant nightlife on Hubbard Street, and visit the iconic Contemporaine Building.

Chicago showing rides

Theatre District

While you're in Theatre District, take in top sights like Michigan Avenue or State Street, and hop on the metro to see more the city at Washington Station or Monroe Station (Blue Line).

Top Illinois Medical District Hotel Reviews

Congress Plaza Hotel

Congress Plaza Hotel

10/10 Excellent
"Great"
Valentina 1-night trip
Posted 4 hours ago
Congress Plaza Hotel

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Frequently asked questions

What's it like in Illinois Medical District?
Guests are sure to enjoy their time checking out all that Chicago's Illinois Medical District neighborhood has to offer.
Where is the best place to stay in Illinois Medical District?
Based on Expedia customer reviews, Hampton Inn & Suites Chicago Medical District UIC is the highest ranked property in Illinois Medical District. This hotel is a short 15-minute walk from United Center, and it offers free breakfast and an indoor pool. Other top choices in the neighborhood include Hyatt House Chicago Medical/University District and Hyatt Place Chicago Medical/University District.
How many hotels are there in the Illinois Medical District area?
If you're searching for places to stay in Chicago, choose from one of Expedia's 11 hotels and other accommodations in Illinois Medical District.
If I need to cancel my hotel reservation in Illinois Medical District, will I receive a refund?
Yes! Most hotel reservations are refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best options available in Illinois Medical District.
Where can I learn more about changing or cancelling my trip to Illinois Medical District?
To access more information about changing or cancelling your trip to Illinois Medical District, head over to our customer service page.
What can I see and do in this Chicago neighborhood?
Don't miss favorite places to visit in the surrounding area, such as Michigan Avenue, United Center, and Soldier Field. Michael Jordan Statue and National Museum of Mexican Art are also worth a visit when you're out sightseeing in Chicago.
How can I get around Illinois Medical District and the greater Chicago area?
Ready to get out and explore the city? Polk Station (Pink Line) is the closest metro station.