Find hotels in Illinois Medical District, Chicago from ¥13,681

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Our top choices for Illinois Medical District hotels

Hyatt House Chicago Medical/University District

Hyatt House Chicago Medical/University District
3.5 star property
Illinois Medical District
9.0 out of 10, Wonderful, (1252)
"Good staff and excellent room."
Mexico
Mario Alberto Cervera
The price is ¥14,490
¥17,010 total
includes taxes & fees
Dec 22 - Dec 23
Hyatt House Chicago Medical/University District

Hyatt Place Chicago Medical/University District

Hyatt Place Chicago Medical/University District
3.0 star property
Illinois Medical District
9.0 out of 10, Wonderful, (1415)
"The food was delicious "
United States
Frank
The price is ¥13,711
¥16,096 total
includes taxes & fees
Dec 22 - Dec 23
Hyatt Place Chicago Medical/University District

Hampton Inn & Suites Chicago Medical District UIC

Hampton Inn & Suites Chicago Medical District UIC
2.5 star property
Illinois Medical District
9.6 out of 10, Exceptional, (366)
"Room was immaculate, breakfast was very good and there was plenty of shops and eats near by "
United States
Surayah
The price is ¥13,586
¥15,949 total
includes taxes & fees
Dec 21 - Dec 22
Hampton Inn & Suites Chicago Medical District UIC

Aloft Chicago Downtown River North

Aloft Chicago Downtown River North
3.5 star property
River North, 4.4 km from Illinois Medical District
9.4 out of 10, Exceptional, (1165)
"Clean room, friendly staff, perfect location"
United States
Matt
The price is ¥16,360
¥19,207 total
includes taxes & fees
Dec 21 - Dec 22
Aloft Chicago Downtown River North

LondonHouse Chicago, Curio Collection by Hilton

LondonHouse Chicago, Curio Collection by Hilton
4.5 star property
The Loop, 4.6 km from Illinois Medical District
9.4 out of 10, Exceptional, (3437)
"Loved the location and view!"
United States
Erica
The price is ¥20,315
¥23,845 total
includes taxes & fees
Jan 4 - Jan 5, 2026
LondonHouse Chicago, Curio Collection by Hilton

The Godfrey Hotel Chicago

The Godfrey Hotel Chicago
4.5 star property
River North, 4.6 km from Illinois Medical District
8.6 out of 10, Excellent, (1925)
"Good value, great cleaning staff "
United Kingdom
farzana
The price is ¥15,575
¥21,944 total
includes taxes & fees
Jan 5 - Jan 6, 2026
The Godfrey Hotel Chicago

Hyatt Regency Chicago

Hyatt Regency Chicago
4.0 star property
The Loop, 4.8 km from Illinois Medical District
9.4 out of 10, Exceptional, (3402)
"I always love staying at this place when I visit"
Canada
William
The price is ¥21,190
¥29,447 total
includes taxes & fees
Dec 28 - Dec 29
Hyatt Regency Chicago

theWit Chicago, a Hilton Hotel

theWit Chicago, a Hilton Hotel
4.5 star property
Theatre District, 4.3 km from Illinois Medical District
9.0 out of 10, Wonderful, (1002)
"Great location and restaurant "
United Kingdom
Asvin
The price is ¥21,592
¥29,918 total
includes taxes & fees
Jan 4 - Jan 5, 2026
theWit Chicago, a Hilton Hotel

InterContinental Chicago Magnificent Mile by IHG

InterContinental Chicago Magnificent Mile by IHG
4.5 star property
Magnificent Mile, 4.9 km from Illinois Medical District
9.0 out of 10, Wonderful, (2626)
"Great hotel, best location, nice and very helpful staff "
United States
Carlos
The price is ¥22,904
¥31,874 total
includes taxes & fees
Jan 13 - Jan 14, 2026
InterContinental Chicago Magnificent Mile by IHG

L7 Chicago by LOTTE

L7 Chicago by LOTTE
4.5 star property
Theatre District, 4.5 km from Illinois Medical District
9.6 out of 10, Exceptional, (3369)
"I loved the location."
United States
Laura
The price is ¥21,960
¥25,780 total
includes taxes & fees
Jan 1 - Jan 2, 2026
L7 Chicago by LOTTE

Club Quarters Hotel Wacker at Michigan, Chicago

Club Quarters Hotel Wacker at Michigan, Chicago
4.0 star property
The Loop, 4.6 km from Illinois Medical District
8.8 out of 10, Excellent, (1989)
"A good place for stay "
United States
Julio
The price is ¥11,654
¥13,681 total
includes taxes & fees
Dec 28 - Dec 29
Club Quarters Hotel Wacker at Michigan, Chicago

Moxy Chicago Downtown

Moxy Chicago Downtown
3.0 star property
River North, 4.3 km from Illinois Medical District
9.4 out of 10, Exceptional, (853)
"Great place to stay"
United States
Mason
The price is ¥17,529
¥20,579 total
includes taxes & fees
Dec 21 - Dec 22
Moxy Chicago Downtown

The Royal Sonesta Chicago River North

The Royal Sonesta Chicago River North
4.5 star property
River North, 4.6 km from Illinois Medical District
9.2 out of 10, Wonderful, (2319)
"Wonderful customer service, great location! "
United States
Michelle
The price is ¥15,566
¥23,258 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Royal Sonesta Chicago River North

The Wade

The Wade
4.5 star property
Streeterville, 5.6 km from Illinois Medical District
8.4 out of 10, Very Good, (1522)
"Great staff and great location. "
United States
Joe
The price is ¥15,737
¥18,475 total
includes taxes & fees
Dec 21 - Dec 22
The Wade

Hyatt Centric Chicago Magnificent Mile

Hyatt Centric Chicago Magnificent Mile
4.0 star property
Streeterville, 5.1 km from Illinois Medical District
9.0 out of 10, Wonderful, (1053)
"Perfect location to surrounding area and activities, friendly staff, clean rooms, amazing gym, and delicious food."
United States
Hannah
The price is ¥15,269
¥22,497 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hyatt Centric Chicago Magnificent Mile

Arlo Chicago

Arlo Chicago
4.0 star property
Theatre District, 4.5 km from Illinois Medical District
9.2 out of 10, Wonderful, (1898)
"Great location, friendly staff rooms were great and clean."
United States
Derrick
The price is ¥17,879
¥25,638 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Arlo Chicago

Radisson Blu Aqua Hotel Chicago

Radisson Blu Aqua Hotel Chicago
4.5 star property
4.9 km from Illinois Medical District
8.6 out of 10, Excellent, (1787)
"Friendly staff and good location to all of the city"
United States
Mark
The price is ¥21,801
¥29,643 total
includes taxes & fees
Dec 28 - Dec 29
Radisson Blu Aqua Hotel Chicago

Cambria Hotel Chicago Loop - Theatre District

Cambria Hotel Chicago Loop - Theatre District
4.0 star property
Theatre District, 4.2 km from Illinois Medical District
8.8 out of 10, Excellent, (1460)
"Clean, modern, friendly/helpful staff, the perfect spot for staying for a show at The Chicago Theatre. Parking was close and easy too. "
United States
Megan
The price is ¥13,587
¥15,947 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Cambria Hotel Chicago Loop - Theatre District

Hilton Chicago/Magnificent Mile Suites

Hilton Chicago/Magnificent Mile Suites
3.5 star property
Streeterville, 5.6 km from Illinois Medical District
9.0 out of 10, Wonderful, (3491)
"Great place to stay "
United States
RaShawna
The price is ¥12,649
¥14,847 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Hilton Chicago/Magnificent Mile Suites

The Royal Sonesta Chicago Downtown

The Royal Sonesta Chicago Downtown
4.0 star property
The Loop, 4.6 km from Illinois Medical District
9.4 out of 10, Exceptional, (3156)
"The location, hotel, and views are absolutely fantastic!"
United States
Frederick
The price is ¥15,986
¥23,753 total
includes taxes & fees
Jan 12 - Jan 13, 2026
The Royal Sonesta Chicago Downtown
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Illinois Medical District

Find the best Illinois Medical District areas and neighborhoods for the activities you enjoy most.

Downtown Chicago

The heart of the Midwest’s glittering metropolis has many offerings, from shopping and dining to parks, museums and exciting contemporary public art.

Magnificent Mile

Upscale shopping district with luxury department stores, boutiques, and acclaimed restaurants, featuring landmarks like the Wrigley Building and Chicago Water Tower. The Magnificent Mile is easily accessible by public transit and seasonal trolley service.

The Loop

Chicago's central business district boasts numerous global businesses, retail establishments, and theaters. Explore the Loop Retail Historic District, Chicago Landmark Historic Michigan Boulevard District, and visit iconic attractions like the Art Institute of Chicago.

River North

Artistic spirit thrives here, with art galleries and a design district featuring luxury interior furnishings. Explore Kingsbury Park, enjoy vibrant nightlife on Hubbard Street, and visit the iconic Contemporaine Building.

Theatre District

While you're in Theatre District, take in top sights like Michigan Avenue or State Street, and hop on the metro to see more the city at Washington Station or Monroe Station (Blue Line).

Top Illinois Medical District Hotel Reviews

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Frequently asked questions

What's it like in Illinois Medical District?
Guests are sure to enjoy their time checking out all that Chicago's Illinois Medical District neighborhood has to offer.
Where is the best place to stay in Illinois Medical District?
Based on Expedia customer reviews, Hampton Inn & Suites Chicago Medical District UIC is the highest ranked property in Illinois Medical District. This hotel is a short 15-minute walk from United Center, and it offers free breakfast and an indoor pool. Other top choices in the neighborhood include Hyatt House Chicago Medical/University District and Hyatt Place Chicago Medical/University District.
How many hotels are there in the Illinois Medical District area?
If you're searching for places to stay in Chicago, choose from one of Expedia's 12 hotels and other accommodations in Illinois Medical District.
If I need to cancel my hotel reservation in Illinois Medical District, will I receive a refund?
Yes! Most hotel reservations are refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best options available in Illinois Medical District.
Where can I learn more about changing or cancelling my trip to Illinois Medical District?
To access more information about changing or cancelling your trip to Illinois Medical District, head over to our customer service page.
What can I see and do in this Chicago neighborhood?
Don't miss favorite places to visit in the surrounding area, such as Michigan Avenue, United Center, and Soldier Field. Michael Jordan Statue and National Museum of Mexican Art are also worth a visit when you're out sightseeing in Chicago.
How can I get around Illinois Medical District and the greater Chicago area?
Ready to get out and explore the city? Polk Station (Pink Line) is the closest metro station.