Find Business Hotels in South San Diego, CA
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check availability on South San Diego Business Hotels
Top South San Diego Business Hotels
Our top choices for South San Diego business-friendly hotels

Hercor Hotel - Urban Boutique
Hercor Hotel - Urban Boutique
8.6 out of 10, Excellent, (1267)
The price is ¥14,668
¥16,163 total
includes taxes & fees
Oct 20 - Oct 21

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
8.0 out of 10, Very Good, (1475)
The price is ¥16,828
¥19,142 total
includes taxes & fees
Oct 1 - Oct 2

Comfort Inn Chula Vista San Diego South
Comfort Inn Chula Vista San Diego South
8.2 out of 10, Very Good, (1112)
The price is ¥14,931
¥16,455 total
includes taxes & fees
Oct 5 - Oct 6

Best Western Chula Vista/Otay Valley Hotel
Best Western Chula Vista/Otay Valley Hotel
7.8 out of 10, Good, (1491)
The price is ¥15,558
¥17,113 total
includes taxes & fees
Oct 12 - Oct 13

Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay Mesa
7.2 out of 10, Good, (1007)
The price is ¥15,942
¥18,134 total
includes taxes & fees
Oct 5 - Oct 6

El Primero Hotel
El Primero Hotel
9.2 out of 10, Wonderful, (1003)
The price is ¥13,152
¥14,467 total
includes taxes & fees
Sep 25 - Sep 26

Howard Johnson Suites by Wyndham San Diego Chula Vista/BayFt
Howard Johnson Suites by Wyndham San Diego Chula Vista/BayFt
6.6 out of 10, (1003)
The price is ¥14,761
¥16,237 total
includes taxes & fees
Sep 25 - Sep 26

Best Western Americana Inn
Best Western Americana Inn
9.0 out of 10, Wonderful, (1162)
The price is ¥18,056
¥20,538 total
includes taxes & fees
Oct 1 - Oct 2
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top South San Diego Hotel Reviews

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
10/10 Excellent
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Top neighborhoods for Business Hotels
Find More Hotels near South San Diego
More Hotel Options in South San Diego
- Adventure Hotels in South San Diego
- Beach Hotels in South San Diego
- Boutique Hotels in South San Diego
- Casinos in South San Diego
- Cheap Hotels in South San Diego
- Family Hotels in South San Diego
- Golf Hotels in South San Diego
- Green Hotels in South San Diego
- Historic Hotels in South San Diego
- Hotel Wedding Venues in South San Diego
- Hotel with a Concierge in South San Diego
- Hotels with Bars in South San Diego
- Hotels with Free Parking in South San Diego
- Hotels with Hot Tubs in South San Diego
- Hotels with WiFi in South San Diego
- Hotels with a Pool in South San Diego
- Hotels with smoking rooms in South San Diego
- Luxury Hotels in South San Diego
- Pet-friendly Hotels in South San Diego
- Resorts & Hotels with Spas in South San Diego
- Romantic Hotels in South San Diego
- Shopping Hotels in South San Diego
- Waterpark Hotels in South San Diego
- Winery Hotels in South San Diego
More Accommodation Types in South San Diego
- Vacation Homes in California
- Condo Rentals in California
- Apartments in California
- Cabin Rentals in California
- Cottages in California
- Villas in California
- Motels in California
- Resorts in California
- Guest Houses in California
- B&B in California
- Aparthotels in California
- Farmstay in California
- Chalets in California
- Lodges in California
- RV Parks in California
- Hostels in California
- Inns in California
- Houseboats in California
- Town Houses in California
- Condo Resorts in California
- Castles in California
- Holiday Park Resorts in California
- Residences in California
- Ranches in California
- Capsule Hotels in California
- Country Houses in California
- Safari Tentalow in California
- Treehouses in California
Hotels near popular South San Diego Attractions
South San Diego Hotels by Star Rating
Explore more hotels
- Days Inn by Wyndham San Diego Hotel Circle
- Best Western Plus Marina Gateway Hotel
- California Suites Hotel
- Paradise Point Resort & Spa
- Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
- Hilton San Diego Mission Valley
- Sheraton San Diego Resort
- San Diego Mission Bay Resort
- Marriott Marquis San Diego Marina
- Legacy Resort Hotel & Spa
- Comfort Inn San Diego Airport At The Harbor
- Embassy Suites by Hilton San Diego Bay Downtown
- Kings Inn San Diego
- Pendry San Diego
- Country Inn & Suites by Radisson, San Diego North, CA
- The Little Italy Hotel Downtown San Diego
- Omni San Diego Hotel at the Ballpark
- DoubleTree by Hilton Hotel San Diego - Mission Valley
- Lafayette Hotel & Club
- The Guild Hotel, San Diego, A Tribute Portfolio Hotel by Marriott
More ways to book
Expedia's Latest Trends
Hotels
Flights
Cars
Activities