Find hotels in Mission Bay, San Francisco

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Mission Bay hotels

LUMA Hotel San Francisco

LUMA Hotel San Francisco
4.0 star property
Mission Bay
9.6 out of 10, Exceptional, (2,454 reviews)
"Overall a great hotel!"
United States
Ashley
The price is ¥34,127
¥40,167 total
includes taxes & fees
Feb 13 - Feb 14
LUMA Hotel San Francisco

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG
3.5 star property
Nob Hill, 3.4 km from Mission Bay
9.0 out of 10, Wonderful, (5,232 reviews)
"Great stay"
United States
Jorge
The price is ¥19,736
¥23,228 total
includes taxes & fees
Feb 9 - Feb 10
Holiday Inn Golden Gateway by IHG

Hilton San Francisco Financial District

Hilton San Francisco Financial District
4.0 star property
Financial District, 2.9 km from Mission Bay
8.8 out of 10, Excellent, (2,368 reviews)
"Good stay and really good hospitality. "
United States
Alfonso
The price is ¥17,777
¥20,923 total
includes taxes & fees
Feb 22 - Feb 23
Hilton San Francisco Financial District

Hotel Zoe Fisherman's Wharf

Hotel Zoe Fisherman's Wharf
4.0 star property
Fisherman's Wharf, 4.4 km from Mission Bay
9.2 out of 10, Wonderful, (1,707 reviews)
"Great location, wonderful staff, and nice hotel. "
United States
Nivia
The price is ¥16,831
¥26,419 total
includes taxes & fees
Feb 8 - Feb 9
Hotel Zoe Fisherman's Wharf

Hotel Zephyr San Francisco

Hotel Zephyr San Francisco
4.0 star property
Fisherman's Wharf, 4.5 km from Mission Bay
8.6 out of 10, Excellent, (2,420 reviews)
"Great location on the wharf, with many restaurants, and activities in the area."
United States
Frank
The price is ¥19,504
¥29,374 total
includes taxes & fees
Feb 9 - Feb 10
Hotel Zephyr San Francisco

Handlery Union Square Hotel

Handlery Union Square Hotel
3.5 star property
Union Square, 2.4 km from Mission Bay
8.8 out of 10, Excellent, (2,855 reviews)
"Friendly staff great location "
United States
Tiffany
The price is ¥19,541
¥22,998 total
includes taxes & fees
Feb 9 - Feb 10
Handlery Union Square Hotel

YOTEL San Francisco

YOTEL San Francisco
3.0 star property
2.1 km from Mission Bay
8.2 out of 10, Very Good, (1,001 reviews)
"Great place to stay in the city. Rooms are small but modern and clean staff is courteous and friendly. There is 24 hour security its a great place and is affordable."
United States
Sherretha
The price is ¥11,316
¥19,737 total
includes taxes & fees
Feb 16 - Feb 17
YOTEL San Francisco

The Pickwick Hotel

The Pickwick Hotel
3.5 star property
South of Market, 1.9 km from Mission Bay
7.8 out of 10, Good, (1,104 reviews)
"Fantastic Service! Loved my stay!"
United States
Kelly
The price is ¥14,959
¥17,576 total
includes taxes & fees
Feb 10 - Feb 11
The Pickwick Hotel

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf
4.0 star property
Fisherman's Wharf, 4.5 km from Mission Bay
9.0 out of 10, Wonderful, (7,288 reviews)
"excellent breakfast and location "
United States
Leslie
The price is ¥18,490
¥28,183 total
includes taxes & fees
Feb 10 - Feb 11
Hotel Riu Plaza Fisherman's Wharf

King George Hotel

King George Hotel
3.0 star property
Union Square, 2.4 km from Mission Bay
8.6 out of 10, Excellent, (2,095 reviews)
"Really a nice place"
United States
Charlene
The price is ¥12,542
¥17,099 total
includes taxes & fees
Mar 4 - Mar 5
King George Hotel

Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf
4.0 star property
Fisherman's Wharf, 4.6 km from Mission Bay
9.0 out of 10, Wonderful, (3,831 reviews)
"Nice hotel and great staff. "
United States
Tomohiro
The price is ¥21,060
¥32,305 total
includes taxes & fees
Feb 11 - Feb 12
Hotel Caza Fisherman's Wharf

Hyatt Centric Fisherman's Wharf San Francisco

Hyatt Centric Fisherman's Wharf San Francisco
4.0 star property
Fisherman's Wharf, 4.5 km from Mission Bay
8.6 out of 10, Excellent, (1,512 reviews)
"Good restaurant."
United States
Neil
The price is ¥21,037
¥31,179 total
includes taxes & fees
Feb 11 - Feb 12
Hyatt Centric Fisherman's Wharf San Francisco

Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco
4.0 star property
Financial District, 2.8 km from Mission Bay
9.0 out of 10, Wonderful, (2,946 reviews)
"Clean room, great staff "
United States
Jennifer
The price is ¥18,350
¥21,597 total
includes taxes & fees
Feb 16 - Feb 17
Club Quarters Hotel in San Francisco

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square
3.5 star property
2.5 km from Mission Bay
9.4 out of 10, Exceptional, (3,185 reviews)
"I loved this stay! Extremely friendly staff and amazing rooms"
United States
Hajar
The price is ¥15,286
¥18,039 total
includes taxes & fees
Feb 11 - Feb 12
Chancellor Hotel on Union Square

Hotel Zelos San Francisco

Hotel Zelos San Francisco
4.0 star property
South of Market, 2 km from Mission Bay
9.0 out of 10, Wonderful, (1,129 reviews)
"Great hotel and staff. Perfect hub while in the city."
United States
Nicholas
The price is ¥24,659
¥35,442 total
includes taxes & fees
Mar 1 - Mar 2
Hotel Zelos San Francisco

Lafayette Park Hotel & Spa

Lafayette Park Hotel & Spa
4.0 star property
29 km from Mission Bay
9.4 out of 10, Exceptional, (1,005 reviews)
"Lovely staff, beautiful room, tasty breakfast "
United States
Julia
The price is ¥34,306
¥37,632 total
includes taxes & fees
Mar 1 - Mar 2
Lafayette Park Hotel & Spa

Comfort Inn by the Bay

Comfort Inn by the Bay
2.5 star property
Cow Hollow, 4.5 km from Mission Bay
8.4 out of 10, Very Good, (1,305 reviews)
"Clean, comfortable beds, good breakfast, friendly staff, good location. "
United States
Charles
The price is ¥15,988
¥18,818 total
includes taxes & fees
Feb 10 - Feb 11
Comfort Inn by the Bay

Staypineapple, An Elegant Hotel, Union Square

Staypineapple, An Elegant Hotel, Union Square
4.0 star property
2.6 km from Mission Bay
8.6 out of 10, Excellent, (1,000 reviews)
"Courteous staff, clean rooms"
United States
Roshan
The price is ¥13,245
¥21,993 total
includes taxes & fees
Feb 17 - Feb 18
Staypineapple, An Elegant Hotel, Union Square

Executive Hotel Vintage Court

Executive Hotel Vintage Court
3.0 star property
Chinatown, 2.6 km from Mission Bay
8.6 out of 10, Excellent, (1,072 reviews)
"The location is good as it is easy to get to touristic destinations quickly both with Uber and public transportation "
Australia
Timothy Matthew
The price is ¥16,329
¥23,206 total
includes taxes & fees
Mar 7 - Mar 8
Executive Hotel Vintage Court

Hotel G San Francisco

Hotel G San Francisco
4.0 star property
2.5 km from Mission Bay
9.0 out of 10, Wonderful, (1,000 reviews)
"Great hotel close to everything you will need. Great restaurants and bars right downstairs for enjoyment. "
United States
Dawaun
The price is ¥19,751
¥29,483 total
includes taxes & fees
Mar 5 - Mar 6
Hotel G San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Mission Bay

Find the best Mission Bay areas and neighborhoods for the activities you enjoy most. Learn more about Mission Bay
Learn more about Mission Bay

Union Square

Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

Downtown San Francisco

Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.

Fisherman's Wharf

Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

Nob Hill

Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.

Top Mission Bay Hotel Reviews

Frequently asked questions

What is Mission Bay like?
Travelers will be sure to enjoy their time in San Francisco's Mission Bay neighborhood. Be sure to check out Chase Center and Lefty O'Doul Bridge as part of your Mission Bay travel plans.
Where is the best place to stay in Mission Bay?
Based on Expedia customer reviews, LUMA Hotel San Francisco is the highest ranked property in Mission Bay. This hotel is a short 5-minute walk from Oracle Park, and it offers a restaurant and a fitness center.
How many hotels are there in Mission Bay?
When you want to kick up your feet after a day of exploring the sights in San Francisco, you can choose from 18 Expedia hotels and other accommodations in Mission Bay.
If I need to cancel my hotel reservation in Mission Bay, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then filter by "fully refundable" to get the best deals in Mission Bay.
Where can I learn more about changing or cancelling my trip to Mission Bay?
To access more information about changing or cancelling your trip to Mission Bay, head over to our customer service page.
What are the top things to see and do in Mission Bay?
Chase Center, Lefty O'Doul Bridge, and Lucky Strike San Francisco are just a few attractions to check out in Mission Bay. While you're out sightseeing, Oracle Park and Pier 39 are a couple of additional sights to visit in San Francisco.
How can I get around Mission Bay and the greater San Francisco area?
For a quick way to explore the city, catch a ride on metro transit at UCSF/Chase Center Stop, Mission Rock Station, or UCSF Mission Bay Stop. To venture out of town, take a train from San Francisco Station.

Explore a world of travel with Expedia