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Find Luxury Hotels in Mission Bay, CA

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Check availability on Mission Bay Luxury Hotels

Tonight
Jul 29 - Jul 30
Tomorrow
Jul 30 - Jul 31
This weekend
Aug 1 - Aug 3
Next weekend
Aug 8 - Aug 10

Top Mission Bay Luxury Hotels

Top Mission Bay Hotel Reviews

Hotel Nikko San Francisco

Hotel Nikko San Francisco

10/10 Excellent
"Excellent property. Will definitely stay there again. "
Teresa 1-night trip
Posted 8 hours ago
Hotel Nikko San Francisco

Frequently asked questions

Are you looking for a luxury hotel for your Mission Bay vacation?
Use Expedia to arrange your flight to Oakland Intl. Airport (OAK) airport or San Francisco Intl. Airport (SFO) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are an important consideration when you plan a trip, so we make it easy to find what you'd like to make your stay special. If you want a posh hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Mission Bay offers. Mission Bay has some interesting things to see and do including Chase Center and Lefty O'Doul Bridge, so you might want to take in the local sights during your visit.
What's the best time to vacation in Mission Bay?
The hottest months are usually September and August with an average temperature of 64°F,
  • Coldest months: January, February, December, and March
  • Driest months: August, July, September, and June
  • Rainiest months: December, January, February, and March
What's there to see and do in Mission Bay?
When you're in Mission Bay, enjoy exploring the sights and attractions here including Chase Center, Lefty O'Doul Bridge, and Lucky Strike San Francisco. If you have some spare time during your trip, you might want to check out Oracle Park and Pier 39.
How can I get around Mission Bay?
It's easier to get around town in style when you know your options. You can walk to nearby metro stations including Mission Rock Station, UCSF/Chase Center Stop, and UCSF Mission Bay Stop.