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Find hotels near UCSF Mission Bay, San Francisco from ￥14,117

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Dec 20 - Dec 21
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Dec 21 - Dec 22
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Dec 26 - Dec 28
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Jan 2 - Jan 4

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Our top choices for UCSF Mission Bay hotels

Exterior
LUMA Hotel San Francisco

LUMA Hotel San Francisco

LUMA Hotel San Francisco
4.0 star property
0.7 km from UCSF Mission Bay
9.6 out of 10, Exceptional, (2383)
"Clean, good location, and walkable things to do"
United States
Landry
The price is ￥30,342
￥35,712 total
includes taxes & fees
Dec 25 - Dec 26
LUMA Hotel San Francisco
Exterior
Hyatt Place San Francisco Downtown

Hyatt Place San Francisco Downtown

Hyatt Place San Francisco Downtown
3.0 star property
1.1 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1861)
"Great stay. "
United States
Jon
The price is ￥26,296
￥30,949 total
includes taxes & fees
Dec 24 - Dec 25
Hyatt Place San Francisco Downtown
Sundeck
Hotel VIA

Hotel VIA

Hotel VIA
4.0 star property
1.2 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1503)
"Smooth check in and check out. Nice room and friendly staff in a great location "
United States
Nancy
The price is ￥25,414
￥29,910 total
includes taxes & fees
Dec 23 - Dec 24
Hotel VIA
Exterior
InterContinental San Francisco by IHG

InterContinental San Francisco by IHG

InterContinental San Francisco by IHG
4.0 star property
South of Market, 1.8 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1027)
"Love this hotel in SF."
United States
JONATHAN
The price is ￥24,609
￥35,463 total
includes taxes & fees
Dec 24 - Dec 25
InterContinental San Francisco by IHG
Room, 1 King Bed (High Floor) | City view
citizenM San Francisco Union Square

citizenM San Francisco Union Square

citizenM San Francisco Union Square
4.0 star property
Union Square, 2.3 km from UCSF Mission Bay
9.4 out of 10, Exceptional, (1427)
"Great location."
United States
Todd
The price is ￥15,739
￥18,524 total
includes taxes & fees
Dec 24 - Dec 25
citizenM San Francisco Union Square
Exterior
Hyatt Regency San Francisco Downtown SOMA

Hyatt Regency San Francisco Downtown SOMA

Hyatt Regency San Francisco Downtown SOMA
4.0 star property
South of Market, 2.2 km from UCSF Mission Bay
9.4 out of 10, Exceptional, (1299)
"Very nice and view was incredible "
United States
Morgan
The price is ￥24,767
￥35,443 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hyatt Regency San Francisco Downtown SOMA
3 bars/lounges
Canopy by Hilton San Francisco SoMa

Canopy by Hilton San Francisco SoMa

Canopy by Hilton San Francisco SoMa
4.0 star property
South Park, 1.7 km from UCSF Mission Bay
9.0 out of 10, Wonderful, (1000)
"Good room , good service, good location "
United States
Albina
The price is ￥23,931
￥28,165 total
includes taxes & fees
Dec 26 - Dec 27
Canopy by Hilton San Francisco SoMa
Lobby sitting area
Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square
3.5 star property
2.6 km from UCSF Mission Bay
9.4 out of 10, Exceptional, (3082)
"Great hotel, great location, super friendly all staff "
Mexico
Claudia
The price is ￥11,947
￥14,117 total
includes taxes & fees
Dec 23 - Dec 24
Chancellor Hotel on Union Square
Lobby
The Clancy, Autograph Collection by Marriott

The Clancy, Autograph Collection by Marriott

The Clancy, Autograph Collection by Marriott
4.0 star property
South Park, 1.9 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1000)
"cleanliness,good service, convenient location"
United States
Harry
The price is ￥23,013
￥33,536 total
includes taxes & fees
Dec 24 - Dec 25
The Clancy, Autograph Collection by Marriott
Lobby
Galleria Park Hotel

Galleria Park Hotel

Galleria Park Hotel
4.0 star property
Financial District, 2.5 km from UCSF Mission Bay
9.6 out of 10, Exceptional, (1009)
"I had a great stay. The room was nice, the bed was comfortable, and the staff were very helpful."
United States
Luke
The price is ￥17,890
￥27,554 total
includes taxes & fees
Dec 25 - Dec 26
Galleria Park Hotel
Property entrance
Orchard Garden Hotel

Orchard Garden Hotel

Orchard Garden Hotel
4.0 star property
Chinatown, 2.7 km from UCSF Mission Bay
9.6 out of 10, Exceptional, (1003)
"Great location "
Canada
Jorge
The price is ￥20,521
￥24,506 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Orchard Garden Hotel
Front of property - evening/night
Hotel Nikko San Francisco

Hotel Nikko San Francisco

Hotel Nikko San Francisco
4.5 star property
Union Square, 2.4 km from UCSF Mission Bay
9.4 out of 10, Exceptional, (2650)
"Clean rooms, great location and welcoming staff"
United Kingdom
Simon
The price is ￥24,001
￥35,499 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hotel Nikko San Francisco
Suite, 1 Bedroom, Corner | Frette Italian sheets, premium bedding, down comforters, pillowtop beds
The St. Regis San Francisco

The St. Regis San Francisco

The St. Regis San Francisco
5.0 star property
South of Market, 2.1 km from UCSF Mission Bay
9.4 out of 10, Exceptional, (696)
"Impeccable service; nice room, overall great experience"
United States
Karla
The price is ￥55,686
￥72,725 total
includes taxes & fees
Dec 22 - Dec 23
The St. Regis San Francisco
Terrace/patio
Four Seasons Hotel San Francisco

Four Seasons Hotel San Francisco

Four Seasons Hotel San Francisco
5.0 star property
South of Market, 2.2 km from UCSF Mission Bay
9.4 out of 10, Exceptional, (1001)
"The staff is fantastic"
United States
Brandon
The price is ￥60,734
￥71,480 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Four Seasons Hotel San Francisco
Exterior
W San Francisco

W San Francisco

W San Francisco
4.5 star property
South Park, 2 km from UCSF Mission Bay
9.0 out of 10, Wonderful, (1002)
"Great location and good accommodations "
United States
Michael
The price is ￥23,820
￥33,609 total
includes taxes & fees
Dec 27 - Dec 28
W San Francisco
View from property
Palace Hotel, a Luxury Collection Hotel, San Francisco

Palace Hotel, a Luxury Collection Hotel, San Francisco

Palace Hotel, a Luxury Collection Hotel, San Francisco
5.0 star property
Financial District, 2.4 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1002)
"Just a spectacular place to stay! Beautifully appointed. All staff were very friendly and accommodating We will definitely be back!"
United States
Mandana
The price is ￥40,092
￥47,186 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Palace Hotel, a Luxury Collection Hotel, San Francisco
Room (Private Apartment) | Egyptian cotton sheets, premium bedding, minibar, in-room safe
The Clift Royal Sonesta San Francisco

The Clift Royal Sonesta San Francisco

The Clift Royal Sonesta San Francisco
4.0 star property
2.6 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1366)
"Staff was amazing. The rooms felt clean and the hotel was very well maintained."
United States
Misty
The price is ￥19,257
￥28,816 total
includes taxes & fees
Jan 5 - Jan 6, 2026
The Clift Royal Sonesta San Francisco
Lobby
Beacon Grand, A Union Square Hotel

Beacon Grand, A Union Square Hotel

Beacon Grand, A Union Square Hotel
4.0 star property
Union Square, 2.6 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1812)
"Amazing place"
Australia
David
The price is ￥20,780
￥30,955 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Beacon Grand, A Union Square Hotel
Premium bedding, pillowtop beds, in-room safe, desk
Inn At Union Square

Inn At Union Square

Inn At Union Square
3.5 star property
2.6 km from UCSF Mission Bay
9.2 out of 10, Wonderful, (1009)
"Everything was perfect location staff room and that continental breakfast was delicious Thankyou "
United Kingdom
robert
The price is ￥16,664
￥23,502 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Inn At Union Square
Breakfast and dinner served
Hotel Zelos San Francisco

Hotel Zelos San Francisco

Hotel Zelos San Francisco
4.0 star property
South of Market, 2.2 km from UCSF Mission Bay
9.0 out of 10, Wonderful, (1104)
"Clean room, friendly staff, convenient location. "
United States
Elizabeth
The price is ￥21,571
￥31,886 total
includes taxes & fees
Dec 28 - Dec 29
Hotel Zelos San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top UCSF Mission Bay Hotel Reviews

InterContinental San Francisco by IHG

InterContinental San Francisco by IHG

10/10 Excellent
"Love "
Theresa Marie 1-night trip
Posted 2 days ago
InterContinental San Francisco by IHG

Hotels near other UCSF Mission Bay attractions

Chase Center San Francisco Skyline Aerial Photography

Chase Center

Catch an event at Chase Center during your trip to San Francisco. Amble around this vibrant area's Chinatown or experience its entertainment choices.
See properties
Anchor Brewing Company

Anchor Brewing Company

During your trip to San Francisco, you can search for that perfect souvenir at Anchor Brewing Company. Discover the top-notch restaurants and acclaimed art scene in this vibrant area.
See properties

Frequently asked questions

What's the area like around UCSF Mission Bay?
UCSF Mission Bay is located in a vibrant area of San Francisco known for its top museums and stunning architecture. If you're looking for a convenient place to stay, check out the 83 hotels and other accommodations you'll find within a mile.
Where is the best place to stay near UCSF Mission Bay?
Hyatt Place San Francisco Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers a bar and free WiFi. It's located just a short 0.7 mi (1.1 km) from UCSF Mission Bay. Other good choices within a short distance include LUMA Hotel San Francisco and Hotel VIA.
How many hotels are there close to UCSF Mission Bay?
Expedia has 83 hotels and other accommodations within a mile from UCSF Mission Bay.
If I need to cancel the hotel reservation for my stay near UCSF Mission Bay, will I receive a refund?
Yes! You'll find that most room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your arrival date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within 24 hours of your booking. Enter your dates, click on "Search", then you can filter by "fully refundable" to get the best options available near UCSF Mission Bay.
Where can I learn more about changing or cancelling my trip in the area near UCSF Mission Bay?
For more information about rescheduling or cancelling your stay near UCSF Mission Bay, go to https://www.expedia.com/service/.
What can I see and do near UCSF Mission Bay?
Study the collections at San Francisco Museum of Modern Art, Asian Art Museum of San Francisco, or Market Street Railway Museum. Sights like San Francisco Mint, 450 Sutter Building, and Ferry Building are landmarks to visit in the area. You can check out the local talent at Golden Gate Theatre, Warfield Theatre, and Orpheum Theatre.
How can I get to UCSF Mission Bay?
With so many transportation options, seeing the area around UCSF Mission Bay is easy. Take advantage of metro transit at Market St & 5th St Stop, Market St & Taylor St Stop, and Powell St & Market St Stop. If you're taking a train into town, San Francisco Station is the closest station to Downtown San Francisco.

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