A beachside restaurant with white tables and chairs, palm trees, and a view of the sea.

Find Luxury Hotels in Key Largo, FL

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Check availability on Key Largo Luxury Hotels

Tonight
Aug 29 - Aug 30
Tomorrow
Aug 30 - Aug 31
Next weekend
Sep 4 - Sep 6
In two weeks
Sep 11 - Sep 13

Our top choices for Key Largo luxury hotels

1. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
Rock Harbor
  • Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.
¥40,687
¥54,598 total
includes taxes & fees
Sep 3 - Sep 4
Playa Largo Resort & Spa, Autograph Collection

2. Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton
Key Largo
  • Beach luxury reimagined at Key Largo resort with private sands, refreshing pools, and coastal dining.
¥37,938
¥51,506 total
includes taxes & fees
Sep 28 - Sep 29
Baker's Cay Resort Key Largo, Curio Collection by Hilton

3. Reefhouse Resort & Marina

Reefhouse Resort & Marina
Key Largo
¥35,060
¥45,847 total
includes taxes & fees
Aug 30 - Aug 31
Reefhouse Resort & Marina

4. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
  • Experience seaside opulence with private beach access, three outdoor pools, and oceanfront dining at this beachfront Matecumbe resort.
¥23,745
¥38,367 total
includes taxes & fees
Sep 8 - Sep 9
Cheeca Lodge & Spa

5. Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
Islamorada
  • Seaside elegance awaits at this Islamorada resort with 3 pools, diverse dining, and a marina.
¥28,048
¥43,261 total
includes taxes & fees
Sep 7 - Sep 8
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

6. Amara Cay Resort

Amara Cay Resort
Matecumbe
  • Florida Keys resort offers private beach paradise with upscale rooms, coastal activities, and luxurious relaxation.
¥21,773
¥36,202 total
includes taxes & fees
Sep 2 - Sep 3
Amara Cay Resort

7. Islander Resort

Islander Resort
Matecumbe
  • Beachfront luxury awaits at Florida Keys haven with private shores, poolside bars, and lavish lanai rooms.
¥37,109
¥52,553 total
includes taxes & fees
Sep 22 - Sep 23
Islander Resort

8. La Siesta Resort & Villas

La Siesta Resort & Villas
Matecumbe
¥21,504
¥35,899 total
includes taxes & fees
Sep 1 - Sep 2
La Siesta Resort & Villas

9. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
¥57,632
¥74,814 total
includes taxes & fees
Aug 30 - Aug 31
The Islands of Islamorada

10. Find Peace - Tiny House in Japanese Garden

Find Peace - Tiny House in Japanese Garden
Homestead
¥23,107
¥51,363 total
includes taxes & fees
Aug 30 - Aug 31
Find Peace - Tiny House in Japanese Garden
View all properties

Top Key Largo Hotel Reviews

Reefhouse Resort & Marina

Reefhouse Resort & Marina

10/10 Excellent
"Overall everything great, expecially"
Rebeca 1-night trip
Posted 3 hours ago
Reefhouse Resort & Marina
Azul del Mar

Azul del Mar

10/10 Excellent
"A amazing location with private beach swimming pool next door and restaurants nearby Ideal chill out spot"
Stephen 2-night trip
Posted 5 hours ago
Azul del Mar
Hampton Inn Key Largo Manatee Bay

Hampton Inn Key Largo Manatee Bay

10/10 Excellent
"All was great"
Asher 2-night trip
Posted 5 hours ago
Hampton Inn Key Largo Manatee Bay
Bayside Inn Key Largo

Bayside Inn Key Largo

8/10 Good
"La pasamos genial. Es un hotel pequeño pero muy animado. Sin dudas recomendable."
Lupe 1-night trip
Posted 23 hours ago
Bayside Inn Key Largo
The Pelican Key Largo Cottages

The Pelican Key Largo Cottages

8/10 Good
"Nice stay, good dock and beach area"
John 3-night trip
Posted 1 day ago
The Pelican Key Largo Cottages
Sunset Cove Beach Resort

Sunset Cove Beach Resort

10/10 Excellent
"Hola. Estoy muy contenta cn este hotel, he hido dos veces y voy a seguir visitando. Fuimos en familia. Me gustó mucho la limpieza,la atención super buena, el desayuno si está un poco pobre porque hay muy pocas cosas pero todo lo demás muy bueno. Se los recomiendo para descansar pk es muy tranquilo y se descansa muchísimo."
Rafael 1-night trip
Posted 1 day ago
Sunset Cove Beach Resort
Waterside Suites & Marina

Waterside Suites & Marina

10/10 Excellent
"Me encantó la verdad. Fuimos un grupo familiar todos. Pero el echo de la cocina. El barbecue abajo. La piscina calentica. La verdad a nosotros nos encantó."
Rene 2-night trip
Posted 2 days ago
Waterside Suites & Marina
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

10/10 Excellent
"The property was situated to make you feel like you were in a tropical paradise tucked away from the rest of the key. Very clean and nice. The staff was amazing and the private beach was one of the best."
Preston 2-night trip
Posted 3 days ago
Playa Largo Resort & Spa, Autograph Collection
Marina Del Mar Resort and Marina

Marina Del Mar Resort and Marina

10/10 Excellent
"My go to spot in Key Largo. Great pool, great quiet location on the canal. Restaurants and bar right there. And free breakfast. 5stars!"
sandra 1-night trip
Posted 4 days ago
Marina Del Mar Resort and Marina

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Key Largo?
During your visit, you might want to enjoy the sunsets and boating which Key Largo is known for.
What's the best high-end place to stay in Key Largo?
Playa Largo Resort & Spa, Autograph Collection is a luxury resort with 3 restaurants and a full-service spa, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your vacation is Reefhouse Resort & Marina.
When can I expect good weather in Key Largo?
Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 72°F. Average annual precipitation for Key Largo is 44 inches.
What's there to see and do in Key Largo?
Take in some sights and attractions while you're in Key Largo by visiting Jimmy Johnson's Big Chill, Bluefin Rock Harbor Marina, and John Pennekamp Coral Reef State Park. If you have a little extra time during your trip, you might want to make a stop at MarineLab Undersea Laboratory and Caribbean Club Bar.

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