A beachside restaurant with white tables and chairs, palm trees, and a view of the sea.

Find Luxury Hotels in Key Largo, FL

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Key Largo Luxury Hotels

Tonight
Oct 11 - Oct 12
Tomorrow
Oct 12 - Oct 13
Next weekend
Oct 16 - Oct 18
In two weeks
Oct 23 - Oct 25

Our top choices for Key Largo luxury hotels

An aerial view of a resort with a large pool, palm trees, and a beach.
A restaurant with wooden tables and chairs, a bar area, and a view of the sea.
A beachside patio with lounge chairs, a table, and a view of the ocean.
A pool area with lounge chairs and umbrellas, a clear sky, and palm trees.

1. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
Rock Harbor
  • Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.
￥41,636
￥55,569 total
includes taxes & fees
Nov 1 - Nov 2
Playa Largo Resort & Spa, Autograph Collection
A dining area with tables set for two, overlooking a beach with palm trees and a sunset view.
A beach with thatched umbrellas, palm trees, and blue lounge chairs.
A poolside area with blue chairs and a thatched-roof structure.
A spacious bar area with high ceilings and large windows, offering views of the ocean.

2. Reefhouse Resort & Marina

Reefhouse Resort & Marina
Key Largo
￥34,670
￥45,337 total
includes taxes & fees
Oct 12 - Oct 13
Reefhouse Resort & Marina
A bathroom with a large bathtub, a window with curtains, and a view of palm trees and the sea.
A spacious lobby with a seating area, a bar, and a large window providing a view of the outdoors.
A tropical resort with a swimming pool, palm trees, and a waterfall.
A hotel room with a large bed, a television, a dining area with chairs, a table, and a view of the ocean.

3. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
  • Experience seaside opulence with private beach access, three outdoor pools, and oceanfront dining at this beachfront Matecumbe resort.
￥26,331
￥41,199 total
includes taxes & fees
Oct 13 - Oct 14
Cheeca Lodge & Spa
A balcony with a wooden table, two chairs, and a view of the ocean and palm trees.
A gated entrance to a resort with palm trees and a clear sky.
A pool area with clear blue water, white lounge chairs, and palm trees.
A beachside patio with a thatched roof, two lounge chairs, and a view of the ocean.

4. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
￥76,853
￥96,723 total
includes taxes & fees
Oct 13 - Oct 14
The Islands of Islamorada
View all properties

Top Key Largo Hotel Reviews

Amoray Dive Resort

Amoray Dive Resort

10/10 Excellent
"Location on the shore is awesome! Loved having access to kayaks, paddleboards and the pool. We took out the kayaks on the last morning and a manatee and her baby came up right between us!!"
Shawn 2-night trip
Posted 15 hours ago
Amoray Dive Resort
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

10/10 Excellent
"This was my second time in Playa Largo of many more to come. The property is beautiful and meticulously maintained. With plenty of amenities and food options I rarely leave the property. Very friendly staff from the front desk to the pool staff, everyone is friendly and welcoming. Would definitely recommend! Best resort in the Keys!"
Nadieska 2-night trip
Posted 15 hours ago
Playa Largo Resort & Spa, Autograph Collection
Reefhouse Resort & Marina

Reefhouse Resort & Marina

10/10 Excellent
"Spacious room and beautiful property."
Timothy 1-night trip
Posted 16 hours ago
Reefhouse Resort & Marina
Sunset Cove Beach Resort

Sunset Cove Beach Resort

10/10 Excellent
"Very nice clean hotel with friendly staff."
Alexey 4-night trip
Posted 2 days ago
Sunset Cove Beach Resort
The Pelican Key Largo Cottages

The Pelican Key Largo Cottages

8/10 Good
"It’s a nice quiet location with beautiful sunset views with new docks to explore the water."
Jay 1-night trip
Posted 2 days ago
The Pelican Key Largo Cottages
Gilbert's Resort

Gilbert's Resort

10/10 Excellent
"It's great for fishing lovers."
Sueviant 1-night trip
Posted 4 days ago
Gilbert's Resort

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Key Largo?
During your visit, you might want to enjoy the sunsets and boating which Key Largo is known for.
What's the best high-end place to stay in Key Largo?
Playa Largo Resort & Spa, Autograph Collection is a luxury resort with 4 restaurants and 3 bars, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your vacation is Reefhouse Resort & Marina.
When can I expect good weather in Key Largo?
Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 72°F. Average annual precipitation for Key Largo is 44 inches.
What's there to see and do in Key Largo?
Take in some sights and attractions while you're in Key Largo by visiting Jimmy Johnson's Big Chill, Jacob's Aquatic Center, and Bluefin Rock Harbor Marina. If you have a little extra time during your trip, you might want to make a stop at John Pennekamp Coral Reef State Park and MarineLab Undersea Laboratory.

Explore a world of travel with Expedia