A beachside restaurant with white tables and chairs, palm trees, and a view of the sea.

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Check availability on Key Largo Luxury Hotels

Tonight
Oct 23 - Oct 24
Tomorrow
Oct 24 - Oct 25
This weekend
Oct 23 - Oct 25
Next weekend
Oct 30 - Nov 1

Our top choices for Key Largo luxury hotels

An aerial view of a resort with a large pool, palm trees, and a beach.
A pool area with lounge chairs and umbrellas, a clear sky, and palm trees.
A beach with clear water, a wooden pier, and lounge chairs under a tree.
A beachside patio with lounge chairs, a table, and a view of the ocean.

1. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
Rock Harbor
  • Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.
￥47,489
￥62,066 total
includes taxes & fees
Nov 9 - Nov 10
Playa Largo Resort & Spa, Autograph Collection
A dining area with tables set for two, overlooking a beach with palm trees and a sunset view.
A spacious living room with large windows, comfortable seating, and decorative plants.
A spacious bar area with high ceilings and large windows, offering views of the ocean.
A beach with thatched umbrellas, palm trees, and blue lounge chairs.

2. Reefhouse Resort & Marina

Reefhouse Resort & Marina
Key Largo
￥34,324
￥44,884 total
includes taxes & fees
Oct 25 - Oct 26
Reefhouse Resort & Marina
A bathroom with a large bathtub, a window with curtains, and a view of palm trees and the sea.
A spacious lobby with a seating area, a bar, and a large window providing a view of the outdoors.
A hotel room with a large bed, a television, a dining area with chairs, a table, and a view of the ocean.
A bar area with a thatched roof, wooden chairs, and a view of the ocean.

3. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
  • Experience seaside opulence with private beach access, three outdoor pools, and oceanfront dining at this beachfront Matecumbe resort.
￥29,318
￥44,445 total
includes taxes & fees
Nov 19 - Nov 20
Cheeca Lodge & Spa
A balcony with a wooden table, two chairs, and a view of the ocean and palm trees.
An aerial view of a resort with multiple bungalow-style buildings, a central swimming pool, and a beach area.
A gated entrance to a resort with palm trees and a clear sky.
A pool area with clear blue water, white lounge chairs, and palm trees.

4. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
￥76,086
￥95,758 total
includes taxes & fees
Oct 29 - Oct 30
The Islands of Islamorada
View all properties

Top Key Largo Hotel Reviews

Bayside Inn Key Largo

Bayside Inn Key Largo

10/10 Excellent
"Had a great vacation here with my wife. Good amenities and Good food next door."
Benjamin 3-night trip
Posted 4 hours ago
Bayside Inn Key Largo
The Pelican Key Largo Cottages

The Pelican Key Largo Cottages

10/10 Excellent
"Great location"
Gregory 4-night trip
Posted 5 hours ago
The Pelican Key Largo Cottages
Waterside Suites & Marina

Waterside Suites & Marina

8/10 Good
"The room was clean and grounds kept nice. Kitchenette - I wish there were better utensils to cook with. The bed was very firm - we sleep on a firm mattress at home, but this was a very firm mattress. Good location and the patio is nice. Didn't even realize there was a pool until the last day we were here."
Kathryn 7-night trip
Posted 1 day ago
Waterside Suites & Marina
Hampton Inn Key Largo Manatee Bay

Hampton Inn Key Largo Manatee Bay

10/10 Excellent
"The staff were wonderful, especially Jolene. The first impression is this hotel needs some TLC. The hotel is going through a renovation, which will be great, but it has so much character now. I ended up loving this quirky hotel. We stayed twice - first we had a room not renovated and second a room that was renovated. The little beach is nice - some people there saw Manatees, but we weren't so lucky. The landscaping in the courtyard is very nice and we were greeted with Iguanas and Ibis, which was fun. The pool looked very inviting and many guests were using it. I'd love to have an opportunity to come back to this hotel."
Jan 1-night trip
Posted 1 day ago
Hampton Inn Key Largo Manatee Bay
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

10/10 Excellent
"I stayed in a two bed suite in early October loved it . It was spacious had the balcony beautiful blue water view. Love that it’s pet friendly, you can take your boat to dock there but unfortunately there is no boat launching or trailer storage . Other than that the beach was awesome prefer it better than the pool . Their restaurants are nice liked all their food I would recommend to come and stay you’ll like it"
Jesus 3-night trip
Posted 1 day ago
Playa Largo Resort & Spa, Autograph Collection
Azul del Mar

Azul del Mar

10/10 Excellent
"We loved everything about this place. The pool was great. We appreciated the free laundry. We really enjoyed our little patio."
Dan 4-night trip
Posted 2 days ago
Azul del Mar

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Key Largo?
During your visit, you might want to enjoy the sunsets and boating which Key Largo is known for.
What's the best high-end place to stay in Key Largo?
Playa Largo Resort & Spa, Autograph Collection is a luxury resort with 4 restaurants and 3 bars, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your vacation is Reefhouse Resort & Marina.
When can I expect good weather in Key Largo?
Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 72°F. Average annual precipitation for Key Largo is 44 inches.
What's there to see and do in Key Largo?
Take in some sights and attractions while you're in Key Largo by visiting Jimmy Johnson's Big Chill, Jacob's Aquatic Center, and Bluefin Rock Harbor Marina. If you have a little extra time during your trip, you might want to make a stop at John Pennekamp Coral Reef State Park and MarineLab Undersea Laboratory.

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