A beachside restaurant with white tables and chairs, palm trees, and a view of the sea.

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Check availability on Key Largo Luxury Hotels

Tonight
Sep 3 - Sep 4
Tomorrow
Sep 4 - Sep 5
This weekend
Sep 4 - Sep 6
Next weekend
Sep 11 - Sep 13

Our top choices for Key Largo luxury hotels

1. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
Rock Harbor
  • Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.
¥40,489
¥54,304 total
includes taxes & fees
Sep 16 - Sep 17
Playa Largo Resort & Spa, Autograph Collection

2. Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton
Key Largo
  • Beach luxury reimagined at Key Largo resort with private sands, refreshing pools, and coastal dining.
¥37,628
¥51,086 total
includes taxes & fees
Sep 28 - Sep 29
Baker's Cay Resort Key Largo, Curio Collection by Hilton

3. Reefhouse Resort & Marina

Reefhouse Resort & Marina
Key Largo
¥34,773
¥45,471 total
includes taxes & fees
Sep 7 - Sep 8
Reefhouse Resort & Marina

4. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
¥62,377
¥80,176 total
includes taxes & fees
Sep 13 - Sep 14
The Islands of Islamorada

5. Find Peace - Tiny House in Japanese Garden

Find Peace - Tiny House in Japanese Garden
Homestead
¥72,245
¥106,794 total
includes taxes & fees
Sep 4 - Sep 5
Find Peace - Tiny House in Japanese Garden

6. Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
Islamorada
  • Seaside elegance awaits at this Islamorada resort with 3 pools, diverse dining, and a marina.
¥28,069
¥43,294 total
includes taxes & fees
Sep 9 - Sep 10
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

7. Islander Resort

Islander Resort
Matecumbe
  • Beachfront luxury awaits at Florida Keys haven with private shores, poolside bars, and lavish lanai rooms.
¥31,082
¥45,685 total
includes taxes & fees
Sep 29 - Sep 30
Islander Resort

8. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
  • Experience seaside opulence with private beach access, three outdoor pools, and oceanfront dining at this beachfront Matecumbe resort.
¥23,658
¥38,228 total
includes taxes & fees
Sep 9 - Sep 10
Cheeca Lodge & Spa

9. La Siesta Resort & Villas

La Siesta Resort & Villas
Matecumbe
¥24,543
¥39,224 total
includes taxes & fees
Sep 7 - Sep 8
La Siesta Resort & Villas

10. Amara Cay Resort

Amara Cay Resort
Matecumbe
  • Florida Keys resort offers private beach paradise with upscale rooms, coastal activities, and luxurious relaxation.
¥23,070
¥37,566 total
includes taxes & fees
Sep 14 - Sep 15
Amara Cay Resort
View all properties

Top Key Largo Hotel Reviews

Reefhouse Resort & Marina

Reefhouse Resort & Marina

10/10 Excellent
"Loved the property. Staff was great. Grounds relaxing. Will go back."
Yvonne 3-night trip
Posted 1 hour ago
Reefhouse Resort & Marina
Waterside Suites & Marina

Waterside Suites & Marina

8/10 Good
"The room was okay. Nothing stood out about it. I didn't realize the bedroom was on the 2nd floor, and the steps are kind of narrow and steep. Maintenance could repair the blinds."
Mark 1-night trip
Posted 14 hours ago
Waterside Suites & Marina
Hampton Inn Key Largo Manatee Bay

Hampton Inn Key Largo Manatee Bay

10/10 Excellent
"We chose this hotel mainly because it was cheaper than the other hotels and closest to John PenneKamp park. The person at the front desk was very nice and allowed up to check in early. The room was very clean and the bathroom was better than we were expecting."
Payam 1-night trip
Posted 21 hours ago
Hampton Inn Key Largo Manatee Bay
The Pelican Key Largo Cottages

The Pelican Key Largo Cottages

10/10 Excellent
"If you’re a first timer like I was be sure to punch in the actual property address and not the resort name or your map will send you to the wrong resort."
Mike 1-night trip
Posted 2 days ago
The Pelican Key Largo Cottages
Amoray Dive Resort

Amoray Dive Resort

10/10 Excellent
"This property was clean and the staff was very friendly. It is a cozy little get away in Key Largo with nice restaurants close by. Would definitely stay again."
P 2-night trip
Posted 2 days ago
Amoray Dive Resort
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

10/10 Excellent
"Perfection!"
Lauren 3-night trip
Posted 2 days ago
Playa Largo Resort & Spa, Autograph Collection
Azul del Mar

Azul del Mar

10/10 Excellent
"A amazing location with private beach swimming pool next door and restaurants nearby Ideal chill out spot"
Stephen 2-night trip
Posted 5 days ago
Azul del Mar

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Key Largo?
During your visit, you might want to enjoy the sunsets and boating which Key Largo is known for.
What's the best high-end place to stay in Key Largo?
Playa Largo Resort & Spa, Autograph Collection is a luxury resort with 3 restaurants and a full-service spa, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your vacation is Reefhouse Resort & Marina.
When can I expect good weather in Key Largo?
Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 72°F. Average annual precipitation for Key Largo is 44 inches.
What's there to see and do in Key Largo?
Take in some sights and attractions while you're in Key Largo by visiting Jimmy Johnson's Big Chill, Bluefin Rock Harbor Marina, and John Pennekamp Coral Reef State Park. If you have a little extra time during your trip, you might want to make a stop at MarineLab Undersea Laboratory and Caribbean Club Bar.

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