A beachside restaurant with white tables and chairs, palm trees, and a view of the sea.

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Check availability on Key Largo Luxury Hotels

Tonight
Sep 6 - Sep 7
Tomorrow
Sep 7 - Sep 8
Next weekend
Sep 11 - Sep 13
In two weeks
Sep 18 - Sep 20

Our top choices for Key Largo luxury hotels

1. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
Rock Harbor
  • Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.
¥39,846
¥53,442 total
includes taxes & fees
Sep 20 - Sep 21
Playa Largo Resort & Spa, Autograph Collection

2. Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton
Key Largo
  • Beach luxury reimagined at Key Largo resort with private sands, refreshing pools, and coastal dining.
¥37,030
¥50,274 total
includes taxes & fees
Sep 28 - Sep 29
Baker's Cay Resort Key Largo, Curio Collection by Hilton

3. Reefhouse Resort & Marina

Reefhouse Resort & Marina
Key Largo
¥34,221
¥44,749 total
includes taxes & fees
Sep 7 - Sep 8
Reefhouse Resort & Marina

4. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
¥61,386
¥78,902 total
includes taxes & fees
Sep 15 - Sep 16
The Islands of Islamorada

5. Find Peace - Tiny House in Japanese Garden

Find Peace - Tiny House in Japanese Garden
Homestead
Find Peace - Tiny House in Japanese Garden

6. Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
Islamorada
  • Seaside elegance awaits at this Islamorada resort with 3 pools, diverse dining, and a marina.
¥28,627
¥43,632 total
includes taxes & fees
Sep 13 - Sep 14
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

7. Islander Resort

Islander Resort
Matecumbe
  • Beachfront luxury awaits at Florida Keys haven with private shores, poolside bars, and lavish lanai rooms.
¥30,588
¥44,960 total
includes taxes & fees
Sep 13 - Sep 14
Islander Resort

8. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
  • Experience seaside opulence with private beach access, three outdoor pools, and oceanfront dining at this beachfront Matecumbe resort.
¥23,283
¥37,620 total
includes taxes & fees
Sep 7 - Sep 8
Cheeca Lodge & Spa

9. La Siesta Resort & Villas

La Siesta Resort & Villas
Matecumbe
¥32,206
¥47,658 total
includes taxes & fees
Sep 7 - Sep 8
La Siesta Resort & Villas

10. Amara Cay Resort

Amara Cay Resort
Matecumbe
  • Florida Keys resort offers private beach paradise with upscale rooms, coastal activities, and luxurious relaxation.
¥22,463
¥36,698 total
includes taxes & fees
Sep 14 - Sep 15
Amara Cay Resort
View all properties

Top Key Largo Hotel Reviews

Waterside Suites & Marina

Waterside Suites & Marina

8/10 Good
"Great suite. Very comfortable and inviting"
Laurence 1-night trip
Posted 6 hours ago
Waterside Suites & Marina
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

10/10 Excellent
"AMAZING STAY! Book here for a couple, family or solo trip. Amazing amenities , private beach, pool and restaurants on site. The grounds are gorgeous and clean. Staff super friendly and rooms are great. Nicky at front desk was a great help Look no further for beautiful sunsets and sunrises"
Irene 1-night trip
Posted 8 hours ago
Baker's Cay Resort Key Largo, Curio Collection by Hilton
The Pelican Key Largo Cottages

The Pelican Key Largo Cottages

10/10 Excellent
"-"
Julie 1-night trip
Posted 13 hours ago
The Pelican Key Largo Cottages
Reefhouse Resort & Marina

Reefhouse Resort & Marina

8/10 Good
"We enjoyed our stay here, were upgraded to a partial view room, and noticed to have been among the only people in the pool or dining area when we took did these activities. The staff was attentive, but seemed bothered by the lack of business that they were having, and we felt like a bit of an afterthought at times despite enjoying the resort being “to ourselves”."
Brian 1-night trip
Posted 1 day ago
Reefhouse Resort & Marina
Amoray Dive Resort

Amoray Dive Resort

10/10 Excellent
"This property was clean and the staff was very friendly. It is a cozy little get away in Key Largo with nice restaurants close by. Would definitely stay again."
P 2-night trip
Posted 4 days ago
Amoray Dive Resort
Azul del Mar

Azul del Mar

10/10 Excellent
"A amazing location with private beach swimming pool next door and restaurants nearby Ideal chill out spot"
Stephen 2-night trip
Posted 8 days ago
Azul del Mar

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Key Largo?
During your visit, you might want to enjoy the sunsets and boating which Key Largo is known for.
What's the best high-end place to stay in Key Largo?
Playa Largo Resort & Spa, Autograph Collection is a luxury resort with 3 restaurants and a full-service spa, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your vacation is Reefhouse Resort & Marina.
When can I expect good weather in Key Largo?
Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 72°F. Average annual precipitation for Key Largo is 44 inches.
What's there to see and do in Key Largo?
Take in some sights and attractions while you're in Key Largo by visiting Jimmy Johnson's Big Chill, Bluefin Rock Harbor Marina, and John Pennekamp Coral Reef State Park. If you have a little extra time during your trip, you might want to make a stop at MarineLab Undersea Laboratory and Caribbean Club Bar.

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