A beachside restaurant with white tables and chairs, palm trees, and a view of the sea.

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Check availability on Key Largo Luxury Hotels

Tonight
Sep 1 - Sep 2
Tomorrow
Sep 2 - Sep 3
This weekend
Sep 4 - Sep 6
Next weekend
Sep 11 - Sep 13

Our top choices for Key Largo luxury hotels

1. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
Rock Harbor
  • Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.
¥40,746
¥54,648 total
includes taxes & fees
Sep 14 - Sep 15
Playa Largo Resort & Spa, Autograph Collection

2. Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton
Key Largo
  • Beach luxury reimagined at Key Largo resort with private sands, refreshing pools, and coastal dining.
¥37,867
¥51,409 total
includes taxes & fees
Sep 28 - Sep 29
Baker's Cay Resort Key Largo, Curio Collection by Hilton

3. Reefhouse Resort & Marina

Reefhouse Resort & Marina
Key Largo
¥34,994
¥45,761 total
includes taxes & fees
Sep 2 - Sep 3
Reefhouse Resort & Marina

4. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
  • Experience seaside opulence with private beach access, three outdoor pools, and oceanfront dining at this beachfront Matecumbe resort.
¥23,809
¥38,471 total
includes taxes & fees
Sep 7 - Sep 8
Cheeca Lodge & Spa

5. Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
Islamorada
  • Seaside elegance awaits at this Islamorada resort with 3 pools, diverse dining, and a marina.
¥29,274
¥44,619 total
includes taxes & fees
Sep 8 - Sep 9
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

6. Amara Cay Resort

Amara Cay Resort
Matecumbe
  • Florida Keys resort offers private beach paradise with upscale rooms, coastal activities, and luxurious relaxation.
¥22,246
¥36,734 total
includes taxes & fees
Sep 3 - Sep 4
Amara Cay Resort

7. Islander Resort

Islander Resort
Matecumbe
  • Beachfront luxury awaits at Florida Keys haven with private shores, poolside bars, and lavish lanai rooms.
¥29,714
¥44,213 total
includes taxes & fees
Sep 13 - Sep 14
Islander Resort

8. La Siesta Resort & Villas

La Siesta Resort & Villas
Matecumbe
¥23,666
¥38,332 total
includes taxes & fees
Sep 3 - Sep 4
La Siesta Resort & Villas

9. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
¥57,524
¥74,673 total
includes taxes & fees
Sep 2 - Sep 3
The Islands of Islamorada

10. Find Peace - Tiny House in Japanese Garden

Find Peace - Tiny House in Japanese Garden
Homestead
¥72,704
¥107,473 total
includes taxes & fees
Sep 2 - Sep 3
Find Peace - Tiny House in Japanese Garden
View all properties

Top Key Largo Hotel Reviews

Amoray Dive Resort

Amoray Dive Resort

10/10 Excellent
"This property was clean and the staff was very friendly. It is a cozy little get away in Key Largo with nice restaurants close by. Would definitely stay again."
P 2-night trip
Posted 1 hour ago
Amoray Dive Resort
Sunset Cove Beach Resort

Sunset Cove Beach Resort

10/10 Excellent
"."
Isabel 1-night trip
Posted 4 hours ago
Sunset Cove Beach Resort
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

8/10 Good
"Loved the overall Resort! The beach thenchair"
Julie Marie 4-night trip
Posted 4 hours ago
Baker's Cay Resort Key Largo, Curio Collection by Hilton
Bayside Inn Key Largo

Bayside Inn Key Largo

10/10 Excellent
"The place is beautiful and clean and affordable. I would definitely be willing to stay there again. The little Inlet gives us time to be by the water and fish or swim or paddle boat for free. Already wanting to make plans for next year thank you Bayside for a wonderful visit."
Debbie Lynn 3-night trip
Posted 5 hours ago
Bayside Inn Key Largo
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

10/10 Excellent
"Perfection!"
Lauren 3-night trip
Posted 9 hours ago
Playa Largo Resort & Spa, Autograph Collection
Waterside Suites & Marina

Waterside Suites & Marina

10/10 Excellent
"Rainbow Reef is next door. Huge patio to dry gear. Scuba divers perfect spot!"
Marcy 4-night trip
Posted 1 day ago
Waterside Suites & Marina
Hampton Inn Key Largo Manatee Bay

Hampton Inn Key Largo Manatee Bay

10/10 Excellent
"The staff was amazing and very, very helpful! Amazing at trouble shooting and went over the top to help us out! The breakfast was very good, better than you would expect for a hotel and we really enjoyed the waterfront area."
Rebecca 4-night trip
Posted 1 day ago
Hampton Inn Key Largo Manatee Bay
The Pelican Key Largo Cottages

The Pelican Key Largo Cottages

10/10 Excellent
"Room was old"
Douglas 2-night trip
Posted 2 days ago
The Pelican Key Largo Cottages
Azul del Mar

Azul del Mar

10/10 Excellent
"A amazing location with private beach swimming pool next door and restaurants nearby Ideal chill out spot"
Stephen 2-night trip
Posted 3 days ago
Azul del Mar

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Key Largo?
During your visit, you might want to enjoy the sunsets and boating which Key Largo is known for.
What's the best high-end place to stay in Key Largo?
Playa Largo Resort & Spa, Autograph Collection is a luxury resort with 3 restaurants and a full-service spa, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your vacation is Reefhouse Resort & Marina.
When can I expect good weather in Key Largo?
Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 72°F. Average annual precipitation for Key Largo is 44 inches.
What's there to see and do in Key Largo?
Take in some sights and attractions while you're in Key Largo by visiting Jimmy Johnson's Big Chill, Bluefin Rock Harbor Marina, and John Pennekamp Coral Reef State Park. If you have a little extra time during your trip, you might want to make a stop at MarineLab Undersea Laboratory and Caribbean Club Bar.

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