A beachside restaurant with white tables and chairs, palm trees, and a view of the sea.

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Check availability on Key Largo Luxury Hotels

Tonight
Sep 18 - Sep 19
Tomorrow
Sep 19 - Sep 20
This weekend
Sep 18 - Sep 20
Next weekend
Sep 25 - Sep 27

Our top choices for Key Largo luxury hotels

1. Reefhouse Resort & Marina

Reefhouse Resort & Marina
Key Largo
¥34,153
¥44,661 total
includes taxes & fees
Sep 20 - Sep 21
Reefhouse Resort & Marina

2. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
Rock Harbor
  • Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.
¥41,015
¥54,740 total
includes taxes & fees
Oct 19 - Oct 20
Playa Largo Resort & Spa, Autograph Collection

3. Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton
Key Largo
  • Beach luxury reimagined at Key Largo resort with private sands, refreshing pools, and coastal dining.
¥36,957
¥50,175 total
includes taxes & fees
Sep 28 - Sep 29
Baker's Cay Resort Key Largo, Curio Collection by Hilton

4. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
¥64,563
¥82,522 total
includes taxes & fees
Oct 1 - Oct 2
The Islands of Islamorada

5. Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
Islamorada
  • Seaside elegance awaits at this Islamorada resort with 3 pools, diverse dining, and a marina.
¥31,066
¥46,354 total
includes taxes & fees
Sep 27 - Sep 28
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

6. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
  • Experience seaside opulence with private beach access, three outdoor pools, and oceanfront dining at this beachfront Matecumbe resort.
¥22,540
¥36,763 total
includes taxes & fees
Sep 20 - Sep 21
Cheeca Lodge & Spa

7. Islander Resort

Islander Resort
Matecumbe
  • Beachfront luxury awaits at Florida Keys haven with private shores, poolside bars, and lavish lanai rooms.
¥33,053
¥47,712 total
includes taxes & fees
Oct 1 - Oct 2
Islander Resort

8. Amara Cay Resort

Amara Cay Resort
Matecumbe
  • Florida Keys resort offers private beach paradise with upscale rooms, coastal activities, and luxurious relaxation.
¥22,419
¥36,627 total
includes taxes & fees
Sep 21 - Sep 22
Amara Cay Resort
View all properties

Top Key Largo Hotel Reviews

Holiday Inn Key Largo by IHG

Holiday Inn Key Largo by IHG

8/10 Good
"Decent hotel to stay at. Breakfast was pricey, we searched elsewhere to eat. We couldn’t connect to the WiFi in the room the whole week. Their tech tried to help, but no luck. Close to restaurants and sites that we wanted to go visit."
Ann 5-night trip
Posted 1 hour ago
Holiday Inn Key Largo by IHG
Waterside Suites & Marina

Waterside Suites & Marina

10/10 Excellent
"Thank you"
Renato 2-night trip
Posted 2 hours ago
Waterside Suites & Marina
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

10/10 Excellent
"Clean room excellent staff good location recommend"
Tania 2-night trip
Posted 3 hours ago
Playa Largo Resort & Spa, Autograph Collection
Bayside Inn Key Largo

Bayside Inn Key Largo

8/10 Good
"great stay will be back again soon."
yosua 1-night trip
Posted 3 hours ago
Bayside Inn Key Largo
Sunset Cove Beach Resort

Sunset Cove Beach Resort

10/10 Excellent
"Highly recommend this retro resort for a Florida Keys getaway! We stayed mid-week in standalone Cottage #3 (across from the dinosaur), which was perfect for relaxing away from Miami. Although we skipped the resort’s beach area for a John Pennekamp snorkel trip, we enjoyed the peaceful sunset in the cove. Staff are extremely helpful and provide everything you need. Note: Breakfast is very minimal, but High Tide Restaurant across the street has amazing homemade biscuits!"
Elizabeth 1-night trip
Posted 7 hours ago
Sunset Cove Beach Resort
The Pelican Key Largo Cottages

The Pelican Key Largo Cottages

10/10 Excellent
"This is so peaceful. We have been 5x now and if you are looking for quaint and peaceful this is it. Very clean very nice people. Literally the only drawback is we cannot bring our jetskis, but get it."
kimberly 1-night trip
Posted 1 day ago
The Pelican Key Largo Cottages
Azul del Mar

Azul del Mar

10/10 Excellent
"Spotlessly clean and comfortable suite! Great location and beautiful view. Excellent communication with staff. We were only there for one night but it exceeded all our expectations, especially for the price. Highly recommend!"
Georgene 1-night trip
Posted 3 days ago
Azul del Mar
Amoray Dive Resort

Amoray Dive Resort

10/10 Excellent
"Clean rooms and staff was nice. We really liked the place. Will come back"
Cathy 1-night trip
Posted 5 days ago
Amoray Dive Resort

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Key Largo?
During your visit, you might want to enjoy the sunsets and boating which Key Largo is known for.
What's the best high-end place to stay in Key Largo?
Playa Largo Resort & Spa, Autograph Collection is a luxury resort with 3 restaurants and a full-service spa, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your vacation is Reefhouse Resort & Marina.
When can I expect good weather in Key Largo?
Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 72°F. Average annual precipitation for Key Largo is 44 inches.
What's there to see and do in Key Largo?
Take in some sights and attractions while you're in Key Largo by visiting Jimmy Johnson's Big Chill, Jacob's Aquatic Center, and Bluefin Rock Harbor Marina. If you have a little extra time during your trip, you might want to make a stop at John Pennekamp Coral Reef State Park and MarineLab Undersea Laboratory.

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