A beachside restaurant with white tables and chairs, palm trees, and a view of the sea.

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Check availability on Key Largo Luxury Hotels

Tonight
Aug 22 - Aug 23
Tomorrow
Aug 23 - Aug 24
Next weekend
Aug 28 - Aug 30
In two weeks
Sep 4 - Sep 6

Our top choices for Key Largo luxury hotels

1. Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton
Key Largo
  • Beach luxury reimagined at Key Largo resort with private sands, refreshing pools, and coastal dining.
¥40,275
¥54,073 total
includes taxes & fees
Sep 21 - Sep 22
Baker's Cay Resort Key Largo, Curio Collection by Hilton

2. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
Rock Harbor
  • Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.
¥39,261
¥52,931 total
includes taxes & fees
Sep 21 - Sep 22
Playa Largo Resort & Spa, Autograph Collection

3. Reefhouse Resort & Marina

Reefhouse Resort & Marina
Key Largo
¥34,810
¥45,520 total
includes taxes & fees
Aug 23 - Aug 24
Reefhouse Resort & Marina

4. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
¥56,078
¥72,973 total
includes taxes & fees
Aug 26 - Aug 27
The Islands of Islamorada

5. Islander Resort

Islander Resort
Matecumbe
  • Beachfront luxury awaits at Florida Keys haven with private shores, poolside bars, and lavish lanai rooms.
¥34,539
¥49,586 total
includes taxes & fees
Sep 2 - Sep 3
Islander Resort

6. Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
Islamorada
  • Seaside elegance awaits at this Islamorada resort with 3 pools, diverse dining, and a marina.
¥32,934
¥48,674 total
includes taxes & fees
Sep 3 - Sep 4
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

7. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
  • Experience seaside opulence with private beach access, three outdoor pools, and oceanfront dining at this beachfront Matecumbe resort.
¥23,685
¥38,271 total
includes taxes & fees
Sep 2 - Sep 3
Cheeca Lodge & Spa

8. Amara Cay Resort

Amara Cay Resort
Matecumbe
  • Florida Keys resort offers private beach paradise with upscale rooms, coastal activities, and luxurious relaxation.
¥24,580
¥39,278 total
includes taxes & fees
Aug 24 - Aug 25
Amara Cay Resort

9. La Siesta Resort & Villas

La Siesta Resort & Villas
Matecumbe
¥24,571
¥39,267 total
includes taxes & fees
Aug 25 - Aug 26
La Siesta Resort & Villas
View all properties

Top Key Largo Hotel Reviews

Holiday Inn Key Largo by IHG

Holiday Inn Key Largo by IHG

10/10 Excellent
"Excellent property all the way around. Will be returning next year for sure!!"
Michael 5-night trip
Posted 10 hours ago
Holiday Inn Key Largo by IHG
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

10/10 Excellent
"We had a wonderful stay at Playa Largo Resort & Spa. The resort is absolutely beautiful, with breathtaking views, a relaxing atmosphere, and excellent amenities. The staff was friendly, attentive, and made us feel welcome throughout our entire stay. We truly enjoyed every moment and created beautiful memories. It was the perfect place to relax and enjoy the Florida Keys. We would definitely love to come back!"
Madelin 3-night trip
Posted 12 hours ago
Playa Largo Resort & Spa, Autograph Collection
Waterside Suites & Marina

Waterside Suites & Marina

10/10 Excellent
"Great stay overall !!! ⭐️⭐️⭐️⭐️⭐️"
Yuniet 2-night trip
Posted 15 hours ago
Waterside Suites & Marina
Hampton Inn Key Largo Manatee Bay

Hampton Inn Key Largo Manatee Bay

10/10 Excellent
"Superb location. Great Tiki bar!"
John 1-night trip
Posted 2 days ago
Hampton Inn Key Largo Manatee Bay
Sunset Cove Beach Resort

Sunset Cove Beach Resort

10/10 Excellent
"The room we stayed was completely renovated very clean and bug free The grounds were well maintained The staff is very friendly and helpful We will be staying here again asap"
Walter 2-night trip
Posted 2 days ago
Sunset Cove Beach Resort

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Key Largo?
During your visit, you might want to enjoy the sunsets and boating which Key Largo is known for.
What's the best high-end place to stay in Key Largo?
Reefhouse Resort & Marina is a luxury hotel with a private beach and 3 restaurants, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your vacation is Playa Largo Resort & Spa, Autograph Collection.
When can I expect good weather in Key Largo?
Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 72°F. Average annual precipitation for Key Largo is 44 inches.
What's there to see and do in Key Largo?
Take in some sights and attractions while you're in Key Largo by visiting Jimmy Johnson's Big Chill, Jacob's Aquatic Center, and John Pennekamp Coral Reef State Park. If you have a little extra time during your trip, you might want to make a stop at MarineLab Undersea Laboratory and Caribbean Club Bar.

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