A beachside restaurant with white tables and chairs, palm trees, and a view of the sea.

Find Luxury Hotels in Key Largo, FL

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Key Largo Luxury Hotels

Tonight
Oct 1 - Oct 2
Tomorrow
Oct 2 - Oct 3
This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Our top choices for Key Largo luxury hotels

A dining area with tables set for two, overlooking a beach with palm trees and a sunset view.
A beach with thatched umbrellas, palm trees, and blue lounge chairs.
A poolside area with blue chairs and a thatched-roof structure.
A spacious bar area with high ceilings and large windows, offering views of the ocean.

1. Reefhouse Resort & Marina

Reefhouse Resort & Marina
Key Largo
￥34,477
￥45,084 total
includes taxes & fees
Oct 4 - Oct 5
Reefhouse Resort & Marina
An aerial view of a resort with a large pool, palm trees, and a beach.
A pool area with lounge chairs and umbrellas, a clear sky, and palm trees.
A restaurant with wooden tables and chairs, a bar area, and a view of the sea.
A beach with clear water, a wooden pier, and lounge chairs under a tree.

2. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
Rock Harbor
  • Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.
￥41,404
￥55,259 total
includes taxes & fees
Oct 15 - Oct 16
Playa Largo Resort & Spa, Autograph Collection
A bathroom with a large bathtub, a window with curtains, and a view of palm trees and the sea.
A tropical resort with a swimming pool, palm trees, and a waterfall.
A spacious lobby with a seating area, a bar, and a large window providing a view of the outdoors.
A hotel room with a large bed, a television, a dining area with chairs, a table, and a view of the ocean.

3. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
  • Experience seaside opulence with private beach access, three outdoor pools, and oceanfront dining at this beachfront Matecumbe resort.
￥20,642
￥34,735 total
includes taxes & fees
Oct 4 - Oct 5
Cheeca Lodge & Spa
A balcony with a wooden table, two chairs, and a view of the ocean and palm trees.
A pool area with clear blue water, white lounge chairs, and palm trees.
A resort with multiple white buildings, each featuring balconies and surrounded by lush greenery and palm trees.
A beachside patio with a thatched roof, two lounge chairs, and a view of the ocean.

4. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
￥76,426
￥96,187 total
includes taxes & fees
Oct 4 - Oct 5
The Islands of Islamorada
View all properties

Top Key Largo Hotel Reviews

Sunset Cove Beach Resort

Sunset Cove Beach Resort

10/10 Excellent
"My daughter and I loved it although it was only a one day stay for our snorkeling adventure she definitely wants to come back soon and hopefully everything will be as perfect as this last visit. Every one was friendly and pleasant. Thanks again 👍"
MariCruz 1-night trip
Posted 2 hours ago
Sunset Cove Beach Resort
The Pelican Key Largo Cottages

The Pelican Key Largo Cottages

10/10 Excellent
"So serene and peaceful Love this place!!"
Kathleen 2-night trip
Posted 10 hours ago
The Pelican Key Largo Cottages
Reefhouse Resort & Marina

Reefhouse Resort & Marina

10/10 Excellent
"Nice property. Disappointed we could not check in earlier."
Marcus B. 2-night trip
Posted 12 hours ago
Reefhouse Resort & Marina
Bayside Inn Key Largo

Bayside Inn Key Largo

10/10 Excellent
"Always my to go place in the Keys! Very friendly staff. Clean rooms."
Lisandra 2-night trip
Posted 20 hours ago
Bayside Inn Key Largo
Hampton Inn Key Largo Manatee Bay

Hampton Inn Key Largo Manatee Bay

10/10 Excellent
"Great stay. Will stay there again"
Tim 1-night trip
Posted 21 hours ago
Hampton Inn Key Largo Manatee Bay
Amoray Dive Resort

Amoray Dive Resort

10/10 Excellent
"Amazing from staff, nice pool deep and good size, clean rooms and quiet environment"
Ariana 1-night trip
Posted 2 days ago
Amoray Dive Resort
Marina Del Mar Resort and Marina

Marina Del Mar Resort and Marina

10/10 Excellent
"Very nice stay. We come every year and really enjoy our stay"
Pamela 2-night trip
Posted 2 days ago
Marina Del Mar Resort and Marina
Gilbert's Resort

Gilbert's Resort

10/10 Excellent
"Very nice stayy"
GRETA 1-night trip
Posted 4 days ago
Gilbert's Resort
Holiday Inn Key Largo by IHG

Holiday Inn Key Largo by IHG

8/10 Good
"Decent hotel to stay at. Breakfast was pricey, we searched elsewhere to eat. We couldn’t connect to the WiFi in the room the whole week. Their tech tried to help, but no luck. Close to restaurants and sites that we wanted to go visit."
Ann 5-night trip
Posted 13 days ago
Holiday Inn Key Largo by IHG

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Key Largo?
During your visit, you might want to enjoy the sunsets and boating which Key Largo is known for.
What's the best high-end place to stay in Key Largo?
Playa Largo Resort & Spa, Autograph Collection is a luxury resort with 4 restaurants and 3 bars, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your vacation is Reefhouse Resort & Marina.
When can I expect good weather in Key Largo?
Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 72°F. Average annual precipitation for Key Largo is 44 inches.
What's there to see and do in Key Largo?
Take in some sights and attractions while you're in Key Largo by visiting Jimmy Johnson's Big Chill, Jacob's Aquatic Center, and Bluefin Rock Harbor Marina. If you have a little extra time during your trip, you might want to make a stop at John Pennekamp Coral Reef State Park and MarineLab Undersea Laboratory.

Explore a world of travel with Expedia