Find hotels in Southeast Missouri, MO from ￥8,273

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Compare 583 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Postcard Cabins St. Francois
Situated in a wooded area, this cabin features a cozy outdoor space with a porch, bench, fire pit, and table.

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (24)
"Had a wonderful time"
The price is ￥13,149
￥19,712 total
includes taxes & fees
Aug 11 - Aug 12
Postcard Cabins St. Francois
The Farmstead Hotel
Welcome to The Farmstead, where a symmetrical facade and central entrance invite you in.

The Farmstead Hotel

2.5 star property
8.8 out of 10, Excellent, (398)
"Great stay!"
The price is ￥11,369
￥12,930 total
includes taxes & fees
Aug 17 - Aug 18
The Farmstead Hotel
Super 8 by Wyndham Farmington
Guests enter through a covered walkway to the hotel's entrance, surrounded by a landscaped area.

Super 8 by Wyndham Farmington

2.0 star property
8.0 out of 10, Very Good, (575)
"Very friendly staff who make sure guests are taken care of! Clean, great location, and safe place to stay. "
The price is ￥8,791
￥10,009 total
includes taxes & fees
Aug 17 - Aug 18
Super 8 by Wyndham Farmington
Drury Inn & Suites Jackson MO
Relax in the hotel's spacious lobby, featuring a comfortable seating area with a sofa, coffee tables, and chairs.

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1005)
"We had a last minute reservation here. The staff was very pleasant, helpful and wonderful overall!!"
The price is ￥13,295
￥14,056 total
includes taxes & fees
Aug 17 - Aug 18
Drury Inn & Suites Jackson MO
Holiday Inn Express & Suites Perryville by IHG
Welcome to our reception area, where guests can check in at the digital station and enjoy the vibrant artwork.

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
9.4 out of 10, Exceptional, (494)
"Super nice staff. Our room smelled so nice and clean. Breakfast was very good too! "
The price is ￥15,513
￥17,759 total
includes taxes & fees
Aug 14 - Aug 15
Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Indulge in a variety of dishes, including turkey sausage and bacon, at our food section.

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

2.5 star property
9.4 out of 10, Exceptional, (665)
"Love staying at the holiday inn ans suites "
The price is ￥17,433
￥19,935 total
includes taxes & fees
Aug 17 - Aug 18
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Super 8 by Wyndham Perryville
Welcome to our hotel, featuring a modern exterior with a covered entrance and inviting outdoor space.

Super 8 by Wyndham Perryville

2.0 star property
8.4 out of 10, Very Good, (891)
" Love the stay and staff was great "
The price is ￥9,544
￥10,926 total
includes taxes & fees
Sep 1 - Sep 2
Super 8 by Wyndham Perryville
Drury Inn & Suites Cape Girardeau
Reception area with a reception desk, flat-screen TV, and seating area.

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (973)
"Easy access and parking"
The price is ￥13,295
￥14,997 total
includes taxes & fees
Aug 17 - Aug 18
Drury Inn & Suites Cape Girardeau
Pear Tree Inn Cape Girardeau West
Welcome to our reception area, featuring a modern reception desk and a cozy seating area with armchairs.

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1000)
"We enjoyed the quick check in and how quiet the property was. "
The price is ￥10,340
￥11,665 total
includes taxes & fees
Aug 11 - Aug 12
Pear Tree Inn Cape Girardeau West
Baymont Inn and Suites by Wyndham Farmington, MO
Welcome to our reception area, where guests can check in and relax in a comfortable seating area.

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 star property
8.0 out of 10, Very Good, (1010)
"everything about the hotel was great. some guest were loud at times when trying to sleep but besides that it was a great stay! "
The price is ￥8,273
￥9,419 total
includes taxes & fees
Aug 17 - Aug 18
Baymont Inn and Suites by Wyndham Farmington, MO
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Relax in the stylish lobby, featuring a fireplace, comfortable seating, and a large flat-screen TV.

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1005)
"Great place to stay. "
The price is ￥14,035
￥15,833 total
includes taxes & fees
Sep 7 - Sep 8
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Festus Inn
Experience the tranquil atmosphere of this beautifully designed space, featuring a central fountain and lush greenery.

Festus Inn

2.0 star property
5.6 out of 10, (27)
"Good price and great location. "
The price is ￥13,252
￥15,153 total
includes taxes & fees
Aug 11 - Aug 12
Festus Inn
Drury Inn & Suites Hayti Caruthersville
Relax in our spacious lobby with a seating area, fireplace, and stunning views.

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1002)
"We enjoyed our stay."
The price is ￥13,886
￥15,826 total
includes taxes & fees
Aug 17 - Aug 18
Drury Inn & Suites Hayti Caruthersville
Pear Tree Inn Cape Girardeau Near the Medical Center
Enjoy meals in the dining area with a view, featuring a long counter, TV, and comfortable seating options.

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1001)
"Excellent place to stay "
The price is ￥10,340
￥11,665 total
includes taxes & fees
Aug 21 - Aug 22
Pear Tree Inn Cape Girardeau Near the Medical Center
Comfort Inn Festus - St Louis South
Relax in our inviting lobby, featuring a central seating area, dining tables, and comfortable furniture.

Comfort Inn Festus - St Louis South

2.5 star property
8.0 out of 10, Very Good, (856)
"Close to restaurants. Comfortable place to stay."
The price is ￥12,056
￥14,087 total
includes taxes & fees
Aug 31 - Sep 1
Comfort Inn Festus - St Louis South
Holiday Inn Poplar Bluff by IHG
Enjoy a drink at the bar, where a variety of beverages are available for service.

Holiday Inn Poplar Bluff by IHG

3.0 star property
8.8 out of 10, Excellent, (669)
"Very clean and comfortable property close to dining options. Would definitely stay again "
The price is ￥15,217
￥17,192 total
includes taxes & fees
Sep 6 - Sep 7
Holiday Inn Poplar Bluff by IHG
The Riverview
Relax in a stylish room with two beds, a desk, and a city view.

The Riverview

2.0 star property
9.4 out of 10, Exceptional, (376)
"A very cool destination!"
The price is ￥15,557
￥17,551 total
includes taxes & fees
Aug 17 - Aug 18
The Riverview
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Enjoy al fresco dining on the outdoor patio with tables and chairs, surrounded by a metal railing.

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
8.8 out of 10, Excellent, (594)
"This was a great hotel at a great price!"
The price is ￥11,804
￥12,775 total
includes taxes & fees
Sep 1 - Sep 2
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Plaza Hotel Cape Girardeau Conference Center
Relax in a stylish lounge area with a curved sofa, coffee table, and large flat-screen TV.

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1005)
"Complimentary happy hour with appetizers was amazing! Great breakfast also."
The price is ￥15,068
￥16,999 total
includes taxes & fees
Aug 14 - Aug 15
Drury Plaza Hotel Cape Girardeau Conference Center
Super 8 by Wyndham Potosi
Relax in a spacious room with a large bed, desk, and framed artwork, set against light blue walls.

Super 8 by Wyndham Potosi

2.0 star property
7.0 out of 10, Good, (365)
"I like how convenient everything was mangers were awesome All my needs were met and I look forward to visiting there again "
The price is ￥8,037
￥8,779 total
includes taxes & fees
Sep 2 - Sep 3
Super 8 by Wyndham Potosi
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:Aug 22 - Aug 24

Image gallery for Tiny Houses of French Village

Cozy living area with a high ceiling, flat-screen TV, and stone fireplace.

Tiny Houses of French Village

2.5 star property
French Village
10/10Exceptional (2 reviews)
18% off
Price is ￥32,670
￥92,118 total
includes taxes & fees
Tiny Houses of French Village
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Stay near popular Southeast Missouri attractions

K Bridge Recreation Area

K Bridge Recreation Area

5/5(1 review)

Explore the great outdoors at K Bridge Recreation Area, a lovely green space in Annapolis. While you're in the area, stroll along the riverfront.

See properties in K Bridge Recreation Area

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.

See all hotels in Southeast Missouri

Top Southeast Missouri Hotel Reviews

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

10/10 Excellent
"Everything "
Bethany 2-night trip
Posted 23 hours ago
Motel 6 Poplar Bluff, MO