Find hotels in Southeast Missouri, MO from ¥8,117

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Compare 575 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1000)
"Convenient location, clean and friendly staff."
The price is ¥13,793
¥15,856 total
includes taxes & fees
Jul 6 - Jul 7
Drury Inn & Suites Sikeston, MO

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1001)
"Great area. Great value"
The price is ¥8,478
¥9,564 total
includes taxes & fees
Jul 2 - Jul 3
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1001)
"Great place to stay with kids "
The price is ¥15,652
¥17,996 total
includes taxes & fees
Jun 30 - Jul 1
Pear Tree Inn Sikeston

Microtel Inn & Suites by Wyndham Sainte Genevieve

2.5 star property
8.8 out of 10, Excellent, (576)
"Clean and affordable "
The price is ¥11,704
¥13,062 total
includes taxes & fees
Jul 6 - Jul 7
Microtel Inn & Suites by Wyndham Sainte Genevieve

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 star property
8.0 out of 10, Very Good, (986)
"Nice place and fairly cheap"
The price is ¥8,117
¥9,240 total
includes taxes & fees
Jul 2 - Jul 3
Baymont Inn and Suites by Wyndham Farmington, MO

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1000)
"Front desk staff was very friendly and helpful."
The price is ¥10,434
¥11,770 total
includes taxes & fees
Jul 3 - Jul 4
Pear Tree Inn Cape Girardeau West

The Farmstead Hotel

2.5 star property
8.8 out of 10, Excellent, (367)
"Property was great for a few nights stay. "
The price is ¥14,349
¥16,318 total
includes taxes & fees
Jun 29 - Jun 30
The Farmstead Hotel

The Riverview

2.0 star property
9.4 out of 10, Exceptional, (306)
"Enjoyed our stay and the Casino"
The price is ¥15,262
¥17,218 total
includes taxes & fees
Jun 29 - Jun 30
The Riverview

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (763)
"Great stay with apparent focus on cleanliness and hospitality! "
The price is ¥14,059
¥15,884 total
includes taxes & fees
Jul 13 - Jul 14
Fairfield Inn & Suites by Marriott Poplar Bluff

Hampton Inn Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (724)
"Room was very nice and it was in a quiet spot"
The price is ¥14,662
¥16,418 total
includes taxes & fees
Jul 13 - Jul 14
Hampton Inn Poplar Bluff

Super 8 by Wyndham Farmington

2.0 star property
8.0 out of 10, Very Good, (554)
"Everything was great. Will stay again."
The price is ¥8,624
¥9,818 total
includes taxes & fees
Jul 1 - Jul 2
Super 8 by Wyndham Farmington

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (717)
"Great place to stay convenient walking to multiple restaurants"
The price is ¥15,893
¥17,929 total
includes taxes & fees
Jul 6 - Jul 7
Hampton Inn Cape Girardeau I 55 East

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (11)
"I couldn’t have found a more perfect place for a much needed escape! The location was peaceful and relaxing, the cabin was clean, and I slept better than ever. I’m going back in two weeks and can’t wait!"
The price is ¥15,798
¥22,458 total
includes taxes & fees
Jun 30 - Jul 1
Postcard Cabins St. Francois

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
9.4 out of 10, Exceptional, (474)
"Was clean. Pool was nice. Breakfast was good"
The price is ¥13,794
¥15,791 total
includes taxes & fees
Jun 29 - Jun 30
Holiday Inn Express & Suites Perryville by IHG

Tru By Hilton Cape Girardeau

2.5 star property
9.8 out of 10, Exceptional, (33)
"It was a quick stay for work but the place was very nice and clean! I like the way they do breakfast too. "
The price is ¥14,661
¥16,687 total
includes taxes & fees
Jul 2 - Jul 3
Tru By Hilton Cape Girardeau

Current River Inn

3.0 star property
8.2 out of 10, Very Good, (140)
"This place is a treasure! So much attention to detail in the room. Comfortable, safe, quiet with wonderful staff! Highly recommend! "
The price is ¥12,820
¥13,873 total
includes taxes & fees
Jun 30 - Jul 1
Current River Inn

Shepherd Mountain Inn

2.5 star property
9.2 out of 10, Wonderful, (277)
"The motel is small well run and convenient to Mark Twain National Forest"
Shepherd Mountain Inn

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1002)
"Great breakfast!"
The price is ¥12,413
¥13,123 total
includes taxes & fees
Jun 30 - Jul 1
Drury Inn & Suites Jackson MO

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1000)
"We were very pleased with this Drury Inn will definitely stay here again "
The price is ¥13,043
¥14,713 total
includes taxes & fees
Jul 1 - Jul 2
Drury Plaza Hotel Cape Girardeau Conference Center

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1000)
"Great place to stay. "
The price is ¥15,972
¥18,019 total
includes taxes & fees
Jul 18 - Jul 19
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.