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Our top choices for Southeast Missouri hotels

A motel with a covered entrance, a flag, and a phone number.

1. Madison Inn Lodge

Fredericktown

Bawan

￥14,715 total

includes taxes & fees

Nov 9 - Nov 10

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

2. Shepherd Mountain Inn

Ironton

Jonathan

￥21,345 total

includes taxes & fees

Nov 9 - Nov 10

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

3. Hampton Inn & Suites By Hilton Festus

Festus

Misty

￥20,211 total

includes taxes & fees

Nov 15 - Nov 16

A hotel lobby with a reception desk, seating area, and a patterned carpet.

4. Holiday Inn Express & Suites Perryville by IHG

Perryville

allan p.

￥18,323 total

includes taxes & fees

Nov 15 - Nov 16

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

5. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

ELAINE

￥17,350 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

6. Fort Davidson Hotel

Ironton

richard

￥21,639 total

includes taxes & fees

Nov 9 - Nov 10

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

7. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Kim

￥9,858 total

includes taxes & fees

Nov 15 - Nov 16

An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

8. Hampton Inn Farmington

Farmington

Charlie

￥18,642 total

includes taxes & fees

Nov 20 - Nov 21

A modern kitchen with a coffee machine, a refrigerator, and a microwave.

9. Super 8 by Wyndham Farmington

Farmington

Marisa

￥10,784 total

includes taxes & fees

Nov 15 - Nov 16

A spacious lobby with a modern design, featuring a seating area with patterned armchairs and a round table, a large window, and a fireplace with decorative wall art.

10. Drury Inn & Suites Hayti Caruthersville

Hayti

Philip

￥17,700 total

includes taxes & fees

Nov 15 - Nov 16

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

11. Crown Pointe Lodge, BW Signature Collection

Farmington

christopher

￥18,330 total

includes taxes & fees

Nov 19 - Nov 20

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

12. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

J

￥13,705 total

includes taxes & fees

Nov 15 - Nov 16

A modern lobby with seating areas, a patterned carpet, and a cityscape mural on the wall.

13. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Festus

Vincent

￥15,249 total

includes taxes & fees

Nov 10 - Nov 11

A reception area with a modern design, featuring a decorative wall piece, a small table with a bowl, and a patterned partition.

14. Holiday Inn Express & Suites Farmington by IHG

Farmington

January

￥20,887 total

includes taxes & fees

Nov 22 - Nov 23

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

15. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

￥18,084 total

includes taxes & fees

Nov 12 - Nov 13

A row of single-story houses with attached garages, a paved driveway, and a clear sky.

16. Microtel Inn & Suites by Wyndham Sainte Genevieve

Ste Genevieve

Samantha

￥16,119 total

includes taxes & fees

Nov 15 - Nov 16

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

17. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Melody

￥17,694 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a bed, a standing lamp, a window with curtains, a wall-mounted air conditioner, and a landscape painting.

18. Hampton Inn Poplar Bluff

Poplar Bluff

Denise

￥15,839 total

includes taxes & fees

Dec 6 - Dec 7

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

19. Super 8 by Wyndham Perryville

Perryville

Matthew

￥12,491 total

includes taxes & fees

Nov 15 - Nov 16

A spacious lobby with a reception desk, seating area, and large windows.

20. Drury Inn & Suites Poplar Bluff

Poplar Bluff

Dean

￥16,112 total

includes taxes & fees

Nov 15 - Nov 16

View all properties

Vacation Rentals in Southeast Missouri

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"Recomend this location"

Aparthotel

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Vacation Home

A wooden deck with two Adirondack chairs and a hammock.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Cottage

A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Cottage

A wooden deck with a hot tub, a small table, and a bench.

Hot Tub & Creek Views: Secluded Perryville Cabin

Perryville

"Such a perfect, nostalgic cabin. You literally have to see it to believe it. We will be back"

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

See all vacation rentals

Hotels recommended for families in Southeast Missouri

Madison Inn Lodge

Fredericktown

￥14,715 total

includes taxes & fees

Nov 9 - Nov 10

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

See properties

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"Very clean and every one very nice and helpful"

Silo Farm Haus- located in the heart of wine country!

10/10 Excellent

"Visited for the weekend with my wife to celebrate our anniversary. The Silo Farm Haus was absolutely perfect! The views of the rolling farmland were gorgeous. Inside was cozy and beautifully decorated. We had a wonderful time and would highly recommend staying here if you get the chance."

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

￥8,621

￥9,858 total

Nov 15 - Nov 16

includes taxes & fees

Find hotels in Southeast Missouri, MO from ￥9,858

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Go beyond your typical stay in Southeast Missouri

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Our top choices for Southeast Missouri hotels

1. Madison Inn Lodge

2. Shepherd Mountain Inn

3. Hampton Inn & Suites By Hilton Festus

4. Holiday Inn Express & Suites Perryville by IHG

5. Fairfield Inn & Suites by Marriott Poplar Bluff

6. Fort Davidson Hotel

7. Baymont Inn and Suites by Wyndham Farmington, MO

8. Hampton Inn Farmington

9. Super 8 by Wyndham Farmington

10. Drury Inn & Suites Hayti Caruthersville

11. Crown Pointe Lodge, BW Signature Collection

12. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

13. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

14. Holiday Inn Express & Suites Farmington by IHG

15. Fairfield Inn & Suites by Marriott Cape Girardeau

16. Microtel Inn & Suites by Wyndham Sainte Genevieve

17. Drury Plaza Hotel Cape Girardeau Conference Center

18. Hampton Inn Poplar Bluff

19. Super 8 by Wyndham Perryville

20. Drury Inn & Suites Poplar Bluff

Vacation Rentals in Southeast Missouri

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Hotels recommended for families in Southeast Missouri

Madison Inn Lodge

Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

Learn more about Southeast Missouri

Top Southeast Missouri Hotel Reviews

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Hotels in Southeast Missouri with star-rating

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