Photo by Bill Dillard

Find hotels in Southeast Missouri, MO from ¥9,036
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Our top choices for Southeast Missouri hotels

Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (897 reviews)
The price is ¥15,918
¥17,983 total
includes taxes & fees
May 17 - May 18

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,010 reviews)
The price is ¥14,182
¥14,994 total
includes taxes & fees
Jun 7 - Jun 8

The Farmstead Hotel
The Farmstead HotelCaruthersville
8.6 out of 10, Excellent, (549 reviews)
The price is ¥14,972
¥17,027 total
includes taxes & fees
May 17 - May 18

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (763 reviews)
The price is ¥14,602
¥15,802 total
includes taxes & fees
May 18 - May 19

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
The price is ¥17,336
¥19,556 total
includes taxes & fees
May 24 - May 25

Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MOPoplar Bluff
8.0 out of 10, Very Good, (1,000 reviews)
The price is ¥10,244
¥11,470 total
includes taxes & fees
May 15 - May 16

Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (1,011 reviews)
The price is ¥14,813
¥16,735 total
includes taxes & fees
May 31 - Jun 1

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (182 reviews)
The price is ¥14,602
¥16,473 total
includes taxes & fees
May 28 - May 29

Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (1,012 reviews)
The price is ¥15,128
¥17,067 total
includes taxes & fees
May 21 - May 22

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,002 reviews)
The price is ¥15,758
¥17,778 total
includes taxes & fees
May 25 - May 26

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis SouthFestus
8.0 out of 10, Very Good, (977 reviews)
The price is ¥15,941
¥18,230 total
includes taxes & fees
May 18 - May 19

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.6 out of 10, Exceptional, (1,000 reviews)
The price is ¥17,492
¥20,111 total
includes taxes & fees
May 19 - May 20

Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (559 reviews)
The price is ¥16,025
¥18,144 total
includes taxes & fees
Jun 7 - Jun 8

Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau WestCape Girardeau
9.0 out of 10, Wonderful, (1,000 reviews)
The price is ¥11,346
¥12,800 total
includes taxes & fees
May 24 - May 25

Super 8 by Wyndham Potosi
Super 8 by Wyndham PotosiPotosi
7.0 out of 10, Good, (396 reviews)
The price is ¥9,434
¥10,304 total
includes taxes & fees
May 18 - May 19

Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (836 reviews)
The price is ¥15,563
¥17,427 total
includes taxes & fees
Jun 14 - Jun 15

Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
8.0 out of 10, Very Good, (1,001 reviews)
The price is ¥9,090
¥9,895 total
includes taxes & fees
Jun 14 - Jun 15

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (77 reviews)
The price is ¥17,336
¥19,629 total
includes taxes & fees
May 28 - May 29

Best Western Plus Sikeston I-55
Best Western Plus Sikeston I-55Sikeston
8.4 out of 10, Very Good, (1,008 reviews)
The price is ¥13,480
¥15,363 total
includes taxes & fees
May 17 - May 18

New Orleans Inn Portageville
New Orleans Inn PortagevillePortageville
8.0 out of 10, Very Good, (764 reviews)
The price is ¥7,864
¥8,492 total
includes taxes & fees
Jun 7 - Jun 8
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Vacation Rentals in Southeast Missouri
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (66 reviews)
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Stay near popular Southeast Missouri attractions
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Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Photo by Bill Dillard
Open Photo by Bill Dillard
More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is ¥9,090 per night from Jun 14 to Jun 15
¥9,090
¥9,895 total
Jun 14 - Jun 15
includes taxes & fees
8/10 Very Good! (1,001 reviews)
Hotels in Southeast Missouri with star-rating

4 Star Hotels
2 properties
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