Find hotels in Southeast Missouri, MO from ¥9,036

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Southeast Missouri hotels

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (897 reviews)
"Nice overnight stop over"
United States
Douglas
The price is ¥15,918
¥17,983 total
includes taxes & fees
May 17 - May 18
Fairfield Inn & Suites by Marriott Poplar Bluff

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,010 reviews)
"Clean room, friendly staff, good breakfast and dinner variety,large open parking, clean pool and exercise room. All around great stay. "
United States
Jeremy
The price is ¥14,182
¥14,994 total
includes taxes & fees
Jun 7 - Jun 8
Drury Inn & Suites Jackson MO

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.6 out of 10, Excellent, (549 reviews)
"Great casino n safe parking. "
United States
Theron
The price is ¥14,972
¥17,027 total
includes taxes & fees
May 17 - May 18
The Farmstead Hotel

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (763 reviews)
"Nice hotel"
United States
Jeff
The price is ¥14,602
¥15,802 total
includes taxes & fees
May 18 - May 19
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
"Room was very clean. Breakfast was good with several options. Would recommend staying here."
United States
Linda
The price is ¥17,336
¥19,556 total
includes taxes & fees
May 24 - May 25
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very Good, (1,000 reviews)
"The staff was great"
United States
Jasmine
The price is ¥10,244
¥11,470 total
includes taxes & fees
May 15 - May 16
Motel 6 Poplar Bluff, MO

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (1,011 reviews)
"Would definitely stay here again! Was a beautiful room and allowed us to have our fur babies!"
United States
Kayla
The price is ¥14,813
¥16,735 total
includes taxes & fees
May 31 - Jun 1
Drury Inn & Suites Poplar Bluff

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (182 reviews)
"Nice room, good breakfast "
United States
KENNETH
The price is ¥14,602
¥16,473 total
includes taxes & fees
May 28 - May 29
Fairfield Inn & Suites by Marriott Cape Girardeau

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,012 reviews)
"Clean and comfortable room for a good price."
United States
Mary
The price is ¥15,128
¥17,067 total
includes taxes & fees
May 21 - May 22
Drury Inn & Suites Cape Girardeau

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,002 reviews)
"We found this property to be everything someone would hope for in an overnight stay away from home."
United States
Richard
The price is ¥15,758
¥17,778 total
includes taxes & fees
May 25 - May 26
Drury Plaza Hotel Cape Girardeau Conference Center

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
8.0 out of 10, Very Good, (977 reviews)
"Staff was super nice! "
United States
Youpeng
The price is ¥15,941
¥18,230 total
includes taxes & fees
May 18 - May 19
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,000 reviews)
"Great travel hotel from Texas to Chicago."
United States
Sally
The price is ¥17,492
¥20,111 total
includes taxes & fees
May 19 - May 20
Drury Inn & Suites Sikeston, MO

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (559 reviews)
"Perfect nights stay!! "
United States
Amanda
The price is ¥16,025
¥18,144 total
includes taxes & fees
Jun 7 - Jun 8
Hampton Inn Sikeston

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1,000 reviews)
"Excellent layover stay"
United States
Wesley H.
The price is ¥11,346
¥12,800 total
includes taxes & fees
May 24 - May 25
Pear Tree Inn Cape Girardeau West

Super 8 by Wyndham Potosi

Super 8 by Wyndham Potosi
2.0 star property
Potosi
7.0 out of 10, Good, (396 reviews)
"Great Staff and Clean Rooms!!!"
United States
James
The price is ¥9,434
¥10,304 total
includes taxes & fees
May 18 - May 19
Super 8 by Wyndham Potosi

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (836 reviews)
"The breakfast was great."
United States
Carolyn
The price is ¥15,563
¥17,427 total
includes taxes & fees
Jun 14 - Jun 15
Hampton Inn Poplar Bluff

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very Good, (1,001 reviews)
"Very nice, clean, friendly staff"
United States
Patty
The price is ¥9,090
¥9,895 total
includes taxes & fees
Jun 14 - Jun 15
Baymont Inn and Suites by Wyndham Farmington, MO

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (77 reviews)
"The breakfast was good, the service was good, and the staff was very friendly"
United States
Angela
The price is ¥17,336
¥19,629 total
includes taxes & fees
May 28 - May 29
Fairfield Inn & Suites by Marriott Sikeston

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1,008 reviews)
"Very nice folks who manage the hotel!!"
United States
Jane
The price is ¥13,480
¥15,363 total
includes taxes & fees
May 17 - May 18
Best Western Plus Sikeston I-55

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (764 reviews)
"The staff was great very helpful and friendly "
United States
Javier
The price is ¥7,864
¥8,492 total
includes taxes & fees
Jun 7 - Jun 8
New Orleans Inn Portageville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Vacation Rentals in Southeast Missouri

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Southeast Missouri attractions

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

More cheap stays in Southeast Missouri

Hotels in Southeast Missouri with star-rating