Top 10 Hotels in Southeast Missouri, MO from ￥9,758 - Competitive Prices

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Go beyond your typical stay in Southeast Missouri

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Our top choices for Southeast Missouri hotels

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

A compact kitchen with wooden cabinets, a stainless steel refrigerator, and a microwave.

A bathroom with a white sink, a large mirror, a hairdryer, a coffee maker, and a microwave.

A hotel room with two beds, a lamp, and a painting on the wall.

1. Shepherd Mountain Inn

Ironton

Jonathan

￥19,342

￥21,127 total

includes taxes & fees

Oct 27 - Oct 28

A motel with a covered entrance, a flag, and a phone number.

A reception desk with a wooden finish, a framed black and white cityscape, and a large framed Eiffel Tower picture.

A spacious kitchen with a dining area, featuring a ceiling fan, a TV mounted on the wall, and a large rug in the center.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

2. Madison Inn Lodge

Fredericktown

Bawan

￥13,805

￥15,079 total

includes taxes & fees

Oct 31 - Nov 1

A hotel lobby with a reception desk, seating area, and a patterned carpet.

A hotel lobby with a seating area, a reception desk, and a bar.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and a ceiling with recessed lighting.

A hotel room with a bed, bedside table, lamp, chair, and a mirror.

3. Holiday Inn Express & Suites Perryville by IHG

Perryville

Perry

￥15,844

￥18,138 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

4. Hampton Inn & Suites By Hilton Festus

Festus

Abram

￥14,214

￥16,253 total

includes taxes & fees

Nov 1 - Nov 2

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

A reception area with a wooden counter, a coffee machine, and a display of pastries.

A corner market with a refrigerated display case and a pantry area.

5. Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

ELAINE

￥15,201

￥17,173 total

includes taxes & fees

Nov 1 - Nov 2

A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

A laundry room with a front-loading washer and dryer, a door, and a light fixture.

A long, narrow hallway with patterned carpet, doors on both sides, and a ceiling light.

A hotel room with a large bed, a smaller bed, a nightstand with a lamp, and two large framed pictures on the wall.

6. Super 8 by Wyndham Farmington

Farmington

Marisa

￥9,335

￥10,674 total

includes taxes & fees

Nov 1 - Nov 2

A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.

A gym with cardio equipment, a bench press, and a squat rack.

A hotel reception area with a glass partition, a reception desk, and a digital kiosk.

7. Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Kim

￥8,534

￥9,758 total

includes taxes & fees

Nov 1 - Nov 2

An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.

A hotel room with a wooden desk, a chair, a television, a microwave, and a minibar.

A modern hotel lobby with multiple seating areas, a large flat-screen TV mounted on the wall, and a visible exit sign.

A hotel room with two beds, a flat-screen TV, a desk, and a window with blinds.

8. Hampton Inn Farmington

Farmington

Charlie

￥15,601

￥17,840 total

includes taxes & fees

Nov 22 - Nov 23

A spacious lobby with a reception desk, seating area, and large windows.

A hotel room with a bed, a desk, a chair, a sofa, and a TV.

An indoor swimming pool with a clear view of the outside through large windows.

A spacious conference room with brick walls, multiple tables and chairs, a large window, and a mounted TV.

9. Drury Inn & Suites Poplar Bluff

Poplar Bluff

Dean

￥14,117

￥15,948 total

includes taxes & fees

Nov 2 - Nov 3

A hotel room with two beds, a desk, a chair, a TV, and a lamp.

A two-story building with a green roof and a large circular sign that reads "Port David Restaurant".

A hotel room with a television, a desk, a chair, a dresser, a radiator, and a bathroom visible through an open door.

A reception desk with a woman standing behind it, a man with a suitcase, and another person standing to the left.

10. Fort Davidson Hotel

Ironton

richard

￥19,609

￥21,419 total

includes taxes & fees

Oct 27 - Oct 28

A living room with a blue wall, a fireplace, a sofa, and a chair.

A bar area with stools and a counter where a bartender is serving drinks.

A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.

A brick building with a sign reading "Mercantile & Hotel".

11. EC Reed's Mercantile and Hotel

Marble Hill

Jan

￥16,493

￥17,953 total

includes taxes & fees

Oct 27 - Oct 28

A modern lobby with seating areas, a patterned carpet, and a cityscape mural on the wall.

A hotel room with a large bed, a bedside table with a lamp, a vanity with a mirror, and a wall with framed pictures.

A spacious lobby with a modern design, featuring a large seating area with purple and gray chairs, a patterned carpet, and a cityscape mural on the wall.

A swimming pool with lounge chairs and a view of the night sky.

12. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Festus

Debra S

￥13,201

￥15,095 total

includes taxes & fees

Nov 1 - Nov 2

A modern hotel with a stone facade, multiple windows, outdoor seating, and a visible sign for the Holiday Inn Express & Suites.

A swimming pool area with a clear pool, a lifeguard chair, and a sign indicating the pool's depth.

A modern kitchen with a central island, built-in appliances, and a view into the dining area.

A hotel room with a bed, a desk, a microwave, a coffee maker, and a TV mounted on the wall.

13. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Festus

Terry

￥14,432

￥16,502 total

includes taxes & fees

Nov 1 - Nov 2

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.

A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

14. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Carlos

￥15,867

￥17,901 total

includes taxes & fees

Nov 1 - Nov 2

A row of single-story houses with attached garages, a paved driveway, and a clear sky.

A reception desk with a digital map of the USA, a wooden reception area, and a sign for 'MICROHOTEL BY JYNDHAMI'.

A modern living room with a flat-screen TV, a desk with a computer, two armchairs, a coffee table, and large windows with a view.

A hotel dining area with tables and chairs, a kitchen area, and a flat-screen TV mounted on the wall.

15. Microtel Inn & Suites by Wyndham Sainte Genevieve

Ste Genevieve

Samantha

￥13,130

￥15,441 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

A spacious lobby with a checkered floor, two sofas with patterned cushions, a computer desk, and a reception area with a glass door.

A hotel lobby with two sofas, a coffee table, lamps, and a large window with a plant.

A hotel room with a kitchenette, a large mirror, a sofa, and a patterned carpet.

16. Super 8 by Wyndham Perryville

Perryville

Matthew

￥10,667

￥12,212 total

includes taxes & fees

Nov 8 - Nov 9

An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.

A spacious hotel lobby with a dining area, kitchen, and large windows.

A lobby with a stone fireplace, two sofas, a coffee table, and two lamps.

17. Crown Pointe Lodge, BW Signature Collection

Farmington

CURTIS

￥15,867

￥18,143 total

includes taxes & fees

Nov 19 - Nov 20

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

18. Hampton Inn Poplar Bluff

Poplar Bluff

Denise

￥14,134

￥15,828 total

includes taxes & fees

Nov 8 - Nov 9

A spacious lobby with a modern design, featuring a seating area with patterned armchairs and a round table, a large window, and a fireplace with decorative wall art.

Two grey armchairs with green cushions, a small side table with a white lamp, and wall-mounted sconces.

A gym with treadmills, elliptical machines, and a mirrored wall.

An indoor swimming pool with multiple lanes, surrounded by seating areas and tables.

19. Drury Inn & Suites Hayti Caruthersville

Hayti

Cynthia

￥15,372

￥17,520 total

includes taxes & fees

Nov 1 - Nov 2

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

20. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Chris

￥15,679

￥17,688 total

includes taxes & fees

Nov 15 - Nov 16

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Vacation Rentals in Southeast Missouri

Cabin

A room with two bunk beds, a single bed, a ceiling fan, and a window with blinds.

Sam A Baker State Park

Patterson

"Pet friendly, great staff. "

Cabin

A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.

A forest with a cabin and a white vehicle parked on a gravel path.

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"Recomend this location"

Aparthotel

A bedroom with a bed, a striped armchair, a mirror, and a fireplace.

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

A building with a sign that reads "The Atrium Boutique Hotel".

A fireplace with a decorative mantel, a framed sign, and a small table with plants.

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Cottage

A dining area with a checkered tablecloth, wooden chairs, and a red rug.

A modern kitchen with wooden cabinets, a microwave, and a refrigerator. There is a staircase leading to another level. A gray sofa with a red pillow is in the living area, and a checkered curtain covers a window.

An outdoor patio with a table and chairs, a grill, and a large umbrella.

A two-story house with a red exterior, a front porch, and a well-maintained lawn.

'turtle Rock' - Ironton Cabin w/ Furnished Patio!

Ironton

"Stroller, pack n play and high chair. This was amazing "

Vacation Home

A wooden deck with two Adirondack chairs and a hammock.

A bedroom with a large bed, wooden ceiling, and a view of the outdoors.

A spacious living room with a wooden ceiling, a ceiling fan, a sofa set, a coffee table, and a large window offering a view of the outdoors.

A spacious living room with a wooden ceiling, a fireplace, and a television.

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Aparthotel

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

A hallway with exposed brick walls, wooden flooring, and a white door.

A modern kitchen with a bar area, a dining area with a sofa and chairs, and a large window with curtains.

A dining area with a brick wall, wooden furniture, and a pineapple centerpiece.

Urban Lofts

Perryville

"Beautiful place and staff was amazing!"

Cottage

A bedroom with a large bed, a sofa, a wooden wardrobe, and a ceiling fan.

A single-story house with a front porch, a stone foundation, and a well-maintained lawn.

A covered porch with yellow chairs, a bench, and a small table.

A kitchen with wooden cabinets, a central island, and a dining area with a table set for four.

Walk to Dtwn: Ironton Home in Historic District

Ironton

"Clean and comfortable "

Cottage

A spacious living area with a dark grey sofa set, a matching ottoman, and a wooden-paneled wall.

A room with wooden paneling, a ceiling fan, a dining table with chairs, and a sofa.

A house with a red door, a porch with rocking chairs, and a wreath on the door.

A spacious dining area with a stone wall, wooden furniture, and a fireplace.

40-acre Poplar Bluff Nature Lovers Paradise!

Poplar Bluff

"Beautiful place enjoyed our stay"

Cottage

A spacious living room with a high wooden ceiling, two sofas, a coffee table, a TV, and a bookshelf.

A red house with a wooden deck and stone steps leading to a porch.

A red house with a wooden deck, large sliding glass doors, and a chimney.

A bedroom with a bed, two bedside tables, a dresser, a ceiling fan, and a window with curtains.

Cozy Belgrade Cottage w/ Wood-burning Stove!

Belgrade

Cottage

A log cabin with a glass door leading to an outdoor patio, a grill, and a table with chairs.

A log cabin interior with a living room, kitchen, and a staircase.

A log cabin interior with a bed, a leather couch, a dresser, and a television.

A cozy cabin interior with wooden walls, a sofa, a loveseat, and a dining area.

Peaceful 2-cabin Property: 1 Mi to Current River!

Van Buren

"We had the best time. We had plenty of room for our families that were in town for a wedding. The rental had everything we needed."

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Hotels recommended for families in Southeast Missouri

Shepherd Mountain Inn

Ironton

￥19,342

￥21,127 total

includes taxes & fees

Oct 27 - Oct 28

Madison Inn Lodge

Fredericktown

￥13,805

￥15,079 total

includes taxes & fees

Oct 31 - Nov 1

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

Fairfield Inn & Suites by Marriott Sikeston

Sikeston

￥15,844

￥18,018 total

includes taxes & fees

Nov 1 - Nov 2

A reception area with a modern design, featuring a decorative wall piece, a small table with a bowl, and a patterned partition.

A hotel room with a bed, a sofa, a desk, and a chair.

A buffet with various food items, including omelets and other dishes, displayed in metal serving trays.

A reception area with a modern abstract wall art, two potted plants, and a wooden console table with a decorative bowl.

Holiday Inn Express & Suites Farmington by IHG

Farmington

￥18,511

￥21,167 total

includes taxes & fees

Nov 8 - Nov 9

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

A restaurant with a brick wall, a flat-screen TV, and a bar area.

A hotel room with two beds, a brick wall, and a wooden headboard.

A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.

Drury Inn & Suites Jackson MO

Jackson

￥12,548

￥13,266 total

includes taxes & fees

Nov 1 - Nov 2

Super 8 by Wyndham Farmington

Farmington

￥9,335

￥10,674 total

includes taxes & fees

Nov 1 - Nov 2

Fort Davidson Hotel

Ironton

￥19,609

￥21,419 total

includes taxes & fees

Oct 27 - Oct 28

Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

￥8,534

￥9,758 total

includes taxes & fees

Nov 1 - Nov 2

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.

Top Southeast Missouri Hotel Reviews

Days Inn and Suites by Wyndham Sikeston

8/10 Good

"It was clean, the room was nice and roomy, bed was very comfortable. Some things were in need of minor repairs, but nothing major."

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"We enjoyed the coffee available, drink beverage vouchers, food was great!"