Find hotels in Southeast Missouri, MO from ￥9,497
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Sep 13 - Sep 14Tomorrow
Sep 14 - Sep 15Next weekend
Sep 18 - Sep 20In two weeks
Sep 25 - Sep 27Our top choices for Southeast Missouri hotels
1. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
Andrew
￥14,232
￥15,402 total
includes taxes & fees
Sep 14 - Sep 15
2. Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
Scott Andrew
￥15,667
￥18,014 total
includes taxes & fees
Sep 18 - Sep 19
3. Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
Sandra
￥15,359
￥17,327 total
includes taxes & fees
Sep 20 - Sep 21
4. Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
Theresa
￥14,359
￥16,079 total
includes taxes & fees
Sep 20 - Sep 21
5. Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
Arsenia
￥15,538
￥17,554 total
includes taxes & fees
Oct 4 - Oct 5
6. Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau WestCape Girardeau
Raidas
￥11,058
￥12,476 total
includes taxes & fees
Sep 20 - Sep 21
7. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
ELAINE
￥15,515
￥17,657 total
includes taxes & fees
Sep 20 - Sep 21
8. Madison Inn Lodge
Madison Inn LodgeFredericktown
Bawan
￥13,442
￥14,683 total
includes taxes & fees
Sep 14 - Sep 15
9. La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis SouthFestus
Lisa-Marie
￥12,926
￥14,781 total
includes taxes & fees
Sep 16 - Sep 17
10. Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
Allen
￥15,515
￥17,567 total
includes taxes & fees
Sep 20 - Sep 21
11. Super 8 by Wyndham Potosi
Super 8 by Wyndham PotosiPotosi
Ross
￥8,943
￥9,768 total
includes taxes & fees
Sep 17 - Sep 18
12. Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
William
￥12,287
￥12,991 total
includes taxes & fees
Sep 21 - Sep 22
13. Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
ILUNGA
￥8,725
￥9,497 total
includes taxes & fees
Sep 20 - Sep 21
14. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)Sikeston
Sharika West
￥9,820
￥11,192 total
includes taxes & fees
Sep 14 - Sep 15
15. Super 8 By Wyndham Marston
Super 8 By Wyndham MarstonMarston
Rachel
￥8,857
￥10,117 total
includes taxes & fees
Sep 16 - Sep 17
16. Best Western Plus Sikeston I-55
Best Western Plus Sikeston I-55Sikeston
Bernice
￥13,393
￥15,265 total
includes taxes & fees
Sep 20 - Sep 21
17. Holiday Inn Express & Suites Sikeston Southwest by IHG
Holiday Inn Express & Suites Sikeston Southwest by IHGSikeston
michael
￥15,054
￥17,046 total
includes taxes & fees
Oct 11 - Oct 12
18. Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MOPoplar Bluff
Mark
￥12,135
￥13,590 total
includes taxes & fees
Sep 14 - Sep 15
19. Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
Darlene
￥13,730
￥15,627 total
includes taxes & fees
Sep 21 - Sep 22
20. Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
Carlos
￥15,538
￥17,528 total
includes taxes & fees
Sep 20 - Sep 21
Vacation Rentals in Southeast Missouri
Cabin
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
"I really enjoyed my time at the stay !"
Cottage
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
'turtle Rock' - Ironton Cabin w/ Furnished Patio!Ironton
"Stroller, pack n play and high chair. This was amazing "
Aparthotel
The Atrium - A Boutique Hotel
The Atrium - A Boutique HotelPerryville
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
Vacation Home
Tiny Houses of French Village
Tiny Houses of French VillageFrench Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Cottage
Walk to Current River: Ozarks Adventure Home!
Walk to Current River: Ozarks Adventure Home!Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
Cottage
Cozy Belgrade Cottage w/ Wood-burning Stove!
Cozy Belgrade Cottage w/ Wood-burning Stove!Belgrade
Cottage
Cottage w/ Yard, Walk to Historic Attractions
Cottage w/ Yard, Walk to Historic AttractionsSte Genevieve
"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "
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Stay near popular Southeast Missouri attractions
Photo by Pat Long
Elephant Rocks State Park
9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Southeast Missouri State University
8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Big Spring
9.8/10 (19 reviews)
Enjoy an outing to Big Spring during your stay in Van Buren. Wander the forest and riverfront while you're in the area.
Current River State Park
9.2/10 (20 reviews)
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
Century Casino & Hotel Cape Girardeau
8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
Century Casino Caruthersville
7.0/10 (57 reviews)
Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
Learn more about Southeast Missouri
Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.
See all hotels in Southeast Missouri
Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Drury Plaza Hotel Cape Girardeau Conference Center
10/10 Excellent
"Great experience- food, cleanliness, friendly staff"
Pear Tree Inn Cape Girardeau West
10/10 Excellent
"Didn't notice bathroom venting."
Baymont Inn and Suites by Wyndham Farmington, MO
10/10 Excellent
"Clean"
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
10/10 Excellent
"This was the perfect stress free getaway. 10 minutes from a gas station and some fast food. 20 minutes from at least 2 cute towns and 3 wineries. It felt quiet without feeling isolated. The cabin was perfectly appointed with everything we needed, including firewood, starters, and lighters. We hope to go back!"
The Riverview
10/10 Excellent
"I can’t rave enough about this hotel. 5 ♥️s. It takes zero effort to be kind. The staff is kind and helpful. Highly recommend to anyone staying in Cape Girardeau, MO. This hotel rises above the chain hotels 🏨."
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
10/10 Excellent
"Excellent breakfast,friendly staff and clean rooms"
Fairfield Inn & Suites by Marriott Cape Girardeau
10/10 Excellent
"The receptionist was very courteous. Helped answer all my questions. We loved the room. And we had a great breakfast before we left."
Motel 6 Poplar Bluff, MO
10/10 Excellent
"Nice"
More cheap stays in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
￥8,725
￥9,497 total
Sep 20 - Sep 21
includes taxes & fees
8/10 Very Good! (1,012 reviews)
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
￥10,186
￥11,610 total
Sep 16 - Sep 17
includes taxes & fees
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
￥11,058
￥12,476 total
Sep 20 - Sep 21
includes taxes & fees
9.2/10 Wonderful! (1,005 reviews)
Comfort Inn Festus - St Louis South
1303 Veterans Blvd Festus MO
￥11,551
￥13,498 total
Oct 11 - Oct 12
includes taxes & fees
The Farmstead Hotel
778 E 3rd St Caruthersville MO
￥13,134
￥14,936 total
Sep 27 - Sep 28
includes taxes & fees
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
￥15,515
￥17,657 total
Sep 20 - Sep 21
includes taxes & fees
9.4/10 Exceptional! (1,002 reviews)
Hotels in Southeast Missouri with star-rating
4 Star Hotels
2 properties
3 Star Hotels
70 properties
2 Star Hotels
90 properties
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