Photo by JG Morris

Find hotels in Southeast Missouri, MO from ￥9,507

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 15 - Dec 16
Tomorrow
Dec 16 - Dec 17
This weekend
Dec 19 - Dec 21
Next weekend
Dec 26 - Dec 28

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Southeast Missouri hotels

Premium bedding, down comforters, pillowtop beds, in-room safe
The Farmstead Hotel

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.8 out of 10, Excellent, (463)
"Nice place "
United States
Debbie
The price is ￥13,322
￥15,151 total
includes taxes & fees
Dec 16 - Dec 17
The Farmstead Hotel
Indoor pool, outdoor pool
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1003)
"Clean room, great location and friendly staff"
United States
Mark
The price is ￥14,021
￥16,120 total
includes taxes & fees
Dec 20 - Dec 21
Drury Inn & Suites Sikeston, MO
Blackout drapes, free WiFi, bed sheets
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
7.8 out of 10, Good, (1005)
"Love the updated rooms and the vending area."
United States
Kathi
The price is ￥11,842
￥12,490 total
includes taxes & fees
Dec 16 - Dec 17
Motel 6 Poplar Bluff, MO
Lobby lounge
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (854)
"Very clean, great check in"
United States
Teresa
The price is ￥16,204
￥18,306 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Fairfield Inn & Suites by Marriott Poplar Bluff
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1003)
"Easy parking , quiet and comfortable bed , we’ll stop again on our way back "
United States
joseph
The price is ￥11,123
￥12,676 total
includes taxes & fees
Dec 21 - Dec 22
Best Western Plus Sikeston
Exterior
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (669)
"Great place "
United States
GUY
The price is ￥13,111
￥14,190 total
includes taxes & fees
Jan 7 - Jan 8, 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Individually decorated, individually furnished, desk, blackout drapes
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (719)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is ￥8,646
￥9,853 total
includes taxes & fees
Dec 16 - Dec 17
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1001)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is ￥14,802
￥16,699 total
includes taxes & fees
Dec 22 - Dec 23
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Reception
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (796)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is ￥15,830
￥17,725 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Hampton Inn Poplar Bluff
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (444)
"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."
United States
Doncheial
The price is ￥14,833
￥16,795 total
includes taxes & fees
Dec 28 - Dec 29
Hampton Inn Sikeston
Hiking
Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (331)
"Staff was very friendly."
United States
Joyce
The price is ￥14,863
￥16,114 total
includes taxes & fees
Dec 16 - Dec 17
Honeysuckle Inn - Mountain View
Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets
New Orleans Inn Portageville

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (726)
"Quiet area and helpful staff. Glad we took a chance on this local hotel while traveling."
United States
Roger
New Orleans Inn Portageville
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1004)
"Great place and staff, very accommodating!"
United States
Megan
The price is ￥14,021
￥15,816 total
includes taxes & fees
Dec 21 - Dec 22
Drury Plaza Hotel Cape Girardeau Conference Center
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1004)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is ￥12,931
￥13,671 total
includes taxes & fees
Dec 16 - Dec 17
Drury Inn & Suites Jackson MO
Lobby
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (964)
"Nice room helpful staff. "
United States
Deborah
The price is ￥14,645
￥16,543 total
includes taxes & fees
Dec 20 - Dec 21
Drury Inn & Suites Poplar Bluff
Fridge, microwave, coffee/tea maker
Shepherd Mountain Inn

Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.4 out of 10, Exceptional, (304)
" Nice room, nice bed, convenient location"
United States
Burton
Shepherd Mountain Inn
Standard Room, 2 Queen Beds | In-room safe, desk, blackout drapes, iron/ironing board
Super 8 by Wyndham Potosi

Super 8 by Wyndham Potosi

Super 8 by Wyndham Potosi
2.0 star property
Potosi
7.0 out of 10, Good, (379)
"The room was very good for the price."
United States
Benjamin
The price is ￥8,609
￥9,405 total
includes taxes & fees
Dec 16 - Dec 17
Super 8 by Wyndham Potosi
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is ￥14,490
￥16,407 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG
Desk, blackout drapes, rollaway beds, free WiFi
Fort Davidson Hotel

Fort Davidson Hotel

Fort Davidson Hotel
2.5 star property
Ironton
9.2 out of 10, Wonderful, (173)
"Friendly staff, spacious room, nice pool!!"
United States
SHARON
The price is ￥18,697
￥20,422 total
includes taxes & fees
Dec 16 - Dec 17
Fort Davidson Hotel
Lobby
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (784)
"Excellent stay"
United States
Christina
The price is ￥15,456
￥17,437 total
includes taxes & fees
Dec 21 - Dec 22
Hampton Inn Cape Girardeau I 55 East
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:Dec 26 - Dec 28

Image gallery for Echo Bluff State Park

Front of property

Echo Bluff State Park

2.5 star property
Eminence
9.6/10Exceptional (217 reviews)
6% off
Price is ￥27,681
￥58,530 total
includes taxes & fees
Echo Bluff State Park
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular Central United States attractions

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
See properties
A huge granite boulder located in Elephant Rocks State Park
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

4.8/5 (52 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train
Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

The Riverview

The Riverview

10/10 Excellent
"Didn’t eat breakfast "
Michael 1-night trip
Posted 4 days ago
The Riverview

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
The price is ￥8,351 per night from Dec 21 to Dec 22
￥8,351
￥9,507 total
Dec 21 - Dec 22
includes taxes & fees
7.8/10 Good! (1,003 reviews)

Hotels in Southeast Missouri with star-rating

Explore a world of travel with Expedia