Photo by Bill Dillard

Find hotels in Southeast Missouri, MO from ¥7,647

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Compare 618 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (851)
"Very clean, great check in"
United States
Teresa
The price is ¥16,154
¥18,252 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Fairfield Inn & Suites by Marriott Poplar Bluff

Motel 6 Poplar Bluff, MO

2.0 star property
Poplar Bluff
7.8 out of 10, Good, (1004)
"Love the updated rooms and the vending area."
United States
Kathi
The price is ¥11,805
¥12,451 total
includes taxes & fees
Dec 9 - Dec 10
Motel 6 Poplar Bluff, MO

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1002)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is ¥14,756
¥16,648 total
includes taxes & fees
Dec 22 - Dec 23
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hampton Inn Poplar Bluff

2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (796)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is ¥14,663
¥16,419 total
includes taxes & fees
Dec 14 - Dec 15
Hampton Inn Poplar Bluff

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
Sikeston
8.4 out of 10, Very Good, (716)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is ¥8,447
¥9,628 total
includes taxes & fees
Dec 8 - Dec 9
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Drury Inn & Suites Sikeston, MO

3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1002)
"Clean room, great location and friendly staff"
United States
Mark
The price is ¥13,978
¥16,070 total
includes taxes & fees
Dec 12 - Dec 13
Drury Inn & Suites Sikeston, MO

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
Jackson
8.8 out of 10, Excellent, (661)
"Great place "
United States
GUY
The price is ¥12,147
¥13,146 total
includes taxes & fees
Jan 4 - Jan 5, 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Drury Inn & Suites Poplar Bluff

3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (957)
"Delicious, well-ran breakfast and quiet peaceful hotel. "
United States
Janene
The price is ¥14,599
¥16,491 total
includes taxes & fees
Dec 11 - Dec 12
Drury Inn & Suites Poplar Bluff

Holiday Inn Poplar Bluff by IHG

3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (696)
"Amazing place"
United States
Mladen
The price is ¥17,086
¥19,304 total
includes taxes & fees
Dec 14 - Dec 15
Holiday Inn Poplar Bluff by IHG

Honeysuckle Inn - Mountain View

3.0 star property
Mountain View
8.6 out of 10, Excellent, (331)
"Staff was very friendly."
United States
Joyce
The price is ¥14,817
¥16,063 total
includes taxes & fees
Dec 8 - Dec 9
Honeysuckle Inn - Mountain View

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (466)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is ¥18,018
¥20,416 total
includes taxes & fees
Dec 21 - Dec 22
Courtyard by Marriott Cape Girardeau Downtown

Echo Bluff State Park

2.5 star property
Eminence
9.6 out of 10, Exceptional, (216)
"Beautiful location…excellent service and facilities / grounds were clean and well kept."
United States
William
The price is ¥22,721
¥24,022 total
includes taxes & fees
Dec 15 - Dec 16
Echo Bluff State Park

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
Perryville
9.2 out of 10, Wonderful, (537)
"Clean room and pleasant staff"
United States
David
The price is ¥13,514
¥15,469 total
includes taxes & fees
Dec 14 - Dec 15
Holiday Inn Express & Suites Perryville by IHG

Hampton Inn Sikeston

2.5 star property
Sikeston
9.0 out of 10, Wonderful, (439)
"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."
United States
Doncheial
The price is ¥14,787
¥16,742 total
includes taxes & fees
Dec 14 - Dec 15
Hampton Inn Sikeston

Shepherd Mountain Inn

2.5 star property
Ironton
9.4 out of 10, Exceptional, (304)
" Nice room, nice bed, convenient location"
United States
Burton
Shepherd Mountain Inn

Best Western Plus Sikeston

2.5 star property
Sikeston
8.4 out of 10, Very Good, (1003)
"Nice location. Great staff. "
United States
Carla
The price is ¥11,089
¥12,637 total
includes taxes & fees
Dec 14 - Dec 15
Best Western Plus Sikeston

The Farmstead Hotel

2.5 star property
Caruthersville
8.8 out of 10, Excellent, (460)
"Clean rooms and really comfortable beds!"
United States
Andrea
The price is ¥12,218
¥13,895 total
includes taxes & fees
Jan 7 - Jan 8, 2026
The Farmstead Hotel

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3.0 star property
Festus
8.0 out of 10, Very Good, (883)
"Staff was very nice ans helpful. Our room was clean and pleasant. "
United States
ELLEN
The price is ¥14,127
¥16,153 total
includes taxes & fees
Jan 4 - Jan 5, 2026
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Drury Inn & Suites Jackson MO

3.0 star property
Jackson
9.6 out of 10, Exceptional, (1005)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is ¥12,891
¥13,629 total
includes taxes & fees
Dec 8 - Dec 9
Drury Inn & Suites Jackson MO

Fort Davidson Hotel

2.5 star property
Ironton
9.2 out of 10, Wonderful, (173)
"Friendly staff, spacious room, nice pool!!"
United States
SHARON
The price is ¥18,640
¥20,360 total
includes taxes & fees
Dec 8 - Dec 9
Fort Davidson Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

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Stay near popular Central United States attractions

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to Walnut Hollow Lake.

Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:

Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.

It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.

This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 

#MTTS2014 #minitakesthestates #go11
#train
Photo by Bill Dillard
Open Photo by Bill Dillard

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