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Find hotels in Southeast Missouri, MO from ￥7,647

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Dec 7 - Dec 8
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Dec 8 - Dec 9
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Compare 618 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Lobby lounge
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (851)
"Very clean, great check in"
United States
Teresa
The price is ￥16,154
￥18,252 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Fairfield Inn & Suites by Marriott Poplar Bluff
Lobby
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2.0 star property
Poplar Bluff
7.8 out of 10, Good, (1004)
"Love the updated rooms and the vending area."
United States
Kathi
The price is ￥11,805
￥12,451 total
includes taxes & fees
Dec 9 - Dec 10
Motel 6 Poplar Bluff, MO
Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1002)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is ￥14,756
￥16,648 total
includes taxes & fees
Dec 22 - Dec 23
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Terrace/patio
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (796)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is ￥14,663
￥16,419 total
includes taxes & fees
Dec 14 - Dec 15
Hampton Inn Poplar Bluff
Exterior
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
Sikeston
8.4 out of 10, Very Good, (716)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is ￥8,447
￥9,628 total
includes taxes & fees
Dec 8 - Dec 9
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1002)
"Clean room, great location and friendly staff"
United States
Mark
The price is ￥13,978
￥16,070 total
includes taxes & fees
Dec 12 - Dec 13
Drury Inn & Suites Sikeston, MO
Property amenity
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
Jackson
8.8 out of 10, Excellent, (661)
"Great place "
United States
GUY
The price is ￥12,147
￥13,146 total
includes taxes & fees
Jan 4 - Jan 5, 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Lobby
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (957)
"Delicious, well-ran breakfast and quiet peaceful hotel. "
United States
Janene
The price is ￥14,599
￥16,491 total
includes taxes & fees
Dec 11 - Dec 12
Drury Inn & Suites Poplar Bluff
Breakfast, lunch, dinner served; Italian cuisine
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (696)
"Amazing place"
United States
Mladen
The price is ￥17,086
￥19,304 total
includes taxes & fees
Dec 14 - Dec 15
Holiday Inn Poplar Bluff by IHG
Children's play area - outdoor
Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View

3.0 star property
Mountain View
8.6 out of 10, Excellent, (331)
"Staff was very friendly."
United States
Joyce
The price is ￥14,817
￥16,063 total
includes taxes & fees
Dec 8 - Dec 9
Honeysuckle Inn - Mountain View
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (466)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is ￥18,018
￥20,416 total
includes taxes & fees
Dec 21 - Dec 22
Courtyard by Marriott Cape Girardeau Downtown
Front of property
Echo Bluff State Park

Echo Bluff State Park

2.5 star property
Eminence
9.6 out of 10, Exceptional, (216)
"Beautiful location…excellent service and facilities / grounds were clean and well kept."
United States
William
The price is ￥22,721
￥24,022 total
includes taxes & fees
Dec 15 - Dec 16
Echo Bluff State Park
Exterior
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
Perryville
9.2 out of 10, Wonderful, (537)
"Clean room and pleasant staff"
United States
David
The price is ￥13,514
￥15,469 total
includes taxes & fees
Dec 14 - Dec 15
Holiday Inn Express & Suites Perryville by IHG
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 star property
Sikeston
9.0 out of 10, Wonderful, (439)
"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."
United States
Doncheial
The price is ￥14,787
￥16,742 total
includes taxes & fees
Dec 14 - Dec 15
Hampton Inn Sikeston
Fridge, microwave, coffee/tea maker
Shepherd Mountain Inn

Shepherd Mountain Inn

2.5 star property
Ironton
9.4 out of 10, Exceptional, (304)
" Nice room, nice bed, convenient location"
United States
Burton
Shepherd Mountain Inn
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

2.5 star property
Sikeston
8.4 out of 10, Very Good, (1003)
"Nice location. Great staff. "
United States
Carla
The price is ￥11,089
￥12,637 total
includes taxes & fees
Dec 14 - Dec 15
Best Western Plus Sikeston
Front of property
The Farmstead Hotel

The Farmstead Hotel

2.5 star property
Caruthersville
8.8 out of 10, Excellent, (460)
"Clean rooms and really comfortable beds!"
United States
Andrea
The price is ￥12,218
￥13,895 total
includes taxes & fees
Jan 7 - Jan 8, 2026
The Farmstead Hotel
Lobby
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3.0 star property
Festus
8.0 out of 10, Very Good, (883)
"Staff was very nice ans helpful. Our room was clean and pleasant. "
United States
ELLEN
The price is ￥14,127
￥16,153 total
includes taxes & fees
Jan 4 - Jan 5, 2026
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

3.0 star property
Jackson
9.6 out of 10, Exceptional, (1005)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is ￥12,891
￥13,629 total
includes taxes & fees
Dec 8 - Dec 9
Drury Inn & Suites Jackson MO
Outdoor pool, sun loungers
Fort Davidson Hotel

Fort Davidson Hotel

2.5 star property
Ironton
9.2 out of 10, Wonderful, (173)
"Friendly staff, spacious room, nice pool!!"
United States
SHARON
The price is ￥18,640
￥20,360 total
includes taxes & fees
Dec 8 - Dec 9
Fort Davidson Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:Dec 19 - Dec 21

Image gallery for Echo Bluff State Park

Front of property

Echo Bluff State Park

2.5 star property
Eminence
9.6/10Exceptional (216 reviews)
8% off
Price is ￥27,008
￥57,108 total
includes taxes & fees
Echo Bluff State Park
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Stay near popular Central United States attractions

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
See properties
A huge granite boulder located in Elephant Rocks State Park
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

4.8/5 (52 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to Walnut Hollow Lake.

See all hotels in Southeast Missouri
Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train
Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

10/10 Excellent
"Very good hotel for the price."
Gareth 1-night trip
Posted 2 days ago
Drury Inn & Suites Jackson MO

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
The price is ￥8,450 per night from Dec 14 to Dec 15
￥8,450
￥9,619 total
Dec 14 - Dec 15
includes taxes & fees
7.8/10 Good! (1,002 reviews)

Hotels in Southeast Missouri with star-rating

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