Our top choices for Southeast Missouri hotels

Drury Inn & Suites Jackson MO

Jackson

William

￥13,891 total

includes taxes & fees

Jul 7 - Jul 8

Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

Travis

￥16,749 total

includes taxes & fees

Jul 5 - Jul 6

Tru By Hilton Cape Girardeau

Cape Girardeau

Kendra

￥16,301 total

includes taxes & fees

Jul 5 - Jul 6

Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Jonna

￥19,884 total

includes taxes & fees

Jun 21 - Jun 22

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Festus

Nancy

￥15,418 total

includes taxes & fees

Jun 21 - Jun 22

Hampton Inn Poplar Bluff

Poplar Bluff

Tammy

￥16,772 total

includes taxes & fees

Jul 12 - Jul 13

Suite, 1 King Bed, Non Smoking (1 Bedroom) | In-room safe, individually decorated, individually furnished, desk

Super 8 by Wyndham Perryville

Perryville

Cynthia

￥12,942 total

includes taxes & fees

Jul 1 - Jul 2

Drury Inn & Suites Poplar Bluff

Poplar Bluff

Stephanie

￥17,014 total

includes taxes & fees

Jun 28 - Jun 29

Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

Alice

￥18,284 total

includes taxes & fees

Jun 21 - Jun 22

Holiday Inn Express & Suites Perryville by IHG

Perryville

Cheryl

￥18,526 total

includes taxes & fees

Jun 22 - Jun 23

Drury Inn & Suites Sikeston, MO

Sikeston

Amanda

￥20,449 total

includes taxes & fees

Jun 22 - Jun 23

Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Joni

￥19,957 total

includes taxes & fees

Jun 21 - Jun 22

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

Kenzia

￥25,690 total

includes taxes & fees

Jun 22 - Jun 23

Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

Daisy

￥10,465 total

includes taxes & fees

Jun 28 - Jun 29

Premium bedding, down comforters, pillowtop beds, in-room safe

The Farmstead Hotel

Caruthersville

Kanyia

￥14,714 total

includes taxes & fees

Jun 17 - Jun 18

Deerfield Inn & Suites Steele Near Blytheville I 55

Steele

￥8,967 total

includes taxes & fees

Jun 16 - Jun 17

Standard Room, 2 Queen Beds | In-room safe, desk, blackout drapes, iron/ironing board

Super 8 by Wyndham Potosi

Potosi

Julie

￥10,766 total

includes taxes & fees

Jun 22 - Jun 23

EC Reed's Mercantile and Hotel

Marble Hill

DANIELLE

￥16,152 total

includes taxes & fees

Jun 18 - Jun 19

Hampton Inn Farmington

Farmington

Kathy

￥21,168 total

includes taxes & fees

Jul 4 - Jul 5

Individually decorated, individually furnished, desk, blackout drapes

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Carolyn

￥12,313 total

includes taxes & fees

Jun 18 - Jun 19

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Vacation Rentals in Southeast Missouri

Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

French Village

"The Experience was amazing and we enjoyed the views and the firepit!"

Vacation Home

Tiny Houses of French Village

French Village

"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "

Aparthotel

The Atrium - A Boutique Hotel

Perryville

"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."

Cottage

Walk to Current River: Ozarks Adventure Home!

Van Buren

"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."

Cottage

40-acre Poplar Bluff Nature Lovers Paradise!

Poplar Bluff

"Beautiful place enjoyed our stay"

Cottage

Cottage w/ Yard, Walk to Historic Attractions

Ste Genevieve

"The little blue cottage was very comfortable, clean and close to everything downtown. We parked the car and walked everywhere. It was on a quiet street. The bed was comfy, clean kitchen. We liked the little back yard, for relaxing. "

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Stay near popular Southeast Missouri attractions

Elephant Rocks State Park

4.8/5 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Clearwater Lake.

See all hotels in Southeast Missouri

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Great place!"

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"The hotel was nice and the staff were nice and professional. I did think it was unnecessary for us to pay a $10 fee because we were an hour early for check in. If the room was ready and we were renting for one night, what difference does it make that we were a little early. I paid the fee because I didn't think that the hotel would appreciate all of us sitting in the hotel lobby drinking. We were on the road for 4 hours and ready to relax. Also, when asking for extra towels and an extra blanket I felt like I was being accused of stealing....they made sure to check our room number and marked it down that we got extras like we were going to steal them...I'm sure it happens a lot and is a huge expense, but it just didn't sit right with me. There were cobwebs in our bathroom that I did not notice until the next morning and our comforter on our bed was dirty...did not notice that until it was too late either. It is easy to access and close to where we needed to be. The way the shower was situated made out bathroom floor wet, which is an accident waiting to happen. The shower needs some sort of barrier. The free breakfast in the morning was adequate...coffee, eggs, sausage, waffles, fruit, toast, muffins, bagels, juice, cereal, milk. The AC in the room was great. "