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Find hotels in Southeast Missouri, MO from ¥9,507

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Our top choices for Southeast Missouri hotels

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.8 out of 10, Excellent, (463)
"Nice place "
United States
Debbie
The price is ¥13,322
¥15,151 total
includes taxes & fees
Dec 16 - Dec 17
The Farmstead Hotel

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1003)
"Clean room, great location and friendly staff"
United States
Mark
The price is ¥14,021
¥16,120 total
includes taxes & fees
Dec 20 - Dec 21
Drury Inn & Suites Sikeston, MO

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
7.8 out of 10, Good, (1005)
"Love the updated rooms and the vending area."
United States
Kathi
The price is ¥11,842
¥12,490 total
includes taxes & fees
Dec 16 - Dec 17
Motel 6 Poplar Bluff, MO

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (854)
"Very clean, great check in"
United States
Teresa
The price is ¥16,204
¥18,306 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Fairfield Inn & Suites by Marriott Poplar Bluff

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1003)
"Easy parking , quiet and comfortable bed , we’ll stop again on our way back "
United States
joseph
The price is ¥11,123
¥12,676 total
includes taxes & fees
Dec 21 - Dec 22
Best Western Plus Sikeston

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (669)
"Great place "
United States
GUY
The price is ¥13,111
¥14,190 total
includes taxes & fees
Jan 7 - Jan 8, 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (719)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is ¥8,646
¥9,853 total
includes taxes & fees
Dec 16 - Dec 17
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1001)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is ¥14,802
¥16,699 total
includes taxes & fees
Dec 22 - Dec 23
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (796)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is ¥15,830
¥17,725 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Hampton Inn Poplar Bluff

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (444)
"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."
United States
Doncheial
The price is ¥14,833
¥16,795 total
includes taxes & fees
Dec 28 - Dec 29
Hampton Inn Sikeston

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (331)
"Staff was very friendly."
United States
Joyce
The price is ¥14,863
¥16,114 total
includes taxes & fees
Dec 16 - Dec 17
Honeysuckle Inn - Mountain View

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (726)
"Quiet area and helpful staff. Glad we took a chance on this local hotel while traveling."
United States
Roger
New Orleans Inn Portageville

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1004)
"Great place and staff, very accommodating!"
United States
Megan
The price is ¥14,021
¥15,816 total
includes taxes & fees
Dec 21 - Dec 22
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1004)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is ¥12,931
¥13,671 total
includes taxes & fees
Dec 16 - Dec 17
Drury Inn & Suites Jackson MO

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (964)
"Nice room helpful staff. "
United States
Deborah
The price is ¥14,645
¥16,543 total
includes taxes & fees
Dec 20 - Dec 21
Drury Inn & Suites Poplar Bluff

Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.4 out of 10, Exceptional, (304)
" Nice room, nice bed, convenient location"
United States
Burton
Shepherd Mountain Inn

Super 8 by Wyndham Potosi

Super 8 by Wyndham Potosi
2.0 star property
Potosi
7.0 out of 10, Good, (379)
"The room was very good for the price."
United States
Benjamin
The price is ¥8,609
¥9,405 total
includes taxes & fees
Dec 16 - Dec 17
Super 8 by Wyndham Potosi

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is ¥14,490
¥16,407 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG

Fort Davidson Hotel

Fort Davidson Hotel
2.5 star property
Ironton
9.2 out of 10, Wonderful, (173)
"Friendly staff, spacious room, nice pool!!"
United States
SHARON
The price is ¥18,697
¥20,422 total
includes taxes & fees
Dec 16 - Dec 17
Fort Davidson Hotel

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (784)
"Excellent stay"
United States
Christina
The price is ¥15,456
¥17,437 total
includes taxes & fees
Dec 21 - Dec 22
Hampton Inn Cape Girardeau I 55 East
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:Dec 26 - Dec 28
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Stay near popular Central United States attractions

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:

Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.

It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.

This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 

#MTTS2014 #minitakesthestates #go11
#train
Photo by Bill Dillard
Open Photo by Bill Dillard

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