Sikeston, MO

Travel Guide

A tree with sunlight filtering through its leaves, creating a warm glow.
A person walking through a cornfield.
A building with three tall chimneys, surrounded by blooming trees with pink and white flowers.
A sign for Lambert's, a place of worship.
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
The price is ￥17,907 per night from Jul 20 to Jul 21
￥17,907
￥20,589 total
Jul 20 - Jul 21
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.6/10 Exceptional! (1,003 reviews)
"Very clean"

Reviewed on Jul 1, 2026

Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
The price is ￥11,247 per night from Jul 19 to Jul 20
￥11,247
￥12,820 total
Jul 19 - Jul 20
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,001 reviews)
"I had a stay at this hotel. The rooms were clean, comfortable, and well maintained. The staff was friendly, professional, and always willing to help. The location was in a convenient place for us to take a quick rest The breakfast was delicious with plenty of options, and the overall atmosphere was ..."

Reviewed on Jul 4, 2026

Days Inn and Suites by Wyndham Sikeston
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
The price is ￥13,680 per night from Jul 26 to Jul 27
￥13,680
￥15,590 total
Jul 26 - Jul 27
includes taxes & fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ...
8.4/10 Very Good! (1,001 reviews)
"Clean room & friendly staff!"

Reviewed on Jul 3, 2026

Best Western Plus Sikeston I-55
See all 319 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
New cabin in the woods with private hot tub

New cabin in the woods with private hot tub

Cobden IL
Stay at this cabin in Anna. Enjoy patios, an in-room coffeemaker, and air conditioning. Popular attractions StarView Vineyards and King Neptune Memorial are ...
10/10 Exceptional! (156 reviews)
"This was a beautiful secluded cabin. I enjoyed the privacy and the beautiful drive"

Reviewed on Jun 16, 2026

New cabin in the woods with private hot tub
Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery

Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery

Cobden IL
Stay at this cabin in Anna. Enjoy patios, an in-room coffeemaker, and in-room fireplaces. Popular attractions StarView Vineyards and King Neptune Memorial are ...
10/10 Exceptional! (169 reviews)
"Nice quiet place to stay, very close to the star view winery. 20 minutes from the Giant City lodge and Bald Knob Cross"

Reviewed on Jun 7, 2026

Brand new cabin in the woods with hot tub 1/2 mile from Starview Winery
Notting Hill Cottage

Notting Hill Cottage

Alto Pass IL
Stay at this vacation home in Alto Pass. Enjoy laundry facilities, patios, and an in-room coffeemaker. Popular attractions Peachbarn Winery and Von Jakob Winery ...
9.6/10 Exceptional! (334 reviews)
"The host was great at communicating with us. The hot tub and deck was so nice! Very quiet and peaceful location! We would stay again!"

Reviewed on Jun 13, 2026

Notting Hill Cottage
See all properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Sikeston attractions

Sikeston Depot Museum

7.6/10 (57 reviews)
You can spend time exploring the galleries in Sikeston Depot Museum in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.
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