Find hotels near Sikeston Depot Museum, Sikeston from ￥9,864

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Dec 30 - Dec 31
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Dec 31 - Jan 1
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Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

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Our top choices for Sikeston Depot Museum hotels

Bar (on property)
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
2.4 km from Sikeston Depot Museum
9.2 out of 10, Wonderful, (43)
"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is ￥16,377
￥18,542 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Fairfield Inn & Suites by Marriott Sikeston
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
2.2 km from Sikeston Depot Museum
9.0 out of 10, Wonderful, (455)
"Very clean and super friendly staff!"
United States
Katherine
The price is ￥15,993
￥18,107 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hampton Inn Sikeston
Bar (on property)
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
2.4 km from Sikeston Depot Museum
9.0 out of 10, Wonderful, (10)
"Great hotel! Very clean, quiet, plenty of amenities, pool was clean, breakfast in the morning was good with lots of options. I would definitely stay here again. "
United States
Scott
The price is ￥19,808
￥22,426 total
includes taxes & fees
Jan 8 - Jan 9, 2026
TownePlace Suites by Marriott Sikeston
Exterior
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
2.1 km from Sikeston Depot Museum
8.6 out of 10, Excellent, (444)
"Stay was excellent "
United States
Kourtney
The price is ￥14,505
￥16,424 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG
Lobby
Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
5 km from Sikeston Depot Museum
9.4 out of 10, Exceptional, (1008)
"Very clean, very friendly! We will be staying again. "
United States
Beth
The price is ￥11,696
￥13,446 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Pear Tree Inn Sikeston
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
5.1 km from Sikeston Depot Museum
9.4 out of 10, Exceptional, (1003)
"This our favorite place to stop for a good night sleep. "
United States
Eileen
The price is ￥14,036
￥16,137 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Drury Inn & Suites Sikeston, MO
Exterior
Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
4.9 km from Sikeston Depot Museum
8.4 out of 10, Very Good, (283)
"The hotel was very clean, beds were comfortable, and staff was friendly and helpful."
United States
aileen
The price is ￥13,788
￥15,715 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Comfort Inn & Suites Sikeston I-55
Exterior
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
5 km from Sikeston Depot Museum
8.4 out of 10, Very Good, (725)
"Clean room and easy access to room"
United States
Anne
The price is ￥8,655
￥9,864 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
5.4 km from Sikeston Depot Museum
8.4 out of 10, Very Good, (1005)
"Great stay, everything was clean and comfortable. "
United States
Charles
The price is ￥12,460
￥14,202 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Best Western Plus Sikeston
Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
4.7 km from Sikeston Depot Museum
6.8 out of 10, (569)
"Excellent check-in process! Extremely friendly staff. Room is very adequate. Everything you need. Price was a great bargain."
United States
Ronald
The price is ￥9,265
￥10,561 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Super 8 by Wyndham Sikeston/Miner Area
Iron/ironing board, free WiFi, bed sheets
Country Yard Inn and Suite

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
5.5 km from Sikeston Depot Museum
6.8 out of 10, (121)
"Great spot en route home from Mississippi. Staff put me in a room that ended up being in a quiet section of the hotel. Great sleep."
United States
Andrew
The price is ￥8,335
￥9,917 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Country Yard Inn and Suite
1 bedroom, desk, laptop workspace, blackout drapes
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
5.4 km from Sikeston Depot Museum
7.2 out of 10, Good, (1005)
"Everything was excellent. Verify happy with everything. Stayed 3 weeks for work and already booked 2 more stays."
United States
James
The price is ￥9,811
￥11,183 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Days Inn and Suites by Wyndham Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Sikeston Depot Museum Hotel Reviews

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston

10/10 Excellent
"My wife has mobility issues and when the reception staff noticed this she changed our room without our even requesting to one close to the lobby. We greatly appreciated this. Plus it’s a great place with friendly people. "
Mark 1-night trip
Posted 3 hours ago
Pear Tree Inn Sikeston

Hotels near other Sikeston Depot Museum attractions

Central Park

3.8/5 (36 reviews)
Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this relaxing area, you can savor the top-notch restaurants.
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City of Miner Convention Center

Learn about the events happening at City of Miner Convention Center during your trip to Miner. While in this relaxing area, you can savor the top-notch restaurants.
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Frequently asked questions

What's the area like around Sikeston Depot Museum?
Sikeston Depot Museum is located in a welcoming area of Sikeston known for its array of dining options. You'll find 15 hotels and other accommodations within a few miles for a convenient home base.
What's the best hotel to stay near Sikeston Depot Museum?
Hampton Inn Sikeston is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 1.4 mi (2.2 km) from Sikeston Depot Museum. Other good choices within 5 miles include Drury Inn & Suites Sikeston, MO and Holiday Inn Express & Suites Sikeston Southwest by IHG.
How many hotels should I expect to find close to Sikeston Depot Museum?
Expedia has 15 hotels and other accommodations a few miles from Sikeston Depot Museum.
If I need to cancel the hotel reservation for my stay near Sikeston Depot Museum, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to get the best deals near Sikeston Depot Museum.
Where can I learn more about changing or cancelling my trip in the area near Sikeston Depot Museum?
To find more details about picking new dates or cancelling your stay near Sikeston Depot Museum, head over to our customer service page.