The Best Hotels Closest to Sikeston Depot Museum in Sikeston for 2026

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Sikeston Depot Museum hotels

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

1. Fairfield Inn & Suites by Marriott Sikeston

2.4 km from Sikeston Depot Museum

Roslyn

￥15,830

￥18,003 total

includes taxes & fees

Oct 29 - Oct 30

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

2. TownePlace Suites by Marriott Sikeston

2.3 km from Sikeston Depot Museum

Rubin

￥17,084

￥19,428 total

includes taxes & fees

Oct 29 - Oct 30

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

3. Hampton Inn Sikeston

2.3 km from Sikeston Depot Museum

Deborah

￥14,921

￥16,968 total

includes taxes & fees

Nov 22 - Nov 23

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A breakfast buffet counter with a bakery section and a display for breakfast items.

An indoor swimming pool with a tiled floor, a lifeguard chair, and a pool ladder.

A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

4. Holiday Inn Express & Suites Sikeston Southwest by IHG

2.1 km from Sikeston Depot Museum

Melissa

￥14,262

￥16,220 total

includes taxes & fees

Nov 22 - Nov 23

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

5. Drury Inn & Suites Sikeston, MO

5.1 km from Sikeston Depot Museum

Tim

￥14,731

￥16,939 total

includes taxes & fees

Nov 2 - Nov 3

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

6. Best Western Plus Sikeston I-55

5.4 km from Sikeston Depot Museum

Shelley

￥12,504

￥14,250 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

A Travel Inn and Suites with a brick facade, a flat roof, and a welcoming entrance.

7. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

5 km from Sikeston Depot Museum

Craig

￥10,112

￥11,526 total

includes taxes & fees

Nov 9 - Nov 10

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A living room with two sofas, a coffee table, a TV, and a cabinet.

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.

8. Comfort Inn & Suites Sikeston I-55

4.9 km from Sikeston Depot Museum

Fred

￥12,413

￥14,148 total

includes taxes & fees

Nov 15 - Nov 16

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A spacious lobby with a central atrium, a piano, and a reception desk.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

9. Days Inn and Suites by Wyndham Sikeston

5.4 km from Sikeston Depot Museum

David

￥10,391

￥11,843 total

includes taxes & fees

Nov 2 - Nov 3

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A motel with a covered entrance, multiple rooms, and a parking lot.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

10. Super 8 by Wyndham Sikeston/Miner Area

4.7 km from Sikeston Depot Museum

Laura

￥9,084

￥10,352 total

includes taxes & fees

Oct 29 - Oct 30

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

A reception area with a counter, a coffee machine, and seating.

A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.

11. Country Yard Inn and Suite

5.5 km from Sikeston Depot Museum

William

￥8,503

￥10,116 total

includes taxes & fees

Nov 1 - Nov 2

View all properties

Compare popular hotels close to Sikeston Depot Museum

Property	Star rating	Guest rating
Fairfield Inn & Suites by Marriott Sikeston	9.4 Exceptional 118 reviews	View
TownePlace Suites by Marriott Sikeston	9.2 Wonderful 27 reviews	View
Hampton Inn Sikeston	9.0 Wonderful 649 reviews	View
Holiday Inn Express & Suites Sikeston Southwest by IHG	8.8 Excellent 518 reviews	View
Drury Inn & Suites Sikeston, MO	9.6 Exceptional 1,000 reviews	View

Top Sikeston Depot Museum Hotel Reviews

Hampton Inn Sikeston

10/10 Excellent

"Great hotel, clean spacious room, good breakfast choice"

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"good, clean, affordable :)"

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"Easy parking, our bathroom sink was leaning forward and we had to place our soap in the sink so it didn't slide on the floor."

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

8/10 Good

"Host is great. I've stayed here many times."

TownePlace Suites by Marriott Sikeston

10/10 Excellent

"My overall experience was amazing from the time I checked in until I left. The staff were super pleasant and incredible. My room was clean and spacious. I never been in an extended stay room before. I definitely will be booking a suite like this one again."

Eagle Inn Charleston

10/10 Excellent

"Great"

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

10/10 Excellent

"The host was very quick to respond and so great to work with for on our stay. "

Other attractions near Sikeston Depot Museum

Central Park

7.2/10 (56 reviews)

Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.

See properties

City of Miner Convention Center

Learn about the events happening at City of Miner Convention Center during your trip to Miner. While in this relaxing area, you can savor the top-notch restaurants.

See properties

Front Street Studio & Art Gallery

8.6/10 (15 reviews)

You can spend time browsing the exhibits at Front Street Studio & Art Gallery during your travels in Blodgett. While in this relaxing area, you can savor the top-notch restaurants.

See properties

Hunter-Dawson State Historic Site

7.6/10 (13 reviews)

You can browse the exhibits at Hunter-Dawson State Historic Site, a museum with a story of its own, during your travels to New Madrid. Amble around the area's parks or experience its museums.

See properties

River Ridge Winery

8.4/10 (15 reviews)

You can enjoy a tasting or tour at River Ridge Winery during your travels to New Madrid. Amble around the area's parks or experience its museums.

See properties

New Madrid Historical Museum

8.2/10 (36 reviews)

You can study the exhibits at New Madrid Historical Museum, a museum with a storied past, during your travels to New Madrid. Amble around the area's parks or experience its museums.

See properties

Dexter Welcome Center Depot and Museum

7.6/10 (12 reviews)

You can study the exhibits at Dexter Welcome Center Depot and Museum, a museum with a story of its own, during your trip to Dexter. While in this family-friendly area, you can enjoy the restaurants.

See properties

The Heritage House

8.4/10 (7 reviews)

Learn about the local history of Dexter when you take a trip to The Heritage House. While in this family-friendly area, you can enjoy the restaurants.

See properties

Frequently asked questions

What's the area like around Sikeston Depot Museum?

Sikeston Depot Museum is located in a welcoming area of Sikeston known for its array of dining options. If you're looking for a convenient place to stay, check out the 5 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay near Sikeston Depot Museum?

Drury Inn & Suites Sikeston, MO is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an outdoor pool. It's located 3.2 mi (5.1 km) from Sikeston Depot Museum. Other good choices within 5 miles include Hampton Inn Sikeston and Days Inn and Suites by Wyndham Sikeston.

How many hotels should I expect to find close to Sikeston Depot Museum?

Expedia has 5 hotels and other accommodations within a mile from Sikeston Depot Museum.

If I need to cancel the hotel reservation for my stay near Sikeston Depot Museum, will I receive a refund?

Yes! The majority of hotel room reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to get the best deals near Sikeston Depot Museum.

Where can I learn more about changing or cancelling my trip in the area near Sikeston Depot Museum?

To find more details about picking new dates or cancelling your stay near Sikeston Depot Museum, head over to our customer service page.

Room 1

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Property class

Guest rating

Our top choices for Sikeston Depot Museum hotels

1. Fairfield Inn & Suites by Marriott Sikeston