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Sikeston Vacation Rentals

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Check prices for these dates

In two weeks
Jan 9 - Jan 11
In two months
Feb 20 - Feb 22
In three months
Mar 20 - Mar 22
In four months
Apr 17 - Apr 19

Our top choices for Sikeston vacation rentals

Interior
Little Blue Cottage on Spanish

Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.6 out of 10, Excellent, (48)
"I would definitely stay here again!"
United States
Bonita
The price is ￥12,647
￥15,770 total
includes taxes & fees
Dec 30 - Dec 31
Little Blue Cottage on Spanish
Fridge, microwave, oven, stovetop
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
Cape Girardeau
9.4 out of 10, Exceptional, (46)
"This place is AWESOME! It's clean, artsy, fun, and if we ever have a chance, we will certainly return!"
United States
Jordan S.
The price is ￥12,788
￥21,601 total
includes taxes & fees
Dec 28 - Dec 29
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
Smart TV, fireplace, stereo
Dexter Homestead. Very Cozy & NEW Remodel !

Dexter Homestead. Very Cozy & NEW Remodel !

Dexter Homestead. Very Cozy & NEW Remodel !
Dexter
7.8 out of 10, Good, (27)
"A weekin Dexter at this old, charming house. "
United States
Susan R.
The price is ￥13,894
￥30,698 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Dexter Homestead. Very Cozy & NEW Remodel !
Exterior
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.6 out of 10, Excellent, (37)
"Very nice house. The pool and hot tub were perfect for a short getaway. Tons of activities and games to keep the fanily entertained. Will definitely come back! "
United States
Emily D.
The price is ￥21,079
￥33,845 total
includes taxes & fees
Dec 28 - Dec 29
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Fridge, microwave, oven, stovetop
Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.
Jackson
10.0 out of 10, Exceptional, (11)
"It was great. "
United States
Benjamin Q.
The price is ￥23,421
￥28,535 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Villa B offers peace and quiet with beautiful views of the countryside.
Fridge, microwave, oven, stovetop
Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (149)
"Such a great place and location"
United States
Tracy H.
The price is ￥23,421
￥38,246 total
includes taxes & fees
Dec 27 - Dec 28
Serenity South -- Gardens, River-Views, and Refreshing Space
TV, fireplace
The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (2)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
The price is ￥19,518
￥30,448 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Cottage, Rusted Route Farms
Terrace/patio
The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (29)
"The place was awesome very clean the host was very accommodating. Nice a quiet for a relaxing stay highly recommend "
United States
Gary C.
The price is ￥37,270
￥53,073 total
includes taxes & fees
Jan 26 - Jan 27, 2026
The Twisted Sassafras Treehouse
Exterior detail
Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (3)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
United States
Chandler G.
The price is ￥31,228
￥48,403 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Gorgeous 1856 Log Cabin, Completely Renovated
Fridge, microwave, oven, stovetop
Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A
Jackson
10.0 out of 10, Exceptional, (33)
"Great place to stay, felt like home away from home. "
United States
Brittany
The price is ￥23,421
￥28,535 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Relax in the country at Countryside Villas! - Villa A
Exterior
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.6 out of 10, Exceptional, (7)
"Nice place, great times"
United States
Jace W.
The price is ￥42,017
￥68,322 total
includes taxes & fees
Dec 28 - Dec 29
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Meeting facility
Building at Cape Girardeau Regional Airport

Building at Cape Girardeau Regional Airport

Building at Cape Girardeau Regional Airport
Scott City
The price is ￥78,070
￥94,777 total
includes taxes & fees
Jan 17 - Jan 18, 2026
Building at Cape Girardeau Regional Airport
Outdoor dining
Beautiful location in the secluded woods

Beautiful location in the secluded woods

Beautiful location in the secluded woods
Pomona
10.0 out of 10, Exceptional, (61)
"It was very nice and clean. We really enjoyed staying there. We would love to rent this place again. "
United States
susan B.
The price is ￥13,405
￥25,790 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Beautiful location in the secluded woods
Fridge, microwave, oven, stovetop
Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite
2.0 star property
Anna
The price is ￥12,366
￥23,035 total
includes taxes & fees
Dec 30 - Dec 31
Cozy and Updated Farmhouse with King Suite
Fridge, microwave, oven, stovetop
Charming 3-bedroom house near ball park in quiet neighborhood

Charming 3-bedroom house near ball park in quiet neighborhood

Charming 3-bedroom house near ball park in quiet neighborhood
Bardwell
10.0 out of 10, Exceptional, (12)
"Quaint stay to see Grand and kids. "
United States
Sheila C.
The price is ￥14,053
￥25,075 total
includes taxes & fees
Jan 14 - Jan 15, 2026
Charming 3-bedroom house near ball park in quiet neighborhood
Private kitchen
Charming 2-bedroom apartment in fabulous Marble Hill with AC

Charming 2-bedroom apartment in fabulous Marble Hill with AC

Charming 2-bedroom apartment in fabulous Marble Hill with AC
Marble Hill
7.6 out of 10, Good, (5)
"Host was not properly notified of the booking, but made the accommodations made several trips to make sure we were checked in and comfortable. Also gave very good advice for local points of interest."
United States
Chrystine H.
The price is ￥11,945
￥20,809 total
includes taxes & fees
Dec 27 - Dec 28
Charming 2-bedroom apartment in fabulous Marble Hill with AC
Exterior
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Makanda
9.8 out of 10, Exceptional, (60)
"The property was extremely clean and well cared for.would definitely stay again. "
United States
Dan H.
The price is ￥14,658
￥28,392 total
includes taxes & fees
Dec 29 - Dec 30
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Exterior
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Makanda
9.6 out of 10, Exceptional, (40)
"The cabin was perfect for our 5 nights in the area. There was plenty of room and everything we needed. The pictures online were nice but in real life, it was a real gem. Can't wait to visit again."
United States
Victoria H.
The price is ￥16,997
￥33,215 total
includes taxes & fees
Dec 31 - Jan 1, 2026
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Dining
Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (35)
"Beautiful place, host was kind and and quick to respond to messages "
United States
Melissa W.
The price is ￥17,566
￥21,927 total
includes taxes & fees
Dec 27 - Dec 28
Cozy cabins on beautiful Horseshoe Lake
Property grounds
Fishing Cabin next to Kinkaid Lake

Fishing Cabin next to Kinkaid Lake

Fishing Cabin next to Kinkaid Lake
Murphysboro
The price is ￥16,218
￥27,269 total
includes taxes & fees
Dec 27 - Dec 28
Fishing Cabin next to Kinkaid Lake
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Sikeston Hotel Reviews

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

10/10 Excellent
"Our room was quiet and comfortable, the staff were super nice and professional, the breakfast was great, and they gave us a late checkout since my husband had to take an unexpected conference call. We will definitely come back."
Kim 1-night trip
Posted 2 days ago
Drury Inn & Suites Jackson MO

Find out more about Sikeston

Search for holiday rentals in Sikeston on Expedia! You can easily find your home rentals, villas, holiday apartments in Sikeston using one of the methods below:

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Frequently asked questions

Can I find a vacation rental in Sikeston?

Yes, there are vacation rentals close to the most popular local attractions in Sikeston, or you can choose a more remote option if you're looking for relaxation. Tourists like the array of shops and top-notch restaurants in Sikeston. Make sure you allow time to enjoy the riverfront during your vacation.

What's the top vacation rental in Sikeston?

Beautiful location in the secluded woods : Visitors like this Sikeston vacation home rental. It offers a fireplace, a patio, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the selection of games in this rental home to help you unwind.

What’s there to see and do in Sikeston?

Cultural attractions include Sikeston Depot Museum, whereas Central Park is a spot to enjoy nature. In the larger area, you’ll find River Ridge Winery and Front Street Studio & Art Gallery.

What’s a vacation rental in Sikeston like?

A vacation rental is a private property you can book for a couple of days or more in Sikeston. Vacation rentals feature extras such as kitchens and laundry facilities so you'll feel right at home. If you're concerned about a clean environment, a vacation rental can offer a sense of security away from public hotel elevators and busy reception areas while still allowing you to travel. You'll also get more space in a vacation rental than in a hotel, which is another reason why a vacation rental is a popular option for a small group gathering.