Sikeston Vacation Rentals

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Jun 5 - Jun 7
In two months
Jul 17 - Jul 19
In three months
Aug 14 - Aug 16
In four months
Sep 11 - Sep 13

Our top choices for Sikeston vacation rentals

Living area

Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very Good, (56 reviews)
"Great cute place. "
United States
Jeremy W.
The price is ￥12,867
￥17,178 total
includes taxes & fees
May 31 - Jun 1
Little Blue Cottage on Spanish
Interior

Charming Secluded Getaway Cabin within minutes of amenities

Charming Secluded Getaway Cabin within minutes of amenities
Cape girardeau
10.0 out of 10, Exceptional, (20 reviews)
"Nice little Cabin in a beautiful area. Blair and her family were wonderful!"
United States
Keegan C.
The price is ￥24,622
￥48,704 total
includes taxes & fees
May 31 - Jun 1
Charming Secluded Getaway Cabin within minutes of amenities
Pool

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
Dexter
7.8 out of 10, Good, (31 reviews)
"Stayed many times. Nice and comfortable "
United States
Susan R.
The price is ￥17,013
￥33,958 total
includes taxes & fees
Jun 2 - Jun 3
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
Interior

The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (34 reviews)
"Amazing stay, loved the bed and hot tub. Close to town but also away. "
United States
Maria B.
The price is ￥34,216
￥49,993 total
includes taxes & fees
Jun 3 - Jun 4
The Twisted Sassafras Treehouse
Dining

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (155 reviews)
"Nice location to river front and downtown. Very lovely place."
United States
Marcie R.
The price is ￥23,828
￥39,335 total
includes taxes & fees
May 29 - May 30
Serenity South -- Gardens, River-Views, and Refreshing Space
Fridge, microwave, oven, stovetop

Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A
Jackson
10.0 out of 10, Exceptional, (34 reviews)
"Great place to stay, felt like home away from home. "
United States
Brittany
The price is ￥23,828
￥28,687 total
includes taxes & fees
May 31 - Jun 1
Relax in the country at Countryside Villas! - Villa A
TV, fireplace

Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (3 reviews)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
United States
Chandler G.
The price is ￥31,770
￥49,720 total
includes taxes & fees
Jun 2 - Jun 3
Gorgeous 1856 Log Cabin, Completely Renovated
Exterior

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (40 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
The price is ￥28,489
￥50,301 total
includes taxes & fees
May 26 - May 27
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Interior

Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.
Jackson
10.0 out of 10, Exceptional, (12 reviews)
"It was great. "
United States
Benjamin Q.
Villa B offers peace and quiet with beautiful views of the countryside.
Interior

Modern 2BR Apt w Electric Fireplace By KeenStays

Modern 2BR Apt w Electric Fireplace By KeenStays
Cape Girardeau
8.0 out of 10, Very Good, (1 review)
The price is ￥15,885
￥32,401 total
includes taxes & fees
Jun 21 - Jun 22
Modern 2BR Apt w Electric Fireplace By KeenStays
Desk, iron/ironing board, WiFi, bed sheets

Studio Apt | King Bed, Full Kitchen · By KeenStays

Studio Apt | King Bed, Full Kitchen · By KeenStays
Cape Girardeau
The price is ￥12,708
￥26,557 total
includes taxes & fees
Jun 21 - Jun 22
Studio Apt | King Bed, Full Kitchen · By KeenStays
1 bedroom, desk, iron/ironing board, WiFi

The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (2 reviews)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
The price is ￥19,856
￥31,611 total
includes taxes & fees
Jun 2 - Jun 3
The Cottage, Rusted Route Farms
TV, offices

Modern Boho Getaway · 1BR Apartment · By KeenStays

Modern Boho Getaway · 1BR Apartment · By KeenStays
Cape Girardeau
The price is ￥12,708
￥26,557 total
includes taxes & fees
Jun 2 - Jun 3
Modern Boho Getaway · 1BR Apartment · By KeenStays
Living area

Enjoy easy access to everything from this centrally located place.

Enjoy easy access to everything from this centrally located place.
Dexter
The price is ￥15,011
￥21,154 total
includes taxes & fees
Jun 2 - Jun 3
Enjoy easy access to everything from this centrally located place.
Pool

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.6 out of 10, Exceptional, (9 reviews)
"Nice place, great times"
United States
Jace W.
The price is ￥53,612
￥87,682 total
includes taxes & fees
Jun 2 - Jun 3
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
TV, fireplace, offices

Luxe 2KBR Apt w/ Electric Fireplace · By KeenStays

Luxe 2KBR Apt w/ Electric Fireplace · By KeenStays
Cape Girardeau
The price is ￥15,885
￥33,195 total
includes taxes & fees
May 31 - Jun 1
Luxe 2KBR Apt w/ Electric Fireplace · By KeenStays
Meeting facility

Building at Cape Girardeau Regional Airport

Building at Cape Girardeau Regional Airport
Scott City
The price is ￥79,425
￥98,447 total
includes taxes & fees
May 31 - Jun 1
Building at Cape Girardeau Regional Airport
Interior

The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
2.0 star property
Perryville
9.4 out of 10, Exceptional, (3 reviews)
"Very nice clean room with comfortable bed and nice shower. Kitchenette was good with microwave and mini fridge, basic dishes. The owner was very easy to communicate with. Good location with Mary Jane’s restaurant bar next door had excellent food and nice atmosphere. My only small suggestion would be to put variable light switches so you could turn down the lighting at night. I would definitely recommend and would stay here again on my next trip to Perryville."
United States
James
The price is ￥11,449
￥24,672 total
includes taxes & fees
Jun 21 - Jun 22
The Atrium - A Boutique Hotel
Exterior

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Makanda
9.8 out of 10, Exceptional, (48 reviews)
"Cabin was clean. Contact with host was very good and helpful."
United States
Steve K.
The price is ￥19,062
￥35,099 total
includes taxes & fees
Jun 17 - Jun 18
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Exterior detail

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Makanda
9.8 out of 10, Exceptional, (64 reviews)
"A nice quiet stay in the Shawnee Forest. Host was easy to communicate with and the cabin had everything we needed for a nice get away. Close to nature or close to shopping and dinner. It was the perfect little spot "
United States
Ruth O.
The price is ￥16,384
￥30,719 total
includes taxes & fees
May 25 - May 26
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Sikeston Hotel Reviews

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

8/10 Good
"clean room and good staff"
Suzanne 2-night trip
Posted 8 hours ago
Candlewood Suites Cape Girardeau by IHG

Find out more about Sikeston

Search for holiday rentals in Sikeston on Expedia! You can easily find your home rentals, villas, holiday apartments in Sikeston using one of the methods below:

  • View our selection of featured holiday rentals in Sikeston
  • Use the map to find apartments and other holiday homes in the Sikeston neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Sikeston while they last

Look no further and take a look at our great range of rental properties in Sikeston!

Frequently asked questions

Can I find a vacation rental in Sikeston?

Yes, there are vacation rentals close to the most popular local attractions in Sikeston, or you can choose a more remote option if you're looking for relaxation. Tourists like the array of shops and top-notch restaurants in Sikeston. Make sure you allow time to enjoy the riverfront during your vacation.

What's the top vacation rental in Sikeston?

Beautiful location in the secluded woods : Visitors like this Sikeston vacation home rental. It offers a fireplace, a patio, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Make the most of the selection of games in this rental home to help you unwind.

What’s there to see and do in Sikeston?

Cultural attractions include Sikeston Depot Museum, whereas Central Park is a spot to enjoy nature. In the larger area, you’ll find Front Street Studio & Art Gallery and Stoddard County Civil War Memorial Cemetery.

What’s a vacation rental in Sikeston like?

A vacation rental is a private property you can book for a couple of days or more in Sikeston. Vacation rentals feature extras such as kitchens and laundry facilities so you'll feel right at home. If you're concerned about a clean environment, a vacation rental can offer a sense of security away from public hotel elevators and busy reception areas while still allowing you to travel. You'll also get more space in a vacation rental than in a hotel, which is another reason why a vacation rental is a popular option for a small group gathering.