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Our top choices for Southeast Missouri family-friendly hotels

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (167 reviews)
"Nearby Mexican restaurant, clean room, pleasant staff, good breakfast choices "
United States
Larry
The price is ¥14,753
¥16,643 total
includes taxes & fees
Mar 29 - Mar 30
Fairfield Inn & Suites by Marriott Cape Girardeau

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1,004 reviews)
"Very nice for overnight stay"
United States
Scott
The price is ¥14,966
¥17,209 total
includes taxes & fees
Mar 26 - Mar 27
Drury Inn & Suites Sikeston, MO

Super 8 by Wyndham Cuba

Super 8 by Wyndham Cuba
2.0 star property
Cuba
8.8 out of 10, Excellent, (1,000 reviews)
"staff very helpful, room clean. food was satisfying "
United States
Judith
The price is ¥11,234
¥12,775 total
includes taxes & fees
Apr 5 - Apr 6
Super 8 by Wyndham Cuba

Comfort Inn Willow Springs US 60 and US 63

Comfort Inn Willow Springs US 60 and US 63
2.5 star property
Willow Springs
9.2 out of 10, Wonderful, (568 reviews)
"This place was vwry clean with a wonderful stagg. Even the breakfast was great. I will defstay there again"
United States
Anthony
The price is ¥17,514
¥18,856 total
includes taxes & fees
Mar 27 - Mar 28
Comfort Inn Willow Springs US 60 and US 63

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
2.5 star property
Murphysboro
9.4 out of 10, Exceptional, (532 reviews)
"Yes, very clean and service was great."
United States
allen
The price is ¥19,585
¥21,736 total
includes taxes & fees
Mar 29 - Mar 30
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (569 reviews)
"Room was great, front desk was professional but friendly. Breakfast was excellent. Spotless — both room and lobby. "
United States
John
The price is ¥15,127
¥17,315 total
includes taxes & fees
Mar 29 - Mar 30
Holiday Inn Express & Suites Perryville by IHG

Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
10.0 out of 10, Exceptional, (15 reviews)
"Great stay "
United States
Ashley
The price is ¥15,538
¥17,448 total
includes taxes & fees
Mar 29 - Mar 30
Hampton Inn By Hilton Dexter

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (726 reviews)
"Very clean and staff was very nice"
United States
Nastassia
The price is ¥14,187
¥15,354 total
includes taxes & fees
Mar 29 - Mar 30
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very Good, (1,003 reviews)
"Great staff and nice accommodations "
United States
Lisa
The price is ¥9,299
¥10,587 total
includes taxes & fees
Mar 30 - Mar 31
Baymont Inn and Suites by Wyndham Farmington, MO

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (1,001 reviews)
"Clean, comfortable room and great staff!"
United States
Kendra
The price is ¥14,966
¥16,907 total
includes taxes & fees
Apr 12 - Apr 13
Drury Inn & Suites Poplar Bluff
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Choose what matters most at family-friendly hotels in Southeast Missouri

Family-friendly hotels with free breakfast in Southeast Missouri

Family-friendly hotels with pools in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Southeast Missouri Hotel Reviews