Photo by Bill Dillard
Find Family Hotels in Southeast Missouri, MO
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check availability on Southeast Missouri Family Hotels
Our top choices for Southeast Missouri family-friendly hotels

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1001)
The price is ¥14,036
¥15,833 total
includes taxes & fees
Jan 5 - Jan 6, 2026

9.4 out of 10, Exceptional, (1000)
The price is ¥14,073
¥16,179 total
includes taxes & fees
Jan 5 - Jan 6, 2026

9.2 out of 10, Wonderful, (972)
The price is ¥16,531
¥18,674 total
includes taxes & fees
Jan 10 - Jan 11, 2026

Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (547)
The price is ¥14,193
¥16,248 total
includes taxes & fees
Jan 4 - Jan 5, 2026

8.0 out of 10, Very Good, (1000)
The price is ¥11,854
¥12,977 total
includes taxes & fees
Jan 1 - Jan 2, 2026

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (145)
The price is ¥13,725
¥15,483 total
includes taxes & fees
Jan 8 - Jan 9, 2026

7.8 out of 10, Good, (914)
The price is ¥11,830
¥13,823 total
includes taxes & fees
Jan 3 - Jan 4, 2026

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
8.8 out of 10, Excellent, (680)
The price is ¥12,628
¥13,667 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southeast Missouri Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center
10/10 Excellent
Explore a world of travel with Expedia
- Luxury Hotels in Bloomfield
- Motels in Black
- Bunker Hotels
- Rv Parks in Jackson
- Motels in Jackson
- Doniphan Hotels
- Poplar Bluff Hotels
- B&B in Ste Genevieve
- B&B in Annapolis
- Cape Girardeau Hotels
- Ski Hotels in Farmington
- Luxury Hotels in Sikeston
- Dexter Hotels
- Hotels near Washington State Park
- Guest Houses in Sikeston
- Rv Parks in Black
- Black Hotels
- Rv Parks in Southeast Missouri
- Aparthotels in Ellington
- Luxury Hotels in Belgrade
- Apartments in Cape Girardeau County
- Pet-Friendly Hotels in Farmington




































