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Find Family Hotels in Southeast Missouri, MO
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Check availability on Southeast Missouri Family Hotels
Our top choices for Southeast Missouri family-friendly hotels

9.4 out of 10, Exceptional, (1000)
The price is ¥14,073
¥16,179 total
includes taxes & fees
Jan 5 - Jan 6, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1001)
The price is ¥14,036
¥15,833 total
includes taxes & fees
Jan 5 - Jan 6, 2026

Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (547)
The price is ¥14,193
¥16,248 total
includes taxes & fees
Jan 4 - Jan 5, 2026

9.2 out of 10, Wonderful, (972)
The price is ¥16,531
¥18,674 total
includes taxes & fees
Jan 10 - Jan 11, 2026

9.0 out of 10, Wonderful, (456)
The price is ¥15,976
¥18,090 total
includes taxes & fees
Jan 25 - Jan 26, 2026

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (145)
The price is ¥13,725
¥15,483 total
includes taxes & fees
Jan 8 - Jan 9, 2026

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)Sikeston
8.4 out of 10, Very Good, (725)
The price is ¥8,655
¥9,864 total
includes taxes & fees
Jan 1 - Jan 2, 2026

Pear Tree Inn Cape Girardeau Near the Medical Center
Pear Tree Inn Cape Girardeau Near the Medical CenterCape Girardeau
9.0 out of 10, Wonderful, (1003)
The price is ¥10,916
¥12,315 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southeast Missouri Hotel Reviews

Motel 6 Poplar Bluff, MO
10/10 Excellent
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