Photo by JG Morris

Find hotels in Southeast Missouri, MO from ￥9,554

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 27 - Dec 28
Tomorrow
Dec 28 - Dec 29
Next weekend
Jan 2 - Jan 4
In two weeks
Jan 9 - Jan 11

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Southeast Missouri hotels

Lobby
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1003)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is ￥12,994
￥13,738 total
includes taxes & fees
Dec 29 - Dec 30
Drury Inn & Suites Jackson MO
Breakfast, lunch, dinner served; Italian cuisine
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (708)
"Amazing place"
United States
Mladen
The price is ￥16,440
￥18,572 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Holiday Inn Poplar Bluff by IHG
Front of property
The Farmstead Hotel

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.8 out of 10, Excellent, (465)
"Clean room, very nice staff"
United States
Mack
The price is ￥13,387
￥15,225 total
includes taxes & fees
Dec 29 - Dec 30
The Farmstead Hotel
Front of property
Echo Bluff State Park

Echo Bluff State Park

Echo Bluff State Park
2.5 star property
Eminence
9.6 out of 10, Exceptional, (217)
"The cabin was beautiful, comfy, & private! The park was FANTASTIC for hiking & scenery! We hope to return and maybe bring family or friends. The staff were all friendly too! :)"
United States
Joanne
The price is ￥23,367
￥24,705 total
includes taxes & fees
Jan 27 - Jan 28, 2026
Echo Bluff State Park
Free daily full breakfast
Best Western Plus Sikeston

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1002)
"Great stay, everything was clean and comfortable. "
United States
Charles
The price is ￥11,835
￥13,488 total
includes taxes & fees
Dec 29 - Dec 30
Best Western Plus Sikeston
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1004)
"Great place and staff, very accommodating!"
United States
Megan
The price is ￥14,090
￥15,894 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Drury Plaza Hotel Cape Girardeau Conference Center
Exterior
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (723)
"Room was good as usual. This is 4th stay over past 5 years. Only issue I had on this stay was the orange juice from breakfast options. "
United States
Todd
The price is ￥8,688
￥9,904 total
includes taxes & fees
Dec 29 - Dec 30
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Lobby lounge
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (859)
"The rooms were very clean and well maintained and th e staff was great and the young lady who checked us in was awsome at her job she helped me get the smart tv workin and has a very professional and respectfull through the hole stay we thank this is the nicest hotel i ve stayed at by far andcwill be back "
United States
Terry
The price is ￥16,283
￥18,395 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Fairfield Inn & Suites by Marriott Poplar Bluff
Lobby
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (969)
"Nice room helpful staff. "
United States
Deborah
The price is ￥16,438
￥18,570 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Drury Inn & Suites Poplar Bluff
Lobby
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very Good, (1000)
"It was a nice stay."
United States
Rebecca
The price is ￥11,899
￥13,026 total
includes taxes & fees
Dec 29 - Dec 30
Motel 6 Poplar Bluff, MO
Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
"This our favorite place to stop for a good night sleep. "
United States
Eileen
The price is ￥14,090
￥16,199 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Drury Inn & Suites Sikeston, MO
Exterior
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (544)
"lean, updated rooms, friendly staff and great breakfast."
United States
Linda
The price is ￥14,248
￥16,311 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Holiday Inn Express & Suites Perryville by IHG
Children's play area - outdoor
Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (334)
"Staff was very friendly."
United States
Joyce
The price is ￥14,089
￥15,274 total
includes taxes & fees
Jan 25 - Jan 26, 2026
Honeysuckle Inn - Mountain View
Business center
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very Good, (1003)
"Room was clean , staff was friendly !"
United States
Sally
The price is ￥8,392
￥9,554 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Baymont Inn and Suites by Wyndham Farmington, MO
Exterior
Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
2.0 star property
Farmington
8.0 out of 10, Very Good, (612)
"Clean, friendly staff, quiet"
United States
Stacy
The price is ￥8,253
￥9,396 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Super 8 by Wyndham Farmington
Terrace/patio
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (797)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is ￥17,198
￥19,258 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Hampton Inn Poplar Bluff
Lobby
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (143)
"Nice hotel, clean and comfortable "
United States
Laura
The price is ￥13,778
￥15,544 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Fairfield Inn & Suites by Marriott Cape Girardeau
Lobby
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
8.0 out of 10, Very Good, (893)
"Breakfast was great! Location right off interstate was perfect. The property is a little old."
United States
Mindy
The price is ￥14,506
￥16,588 total
includes taxes & fees
Jan 4 - Jan 5, 2026
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Exterior
Hampton Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (453)
"clean room, comfy bedding, nice staff, convenient location "
United States
Alexa
The price is ￥15,278
￥17,299 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hampton Inn Sikeston
Outdoor pool, sun loungers
Fort Davidson Hotel

Fort Davidson Hotel

Fort Davidson Hotel
2.5 star property
Ironton
9.2 out of 10, Wonderful, (174)
"Friendly staff, spacious room, nice pool!!"
United States
SHARON
The price is ￥18,788
￥20,521 total
includes taxes & fees
Dec 29 - Dec 30
Fort Davidson Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:Jan 9 - Jan 11

Image gallery for Carol's Cottage

Interior

Carol's Cottage

Valles Mines
10/10Exceptional (8 reviews)
10% off
Price is ￥45,515
￥115,298 total
includes taxes & fees
Carol's Cottage
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular Central United States attractions

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
See properties
A huge granite boulder located in Elephant Rocks State Park
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

4.8/5 (52 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train
Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

10/10 Excellent
"Our room was quiet and comfortable, the staff were super nice and professional, the breakfast was great, and they gave us a late checkout since my husband had to take an unexpected conference call. We will definitely come back."
Kim 1-night trip
Posted 3 days ago
Drury Inn & Suites Jackson MO

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
The price is ￥8,392 per night from Jan 4 to Jan 5
￥8,392
￥9,554 total
Jan 4 - Jan 5, 2026
includes taxes & fees
7.8/10 Good! (1,002 reviews)

Hotels in Southeast Missouri with star-rating