Photo by Bill Dillard

Find hotels in Southeast Missouri, MO from ¥9,001
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Our top choices for Southeast Missouri hotels

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (65 reviews)
The price is ¥15,562
¥23,510 total
includes taxes & fees
May 14 - May 15

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,009 reviews)
The price is ¥13,202
¥13,957 total
includes taxes & fees
May 25 - May 26

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (182 reviews)
The price is ¥14,564
¥16,431 total
includes taxes & fees
May 31 - Jun 1

EC Reed's Mercantile and Hotel
EC Reed's Mercantile and HotelMarble Hill
9.6 out of 10, Exceptional, (90 reviews)
The price is ¥12,927
¥14,071 total
includes taxes & fees
May 25 - May 26

New Orleans Inn Portageville
New Orleans Inn PortagevillePortageville
8.0 out of 10, Very Good, (764 reviews)
The price is ¥7,933
¥8,567 total
includes taxes & fees
Jun 7 - Jun 8

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,000 reviews)
The price is ¥15,717
¥17,731 total
includes taxes & fees
May 18 - May 19

Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (125 reviews)
The price is ¥15,289
¥17,400 total
includes taxes & fees
Jun 4 - Jun 5

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)Sikeston
8.4 out of 10, Very Good, (776 reviews)
The price is ¥10,158
¥11,577 total
includes taxes & fees
May 18 - May 19

Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
8.6 out of 10, Excellent, (352 reviews)
The price is ¥14,994
¥16,255 total
includes taxes & fees
May 15 - May 16

Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (836 reviews)
The price is ¥16,249
¥18,195 total
includes taxes & fees
Jun 6 - Jun 7

Arcadia Academy
Arcadia AcademyArcadia
9.8 out of 10, Exceptional, (12 reviews)
The price is ¥21,405
¥23,220 total
includes taxes & fees
May 14 - May 15

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.6 out of 10, Exceptional, (1,017 reviews)
The price is ¥17,390
¥19,994 total
includes taxes & fees
May 18 - May 19

Century Casino & Hotel Caruthersville
Century Casino & Hotel CaruthersvilleCaruthersville
8.6 out of 10, Excellent, (153 reviews)
The price is ¥16,425
¥18,679 total
includes taxes & fees
May 23 - May 24

Echo Bluff State Park
Echo Bluff State ParkEminence
9.4 out of 10, Exceptional, (249 reviews)
The price is ¥28,779
¥30,427 total
includes taxes & fees
May 18 - May 19

Lake Wappapello
Lake WappapelloWilliamsville
10.0 out of 10, Exceptional, (2 reviews)
The price is ¥13,361
¥14,093 total
includes taxes & fees
May 14 - May 15

Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (1,011 reviews)
The price is ¥16,032
¥18,111 total
includes taxes & fees
May 25 - May 26

Hampton Inn By Hilton Dexter
Hampton Inn By Hilton DexterDexter
10.0 out of 10, Exceptional, (28 reviews)
The price is ¥15,289
¥17,167 total
includes taxes & fees
May 20 - May 21

Super 8 By Wyndham Marston
Super 8 By Wyndham MarstonMarston
8.0 out of 10, Very Good, (63 reviews)
The price is ¥10,525
¥12,021 total
includes taxes & fees
May 30 - May 31

Current River Inn
Current River InnVan Buren
8.2 out of 10, Very Good, (173 reviews)
The price is ¥15,920
¥17,230 total
includes taxes & fees
May 15 - May 16

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (77 reviews)
The price is ¥17,291
¥19,577 total
includes taxes & fees
Jun 4 - Jun 5
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Vacation Rentals in Southeast Missouri
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (65 reviews)
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Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Hayti Caruthersville
10/10 Excellent
More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is ¥9,054 per night from Jun 2 to Jun 3
¥9,054
¥9,854 total
Jun 2 - Jun 3
includes taxes & fees
8/10 Very Good! (1,001 reviews)
Hotels in Southeast Missouri with star-rating

4 Star Hotels
2 properties
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