Southeast Missouri Vacations from ￥354,717

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ￥45,448 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Southeast Missouri Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was ￥395,015, price is now ￥354,717 per person
￥354,717
per person
May 2 - May 5
found 9 hours ago
Roundtrip flight included
Osaka (KIX) to St. Louis (STL)
9.2/10 Wonderful! (1,626 reviews)
We stayed for 1 night, overall good experience. The pool water was pretty cold and the hot tub is small (max occupancy 2). I was a little disappointed in the continental breakfast. Make your own waffles, cereal, and assorted breads. Wished for a larger selection and ready-made hot foods.

Reviewed on Mar 8, 2026

Landing Apartments - Eureka

Landing Apartments - Eureka

4 out of 5
Price was ￥444,204, price is now ￥409,148 per person
￥409,148
per person
May 2 - May 5
found 9 hours ago
Roundtrip flight included
Osaka (KIX) to St. Louis (STL)
No reviews
The Cheshire

The Cheshire

4 out of 5
Price was ￥386,876, price is now ￥367,980 per person
￥367,980
per person
May 2 - May 5
found 9 hours ago
Roundtrip flight included
Osaka (KIX) to St. Louis (STL)
8.6/10 Excellent! (1,001 reviews)
Bar and restaurant were both great!

Reviewed on Mar 9, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

4 out of 5
Grand Center
Price was ￥384,136, price is now ￥365,464 per person
￥365,464
per person
May 2 - May 5
found 9 hours ago
Roundtrip flight included
Osaka (KIX) to St. Louis (STL)
8.8/10 Excellent! (1,056 reviews)
The property was beautiful and unique. The food was a disappointment. Unfortunately it was just too greasy for us.

Reviewed on Mar 6, 2026

The Knight Center at Washington University

The Knight Center at Washington University

2.5 out of 5
Price was ￥378,930, price is now ￥363,402 per person
￥363,402
per person
May 2 - May 5
found 9 hours ago
Roundtrip flight included
Osaka (KIX) to St. Louis (STL)
9.4/10 Exceptional! (486 reviews)
The property locates on campus, convenient location. Newly renovated, quiet and clean. It would be great if the hotel can provide day time hot coffee in the lobby.

Reviewed on Mar 9, 2026

Find the Best Southeast Missouri Vacation Packages

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is ￥15,776 per night from Mar 15 to Mar 16
￥15,776
￥17,798 total
Mar 15 - Mar 16
includes taxes & fees
9.6/10 Exceptional! (1,019 reviews)
Clean room , nice staff

Reviewed on Mar 6, 2026

Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is ￥14,130 per night from Mar 15 to Mar 16
￥14,130
￥15,939 total
Mar 15 - Mar 16
includes taxes & fees
9.4/10 Exceptional! (524 reviews)
Lovely property. I don’t gamble, but if you do, it’s clearly convenient to the casino. Comfortable bed, very clean room, lovely staff

Reviewed on Mar 8, 2026

The Riverview
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is ￥14,206 per night from Mar 15 to Mar 16
￥14,206
￥16,026 total
Mar 15 - Mar 16
includes taxes & fees
9.4/10 Exceptional! (1,007 reviews)
Great experience. We will pick Drury every time we travel.

Reviewed on Mar 8, 2026

Drury Inn & Suites Cape Girardeau
See all 624 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Southeast Missouri

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.5/5(76 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Southeast Missouri State University

Alley Spring & Mill

4.5/5(4 reviews)

Learn about the local history of Eminence with a stop at Alley Spring & Mill. While you're in the area, stroll along the riverfront.

Alley Spring & Mill

What to do in Southeast Missouri

Pythian Castle

Night Ghost Tour of Pythian Castle in Springfield Missouri

￥3,117
per adult
100% of travellers recommend
Night Ghost Tour of Pythian Castle in Springfield Missouri
Castle Entrance

History Tour of Pythian Castle in Springfield Missouri

￥1,988
per adult
90% of travellers recommend
History Tour of Pythian Castle in Springfield Missouri
Ozark Craft Beverage - Brewery Tour

Ozark Craft Beverage - Brewery Tour

￥24,200
per adult
Ozark Craft Beverage - Brewery Tour
See all activities in Southeast Missouri

Frequently asked questions

Can I cancel my flight booking to Southeast Missouri due to COVID-19?
Many airlines now offer greater flexibility due to COVID-19. Our handy Customer Service Portal will help you answer most queries about which policies apply to your Southeast Missouri flight. It's also wise to check the terms and conditions of your fare — preferably before locking in your tickets!
What's the best way to find cheap flights to Southeast Missouri that have flexible change policies?
It's as easy as counting to three with Expedia. Step 1: Enter your travel details and click on the "Search" button. Step 2? Check "No change fee" directly underneath the "Flexible change policies" filter to the left of your screen. Step 3. Book your flexible and cheap ticket to Southeast Missouri.
What are some of the general tips for travelers to Southeast Missouri during the COVID-19 outbreak?
With new rules, restrictions and safety measures to adhere to, travel looks a little different right now. Here's what you should know before you hop on that plane to Southeast Missouri:
  • Find out what, if any, rules or restrictions apply to both your origin and destination. It may not be possible to travel depending on local circumstances, so be sure to check before you lock in your flight.
  • When you pass through airport screening, keep your face mask on. You will be asked to lower it briefly for identification purposes. Those who refuse to wear a mask may be fined and denied entry.
  • Instead of handing a TSA agent your boarding pass, position it straight on the reader yourself. Once that's done, hold it up for inspection.
  • One container of liquid hand sanitizer is now permitted in your carry-on baggage. It must be no bigger than 12 oz (350 ml), and you'll need to take it out of your bag for scanning.
  • Empty your personal items from your pockets, like your keys, phone and wallet, and put them in your carry-on instead of the bins. This will minimize handling during screening.
  • Separate any food you have for screening. Food items often set off the alarm. Placing them in a clear plastic bag and into a bin reduces the need for a TSA officer to touch and inspect your belongings.

Which airlines fly to Southeast Missouri?
Contour Aviation is a major airline servicing Southeast Missouri. Search for a fare to Waynesville Regional Airport (TBN) and you'll have 56 Contour Aviation flights a month to pick from.
How can I find cheap tickets to Southeast Missouri?
You'll always score an unbeatable deal with Expedia, but our "flexible dates" search function makes it that much easier. Enter your preferred flight date, then tick the flexible dates box above to see a list of prices for nearby days. was the lowest price for a flight to Southeast Missouri in the last seven days.
How much is a flight to Southeast Missouri?
If you were jetting one way from (), you could've snapped up a cheap fare for just in the last seven days. Return flights to Southeast Missouri ranged from to over the same period.
What are the most popular airports to fly into in Southeast Missouri?
Southeast Missouri's main entryway is Waynesville Regional Airport (TBN). Get your next big journey underway by reserving a ticket on one of the 56 flights a month to this destination.
When is the cheapest time to fly to Southeast Missouri?
If you'd rather spend your vacation savings enjoying the best of Southeast Missouri rather than on your flight there, depart earlier in the week. The most cost-effective day to travel is normally Tuesday, with Monday a close second. With many folks traveling on the weekend, Saturday often has the highest airfares.
How much is a plane ticket to Southeast Missouri?
In the last seven days, plane tickets varied between and . Browse through our fantastic deals to Southeast Missouri, make a booking and then start packing your things!
Which airlines with flights to Southeast Missouri employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, airlines have implemented new rules and standards to help their passengers fly with extra peace of mind. Check out what these carriers are doing:
  • Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.