Southeast Missouri Vacations

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  • Better together

    Save up to ￥109,000 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Find the Best Southeast Missouri Vacation Packages

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
The price is ￥16,371 per night from Aug 5 to Aug 6
￥16,371
￥18,469 total
Aug 5 - Aug 6
includes taxes & fees
Drury Plaza Hotel Cape Girardeau Conference Center
Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
The price is ￥9,693 per night from Aug 10 to Aug 11
￥9,693
￥10,551 total
Aug 10 - Aug 11
includes taxes & fees
8/10 Very Good! (1,009 reviews)
"Entering the hotel there was an Oder that was sickening. I asked the front desk what it was and they said they could not smell it. I told them to step outside & come back in. They did spray. I told them if my sleeping room smelled that bad I could not stay. My sleeping room was fine, but every time ..."

Reviewed on Jul 28, 2026

Baymont Inn and Suites by Wyndham Farmington, MO
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is ￥17,031 per night from Aug 3 to Aug 4
￥17,031
￥19,213 total
Aug 3 - Aug 4
includes taxes & fees
9.4/10 Exceptional! (635 reviews)
"Very clean property all the way around!"

Reviewed on Jul 27, 2026

The Riverview
See all 670 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
See properties

What to do in Southeast Missouri

Pythian Castle

Night Ghost Tour of Pythian Castle in Springfield Missouri

￥3,249
per adult
96% of travellers recommend
Night Ghost Tour of Pythian Castle in Springfield Missouri
Castle Entrance

History Tour of Pythian Castle in Springfield Missouri

￥2,072
per adult
90% of travellers recommend
History Tour of Pythian Castle in Springfield Missouri
Ozark Craft Beverage - Brewery Tour

Ozark Craft Beverage - Brewery Tour

￥25,229
per adult
Ozark Craft Beverage - Brewery Tour
See all activities in Southeast Missouri

Frequently asked questions

How much does a Southeast Missouri vacation package cost?
Cross off another part of the world with our Southeast Missouri vacation packages, which start from just . Select the flights and hotels that match your travel plans. Then, add on one or two tours or experiences for an unforgettable adventure.
How do I get a cheap travel package to Southeast Missouri?
Browse and book everything in the one place with our Southeast Missouri vacation packages. You'll find deals on flights, hotels, tours and more that'll keep your pocket happy and your adventurous spirit alive. And, with more than 550 partner airlines and 1,000,000 hotels around the world to select from, you'll have endless opportunities to mix and match your own way.
What are the top hotels in Southeast Missouri?
When it comes to properties in Cape Girardeau, Drury Plaza Hotel Cape Girardeau Conference Center and Pear Tree Inn Cape Girardeau West are a couple of favorites. If you're considering heading to Ste Genevieve, City Place St. Louis Downtown and The Branson Hillside Hotel are waiting to welcome you.
How far in advance should I book my Southeast Missouri vacation?
It's tricky picking the perfect time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to a year in advance. If you can't book ahead, don't worry. Cheap prices appear from time to time within a few weeks of departure dates.
What does an Expedia Southeast Missouri travel package include?
From hotels and flights to car rentals, Expedia can help you craft a Southeast Missouri package that fits you. Vacationing for a week or two? Look into a rental car, hotel and flight bundle. If you're taking a quick break, a hotel and airfare deal may suit you better. Experiences can also be added once you've made your booking. Our packages make it a breeze to plan and save.
What should I know before booking a Southeast Missouri travel package?
When you book your flights, hotels and car rentals together, you'll pick up terrific discounts. Whether you're planning a beach escape in a villa or prefer to stay in a comfortable hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Southeast Missouri Expedia vacation package?
You can, and with over 550 airlines to pick from around the world, you're spoiled for choice. Have a look through the available options and see which airline best suits your budget and needs.
If I'm not able to travel, can I cancel my Southeast Missouri vacation package?
Because we understand life is full of surprises, the answer is yes. To learn more, head to our Customer Service Portal. But generally speaking, if you've booked your Southeast Missouri vacation package in the last 24 hours, you may be able to cancel or change it for no charge. Your hotel, airline or car rental company may charge a fee if your booking is older than that.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.