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Find hotels in Southeast Missouri, MO from ¥8,936

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Our top choices for Southeast Missouri hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,002 reviews)
"Great place!"
United States
Jennifer
The price is ¥17,952
¥20,639 total
includes taxes & fees
Jul 20 - Jul 21
Drury Inn & Suites Sikeston, MO

Deerfield Inn & Suites Steele Near Blytheville I 55

Deerfield Inn & Suites Steele Near Blytheville I 55
2.5 star property
Steele
The price is ¥7,781
¥9,004 total
includes taxes & fees
Jun 30 - Jul 1
Deerfield Inn & Suites Steele Near Blytheville I 55

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,005 reviews)
"Wonderful room and food offerings were extra thoughtful."
United States
Jonna
The price is ¥16,172
¥18,245 total
includes taxes & fees
Jul 5 - Jul 6
Drury Plaza Hotel Cape Girardeau Conference Center

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very Good, (1,005 reviews)
"It was a great stay"
United States
Daisy
The price is ¥10,772
¥11,725 total
includes taxes & fees
Jul 12 - Jul 13
Baymont Inn and Suites by Wyndham Farmington, MO

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1,000 reviews)
"Great hotel"
United States
mason
The price is ¥11,644
¥13,137 total
includes taxes & fees
Jul 5 - Jul 6
Pear Tree Inn Cape Girardeau West

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (925 reviews)
"Hotel Staff was very friendly!"
United States
Alice
The price is ¥16,336
¥18,455 total
includes taxes & fees
Jul 26 - Jul 27
Fairfield Inn & Suites by Marriott Poplar Bluff

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.6 out of 10, Excellent, (568 reviews)
"Rooms are very clean. Easy and fast check in"
United States
Kanyia
The price is ¥13,060
¥14,852 total
includes taxes & fees
Jun 29 - Jun 30
The Farmstead Hotel

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
7.8 out of 10, Good, (1,001 reviews)
"Clean room, check in was easy. It was a good stopover for 1 night."
United States
Nancy
The price is ¥14,411
¥16,478 total
includes taxes & fees
Jul 2 - Jul 3
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (788 reviews)
"Beautiful hotel at a very good price."
United States
Sheldon
The price is ¥14,985
¥16,218 total
includes taxes & fees
Jul 5 - Jul 6
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Super 8 by Wyndham Potosi

Super 8 by Wyndham Potosi
2.0 star property
Potosi
7.2 out of 10, Good, (403 reviews)
"Owner was very kind. He knew we were running a long trail race the next morning and got up an hour early so he could make coffee and put out breakfast for us at 5:30 am. We were so grateful!"
United States
Julie
The price is ¥9,417
¥10,285 total
includes taxes & fees
Jul 5 - Jul 6
Super 8 by Wyndham Potosi

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,002 reviews)
"The breakfast and nightly gathering makes this location a fantastic value and will be our choice of stops when heading south again!"
United States
William
The price is ¥13,261
¥14,020 total
includes taxes & fees
Jul 26 - Jul 27
Drury Inn & Suites Jackson MO

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very Good, (1,001 reviews)
"Clean room and convenient location."
United States
Morgan
The price is ¥12,131
¥13,585 total
includes taxes & fees
Jun 28 - Jun 29
Motel 6 Poplar Bluff, MO

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (879 reviews)
The price is ¥15,807
¥17,701 total
includes taxes & fees
Jul 5 - Jul 6
Hampton Inn Poplar Bluff

Perryville RV Resort

Perryville RV Resort
2.0 star property
Perryville
The price is ¥11,933
¥13,659 total
includes taxes & fees
Jun 28 - Jun 29
Perryville RV Resort

Microtel Inn & Suites by Wyndham Sainte Genevieve

Microtel Inn & Suites by Wyndham Sainte Genevieve
2.5 star property
Ste Genevieve
8.8 out of 10, Excellent, (646 reviews)
"Everything was great, enjoyed our time there "
United States
David and Lizbeth
The price is ¥13,246
¥14,782 total
includes taxes & fees
Jun 28 - Jun 29
Microtel Inn & Suites by Wyndham Sainte Genevieve

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,002 reviews)
"Staff and breakfast were excellent."
United States
James
The price is ¥17,791
¥20,071 total
includes taxes & fees
Jul 5 - Jul 6
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (793 reviews)
"I love it there."
United States
Sharika West
The price is ¥10,716
¥12,212 total
includes taxes & fees
Jun 28 - Jun 29
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (203 reviews)
"The room was clean, the staff was extremely helpful with our check in!"
United States
Travis
The price is ¥14,985
¥16,904 total
includes taxes & fees
Jul 26 - Jul 27
Fairfield Inn & Suites by Marriott Cape Girardeau

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.2 out of 10, Very Good, (65 reviews)
The price is ¥13,392
¥15,297 total
includes taxes & fees
Jun 29 - Jun 30
Super 8 By Wyndham Marston

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (777 reviews)
"Great stay with Great people, very clean and welcoming"
United States
Mircea
The price is ¥7,843
¥8,469 total
includes taxes & fees
Jun 28 - Jun 29
New Orleans Inn Portageville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Walnut Hollow Lake to K Bridge Recreation Area.

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard
Open Photo by Bill Dillard

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