Find hotels in Southeast Missouri, MO from ¥8,201

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Compare 587 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1005)
"Will stay again"
The price is ¥13,179
¥15,152 total
includes taxes & fees
Aug 17 - Aug 18
Drury Inn & Suites Sikeston, MO

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (19)
"Had a wonderful time"
The price is ¥13,034
¥19,540 total
includes taxes & fees
Aug 5 - Aug 6
Postcard Cabins St. Francois

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1002)
"Great stay!"
The price is ¥13,765
¥15,688 total
includes taxes & fees
Aug 1 - Aug 2
Drury Inn & Suites Hayti Caruthersville

The Farmstead Hotel

2.5 star property
8.8 out of 10, Excellent, (388)
"Great stay!"
The price is ¥13,913
¥15,822 total
includes taxes & fees
Jul 25 - Jul 26
The Farmstead Hotel

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1007)
"We enjoyed the quick check in and how quiet the property was. "
The price is ¥10,250
¥11,564 total
includes taxes & fees
Jul 27 - Jul 28
Pear Tree Inn Cape Girardeau West

Microtel Inn & Suites by Wyndham Sainte Genevieve

2.5 star property
8.8 out of 10, Excellent, (582)
"It was a great stay. Only thimg maybe more variety or hot breakfast."
The price is ¥13,075
¥14,592 total
includes taxes & fees
Aug 14 - Aug 15
Microtel Inn & Suites by Wyndham Sainte Genevieve

The Riverview

2.0 star property
9.4 out of 10, Exceptional, (359)
"Wonderful place to stay. Very clean and affordable!"
The price is ¥15,421
¥17,397 total
includes taxes & fees
Jul 27 - Jul 28
The Riverview

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1005)
"Excellent place to stay "
The price is ¥10,250
¥11,564 total
includes taxes & fees
Jul 31 - Aug 1
Pear Tree Inn Cape Girardeau Near the Medical Center

Fairfield Inn & Suites by Marriott Sikeston

2.5 star property
9.8 out of 10, Exceptional, (15)
"Nice hotel "
The price is ¥17,445
¥19,753 total
includes taxes & fees
Jul 27 - Jul 28
Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (775)
"Great location. Property well maintained. "
The price is ¥14,499
¥16,380 total
includes taxes & fees
Aug 17 - Aug 18
Fairfield Inn & Suites by Marriott Poplar Bluff

Shepherd Mountain Inn

2.5 star property
9.2 out of 10, Wonderful, (286)
"Wonderful small town motel in a beautiful & quiet location."
Shepherd Mountain Inn

Tru By Hilton Cape Girardeau

2.5 star property
9.6 out of 10, Exceptional, (49)
"Great overall stay"
The price is ¥14,813
¥16,859 total
includes taxes & fees
Jul 30 - Jul 31
Tru By Hilton Cape Girardeau

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (962)
"Love the property. Staff is always amazing."
The price is ¥13,179
¥14,866 total
includes taxes & fees
Jul 31 - Aug 1
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1004)
"Great breakfast!"
The price is ¥13,179
¥13,933 total
includes taxes & fees
Jul 28 - Jul 29
Drury Inn & Suites Jackson MO

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
9.4 out of 10, Exceptional, (114)
"Hotel was very clean and the lady that checked us in was very friendly. "
The price is ¥13,620
¥15,365 total
includes taxes & fees
Jul 31 - Aug 1
Fairfield Inn & Suites by Marriott Cape Girardeau

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
9.4 out of 10, Exceptional, (486)
"Good place "
The price is ¥15,084
¥17,267 total
includes taxes & fees
Aug 23 - Aug 24
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1006)
"Great place to stay. "
The price is ¥14,206
¥16,026 total
includes taxes & fees
Aug 22 - Aug 23
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (728)
"Close distance to good restaurants "
The price is ¥16,058
¥18,115 total
includes taxes & fees
Aug 3 - Aug 4
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (743)
"Excellent property, great location. "
The price is ¥14,191
¥15,891 total
includes taxes & fees
Aug 17 - Aug 18
Hampton Inn Poplar Bluff

Crown Pointe Lodge, BW Signature Collection

2.5 star property
9.0 out of 10, Wonderful, (539)
"The employees are very good here. This is an excellent property!"
The price is ¥18,189
¥20,708 total
includes taxes & fees
Aug 10 - Aug 11
Crown Pointe Lodge, BW Signature Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Stay near popular Southeast Missouri attractions

K Bridge Recreation Area

K Bridge Recreation Area

Explore the great outdoors at K Bridge Recreation Area, a lovely green space in Annapolis. While you're in the area, stroll along the riverfront.

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Top Southeast Missouri Hotel Reviews