
Find hotels in Southeast Missouri, MO from ¥8,936
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Southeast Missouri
Cabin
Family friendly
Check prices for these dates
Our top choices for Southeast Missouri hotels

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.6 out of 10, Exceptional, (1,002 reviews)
The price is ¥17,952
¥20,639 total
includes taxes & fees
Jul 26 - Jul 27

Deerfield Inn & Suites Steele Near Blytheville I 55
Deerfield Inn & Suites Steele Near Blytheville I 55Steele
The price is ¥7,781
¥9,004 total
includes taxes & fees
Jul 3 - Jul 4

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,005 reviews)
The price is ¥16,172
¥18,245 total
includes taxes & fees
Jul 5 - Jul 6

Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
8.0 out of 10, Very Good, (1,005 reviews)
The price is ¥9,575
¥10,422 total
includes taxes & fees
Jul 12 - Jul 13

Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau WestCape Girardeau
9.0 out of 10, Wonderful, (1,000 reviews)
The price is ¥11,644
¥13,137 total
includes taxes & fees
Jul 5 - Jul 6

Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (925 reviews)
The price is ¥16,983
¥19,187 total
includes taxes & fees
Jul 5 - Jul 6

The Farmstead Hotel
The Farmstead HotelCaruthersville
8.6 out of 10, Excellent, (568 reviews)
The price is ¥13,060
¥14,852 total
includes taxes & fees
Jun 29 - Jun 30

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis SouthFestus
7.8 out of 10, Good, (1,001 reviews)
The price is ¥13,610
¥15,563 total
includes taxes & fees
Jul 2 - Jul 3

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (788 reviews)
The price is ¥14,985
¥16,218 total
includes taxes & fees
Jul 5 - Jul 6

Super 8 by Wyndham Potosi
Super 8 by Wyndham PotosiPotosi
7.2 out of 10, Good, (403 reviews)
The price is ¥9,417
¥10,285 total
includes taxes & fees
Jul 5 - Jul 6

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,002 reviews)
The price is ¥13,261
¥14,020 total
includes taxes & fees
Jul 26 - Jul 27

Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MOPoplar Bluff
8.0 out of 10, Very Good, (1,001 reviews)
The price is ¥12,134
¥13,588 total
includes taxes & fees
Jun 28 - Jun 29

Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (879 reviews)
The price is ¥15,789
¥17,679 total
includes taxes & fees
Jul 26 - Jul 27

Perryville RV Resort
Perryville RV ResortPerryville
The price is ¥11,933
¥13,659 total
includes taxes & fees
Jun 28 - Jun 29

Microtel Inn & Suites by Wyndham Sainte Genevieve
Microtel Inn & Suites by Wyndham Sainte GenevieveSte Genevieve
8.8 out of 10, Excellent, (646 reviews)
The price is ¥13,246
¥14,782 total
includes taxes & fees
Jun 28 - Jun 29

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
The price is ¥17,791
¥20,071 total
includes taxes & fees
Jul 5 - Jul 6

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)Sikeston
8.4 out of 10, Very Good, (793 reviews)
The price is ¥10,718
¥12,214 total
includes taxes & fees
Jun 28 - Jun 29

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (203 reviews)
The price is ¥14,985
¥16,904 total
includes taxes & fees
Jul 26 - Jul 27

Super 8 By Wyndham Marston
Super 8 By Wyndham MarstonMarston
8.2 out of 10, Very Good, (65 reviews)
The price is ¥13,395
¥15,299 total
includes taxes & fees
Jun 28 - Jun 29

New Orleans Inn Portageville
New Orleans Inn PortagevillePortageville
8.0 out of 10, Very Good, (777 reviews)
The price is ¥7,843
¥8,469 total
includes taxes & fees
Jun 28 - Jun 29
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Vacation Rentals in Southeast Missouri
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (80 reviews)
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Southeast Missouri attractions
Learn more about Southeast Missouri
Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Walnut Hollow Lake to K Bridge Recreation Area.

Photo by Bill Dillard
Open Photo by Bill Dillard
More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is ¥9,575 per night from Jul 12 to Jul 13
¥9,575
¥10,422 total
Jul 12 - Jul 13
includes taxes & fees
8/10 Very Good! (1,005 reviews)
Hotels in Southeast Missouri with star-rating

4 Star Hotels
2 properties
Explore a world of travel with Expedia
- Cape Girardeau Hotels
- Guest Houses in Sikeston
- Pet-Friendly Hotels in Farmington
- Rv Parks in Southeast Missouri
- Aparthotels in Ellington
- Luxury Hotels in Belgrade
- Poplar Bluff Hotels
- Motels in Black
- Luxury Hotels in Sikeston
- Bunker Hotels
- Black Hotels
- Luxury Hotels in Bloomfield
- Rv Parks in Black
- B&B in Ste Genevieve
- Hotels near Washington State Park
- Motels in Jackson
- Ski Hotels in Farmington
- Apartments in Cape Girardeau County
- B&B in Annapolis
- Dexter Hotels
- Doniphan Hotels
- Rv Parks in Jackson

































































































