Photo by Bill Dillard

Find hotels in Southeast Missouri, MO from ¥9,120
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check prices for these dates
Our top choices for Southeast Missouri hotels

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.4 out of 10, Exceptional, (1,004 reviews)
The price is ¥17,677
¥20,324 total
includes taxes & fees
Apr 19 - Apr 20

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,004 reviews)
The price is ¥17,200
¥19,404 total
includes taxes & fees
May 4 - May 5

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (743 reviews)
The price is ¥14,191
¥15,358 total
includes taxes & fees
Apr 13 - Apr 14

Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (531 reviews)
The price is ¥17,126
¥19,391 total
includes taxes & fees
May 7 - May 8

Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (887 reviews)
The price is ¥17,520
¥19,794 total
includes taxes & fees
Apr 13 - Apr 14

Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
8.0 out of 10, Very Good, (1,003 reviews)
The price is ¥9,556
¥10,879 total
includes taxes & fees
Apr 29 - Apr 30

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
The price is ¥16,723
¥18,867 total
includes taxes & fees
Apr 19 - Apr 20

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (173 reviews)
The price is ¥14,576
¥16,444 total
includes taxes & fees
Apr 27 - Apr 28

Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MOPoplar Bluff
8.0 out of 10, Very Good, (1,001 reviews)
The price is ¥10,353
¥10,920 total
includes taxes & fees
Apr 12 - Apr 13

Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau WestCape Girardeau
9.0 out of 10, Wonderful, (1,004 reviews)
The price is ¥11,466
¥12,935 total
includes taxes & fees
Apr 23 - Apr 24

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,007 reviews)
The price is ¥13,218
¥13,976 total
includes taxes & fees
Apr 23 - Apr 24

Best Western Plus Sikeston I-55
Best Western Plus Sikeston I-55Sikeston
8.4 out of 10, Very Good, (1,002 reviews)
The price is ¥13,043
¥14,863 total
includes taxes & fees
Apr 12 - Apr 13

Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (816 reviews)
The price is ¥14,889
¥16,672 total
includes taxes & fees
Apr 26 - Apr 27

Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (1,009 reviews)
The price is ¥14,651
¥16,528 total
includes taxes & fees
Apr 19 - Apr 20

Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (1,003 reviews)
The price is ¥16,562
¥18,710 total
includes taxes & fees
Apr 16 - Apr 17

The Farmstead Hotel
The Farmstead HotelCaruthersville
8.6 out of 10, Excellent, (536 reviews)
The price is ¥15,131
¥17,207 total
includes taxes & fees
Apr 20 - Apr 21

Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (578 reviews)
The price is ¥16,086
¥18,414 total
includes taxes & fees
Apr 19 - Apr 20

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (69 reviews)
The price is ¥17,520
¥19,837 total
includes taxes & fees
May 3 - May 4

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis SouthFestus
8.0 out of 10, Very Good, (955 reviews)
The price is ¥14,191
¥16,228 total
includes taxes & fees
Apr 26 - Apr 27

Super 8 by Wyndham Potosi
Super 8 by Wyndham PotosiPotosi
7.0 out of 10, Good, (390 reviews)
The price is ¥8,881
¥9,699 total
includes taxes & fees
Apr 26 - Apr 27
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Vacation Rentals in Southeast Missouri
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (58 reviews)
Save an average of 15% on thousands of hotels when you're signed in
Top Southeast Missouri Hotel Reviews
Hotels in Southeast Missouri with star-rating
Explore a world of travel with Expedia
- Cape Girardeau Hotels
- Guest Houses in Sikeston
- Pet-Friendly Hotels in Farmington
- Rv Parks in Southeast Missouri
- Aparthotels in Ellington
- Luxury Hotels in Belgrade
- Poplar Bluff Hotels
- Motels in Black
- Luxury Hotels in Sikeston
- Bunker Hotels
- Black Hotels
- Luxury Hotels in Bloomfield
- Rv Parks in Black
- B&B in Ste Genevieve
- Hotels near Washington State Park
- Motels in Jackson
- Ski Hotels in Farmington
- Apartments in Cape Girardeau County
- B&B in Annapolis
- Dexter Hotels
- Doniphan Hotels
- Rv Parks in Jackson



































































































