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Jan 16 - Jan 17
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Jan 17 - Jan 18
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Jan 16 - Jan 18
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Jan 23 - Jan 25

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Our top choices for Southeast Missouri hotels

Lobby

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,002 reviews)
"Room was spotless, staff was SO kind. 5 day trip, stayed in 4 different hotels & this one was BY FAR the nicest. Breakfast was fabulous. 10 out of 10 recommend!! "
United States
Brenda
The price is ￥13,150
￥13,903 total
includes taxes & fees
Jan 19 - Jan 20
Drury Inn & Suites Jackson MO
Premium bedding, down comforters, pillowtop beds, in-room safe

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.8 out of 10, Excellent, (472 reviews)
"Clean room, very nice staff"
United States
Mack
The price is ￥12,053
￥13,707 total
includes taxes & fees
Jan 30 - Jan 31
The Farmstead Hotel
Lobby

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,005 reviews)
"Great place "
United States
Kelly
The price is ￥14,259
￥16,084 total
includes taxes & fees
Jan 21 - Jan 22
Drury Plaza Hotel Cape Girardeau Conference Center
Blackout drapes, free WiFi, bed sheets

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
7.8 out of 10, Good, (1,000 reviews)
"Clean room/friendly staff "
United States
Sloan
The price is ￥9,031
￥9,525 total
includes taxes & fees
Jan 18 - Jan 19
Motel 6 Poplar Bluff, MO
Lobby

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (978 reviews)
"Great location and room "
United States
Curtis
The price is ￥16,477
￥18,614 total
includes taxes & fees
Feb 6 - Feb 7
Drury Inn & Suites Poplar Bluff
Front of property

Echo Bluff State Park

Echo Bluff State Park
2.5 star property
Eminence
9.4 out of 10, Exceptional, (219 reviews)
"The cabin was beautiful, comfy, & private! The park was FANTASTIC for hiking & scenery! We hope to return and maybe bring family or friends. The staff were all friendly too! :)"
United States
Joanne
The price is ￥24,428
￥25,827 total
includes taxes & fees
Jan 19 - Jan 20
Echo Bluff State Park
Lobby lounge

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (864 reviews)
"The size of the room. The staff were great. The room was very clean. Will definitely stay there again."
United States
Brenda
The price is ￥16,431
￥18,563 total
includes taxes & fees
Feb 6 - Feb 7
Fairfield Inn & Suites by Marriott Poplar Bluff
Reception

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (798 reviews)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is ￥17,177
￥19,234 total
includes taxes & fees
Feb 14 - Feb 15
Hampton Inn Poplar Bluff
Free daily full breakfast

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1,011 reviews)
"Great stay, everything was clean and comfortable. "
United States
Charles
The price is ￥11,312
￥12,892 total
includes taxes & fees
Jan 21 - Jan 22
Best Western Plus Sikeston
Exterior

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (551 reviews)
"lean, updated rooms, friendly staff and great breakfast."
United States
Linda
The price is ￥14,419
￥16,506 total
includes taxes & fees
Jan 18 - Jan 19
Holiday Inn Express & Suites Perryville by IHG
Indoor pool, outdoor pool

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1,002 reviews)
"Breakfast was excellent, and fresh. Room was clean and spacious. We enjoyed our brief stay."
United States
Nicole
The price is ￥14,272
￥16,408 total
includes taxes & fees
Jan 20 - Jan 21
Drury Inn & Suites Sikeston, MO
Individually decorated, individually furnished, desk, blackout drapes

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (730 reviews)
"Clean room and easy access to room"
United States
Anne
The price is ￥8,792
￥10,020 total
includes taxes & fees
Jan 19 - Jan 20
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Breakfast, lunch, dinner served; Italian cuisine

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (714 reviews)
"Amazing place"
United States
Mladen
The price is ￥17,445
￥19,711 total
includes taxes & fees
Jan 24 - Jan 25
Holiday Inn Poplar Bluff by IHG
Hiking

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (336 reviews)
"Staff was very friendly."
United States
Joyce
The price is ￥14,271
￥15,471 total
includes taxes & fees
Jan 18 - Jan 19
Honeysuckle Inn - Mountain View
Exterior

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (687 reviews)
"Conveniently located, clean, friendly staff."
United States
Philip
The price is ￥12,795
￥13,848 total
includes taxes & fees
Jan 26 - Jan 27
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Exterior

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (150 reviews)
"Great hotel - super clean, fast check-in, convenient, etc. We’ll definitely stay here again. "
United States
Richard
The price is ￥13,944
￥15,730 total
includes taxes & fees
Jan 25 - Jan 26
Fairfield Inn & Suites by Marriott Cape Girardeau
Exterior

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (463 reviews)
"Very clean and super friendly staff!"
United States
Katherine
The price is ￥16,140
￥18,275 total
includes taxes & fees
Feb 1 - Feb 2
Hampton Inn Sikeston
Front of property

Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1,001 reviews)
"Staff great. "
United States
Nancy
The price is ￥16,794
￥18,946 total
includes taxes & fees
Jan 18 - Jan 19
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
8.0 out of 10, Very Good, (905 reviews)
"Breakfast was great! Location right off interstate was perfect. The property is a little old."
United States
Mindy
The price is ￥14,546
￥16,634 total
includes taxes & fees
Jan 18 - Jan 19
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Free buffet breakfast

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
2.5 star property
Festus
9.4 out of 10, Exceptional, (706 reviews)
"Clean room and great staff"
United States
Stacy
The price is ￥19,331
￥22,105 total
includes taxes & fees
Jan 25 - Jan 26
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:Jan 23 - Jan 25

Image gallery for Johnson's Shut-ins State Park

Living area

Johnson's Shut-ins State Park

3.0 star property
Middle Brook
10/10Exceptional (1 review)
Member Price available
Price is ￥39,964
￥84,506 total
Total includes taxes and fees
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Johnson's Shut-ins State Park
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Stay near popular Central United States attractions

Panorama of Academic Hall, Southeast Missouri State University

Southeast Missouri State University

4.4/5 (137 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
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A huge granite boulder located in Elephant Rocks State Park
Photo by Pat Long
Open Photo by Pat Long

Elephant Rocks State Park

4.8/5 (52 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
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Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train
Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Loved the happy hour, and pet friendly & shower."
Jackie 1-night trip
Posted 3 days ago
Drury Inn & Suites Cape Girardeau

More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
The price is ￥8,366 per night from Jan 25 to Jan 26
￥8,366
￥9,524 total
Jan 25 - Jan 26
includes taxes & fees
7.8/10 Good! (1,000 reviews)

Hotels in Southeast Missouri with star-rating