Find 5 Star Hotels in Santa Maria Novella from ¥17,184
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check availability on Santa Maria Novella 5 Star Hotels
Compare Santa Maria Novella 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Our top choices for Santa Maria Novella 5-star hotels

Anglo American Hotel Florence, Curio Collection by Hilton
Anglo American Hotel Florence, Curio Collection by Hilton
8.4 out of 10, Very Good, (801)
The price is ¥46,350
¥53,743 total
includes taxes & fees
Sep 7 - Sep 8

Sina Villa Medici, Autograph Collection
Sina Villa Medici, Autograph Collection
8.6 out of 10, Excellent, (304)
The price is ¥82,802
¥93,846 total
includes taxes & fees
Sep 7 - Sep 8

The St. Regis Florence
The St. Regis Florence
9.6 out of 10, Exceptional, (261)
The price is ¥226,170
¥251,551 total
includes taxes & fees
Sep 7 - Sep 8

Dimora Palanca Boutique & SPA
Dimora Palanca Boutique & SPA
9.4 out of 10, Exceptional, (48)
The price is ¥54,955
¥63,214 total
includes taxes & fees
Sep 4 - Sep 5

The Excelsior, a Luxury Collection Hotel, Florence
The Excelsior, a Luxury Collection Hotel, Florence
9.4 out of 10, Exceptional, (348)
The price is ¥155,126
¥173,396 total
includes taxes & fees
Sep 13 - Sep 14
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Santa Maria Novella.

c-hotels Ambasciatori
Via Luigi Alamanni 3, Florence, FI
The price is ¥23,308 per night from Sep 7 to Sep 8
¥23,308
¥28,052 total
Sep 7 - Sep 8
includes taxes & fees
Still don't see what you're looking for?
See all properties in Santa Maria Novella.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Santa Maria Novella Hotel Reviews
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in Santa Maria Novella Neighborhoods
Stay near popular Santa Maria Novella attractions
- Hotels near Basilica of Santa Maria Novella
- Hotels near Fortezza da Basso
- Hotels near Palazzo dei Congressi
- Hotels near Via Faenza
- Hotels near Uffizi Gallery
- Hotels near Ponte Vecchio
- Hotels near Cathedral of Santa Maria del Fiore
- Hotels near Piazza del Duomo
- Hotels near Piazza della Signoria
- Hotels near Palazzo Vecchio
- Hotels near Pitti Palace
- Hotels near Mugello Circuit
- Hotels near Piazzale Michelangelo
- Hotels near Gallery of the Academy of Florence
- Hotels near Central Market
Explore more hotels
- Croce Di Malta Hotel
- Grand Hotel Minerva
- Hotel L'Orologio Firenze
- c-hotels Joy
- Hotel Santa Maria Novella
- Hotel Nuova Italia
- Hotel Embassy
- Hotel Palazzo Vecchio
- Hotel Albani Firenze
- Sina Villa Medici, Autograph Collection
- The St. Regis Florence
- The Moon Boutique Hotel & Spa
- Hotel Leonardo Da Vinci
- Eco Urban B&B
- Aurum Firenze
- c-hotels Club
- Hotel Kraft
- Hotel Boccaccio
- Hotel Lombardia