One of the northermost cypress swamps in the States, the Cache River State Natural area is home to Cypress trees that are over 1000 years old. This is shot from the hiking trail (no boat), and was just a sampling of the scores of cypress trees all around. #treetrove

Find all hotels by Motel 6 in Southwest Illinois, IL from ￥10,233

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Southwest Illinois Motel 6

Motel 6 Caseyville, IL - Caseyville Il

Caseyville

"I stay here every few weeks and totally recommend this place. Sometimes I just don't want to commute back and forth for events to St. Louis, so this Motel 6 is convenient. Always friendly staff at check-in and room is clean. I stay at a lot of Motel 6 across the country when traveling and this one is affordable and well worth the money spent. If you're doing things in St. Louis, this place is easy to drive to and from without being a pain on the short commute on I-64."

Nicole

￥10,233 total

includes taxes & fees

Jan 1 - Jan 2, 2026

Motel 6 Mount Vernon, IL

Mount Vernon

kai

￥10,911 total

includes taxes & fees

Jan 5 - Jan 6, 2026

Motel 6 Marion, IL

Marion

Corey

￥11,293 total

includes taxes & fees

Dec 29 - Dec 30

Deluxe Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave | Laptop workspace, free WiFi, bed sheets

Motel 6 Troy, IL

Troy

Michael

￥11,351 total

includes taxes & fees

Jan 2 - Jan 3, 2026

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Top Southwest Illinois Hotel Reviews

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent

"Arrived early on Christmas Day. Promptly greeted by the front desk. Checked in quickly and made it to our room. Very clean and nice suite. Everything worked and the staff was very friendly. "

Drury Inn & Suites Marion

10/10 Excellent

"The room was spacious, clean and comfortable. The bathroom was clean and roomy as well. The common area amenities were great including the breakfast and the marketplace. It was an overall great value. The only thing that I would have changed was that the television wasn’t a smart tv. It’s been a long time since I stayed in a hotel where the tv was not WiFi capable and I couldn’t stream or cast to it. The tv in our room was standard with cable channels and only had hdmi adapters. Other than that the stay was great."

Drury Inn & Suites St. Louis Fairview Heights

10/10 Excellent

"Wonderful stay! Staff was kind, efficient, and informative. Having drinks, appetizers, and a full breakfast was a definite plus. The best night of rest in 2 weeks away from home, the bed was not a board! Definitely choosing Drury again over others!"