Southwest Illinois Vacations

Book a Hotel + Flight or Car together to unlock savings

Photo by Southernmost Illinois Tourism Bureau

  • Plan, book, travel with confidence

  • Better together

    Save up to ￥45,448 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Southwest Illinois

Find the best Southwest Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southwest Illinois
Aerial view of the iconic Gateway Arch and Mississippi River with urban skyline and bridges, Downtown St. Louis, Missouri, United States.

Eastport

1 out of top 10 points of interest in this area

If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.

Find hotels in Eastport

Find the Best Southwest Illinois Vacation Packages

Southwest Illinois Hotel Deals

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street  Mount Vernon IL
Fully refundableReserve now, pay when you stay
The price is ￥16,956 per night from Feb 21 to Feb 22
￥16,956
￥19,124 total
Feb 21 - Feb 22
includes taxes & fees
9.6/10 Exceptional! (1,659 reviews)
Cleanliness friendliness of staff, extra lil amenities like the free drinks & apps between 5:30-7. Modern looking & clean!

Reviewed on Feb 8, 2026

Drury Plaza Hotel Mt. Vernon
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

3 out of 5
12 Ludwig Dr Fairview Heights IL
Fully refundableReserve now, pay when you stay
The price is ￥14,359 per night from Feb 18 to Feb 19
￥14,359
￥16,223 total
Feb 18 - Feb 19
includes taxes & fees
9/10 Wonderful! (1,013 reviews)
Great

Reviewed on Feb 10, 2026

Drury Inn & Suites St. Louis Fairview Heights
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr O'Fallon IL
Fully refundableReserve now, pay when you stay
The price is ￥7,272 per night from Feb 22 to Feb 23
￥7,272
￥8,361 total
Feb 22 - Feb 23
includes taxes & fees
7/10 Good! (1,003 reviews)
Room and service amazing as always

Reviewed on Feb 3, 2026

Super 8 by Wyndham O'Fallon
See all 745 properties in Southwest Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Southwest Illinois

Campus Lake at Southern Illinois University in Carbondale, IL.

Southern Illinois University

4.5/5(173 reviews)

Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.

Southern Illinois University
Ferne Clyffe Waterfall Detail Goreville IL #detail

Ferne Clyffe State Park

4.5/5(10 reviews)

You can take time to visit Ferne Clyffe State Park during your travels to Goreville. While you're in the area, wander around the parks.

Ferne Clyffe State Park

Frequently asked questions

Can I cancel my flight booking to Southwest Illinois due to COVID-19?
If you haven't booked yet, glance over the terms and conditions of the airfare you're considering. If you've already reserved your flight to Southwest Illinois, visit our Customer Service Portal. It will help you figure out which COVID-19 policies are applicable to your reservation and offer advice on the next steps.
What's the best way to find cheap flights to Southwest Illinois that have flexible change policies?
When it comes to flying these days, flexibility is crucial. That's why we have a "No change fee" search function to help you track down flexible, affordable flights to Southwest Illinois. It's at the top left of your screen directly below the "Flexible change policies" subheading.
What are some of the general tips for travelers to Southwest Illinois during the COVID-19 outbreak?
The COVID-19 pandemic has affected how the world works in a profound way, including our approach to travel. These tips will help you understand these new challenges and prepare you for your vacation in Southwest Illinois:
  • Research what, if any, restrictions or rules apply to both your origin and destination. It may not be possible to travel depending on local circumstances, so don't forget to check in advance.
  • When you go through airport screening, keep your face mask on. You will be required to lower it briefly for ID purposes. Anyone refusing to wear a face mask may face civil penalties and may also be denied boarding.
  • To reduce the likelihood of cross-contamination, position your boarding pass on the reader yourself and then hold it up for inspection. Do not hand your boarding pass directly to a TSA agent.
  • One liquid hand sanitizer container is now allowed in your carry-on luggage. It must be no larger than 12 oz (350 ml), and you'll need to remove it from your bag at the X-ray machine for scanning.
  • To minimize handling during the screening process, put items such as your phone, keys and wallet into your carry-on instead of the bins.
  • Separate any food you have for X-ray scanning. Food items often set off the alarm. Placing them in a clear plastic bag and into a bin reduces the need for a TSA officer to handle and inspect your belongings.

Which airlines fly to Southwest Illinois?
Organize your fare with Delta and then start planning your Southwest Illinois travel itinerary. This top airline provides 121 flights each month to Evansville Regional Airport (EVV), a main gateway.
How can I find cheap tickets to Southwest Illinois?
A useful strategy for getting your hands on cheap fares is to be flexible with your dates. Begin with searching for your flight to Southwest Illinois, then click on the "flexible dates" link for a list of prices for nearby days. Another helpful hint? Book ahead of time. For an idea of costs, was the lowest price for a flight to Southwest Illinois in the last seven days.
How much is a flight to Southwest Illinois?
If you were jetting one way from (), you could've snapped up a cheap seat for just in the last seven days. Return flights to Southwest Illinois ranged from only to over the same period.
What are the most popular airports to fly into in Southwest Illinois?
Southwest Illinois's main entryway is Evansville Regional Airport (EVV). Get your awesome journey underway by securing an airfare on one of the 381 flights every month to this destination.
When is the cheapest time to fly to Southwest Illinois?
If you'd rather spend your vacation money enjoying Southwest Illinois rather than on getting there, depart early in the week. The most economical day to fly is usually Tuesday, followed by Monday. With many people traveling on weekends, Saturday typically has the most expensive fares.
How much is a plane ticket to Southwest Illinois?
Seats ranged from to over the last seven days. When you're ready to book, we're here to help lock in a fabulous deal to Southwest Illinois.
Which airlines with flights to Southwest Illinois employ COVID-19 cleanliness policies?
In response to the COVID-19 pandemic, airlines have adopted enhanced measures and standards to help their passengers and staff fly with peace of mind. Here are just a few examples:
  • Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.