Southwest Illinois Vacations

Book a Hotel + Flight or Car together to unlock savings

Photo by Southernmost Illinois Tourism Bureau

  • Plan, book, travel with confidence

  • Better together

    Save up to ￥45,448 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Southwest Illinois

Find the best Southwest Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southwest Illinois
Default Image

Eastport

If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.

Find hotels in Eastport

Find the Best Southwest Illinois Vacation Packages

Southwest Illinois Hotel Deals

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

3 out of 5
145 North 44th Street , Mount Vernon, IL
Fully refundableReserve now, pay when you stay
The price is ￥14,534 per night from Nov 23 to Nov 24
￥14,534
￥16,439 total
Nov 23 - Nov 24
includes taxes & fees
9.6/10 Exceptional! (1,525 reviews)
Friendly front desk, clean room, felt safe

Reviewed on Nov 11, 2025

Drury Plaza Hotel Mt. Vernon
Super 8 by Wyndham O'Fallon

Super 8 by Wyndham O'Fallon

2 out of 5
1100 Eastgate Dr, O'Fallon, IL
Fully refundableReserve now, pay when you stay
The price is ￥7,492 per night from Nov 23 to Nov 24
￥7,492
￥8,614 total
Nov 23 - Nov 24
includes taxes & fees
7.2/10 Good! (1,006 reviews)
Everything ok nice price

Reviewed on Nov 8, 2025

Super 8 by Wyndham O'Fallon
Quality Inn & Suites near St. Louis and I-255

Quality Inn & Suites near St. Louis and I-255

2.5 out of 5
1607 Pontiac Dr, East St. Louis, IL
Fully refundableReserve now, pay when you stay
The price is ￥10,383 per night from Nov 23 to Nov 24
￥10,383
￥11,733 total
Nov 23 - Nov 24
includes taxes & fees
7.4/10 Good! (1,002 reviews)
Staff very cordial. We were satisfied with our stay. Location is near food and commerce options. LOTS of handicap parking = the WHOLE front row near the building. Trim strip missing in bathroom made it appear less than clean. HARD TO GET IN & OUT OF TUB FOR BATH as only one puny grab bar = likely ...

Reviewed on Nov 4, 2025

Quality Inn & Suites near St. Louis and I-255
See all 722 properties in Southwest Illinois
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Southwest Illinois

Campus Lake at Southern Illinois University in Carbondale, IL.

Southern Illinois University

Take a campus tour or just explore the area of Southern Illinois University, during your trip to Carbondale. Check out the shops and top-notch restaurants in this family-friendly area.

Southern Illinois University
Ferne Clyffe Waterfall Detail Goreville IL #detail

Ferne Clyffe State Park

You can take time to visit Ferne Clyffe State Park during your travels to Goreville. While you're in the area, wander around the parks.

Ferne Clyffe State Park

Frequently asked questions

Can I cancel my flight booking to Southwest Illinois due to COVID-19?
If you haven't booked yet, glance over the terms and conditions of the airfare you're considering. If you've already reserved your flight to Southwest Illinois, visit our Customer Service Portal. It will help you figure out which COVID-19 policies are applicable to your reservation and offer advice on the next steps.
What's the best way to find cheap flights to Southwest Illinois that have flexible change policies?
When it comes to flying these days, flexibility is crucial. That's why we have a "No change fee" search function to help you track down flexible, affordable flights to Southwest Illinois. It's at the top left of your screen directly below the "Flexible change policies" subheading.
What are some of the general tips for travelers to Southwest Illinois during the COVID-19 outbreak?
The COVID-19 pandemic has affected how the world works in a profound way, including our approach to travel. These tips will help you understand these new challenges and prepare you for your vacation in Southwest Illinois:
  • Research what, if any, restrictions or rules apply to both your origin and destination. It may not be possible to travel depending on local circumstances, so don't forget to check in advance.
  • When you go through airport screening, keep your face mask on. You will be required to lower it briefly for ID purposes. Anyone refusing to wear a face mask may face civil penalties and may also be denied boarding.
  • To reduce the likelihood of cross-contamination, position your boarding pass on the reader yourself and then hold it up for inspection. Do not hand your boarding pass directly to a TSA agent.
  • One liquid hand sanitizer container is now allowed in your carry-on luggage. It must be no larger than 12 oz (350 ml), and you'll need to remove it from your bag at the X-ray machine for scanning.
  • To minimize handling during the screening process, put items such as your phone, keys and wallet into your carry-on instead of the bins.
  • Separate any food you have for X-ray scanning. Food items often set off the alarm. Placing them in a clear plastic bag and into a bin reduces the need for a TSA officer to handle and inspect your belongings.

Which airlines fly to Southwest Illinois?
Organize your fare with Delta and then start planning your Southwest Illinois travel itinerary. This top airline provides 121 flights each month to Evansville Regional Airport (EVV), a main gateway.
How can I find cheap tickets to Southwest Illinois?
A useful strategy for getting your hands on cheap fares is to be flexible with your dates. Begin with searching for your flight to Southwest Illinois, then click on the "flexible dates" link for a list of prices for nearby days. Another helpful hint? Book ahead of time. For an idea of costs, was the lowest price for a flight to Southwest Illinois in the last seven days.
How much is a flight to Southwest Illinois?
If you were jetting one way from (), you could've snapped up a cheap seat for just in the last seven days. Return flights to Southwest Illinois ranged from only to over the same period.
What are the most popular airports to fly into in Southwest Illinois?
Southwest Illinois's main entryway is Evansville Regional Airport (EVV). Get your awesome journey underway by securing an airfare on one of the 381 flights every month to this destination.
When is the cheapest time to fly to Southwest Illinois?
If you'd rather spend your vacation money enjoying Southwest Illinois rather than on getting there, depart early in the week. The most economical day to fly is usually Tuesday, followed by Monday. With many people traveling on weekends, Saturday typically has the most expensive fares.
How much is a plane ticket to Southwest Illinois?
Seats ranged from to over the last seven days. When you're ready to book, we're here to help lock in a fabulous deal to Southwest Illinois.
Which airlines with flights to Southwest Illinois employ COVID-19 cleanliness policies?
In response to the COVID-19 pandemic, airlines have adopted enhanced measures and standards to help their passengers and staff fly with peace of mind. Here are just a few examples:
  • Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.
  • Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.