Photo by Carl Anderson

Find Business Hotels in Southwest Illinois, IL

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Southwest Illinois Business Hotels

Tonight
Dec 28 - Dec 29
Tomorrow
Dec 29 - Dec 30
Next weekend
Jan 2 - Jan 4
In two weeks
Jan 9 - Jan 11

Our top choices for Southwest Illinois business-friendly hotels

Exterior
Drury Inn & Suites Marion

Drury Inn & Suites Marion

Drury Inn & Suites Marion
3.0 star property
Marion
9.4 out of 10, Exceptional, (1005)
"Very nice hotel! Friendly staff and great amenities. We will definitely stay again during our travels. "
United States
Renee
The price is ￥10,175
￥12,209 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Drury Inn & Suites Marion
Terrace/patio
Comfort Suites Mount Vernon

Comfort Suites Mount Vernon

Comfort Suites Mount Vernon
2.5 star property
Mount Vernon
9.0 out of 10, Wonderful, (1005)
"Check in was quick, staff was friendly and helpful, room was very nice and clean."
United States
Don
The price is ￥17,014
￥19,195 total
includes taxes & fees
Dec 30 - Dec 31
Comfort Suites Mount Vernon
Free daily self-serve breakfast
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
2.5 star property
Murphysboro
9.4 out of 10, Exceptional, (512)
"great property, great breakfast, friendly and knowledgable staff."
United States
Ronald
The price is ￥15,187
￥16,854 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Lobby
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
3.0 star property
Mount Vernon
9.6 out of 10, Exceptional, (1596)
"Amazing room, clean, staff were kind! "
United States
Stephanie
The price is ￥14,716
￥16,645 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Drury Plaza Hotel Mt. Vernon
Lobby
SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake

SureStay Hotel by Best Western Whittington Rend Lake
2.5 star property
Whittington
8.8 out of 10, Excellent, (912)
"Great place to stay."
United States
Stephen
The price is ￥11,271
￥12,509 total
includes taxes & fees
Jan 4 - Jan 5, 2026
SureStay Hotel by Best Western Whittington Rend Lake
Room, 1 Queen Bed, Accessible, Non Smoking | Desk, blackout drapes, iron/ironing board, free cribs/infant beds
Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL

Super 8 by Wyndham Mt. Vernon IL
2.5 star property
Mount Vernon
7.8 out of 10, Good, (1003)
"reception was great, room clean, and the price was right."
United States
tom
The price is ￥9,864
￥11,260 total
includes taxes & fees
Jan 13 - Jan 14, 2026
Super 8 by Wyndham Mt. Vernon IL
Lobby sitting area
Baymont by Wyndham Marion

Baymont by Wyndham Marion

Baymont by Wyndham Marion
2.5 star property
Marion
8.4 out of 10, Very Good, (1082)
"This place was nice for the money and our 1 night stay. "
United States
Charles
The price is ￥11,899
￥14,277 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Baymont by Wyndham Marion
Seasonal outdoor pool, pool umbrellas, sun loungers
Quality Inn & Suites Vandalia near I-70 and Hwy 51

Quality Inn & Suites Vandalia near I-70 and Hwy 51

Quality Inn & Suites Vandalia near I-70 and Hwy 51
2.5 star property
Vandalia
8.4 out of 10, Very Good, (1002)
"Awesome place to stay. Clean room, comfortable bed, amenities were accommodating, plenty of restaurants near by to choose from, and near the highway."
United States
Evelyn
The price is ￥10,381
￥11,313 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Quality Inn & Suites Vandalia near I-70 and Hwy 51
Lobby
Ramada by Wyndham Vandalia

Ramada by Wyndham Vandalia

Ramada by Wyndham Vandalia
2.0 star property
Vandalia
7.8 out of 10, Good, (812)
"Staffing was awesome and helpful. "
United States
Warren
The price is ￥10,647
￥11,603 total
includes taxes & fees
Dec 30 - Dec 31
Ramada by Wyndham Vandalia
Reception
Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites
2.5 star property
Centralia
9.6 out of 10, Exceptional, (608)
"Very beautiful place to stay "
United States
Valerie
The price is ￥18,882
￥21,143 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Best Western Plus Centralia Hotel & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southwest Illinois Hotel Reviews

Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent
"Arrived early on Christmas Day. Promptly greeted by the front desk. Checked in quickly and made it to our room. Very clean and nice suite. Everything worked and the staff was very friendly. "
Glenn 1-night trip
Posted 19 hours ago
Drury Inn & Suites St. Louis O'Fallon, IL

Frequently asked questions

How much do business-friendly hotels in Southwest Illinois cost?
You'll pay between ￥11,260 and ￥21,143 per night for business-friendly hotels in Southwest Illinois. Top deals on stays that cater to work-related travelers are only a click away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Southwest Illinois?
There are multiple business-friendly hotels in Southwest Illinois with a total average guest review rating of 8.7, so you're sure to discover the perfect place. On your way to O'Fallon? Drury Inn & Suites St. Louis O'Fallon, IL is a top pick with corporate travelers. This 3-stars option has amenities like a swimming pool and WiFi. Hampton Inn O'Fallon also scores top marks from business guests. Take advantage of a swimming pool and an electric car charging station at this 2.5-stars escape in O'Fallon.
How many business-friendly hotels are there in Southwest Illinois?
Southwest Illinois has 105 business-friendly hotels to choose from. Whether you're attending a conference or meeting or simply working remotely, these properties are equipped with the amenities you need to keep you comfortable and productive.
What are the best cheap business-friendly hotels in Southwest Illinois?
When you need to make and close deals on the go in Southwest Illinois, Expedia will help you find the perfect business-friendly hotel. Hampton Inn O'Fallon is a popular budget option in O'Fallon. An electric car charging station and a swimming pool are among its many amenities. In search of low-cost stays in Marion? Comfort Inn & Suites Marion I-57 is recommended by many corporate guests. It comes with conveniences that make it easy to both work and relax, including pool sun loungers and a swimming pool. Business-friendly hotels in Southwest Illinois start at just ￥11,260 a night. Like to sightsee around Southwest Illinois without the high admission prices? Take a break from your work commitments to visit awesome free attractions like St. Clair Bowl in O'Fallon. Marion also has many things to do that don't cost a penny, including Williamson County Historical Museum. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Southwest Illinois that are also business friendly?
If you're traveling for business in Southwest Illinois and bringing family along with you, Expedia will help you locate a cozy and convenient stay. Drury Inn & Suites St. Louis O'Fallon, IL in O'Fallon is the perfect option for those combining work and pleasure. This 3-stars property comes with all the necessary amenities, like complimentary breakfast and a laundry service. Drury Inn & Suites St. Louis Fairview Heights is another terrific choice in O'Fallon. Get the best of both worlds — combine corporate travel and quality time with your family at this 3-stars property. Complimentary breakfast and WiFi are among the conveniences you'll find here. Once you've gotten work out of the way, get out and see O'Fallon with the kids. Popular family-friendly attractions include The Edge and St. Clair Bowl.
Why book your business-friendly hotel in Southwest Illinois with Expedia?
At Expedia, our top task is to help you land the ideal stay at the right price. From upmarket, corporate-friendly properties to affordable motels filled with all the amenities you need, you'll have your next work trip arranged in a few simple clicks.
How can I find cheap business-friendly hotels in Southwest Illinois?
When work takes you to Southwest Illinois, our "business friendly" filter will help you find a suitable hotel. From fast WiFi to meeting rooms and workspaces, they come with the amenities you need for a comfortable and productive stay. Another tip? Narrow your search by your budget and preferred star rating to see the cheapest accommodations.
What is there to do in Southwest Illinois near my business-friendly hotel?
Wherever your travels take you in Southwest Illinois, there's plenty to keep you busy. Staying a few days in O'Fallon? The Edge is a top attraction to include on your itinerary.

Explore a world of travel with Expedia