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Aug 31 - Sep 1
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Discover 1,775 Midtown hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Our top choices for Midtown hotels

Drury Inn & Suites St. Louis Collinsville
Lobby

Drury Inn & Suites St. Louis Collinsville

3.0 star property
9.6 out of 10, Exceptional, (1005)
"Great place to stay "
The price is ￥16,321
￥18,766 total
includes taxes & fees
Sep 8 - Sep 9
Drury Inn & Suites St. Louis Collinsville
Drury Plaza Hotel St. Louis St. Charles
Lobby

Drury Plaza Hotel St. Louis St. Charles

3.0 star property
9.6 out of 10, Exceptional, (1019)
"We had a great stay. Would stay here again if we are ever back in St Charles "
The price is ￥16,174
￥18,750 total
includes taxes & fees
Sep 21 - Sep 22
Drury Plaza Hotel St. Louis St. Charles
The Principal Hotel
Exterior

The Principal Hotel

3.5 star property
9.8 out of 10, Exceptional, (125)
"Perfect stay! "
The price is ￥14,931
￥16,571 total
includes taxes & fees
Sep 14 - Sep 15
The Principal Hotel
Element St. Louis Midtown
Courtyard

Element St. Louis Midtown

3.0 star property
9.0 out of 10, Wonderful, (573)
"Loved it thank you for a wonderful week stay"
The price is ￥19,852
￥23,213 total
includes taxes & fees
Sep 15 - Sep 16
Element St. Louis Midtown
Residence Inn by Marriott St Louis Downtown
BBQ/picnic area

Residence Inn by Marriott St Louis Downtown

3.0 star property
8.0 out of 10, Very Good, (1005)
"Breakfast was wonderful, staff is amazing, wonderful stay!!"
The price is ￥16,764
￥19,938 total
includes taxes & fees
Sep 14 - Sep 15
Residence Inn by Marriott St Louis Downtown
Pear Tree Inn St. Louis Arnold
Lobby

Pear Tree Inn St. Louis Arnold

2.5 star property
9.2 out of 10, Wonderful, (1010)
"The staff was super friendly!"
The price is ￥13,233
￥15,296 total
includes taxes & fees
Sep 7 - Sep 8
Pear Tree Inn St. Louis Arnold
Moonrise Hotel
Exterior

Moonrise Hotel

4.0 star property
9.0 out of 10, Wonderful, (1863)
"Great staff, comfy room!"
The price is ￥19,100
￥22,716 total
includes taxes & fees
Sep 8 - Sep 9
Moonrise Hotel
River City Casino & Hotel
Daily cooked-to-order breakfast for a fee

River City Casino & Hotel

4.0 star property
9.0 out of 10, Wonderful, (1348)
"Place was nice and staff was very friendly "
The price is ￥22,056
￥27,838 total
includes taxes & fees
Sep 17 - Sep 18
River City Casino & Hotel
Drury Inn & Suites St. Louis Fairview Heights
1 bedroom, desk, blackout drapes, iron/ironing board

Drury Inn & Suites St. Louis Fairview Heights

3.0 star property
9.2 out of 10, Wonderful, (1012)
"Great stay! "
The price is ￥13,748
￥15,532 total
includes taxes & fees
Sep 11 - Sep 12
Drury Inn & Suites St. Louis Fairview Heights
Super 8 by Wyndham Troy IL/St. Louis Area
Free daily continental breakfast

Super 8 by Wyndham Troy IL/St. Louis Area

2.0 star property
8.0 out of 10, Very Good, (1004)
"Nice place to stay "
The price is ￥9,999
￥11,097 total
includes taxes & fees
Sep 1 - Sep 2
Super 8 by Wyndham Troy IL/St. Louis Area
The Knight Center at Washington University
Pub

The Knight Center at Washington University

2.5 star property
9.4 out of 10, Exceptional, (387)
"Great location and staff!"
The price is ￥22,366
￥25,719 total
includes taxes & fees
Sep 1 - Sep 2
The Knight Center at Washington University
Pear Tree Inn St. Louis Airport
Lobby

Pear Tree Inn St. Louis Airport

2.5 star property
9.4 out of 10, Exceptional, (2690)
"Great place to stay!"
The price is ￥13,233
￥15,578 total
includes taxes & fees
Sep 7 - Sep 8
Pear Tree Inn St. Louis Airport
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Lobby sitting area

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
8.4 out of 10, Very Good, (1009)
"Very good hotel for the price"
The price is ￥13,124
￥15,158 total
includes taxes & fees
Sep 1 - Sep 2
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Drury Plaza Hotel St. Louis at the Arch
Rooftop terrace

Drury Plaza Hotel St. Louis at the Arch

3.0 star property
9.4 out of 10, Exceptional, (3007)
"Great location, great food at reception, wonderful breakfast."
The price is ￥17,645
￥20,632 total
includes taxes & fees
Sep 28 - Sep 29
Drury Plaza Hotel St. Louis at the Arch
Best Western St. Louis-Kirkwood Route 66
Lobby

Best Western St. Louis-Kirkwood Route 66

3.5 star property
8.4 out of 10, Very Good, (1277)
"Good place to stay "
The price is ￥14,490
￥16,952 total
includes taxes & fees
Sep 4 - Sep 5
Best Western St. Louis-Kirkwood Route 66
Hyatt Regency St. Louis at The Arch
Lobby

Hyatt Regency St. Louis at The Arch

4.0 star property
8.4 out of 10, Very Good, (4011)
"Great hotel"
The price is ￥19,852
￥23,411 total
includes taxes & fees
Sep 1 - Sep 2
Hyatt Regency St. Louis at The Arch
The Cheshire
Terrace/patio

The Cheshire

4.0 star property
8.6 out of 10, Excellent, (1006)
"Great place to stay!"
The price is ￥19,705
￥23,397 total
includes taxes & fees
Sep 3 - Sep 4
The Cheshire
Casino Queen Hotel
Lobby

Casino Queen Hotel

3.0 star property
7.8 out of 10, Good, (1914)
"Staff were so nice !! Perfect for our overnight for the game . Free shuttle was clutch too! "
The price is ￥12,374
￥14,351 total
includes taxes & fees
Sep 8 - Sep 9
Casino Queen Hotel
Super 8 by Wyndham Waterloo
Lobby

Super 8 by Wyndham Waterloo

2.0 star property
7.6 out of 10, Good, (359)
"Overall good experience, clean, affordable and the staff was ver accommodating . The breakfast bar could use some upgrades."
The price is ￥11,249
￥12,484 total
includes taxes & fees
Sep 1 - Sep 2
Super 8 by Wyndham Waterloo
Comfort Inn & Suites
Suite, 2 Queen Beds, Non Smoking | Premium bedding, desk, soundproofing, iron/ironing board

Comfort Inn & Suites

2.5 star property
8.2 out of 10, Very Good, (223)
"Overall great stay. Clean and spacious room."
The price is ￥15,087
￥17,641 total
includes taxes & fees
Sep 3 - Sep 4
Comfort Inn & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Midtown

Find the best Midtown areas and neighborhoods for the activities you enjoy most.
Meeting of the Waters Fountain showing a statue or sculpture and a fountain

Downtown St. Louis

2 out of top 10 points of interest in this area

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

Clayton

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

Central West End

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Saint Louis Abbey while you're in town.

St. Louis which includes interior views

Downtown West

1 out of top 10 points of interest in this area

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

Top Midtown Hotel Reviews

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

What is Midtown like?

Travelers are sure to enjoy a stay in St. Louis's Midtown neighborhood. Be sure to check out Chaifetz Arena and Washington Avenue Historic District as part of your Midtown travel plans.

Where is the best place to stay in Midtown?

Based on Expedia customer reviews, Element St. Louis Midtown is the highest ranked property in Midtown. This hotel is a short 6-minute walk from St. Louis University, and it offers free breakfast and an indoor pool. Another top choice in the area is Residence Inn by Marriott St Louis Downtown.

How many hotels will I be able to find in the Midtown area?

If you're searching for places to stay in St. Louis, Expedia has something to meet your needs with 26 Midtown hotels and other accommodations to choose from.

If I need to cancel my hotel reservation in Midtown, will I receive a refund?

Yes, most hotel bookings are fully refundable if cancelled prior to the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to cancel it and get a refund within 24 hours of booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best options available in Midtown.

Where can I learn more about changing or cancelling my trip to Midtown?

To access more information about picking new dates or cancelling your trip to Midtown, go to https://www.expedia.com/service/.

What are the top things to see and do in Midtown?

Explore Midtown's landmarks like Washington Avenue Historic District, Samuel Cupples House, and Scott Joplin House State Historic Site and learn about the local history. Chaifetz Arena and Topgolf are also a couple of places to visit in the neighborhood. Favorite places to visit in the surrounding area include St. Louis Union Station, Busch Stadium, and Gateway Arch. While you're out sightseeing, .ZACK Theater and The MOTO Museum are a couple of additional sights to visit in St. Louis.

How can I get around Midtown and the greater St. Louis area?

Ready to get out and explore the city? Grand Station is the closest metro station.