Find Business Hotels in Downtown San Diego, CA

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Check availability on Downtown San Diego Business Hotels

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Our top choices for Downtown San Diego business-friendly hotels

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
3.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (1240)
"Clean, courteous staff, good location. "
United States
Carla
The price is ¥15,500
¥17,971 total
includes taxes & fees
Dec 29 - Dec 30
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina
4.0 star property
Mission Bay
8.4 out of 10, Very Good, (1583)
"Totally Recommend! Rooms are really clean and comfortable, the staff are great as well. "
United States
Fernando
The price is ¥18,882
¥29,987 total
includes taxes & fees
Jan 10 - Jan 11, 2026
Hyatt Regency Mission Bay Spa and Marina

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (2880)
"Everything was great and so convenient to everywhere we wanted to go to"
United States
Julio J
The price is ¥27,556
¥40,480 total
includes taxes & fees
Dec 29 - Dec 30
Manchester Grand Hyatt San Diego

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Downtown San Diego
9.2 out of 10, Wonderful, (1959)
"Best place to stay with family in San diego"
United States
vishakha
The price is ¥27,400
¥39,999 total
includes taxes & fees
Jan 3 - Jan 4, 2026
Marriott Marquis San Diego Marina

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
Downtown San Diego
8.4 out of 10, Very Good, (6039)
"Always an amazing stay"
United States
Jana
The price is ¥21,160
¥29,076 total
includes taxes & fees
Dec 30 - Dec 31
Wyndham San Diego Bayside

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection
3.0 star property
Downtown San Diego
8.8 out of 10, Excellent, (804)
"would stay again and recommend "
United States
Brendi
The price is ¥16,283
¥18,879 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The DEXTRO Little Italy, BW Premier Collection

Hilton San Diego Bayfront

Hilton San Diego Bayfront
4.0 star property
Downtown San Diego
8.6 out of 10, Excellent, (1895)
"Enjoyed my stay"
United States
Brandon
The price is ¥18,807
¥29,481 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Hilton San Diego Bayfront

San Diego Marriott Gaslamp Quarter

San Diego Marriott Gaslamp Quarter
4.0 star property
Downtown San Diego
8.8 out of 10, Excellent, (1608)
"Very friendly staff!"
United States
kelli
The price is ¥21,160
¥24,533 total
includes taxes & fees
Jan 4 - Jan 5, 2026
San Diego Marriott Gaslamp Quarter

Hampton Inn San Diego-Downtown

Hampton Inn San Diego-Downtown
2.5 star property
Downtown San Diego
8.2 out of 10, Very Good, (2309)
"Nice and convenient place to stay!"
United States
Esperanza
The price is ¥15,656
¥18,151 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Hampton Inn San Diego-Downtown

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay
8.4 out of 10, Very Good, (1314)
"Room was super clean and updated, location up against the bay was perfect. We really enjoyed our stay and want to come back soon!"
United States
Haley
The price is ¥22,148
¥32,517 total
includes taxes & fees
Jan 1 - Jan 2, 2026
San Diego Mission Bay Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Price trends for hotels in Downtown San Diego

Less expensive
More expensive
Next month
January
October
¥26,268
Month
Price
January
¥26,268
February
¥42,005
March
¥37,079
April
¥44,221
May
¥43,903
June
¥47,821
July
¥50,831
August
¥45,128
September
¥48,482
October
¥55,623
November
¥40,097
December
¥27,243
Price trend information excludes taxes and fees and is based on base rates for a nightly stay for 2 adults found in the last 7 days on our site and averaged for commonly viewed hotels in Downtown San Diego.

Top Downtown San Diego Hotel Reviews

Frequently asked questions

Why book your business-friendly hotel in Downtown San Diego with Expedia?
Expedia is here to help you find a fantastic business-friendly hotel when work takes you out of town. From free parking and WiFi to on-site restaurants and cafés, our stays come with all you'll need to settle that big contract.
How can I find cheap business-friendly hotels in Downtown San Diego?
Expedia can help you easily find cheap business-friendly hotels in Downtown San Diego. Head to our "traveler experience" filter and click on "business friendly." This will show you stays with amenities designed to help you work and rest comfortably, like free WiFi and included breakfast. You can also choose your budget and hotel star rating to keep costs down.

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