Find Boutique Hotels in Little Italy, CA

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Little Italy Boutique Hotels

Our top choices for Little Italy boutique hotels

Lobby
Hotel Republic San Diego, Autograph Collection

Hotel Republic San Diego, Autograph Collection

Hotel Republic San Diego, Autograph Collection
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (1184)
"Amazing stay "
United States
Aaron
The price is ￥19,896
￥30,298 total
includes taxes & fees
Dec 28 - Dec 29
Hotel Republic San Diego, Autograph Collection
Junior Suite, 2 Queen Beds, Ocean View | Hypo-allergenic bedding, in-room safe, desk, iron/ironing board
Pacific Terrace Hotel

Pacific Terrace Hotel

Pacific Terrace Hotel
4.0 star property
Pacific Beach
9.6 out of 10, Exceptional, (1005)
"Amazing location and staff"
United States
Travis
The price is ￥28,233
￥32,455 total
includes taxes & fees
Jan 12 - Jan 13, 2026
Pacific Terrace Hotel
Lobby lounge
The Bristol Hotel San Diego

The Bristol Hotel San Diego

The Bristol Hotel San Diego
3.5 star property
Downtown San Diego
8.6 out of 10, Excellent, (1448)
"So clean, Very Nice staff, convenient location ! "
United States
Cindy
The Bristol Hotel San Diego
Front of property
The Pearl Hotel

The Pearl Hotel

The Pearl Hotel
4.0 star property
Point Loma
8.6 out of 10, Excellent, (1005)
"Lovely spot would stay again "
United States
danixa
The price is ￥21,411
￥24,182 total
includes taxes & fees
Jan 4 - Jan 5, 2026
The Pearl Hotel
Presidential Suite, 2 Bedrooms | Living room | 36-inch LCD TV with digital channels, TV, pay movies
Alma San Diego Downtown, a Tribute Portfolio Hotel

Alma San Diego Downtown, a Tribute Portfolio Hotel

Alma San Diego Downtown, a Tribute Portfolio Hotel
4.0 star property
Downtown San Diego
9.0 out of 10, Wonderful, (870)
"Staff was amazing. Room was really nice and the view was PERFECT."
United States
Porscha
The price is ￥16,793
￥25,781 total
includes taxes & fees
Dec 29 - Dec 30
Alma San Diego Downtown, a Tribute Portfolio Hotel
Interior entrance
Westgate Hotel

Westgate Hotel

Westgate Hotel
4.5 star property
Downtown San Diego
9.0 out of 10, Wonderful, (1006)
"Everything about the Hotel including staff was fantastic"
Canada
Donna
Westgate Hotel
Exterior
Hotel Indigo San Diego-Gaslamp Quarter by IHG

Hotel Indigo San Diego-Gaslamp Quarter by IHG

Hotel Indigo San Diego-Gaslamp Quarter by IHG
4.0 star property
Downtown San Diego
8.8 out of 10, Excellent, (1004)
"Large, comfy room, good service, good location"
United States
Thanapong
The price is ￥20,991
￥30,107 total
includes taxes & fees
Dec 16 - Dec 17
Hotel Indigo San Diego-Gaslamp Quarter by IHG
Exterior
Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
Chula Vista
8.6 out of 10, Excellent, (1316)
"Great value and location "
United States
Andrew
The price is ￥13,078
￥14,411 total
includes taxes & fees
Dec 15 - Dec 16
Hercor Hotel - Urban Boutique
Exterior
Tower23 Hotel

Tower23 Hotel

Tower23 Hotel
4.0 star property
Pacific Beach
9.6 out of 10, Exceptional, (1002)
"Great hotel!!"
Canada
RYAN
The price is ￥35,607
￥40,217 total
includes taxes & fees
Dec 16 - Dec 17
Tower23 Hotel
Exterior
Scripps Inn La Jolla Cove

Scripps Inn La Jolla Cove

Scripps Inn La Jolla Cove
3.5 star property
Village of La Jolla
9.2 out of 10, Wonderful, (913)
"The room was great and had a great view of the ocean. "
United States
Christine
Scripps Inn La Jolla Cove
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Little Italy Hotel Reviews

Bay Club Hotel & Marina

Bay Club Hotel & Marina

10/10 Excellent
"ROOM WAS FANTASTIC LOCATION WA GREAT STAFF WAS IMPECCABLE "
Stephanie 1-night trip
Posted 2 days ago
Bay Club Hotel & Marina

Explore a world of travel with Expedia

Frequently asked questions

What's there to see and do in Little Italy?
The shopping, art, and restaurants are just some of the things to enjoy while you're in the area. While you're out and about in Little Italy, popular attractions like San Diego Zoo, Port of San Diego, and Petco Park are worth a visit. You might also want to see noteworthy spots like Mission Bay, Mission Beach, and San Ysidro Border Crossing during your trip.
What's the best way to get to my boutique hotel in Little Italy?
You have a few options for traveling to and around Little Italy. The nearest major airport is San Diego Intl. Airport (SAN), which is located 1.7 mi (2.7 km) away, but San Diego, CA (MYF-Montgomery Field) may also be an option. Head to County Center - Little Italy Station for metro transit.