Missouri Resorts & Hotels with Spas from ￥11,697

A city square with a fountain, modern buildings, and a historic tower.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Top Cities in Missouri

A cityscape with a prominent historic building featuring arched entrances and a large central dome, surrounded by modern skyscrapers and a well-maintained park with a fountain.

Check availability on Missouri Resorts & Hotels with Spas

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Missouri hotels with a spa

Couples treatment rooms, hot tub, body treatments, hydrotherapy

1. The Elms Hotel & Spa, a Destination by Hyatt Hotel

Excelsior Springs

Immerse in a rejuvenating spa retreat with 17 treatment rooms, hot tubs, and beautiful garden views at this historic hotel.

￥31,615 total

includes taxes & fees

Sep 30 - Oct 1

Couples treatment rooms, body treatments, hydrotherapy, aromatherapy

2. Camden on the Lake Resort & Spa

Lake Ozark

Relax at this lakeside resort with four treatment rooms at Spa 54, featuring hot stone massages, hydrotherapy, and couples' services.

￥24,536 total

includes taxes & fees

Sep 7 - Sep 8

Couples treatment rooms, hot tub, body treatments, aromatherapy

3. Four Seasons Hotel St Louis

Downtown St. Louis

Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.

￥70,066 total

includes taxes & fees

Sep 3 - Sep 4

4. Margaritaville Lake Resort Lake of the Ozarks

Osage Beach

Lakeside spa resort with golf course offers rejuvenating massages, body treatments, and poolside relaxation.

￥27,814 total

includes taxes & fees

Sep 30 - Oct 1

5. Embassy Suites by Hilton St. Louis St. Charles

St. Charles

￥25,450 total

includes taxes & fees

Sep 27 - Sep 28

6. Drury Plaza Hotel St. Louis at the Arch

Downtown St. Louis

￥28,585 total

includes taxes & fees

Sep 5 - Sep 6

7. Hyatt Regency St. Louis at The Arch

Downtown St. Louis

￥25,271 total

includes taxes & fees

Sep 4 - Sep 5

8. Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Clayton

￥24,528 total

includes taxes & fees

Sep 13 - Sep 14

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Top Missouri Hotel Reviews

Westgate Branson Woods Resort and Cabins

8/10 Good

"King size bed was comfortable with plenty of room around it. Walk-in shower was a plus. The area was pleasant without a lot of activity. Check-in was quick and easy."

Lodge Of The Ozarks

10/10 Excellent

"This property has many advantages: on the main drag (walking distance from White Water park, go-karts, Ferris wheel, mini-golf, theaters and museums, year-round indoor pool, breakfast (even with a buffet - quality is average, but it is abundant and more diversified than just continental breakfast), giant building size (originally intended/ used for conferences), decent-sized rooms, good rates. It pretty much checks all the boxes and provides the most value for your money. Highly recommend!"

Loews Kansas City Hotel

10/10 Excellent

"My wife Lina and I stayed at the Loews Kansas City Hotel during our trip to catch a Royals game at Kauffman Stadium, and it was a flawless experience. The location is absolutely great, serving as the perfect home base for exploring the city, including our night out at the Green Lady Lounge. Every aspect of the hospitality was top-notch. The staff was extremely helpful from the moment we arrived, making check-in effortless. Our room was extremely clean, well-maintained, and incredibly comfortable. The on-site dining and drinks were a major highlight. The sports bar area is fantastic, featuring exposed silver ventilation pipes and vibrant blue ambient lighting that gives it a lively, modern energy—making it an ideal spot to grab a drink, socialize, and watch a game. Just steps away, the lobby bar serves as a stunning architectural centerpiece, featuring towering, illuminated circular liquor displays that create a sophisticated, luxurious environment. Relaxing on the comfortable leather sofas there with a glass of Malbec was the absolute perfect way to wind down. The food was excellent across the board. I cannot find a single thing wrong with this hotel. It is definitely one of the best franchise hotels I have ever stayed at, and we will absolutely be going back."

Explore a world of travel with Expedia

More ways to book

Book Resorts & Hotels with Spas in Missouri on Expedia.com

Room 1

Change your mind

Treat yourself

Be picky

Top Cities in Missouri

Kansas City

Check availability on Missouri Resorts & Hotels with Spas

Our top choices for Missouri hotels with a spa

1. The Elms Hotel & Spa, a Destination by Hyatt Hotel

2. Camden on the Lake Resort & Spa

3. Four Seasons Hotel St Louis

4. Margaritaville Lake Resort Lake of the Ozarks

5. Embassy Suites by Hilton St. Louis St. Charles

6. Drury Plaza Hotel St. Louis at the Arch

7. Hyatt Regency St. Louis at The Arch

8. Hampton Inn & Suites Clayton/St. Louis-Galleria Area

9. Drury Inn & Suites St. Louis Arnold

10. Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Top Missouri Hotel Reviews

Westgate Branson Woods Resort and Cabins

Orangewood Inn & Suites Kansas City Airport

Drury Plaza Hotel St. Louis at the Arch

Hyatt Regency St. Louis at The Arch

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Renaissance St. Louis Airport Hotel

Lodge Of The Ozarks

Chateau On The Lake Resort Spa and Convention Center

Loews Kansas City Hotel

Explore a world of travel with Expedia

Resorts & Hotels with Spas in Missouri from ￥11,697

Change your mind

Treat yourself

Be picky

Top Cities in Missouri

Kansas City

Check availability on Missouri Resorts & Hotels with Spas

Our top choices for Missouri hotels with a spa

1. The Elms Hotel & Spa, a Destination by Hyatt Hotel

2. Camden on the Lake Resort & Spa

3. Four Seasons Hotel St Louis

4. Margaritaville Lake Resort Lake of the Ozarks

5. Embassy Suites by Hilton St. Louis St. Charles

6. Drury Plaza Hotel St. Louis at the Arch

7. Hyatt Regency St. Louis at The Arch

8. Hampton Inn & Suites Clayton/St. Louis-Galleria Area

9. Drury Inn & Suites St. Louis Arnold

10. Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Top Missouri Hotel Reviews

Westgate Branson Woods Resort and Cabins

Explore a world of travel with Expedia