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Find Resorts & Hotels with Spas in St. Charles, MO

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Check availability on St. Charles Resorts & Hotels with Spas

Tonight
Oct 22 - Oct 23
Tomorrow
Oct 23 - Oct 24
This weekend
Oct 23 - Oct 25
Next weekend
Oct 30 - Nov 1

Our top choices for St. Charles hotels with a spa

A modern spa with a curved reception desk, a large mirror, and a decorative water feature.
An indoor swimming pool with clear glass walls, metal railings, and a tiled floor.
A modern tavern with a large sign, glass doors, and indoor seating visible through the windows.
A bakery display case with various pastries and cakes.

1. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
St. Charles
  • Riverside wellness oasis offers full-service spa with aromatherapy and hydrotherapy for a restorative retreat.
￥20,647
￥26,751 total
includes taxes & fees
Nov 22 - Nov 23
Ameristar Casino Resort and Spa
A reception desk with a wooden finish and the name "IDOL WOLF" on it.
A reception area with a curved wooden desk, a laptop, and a chair. The wall has a sign reading "Locust Street Athletic and Swim Club."
A spacious lobby with a large spherical sculpture, a seating area, and a view of the outside through a large window.
A modern bathroom with a bathtub, a vanity with a mirror, and a shower area.

2. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
Downtown West
  • Discover spa services, a steam room, and an Olympic-sized indoor pool at this modern hotel, all designed for rejuvenating getaways.
￥22,721
￥27,359 total
includes taxes & fees
Nov 15 - Nov 16
21C Museum Hotel St Louis
A couple relaxing by a window overlooking a bridge and water.
A room with large windows overlooking a bridge and water, featuring wooden chairs and a small table.
A modern dining area with a long table set for a meal, large windows offering a view of a bridge, and a stone accent wall.
A modern hotel lobby with a glass facade, seating area, and a staircase.

3. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
Downtown St. Louis
  • Discover a tranquil haven with 12 treatment rooms, outdoor pool, and breathtaking views at this rejuvenating spa retreat.
￥58,774
￥68,724 total
includes taxes & fees
Nov 3 - Nov 4
Four Seasons Hotel St Louis
A modern kitchen with wooden cabinets, a central island, and framed artwork on the walls.
An indoor dining area with a long table, chairs, hanging plants, and a view of a brick building through large windows.
A bar area with leather seating, a bar counter, and shelves of bottles.
An outdoor seating area with modern furniture, a bar, and large windows offering views of a cityscape.

4. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
Clayton
  • Revel in a rejuvenating spa retreat with aromatherapy treatments and hot stone massages at this luxury St. Louis hotel.
￥91,580
￥106,908 total
includes taxes & fees
Nov 1 - Nov 2
The Ritz-Carlton, St. Louis
A bathroom with a white sink, dark wooden door, and a shower area with striped glass walls.
A room with a fireplace, curtains, a woven basket, and a chair.
A room with a green armchair, a round table, a lamp, and a mirror on the wall.
A neatly made bed with white bedding and a green pillow, a small box with a black ribbon, and a brown blanket partially visible.

5. Truitt Hotel

Truitt Hotel
Lafayette Square
￥26,573
￥32,257 total
includes taxes & fees
Oct 25 - Oct 26
Truitt Hotel
View all properties

Choose what matters most at spa hotels in St. Charles

Pool
Hot tub
Breakfast included
4 stars
5 stars

Top St. Charles Hotel Reviews

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent
"I have stayed here several times-great location!"
Jessica 2-night trip
Posted less than an hour ago
Country Inn & Suites by Radisson, St. Charles Historic District
Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station

10/10 Excellent
"Great location, friendly staff. Well maintained and clean."
Matt 1-night trip
Posted less than an hour ago
Drury Plaza Hotel St. Louis Union Station
Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles

10/10 Excellent
"just a. overnight stop & was great"
Angela 1-night trip
Posted 1 hour ago
Drury Plaza Hotel St. Louis St. Charles
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

10/10 Excellent
"The hotel was in a great location close to restaurants and shopping, and seemed like a very safe area. The beds were very comfortable!"
Teresa 3-night trip
Posted 4 hours ago
Hampton Inn St. Charles St. Peters
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

10/10 Excellent
"We have stayed here a few times, staff is top notch. Front desk and support staff are always helpful and polite. Motel is clean and quiet, breakfast is very good."
Jennifer 1-night trip
Posted 9 hours ago
Pear Tree Inn St. Louis Near Union Station
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

8/10 Good
"Breakfast is awesome and definitely worth it. However, this hotel is very outdated, very chopped up floor plan and would definitely be elevated by a remodel."
Stephanie 3-night trip
Posted 9 hours ago
Clayton Plaza Hotel & Extended Stay

Frequently asked questions

Looking for a spa hotel in St. Charles?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travelers highly recommend the restaurants in St. Charles. Enjoy the historical sites and riverfront during your vacation. Hotels with spas are a great way to break away from your daily routine and add a layer of luxury to your vacation.
What is the best spa hotel in St. Charles?
Ameristar Casino Resort and Spa is a top luxury spa hotel featuring 6 restaurants, a casino, a 24-hour fitness center, and an outdoor pool. Treat yourself to a facial, body scrub, or hydrotherapy at Ara.
How many spa hotels will I find in St. Charles?
Among Expedia's 178 accommodation options in St. Charles, there is 1 spa hotel.
What's there to see and do in St. Charles?
Experience all that St. Charles has to offer when you visit Historic Main Street, Katy Trail, and Lewis & Clark Boathouse and Nature Center. If you have some spare time during your trip, you might want to check out St Charles Convention Center and Ameristar Casino St. Charles.
What is a St. Charles spa hotel?
Spa hotels in St. Charles provide lodging and have an on-site spa which offers services like couples massages as well as body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.

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