A calm body of water, a sandy beach, and a forested area in the distance.

Find Resorts & Hotels with Spas in Cape Girardeau, MO

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Check availability on Cape Girardeau Resorts & Hotels with Spas

Tonight
Aug 9 - Aug 10
Tomorrow
Aug 10 - Aug 11
Next weekend
Aug 14 - Aug 16
In two weeks
Aug 21 - Aug 23

Our top choices for Cape Girardeau hotels with a spa

Exterior
Exterior
Indoor pool, open 8 AM to 11 PM, sun loungers
Suite, 1 Bedroom (Feature) | Premium bedding, down comforters, pillowtop beds, in-room safe

1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
  • Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
￥16,249
￥18,330 total
includes taxes & fees
Sep 6 - Sep 7
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
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Choose what matters most at spa hotels in Cape Girardeau

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Cape Girardeau Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Friendly staff, clean room. Great food. Highly recommend this hotel."
Sareh 4-night trip
Posted 6 hours ago
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Everything was awesome, highly recommended this hotel"
Meredith 2-night trip
Posted 1 day ago
Drury Inn & Suites Cape Girardeau

Frequently asked questions

Looking for a spa hotel in Cape Girardeau?
Treat yourself to some pampering and book a hotel with a spa. Travelers recommend the gourmet restaurants in Cape Girardeau. Enjoy the historical sites and riverfront during your vacation. Hotels with spas are a great way to break away from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Cape Girardeau?
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is a top spa hotel featuring a pool and a fitness center.
How many spa hotels will I find in Cape Girardeau?
Among Expedia's 67 accommodation options in Cape Girardeau, there is 1 spa hotel.
What's there to see and do in Cape Girardeau?
Experience all that Cape Girardeau has to offer when you visit Century Casino & Hotel Cape Girardeau, Cape Splash Family Aquatic Center, and Trail of Tears State Park. If you have a bit of extra time while you're in the area, you might want to check out Shawnee National Forest and Mississippi River.
What is a Cape Girardeau spa hotel?
Spa hotels in Cape Girardeau have full on-site spas offering services such as massages and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation, and relaxation.

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