Photo by Alice Burghart

Find Resorts & Hotels with Spas in Cape Girardeau, MO

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Cape Girardeau Resorts & Hotels with Spas

Tonight
Dec 6 - Dec 7
Tomorrow
Dec 7 - Dec 8
Next weekend
Dec 12 - Dec 14
In two weeks
Dec 19 - Dec 21

Top Cape Girardeau Resorts & Hotels with Spas

Exterior
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1002)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is ￥15,378
￥17,349 total
includes taxes & fees
Dec 14 - Dec 15
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Cape Girardeau Hotel Reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"I do love this hotel chain. Another great visit!"
Mark 1-night trip
Posted 5 days ago
Drury Inn & Suites Cape Girardeau
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Great "
Megan 1-night trip
Posted 6 days ago
Drury Plaza Hotel Cape Girardeau Conference Center

Explore a world of travel with Expedia

Frequently asked questions

Looking for a spa hotel in Cape Girardeau?
Treat yourself to some pampering and book a hotel with a spa. Travelers recommend the gourmet restaurants in Cape Girardeau. Enjoy the historical sites and riverfront during your vacation. Hotels with spas are a great way to break away from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Cape Girardeau?
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is a top spa hotel featuring a pool and a fitness center.
How many spa hotels will I find in Cape Girardeau?
Among Expedia's 57 accommodation options in Cape Girardeau, there is 1 spa hotel.
What's there to see and do in Cape Girardeau?
Experience all that Cape Girardeau has to offer when you visit Isle Casino Cape Girardeau, Show Me Center, and Cape Splash Family Aquatic Center. If you have a bit of extra time while you're in the area, you might want to check out Hunter Valley Winery and Trail of Tears State Park.
What is a Cape Girardeau spa hotel?
Spa hotels in Cape Girardeau have full on-site spas offering services such as massages and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation, and relaxation.