A calm body of water, a sandy beach, and a forested area in the distance.

Find Resorts & Hotels with Spas in Cape Girardeau, MO

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Check availability on Cape Girardeau Resorts & Hotels with Spas

Tonight
Sep 26 - Sep 27
Tomorrow
Sep 27 - Sep 28
Next weekend
Oct 2 - Oct 4
In two weeks
Oct 9 - Oct 11

Our top choices for Cape Girardeau hotels with a spa

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
  • Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
￥15,885
￥18,079 total
includes taxes & fees
Oct 4 - Oct 5
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
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Choose what matters most at spa hotels in Cape Girardeau

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Cape Girardeau Hotel Reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Great hotel, had zero issues and staff was lovely"
Kegan 3-night trip
Posted 5 days ago
Drury Inn & Suites Cape Girardeau

Frequently asked questions

Looking for a spa hotel in Cape Girardeau?
Treat yourself to some pampering and book a hotel with a spa. Travelers recommend the gourmet restaurants in Cape Girardeau. Enjoy the historical sites and riverfront during your vacation. Hotels with spas are a great way to break away from your routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Cape Girardeau?
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is a top spa hotel featuring a pool and a fitness center.
How many spa hotels will I find in Cape Girardeau?
Among Expedia's 69 accommodation options in Cape Girardeau, there is 1 spa hotel.
What's there to see and do in Cape Girardeau?
Experience all that Cape Girardeau has to offer when you visit Century Casino & Hotel Cape Girardeau, Show Me Center, and Hunter Valley Winery. If you have a bit of extra time while you're in the area, you might want to check out Trail of Tears State Park and Shawnee National Forest.
What is a Cape Girardeau spa hotel?
Spa hotels in Cape Girardeau have full on-site spas offering services such as massages and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation, and relaxation.

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