Find Business Hotels in South Carolina Midlands, SC

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Check availability on South Carolina Midlands Business Hotels

Tonight
Dec 20 - Dec 21
Tomorrow
Dec 21 - Dec 22
Next weekend
Dec 26 - Dec 28
In two weeks
Jan 2 - Jan 4

Our top choices for South Carolina Midlands business-friendly hotels

Lobby
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area
2.5 star property
Florence
9.2 out of 10, Wonderful, (1170)
"Enjoyed our stay there. "
United States
Cathy
The price is ￥15,286
￥17,118 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Comfort Inn & Suites Florence Center Area
Exterior
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC
2.5 star property
Florence
9.0 out of 10, Wonderful, (2195)
"Breakfast was great, room very clean ."
United States
Leann
The price is ￥13,164
￥14,743 total
includes taxes & fees
Dec 23 - Dec 24
Park Inn by Radisson Florence, SC
Free daily full breakfast
La Quinta Inn by Wyndham Columbia SE / Fort Jackson

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

La Quinta Inn by Wyndham Columbia SE / Fort Jackson
3.0 star property
Columbia
7.6 out of 10, Good, (1006)
"Great breakfast and great staff"
United States
Jean
The price is ￥10,995
￥12,314 total
includes taxes & fees
Dec 21 - Dec 22
La Quinta Inn by Wyndham Columbia SE / Fort Jackson
Front of property - evening/night
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown
3.0 star property
Florence
8.8 out of 10, Excellent, (1006)
"Very nice but pricey Lots of eats nearby"
United States
Raymond
The price is ￥15,775
￥17,670 total
includes taxes & fees
Jan 5 - Jan 6, 2026
Hyatt Place Florence Downtown
Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi
Baymont by Wyndham Santee

Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1418)
"Very friendly staff. "
United States
Ramil
The price is ￥12,446
￥13,815 total
includes taxes & fees
Jan 20 - Jan 21, 2026
Baymont by Wyndham Santee
Exterior
Tru By Hilton Columbia Greystone

Tru By Hilton Columbia Greystone

Tru By Hilton Columbia Greystone
2.5 star property
Columbia
9.2 out of 10, Wonderful, (1005)
"Nice place to stay"
United States
Beth
The price is ￥15,393
￥17,548 total
includes taxes & fees
Dec 27 - Dec 28
Tru By Hilton Columbia Greystone
Breakfast and dinner served, American cuisine
Cambria Hotel Columbia Downtown The Vista

Cambria Hotel Columbia Downtown The Vista

Cambria Hotel Columbia Downtown The Vista
3.5 star property
Downtown Columbia
9.4 out of 10, Exceptional, (1147)
"Awesome accommodation "
United States
Sheryl
The price is ￥16,280
￥18,232 total
includes taxes & fees
Dec 27 - Dec 28
Cambria Hotel Columbia Downtown The Vista
Free daily buffet breakfast
Hampton Inn & Suites Lexington Columbia

Hampton Inn & Suites Lexington Columbia

Hampton Inn & Suites Lexington Columbia
2.5 star property
Lexington
9.8 out of 10, Exceptional, (595)
"Clean and comfortable room, friendly staff, great location."
United States
Allison
The price is ￥15,652
￥17,373 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Hampton Inn & Suites Lexington Columbia
Free continental breakfast
Holiday Inn Express & Suites Newberry by IHG

Holiday Inn Express & Suites Newberry by IHG

Holiday Inn Express & Suites Newberry by IHG
2.5 star property
Newberry
9.0 out of 10, Wonderful, (633)
"Room was clean staff was great !"
United States
R Scott
The price is ￥13,409
￥14,481 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Holiday Inn Express & Suites Newberry by IHG
Lobby
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence
2.0 star property
Florence
8.6 out of 10, Excellent, (2506)
"I nice place to stay, very quiet, good breakfast, nice staff, spotless room. "
United States
Timothy
The price is ￥9,662
￥10,821 total
includes taxes & fees
Dec 23 - Dec 24
Howard Johnson by Wyndham Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top South Carolina Midlands Hotel Reviews

Graduate by Hilton Columbia SC

Graduate by Hilton Columbia SC

10/10 Excellent
"Everything was awsome! My daughter had an exam early so we drove up the night before and it made everything perfect."
Jennifer 1-night trip
Posted 2 days ago
Graduate by Hilton Columbia SC

Frequently asked questions

How much do business-friendly hotels in South Carolina Midlands cost?
You can expect to pay between ￥10,821 and ￥18,232 per night for business-friendly hotels in South Carolina Midlands. Epic deals on stays that cater to work-related guests are a few clicks away on Expedia. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in South Carolina Midlands?
There are multiple business-friendly hotels in South Carolina Midlands with a total average guest review rating of 8.8, so you're sure to discover a place that suits your needs. Basing yourself in Columbia? Staybridge Suites Columbia, an IHG Hotel is popular with corporate travelers. This 3-stars option offers conveniences like a barbecue grill and a swimming pool. Hampton Inn Columbia I-26/Harbison Blvd. also scores top marks from business guests. Take advantage of complimentary use of a nearby fitness center and a swimming pool at this 2.5-stars property in Columbia.
How many business-friendly hotels are there in South Carolina Midlands?
When your next meeting or networking event takes you someplace in South Carolina Midlands, you'll have 268 business-friendly hotels to choose from.
What are the best cheap business-friendly hotels in South Carolina Midlands?
That depends on where in South Carolina Midlands your journey is taking you. If your destination is Columbia, Hampton Inn Columbia I-26/Harbison Blvd. meets the needs of business travelers at an affordable price. A terrace and pool sun loungers are among its many conveniences. On your way to Florence? Consider staying at Hampton Inn & Suites Florence Center. A swimming pool and WiFi help make this cheaper property a top choice for corporate guests. Business-friendly hotels start from ￥10,821 a night, so your next work trip doesn't have to cost a lot. Want to see the sights of South Carolina Midlands without the high admission prices? Take time out from your business commitments to visit free attractions like Trinity Episcopal Cathedral in Columbia. Florence also has plenty of things to do that don't cost anything, including Florence Museum. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the top business-friendly motels in South Carolina Midlands?
If your South Carolina Midlands business visit includes Columbia, check in to Days Inn by Wyndham Columbia. Around 6 kilometers northwest of the downtown area and offering a swimming pool and a terrace, it's popular with corporate guests. Alternatively, work comfortably from America's Best Inn Columbia. A balcony and front desk services are among the conveniences at this property, located around 6 kilometers northwest of the center of Columbia.There's no shortage of things to keep you entertained during your downtime in Columbia. Riverbanks Zoo and Garden and Township Auditorium should be on your travel itinerary.
Are there any family-friendly hotels in South Carolina Midlands that are also business friendly?
If you're traveling for business in South Carolina Midlands and bringing family along with you, Expedia will help you find a cozy and convenient stay. Hampton Inn Columbia I-26/Harbison Blvd. in Columbia is the perfect option for those juggling work and pleasure. This 2.5-stars hotel offers all the amenities you need, like a playground and complimentary breakfast. Holiday Inn Columbia - Downtown, an IHG Hotel is another good choice in Columbia. You'll be able to combine corporate travel and quality time with your family at this 3-stars property. Laundry facilities and housekeeping services are among the numerous conveniences here. There are plenty of exciting things to do with your little travelers in Columbia. Riverbanks Zoo and Garden and South Carolina State Museum offer a memorable day out.
Why book your business-friendly hotel in South Carolina Midlands with Expedia?
Expedia is here to help you find a fabulous business-friendly hotel when work takes you out of town. From free WiFi and parking to on-site cafés and restaurants, our stays have the things you need to get the job done.
How can I find cheap business-friendly hotels in South Carolina Midlands?
Expedia can help you narrow down your search for cheap business-friendly hotels in South Carolina Midlands. Simply go to the "traveler experience" filter and click on "business friendly." This will show you stays with amenities designed to help you work effectively and comfortably, like free WiFi and included breakfast. You can also choose your preferred star rating and budget to keep costs to a minimum.
What is there to do in South Carolina Midlands near my business-friendly hotel?
You'll discover plenty of things to keep you entertained in South Carolina Midlands. If you're making your way to Columbia, drop by Riverbanks Zoo and Garden, Township Auditorium and South Carolina State Museum. Packing your suitcases for Florence? Florence Museum, Mcleod Regional Medical Center and Florence National Cemetery are top attractions here.

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