A monument with a statue on top, in front of a large building with columns.

South Carolina Midlands Vacation Rentals

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November 2026

December 2026

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Our top choices for South Carolina Midlands vacation rentals

A multi-story hotel building with a modern design, featuring a prominent 'STUDIORES BY MARRIOTT' sign.

1. StudioRes by Marriott Columbia Harbison

Columbia

Cameron

￥15,044 total

includes taxes & fees

Nov 15 - Nov 16

A modern hotel with a 'Stay Apt Suites' sign, featuring a brick facade, large windows, and a parking lot.

2. stayAPT Suites Columbia-Irmo Harbison

Irmo

Kaye

￥17,361 total

includes taxes & fees

Nov 12 - Nov 13

A reception area with a counter, a clock, and a television on the wall.

3. King Bed Non-Smoking

Ridgeway, SC

Anonymous traveler

￥11,380 total

includes taxes & fees

Nov 12 - Nov 13

A modern kitchen with red cabinets, stainless steel appliances, and a bar area with stools.

4. The Hangar Lofts Hotel

Rosewood

Brent

￥29,731 total

includes taxes & fees

Nov 23 - Nov 24

5. 2 Queen Beds Non-Smoking

Ridgeway, SC

Anonymous traveler

￥12,447 total

includes taxes & fees

Nov 12 - Nov 13

A room with a wooden floor, a dining area with yellow chairs, and a balcony with a wooden railing.

6. Cozy and Quiet- Private Upstairs Duplex

Columbia

Coby T.

￥26,176 total

includes taxes & fees

Nov 16 - Nov 17

A tent with a porch, steps, and string lights.

7. Peaceful Off-Grid Yurt Farm Stay with Modern Comforts - Optional Farm Breakfast

Blythewood

Camilla V.

￥22,932 total

includes taxes & fees

Nov 12 - Nov 13

A brick pathway leading to a white building with a porch and a door labeled "Around Entrance."

8. Cozy 1-bedroom apartment at Greenleaf Villa. Downtown Camden, SC.

Camden

Brent U.

￥22,298 total

includes taxes & fees

Nov 15 - Nov 16

A hotel room with two beds, a large window, and a wooden floor.

9. Newly Renovated Hotel - 2 Bedroom Suites with Kitchen in beautiful Columbia

Columbia

Kevin H.

￥24,776 total

includes taxes & fees

Nov 23 - Nov 24

A modern living room with a sofa, coffee table, and a kitchen area in the background.

10. Stylish & Cozy Apartment ?Close to Everything!

Downtown Columbia

sergio h.

An outdoor patio with a pergola, dining table, chairs, and a fire pit.

11. The Rainbow Room | 1 BR 1 BA Studio Apartment

Downtown Columbia

Jason H.

￥34,757 total

includes taxes & fees

Nov 16 - Nov 17

A reception area with a counter, a number 6 sign, and a door.

12. 1 King Bed|Smoking,Micfridge

West Columbia

Anonymous traveler

￥12,332 total

includes taxes & fees

Nov 18 - Nov 19

A room with a wooden dining table, a chair, a vase with pink flowers, and a window with a view of greenery.

13. Charming cottage in great neighborhood...close to downtown, fort and university

Columbia

Michelle W.

A compact kitchen with white cabinets, a wooden countertop, a built-in microwave, and a refrigerator.

14. Pet-Friendly Hunt Country Cottage with Pool on 7.5 Acres

Camden

Paul C.

A room with a wooden bench, a white door, and a sign indicating quiet hours.

15. Aralia-5Min. to Williams-Brice/10Min. to Ft.Jackson

Rosewood

Ryan B.

￥48,301 total

includes taxes & fees

Nov 22 - Nov 23

A spacious living area with a high ceiling, wooden beams, a sofa set, and a kitchen in the background.

16. The Turquoise Door in Town of Lexington

Lexington

Denee C.

￥48,680 total

includes taxes & fees

Dec 7 - Dec 8

A kitchen with granite countertops, stainless steel appliances, and a built-in microwave.

17. Renovated 1 BR, 1 BA in the Heart of USC Campus

Downtown Columbia

Kyle J.

￥43,712 total

includes taxes & fees

Dec 6 - Dec 7

A campervan interior with a wooden ceiling, potted plants, a patterned rug, and a small seating area.

18. 1972 Airstream luxury tiny living at it's best in Columbia near Lake Murray!

Columbia

Dawn L.

￥25,768 total

includes taxes & fees

Nov 17 - Nov 18

A covered porch with columns, a ceiling fan, hanging plants, and a door with glass panels.

19. Charming Cottage/ Full Kitchen & Private yard

Lake Carolina

Jean-Jacques D.

￥51,943 total

includes taxes & fees

Nov 12 - Nov 13

A hotel room with two beds, a dark headboard, bedside lamps, and a door with a lock.

20. 2 Full Beds|Non-Smoking|Micfridge

West Columbia

Anonymous traveler

￥12,332 total

includes taxes & fees

Nov 18 - Nov 19

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Find vacation rentals that suit your style

Top South Carolina Midlands Hotel Reviews

A modern dining area with multiple seating options, including tables and booths, and large windows providing a view of the outdoors.

Springhill Suites By Marriott Columbia North

Columbia

10/10 Excellent

Terrica

A modern living room with a blue cabinet, a blue sofa, a round coffee table, and patterned ottomans.

Hotel Trundle

Downtown Columbia

10/10 Excellent

Loretta

A patio area with wicker furniture, a stone fire pit, and outdoor seating.

Fairfield Inn & Suites by Marriott Santee

Santee

10/10 Excellent

Choose this hotel for a pet-friendly stop-over on our drive to Florida and had a great experience. This staff was super-friendly and this nearly-brand-new property was immaculate. They have us a great 1st floor room with easy access to the walking and parking area. We took advantage of the patio to have dinner (take-out from a local restaurant) and breakfast with our dog. The breakfast was excellent, including hot omelets, eggs, and sausage, and the 6 am start (on a Sunday) allowed us to get...

Douglas

An outdoor patio with a stone fire pit, seating, and a covered area with lights.

Springhill Suites by Marriott Columbia near Fort Jackson

Columbia

10/10 Excellent

Savannah

A hotel dining area with multiple tables and chairs, a large flat-screen TV, and a patterned wall design.

Hampton Inn Santee-I-95

Santee

10/10 Excellent

Michael

A modern bar area with a central island, bar stools, and a television.

Cambria Hotel Columbia Downtown The Vista

Downtown Columbia

10/10 Excellent

Carla

A modern hotel building with a prominent 'tru by Hilton' sign, multiple floors, and a well-lit entrance.

TRU BY Hilton North Augusta

North Augusta

10/10 Excellent

kennya

An outdoor patio with a bar area, seating, and a grill station.

Tru By Hilton Columbia Downtown

Downtown Columbia

10/10 Excellent

Hynrie Emerlou

A multi-story building with white balconies, a palm tree, and landscaped garden beds.

Carriage House Inn

Aiken

10/10 Excellent

Teree

A hotel with a modern exterior, featuring a brick facade, large windows, and a well-lit outdoor area with palm trees and a landscaped garden.

Holiday Inn Express & Suites Lexington by IHG

Downtown Lexington

10/10 Excellent

Warning: I’ll be naming names in this review. To say that I was impressed is the understatement of the year! I am every hotels worst nightmare when it comes to my level of pickiness as a guest because I check everywhere. Well, this hotel beat me to the punch! Room 113 was so clean that we booked a second night just to extend our stay there. Sindy was responsible for cleaning my room so I found her and asked how she got it so clean. When she told me the entire cleaning staff uses black...

Jacqueline

A Holiday Inn Express & Suites hotel with a central entrance, multiple floors, and a well-lit facade.

Holiday Inn Express & Suites Aiken by IHG

Aiken

10/10 Excellent

Craig

A Hampton Inn & Suites with a rooftop pool, outdoor seating, and a modern architectural design.

Hampton Inn & Suites Columbia Killian Road

Columbia

10/10 Excellent

Christine

A Hampton Inn & Suites hotel with a modern design, featuring a parking lot and a well-lit entrance.

Hampton Inn & Suites Orangeburg

Orangeburg

10/10 Excellent

Kevin

A hotel entrance with a covered walkway, a brick pathway, and a well-maintained garden.

Staybridge Suites Florence - Civic Center by IHG

Florence

10/10 Excellent

William

Find out more about South Carolina Midlands

Vacation Apartments in South Carolina Midlands

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South Carolina Midlands Vacation Rentals

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for South Carolina Midlands vacation rentals

1. StudioRes by Marriott Columbia Harbison

2. stayAPT Suites Columbia-Irmo Harbison

3. King Bed Non-Smoking

4. The Hangar Lofts Hotel

5. 2 Queen Beds Non-Smoking

6. Cozy and Quiet- Private Upstairs Duplex

7. Peaceful Off-Grid Yurt Farm Stay with Modern Comforts - Optional Farm Breakfast

8. Cozy 1-bedroom apartment at Greenleaf Villa. Downtown Camden, SC.

9. Newly Renovated Hotel - 2 Bedroom Suites with Kitchen in beautiful Columbia

10. Stylish & Cozy Apartment ?Close to Everything!

11. The Rainbow Room | 1 BR 1 BA Studio Apartment

12. 1 King Bed|Smoking,Micfridge

13. Charming cottage in great neighborhood...close to downtown, fort and university

14. Pet-Friendly Hunt Country Cottage with Pool on 7.5 Acres

15. Aralia-5Min. to Williams-Brice/10Min. to Ft.Jackson

16. The Turquoise Door in Town of Lexington

17. Renovated 1 BR, 1 BA in the Heart of USC Campus

18. 1972 Airstream luxury tiny living at it's best in Columbia near Lake Murray!

19. Charming Cottage/ Full Kitchen & Private yard

20. 2 Full Beds|Non-Smoking|Micfridge

Find vacation rentals that suit your style

Top South Carolina Midlands Hotel Reviews

Springhill Suites By Marriott Columbia North

10/10 Excellent

Find out more about South Carolina Midlands

Vacation Apartments in South Carolina Midlands

Explore a world of travel with Expedia