Find hotels in South Carolina Midlands, SC from ￥9,961

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 14 - Dec 15
Tomorrow
Dec 15 - Dec 16
Next weekend
Dec 19 - Dec 21
In two weeks
Dec 26 - Dec 28

Filter by

Guest rating
Guest rating
Star rating

Our top choices for South Carolina Midlands hotels

Lobby
Tru By Hilton Santee

Tru By Hilton Santee

Tru By Hilton Santee
2.5 star property
Santee
9.2 out of 10, Wonderful, (637)
"Nice place to stay"
Canada
Tanya
The price is ￥15,082
￥16,741 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Tru By Hilton Santee
Exterior
Holiday Inn Express & Suites Latta by IHG

Holiday Inn Express & Suites Latta by IHG

Holiday Inn Express & Suites Latta by IHG
2.5 star property
Latta
9.4 out of 10, Exceptional, (532)
"Clean and beautiful, very friendly staff "
United States
claudia
The price is ￥17,451
￥19,022 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Holiday Inn Express & Suites Latta by IHG
Room, 2 Queen Beds, Non Smoking | Desk, blackout drapes, iron/ironing board, free WiFi
Baymont by Wyndham Santee

Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very Good, (1414)
"Very friendly staff. "
United States
Ramil
The price is ￥12,463
￥13,834 total
includes taxes & fees
Dec 16 - Dec 17
Baymont by Wyndham Santee
Lobby
Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area

Comfort Inn & Suites Florence Center Area
2.5 star property
Florence
9.2 out of 10, Wonderful, (1165)
"Enjoyed our stay there. "
United States
Cathy
The price is ￥15,422
￥17,274 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Comfort Inn & Suites Florence Center Area
Front of property - evening/night
Hyatt Place Florence Downtown

Hyatt Place Florence Downtown

Hyatt Place Florence Downtown
3.0 star property
Florence
8.8 out of 10, Excellent, (1006)
"Great stay"
United States
Michaelle
The price is ￥15,581
￥17,451 total
includes taxes & fees
Dec 22 - Dec 23
Hyatt Place Florence Downtown
Lobby
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence
2.0 star property
Florence
8.6 out of 10, Excellent, (2493)
"I nice place to stay, very quiet, good breakfast, nice staff, spotless room. "
United States
Timothy
The price is ￥9,676
￥10,837 total
includes taxes & fees
Dec 16 - Dec 17
Howard Johnson by Wyndham Florence
Property amenity
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
2.5 star property
Santee
9.8 out of 10, Exceptional, (1005)
"Spotless clean room The staff was so courteous and friendly "
United States
Amani
The price is ￥18,853
￥20,928 total
includes taxes & fees
Dec 21 - Dec 22
Fairfield Inn & Suites by Marriott Santee
Exterior
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC
2.5 star property
Florence
9.0 out of 10, Wonderful, (2194)
"Breakfast was great, room very clean ."
United States
Leann
The price is ￥13,322
￥14,920 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Park Inn by Radisson Florence, SC
Property amenity
Lexington Expo Hotel by IHG

Lexington Expo Hotel by IHG

Lexington Expo Hotel by IHG
3.0 star property
Lexington
9.2 out of 10, Wonderful, (1003)
"Room was great staff was great"
United States
Stephen
The price is ￥16,204
￥17,986 total
includes taxes & fees
Dec 21 - Dec 22
Lexington Expo Hotel by IHG
Reception
Hampton Inn & Suites Florence Center

Hampton Inn & Suites Florence Center

Hampton Inn & Suites Florence Center
2.5 star property
Florence
9.0 out of 10, Wonderful, (816)
"Very friendly and responsive staff. Very clean and comfortable room. Would definitely stay there again when we pass this way. "
United States
Maggie
The price is ￥14,833
￥16,613 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Hampton Inn & Suites Florence Center
Terrace/patio
Tru by Hilton Florence I-95

Tru by Hilton Florence I-95

Tru by Hilton Florence I-95
2.5 star property
Florence
8.4 out of 10, Very Good, (1005)
"Hotel was clean , friendly staff"
United States
Gabriela
The price is ￥14,210
￥16,461 total
includes taxes & fees
Dec 21 - Dec 22
Tru by Hilton Florence I-95
Exterior
Holiday Inn Express Richburg by IHG

Holiday Inn Express Richburg by IHG

Holiday Inn Express Richburg by IHG
2.5 star property
Richburg
9.2 out of 10, Wonderful, (645)
"Everything was enjoyable "
United States
George
The price is ￥16,048
￥17,973 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Holiday Inn Express Richburg by IHG
Exterior
Country Inn & Suites by Radisson, Columbia Airport, SC

Country Inn & Suites by Radisson, Columbia Airport, SC

Country Inn & Suites by Radisson, Columbia Airport, SC
2.5 star property
Cayce
8.2 out of 10, Very Good, (1004)
"Clean and friendly staff easy check in and out"
United States
Leslie
The price is ￥14,171
￥15,730 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Country Inn & Suites by Radisson, Columbia Airport, SC
Breakfast and dinner served, American cuisine
Cambria Hotel Columbia Downtown The Vista

Cambria Hotel Columbia Downtown The Vista

Cambria Hotel Columbia Downtown The Vista
3.5 star property
Downtown Columbia
9.4 out of 10, Exceptional, (1140)
"Awesome accommodation "
United States
Sheryl
The price is ￥15,830
￥17,730 total
includes taxes & fees
Dec 23 - Dec 24
Cambria Hotel Columbia Downtown The Vista
Premium bedding, in-room safe, desk, iron/ironing board
Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center
2.5 star property
Florence
7.8 out of 10, Good, (1255)
"Room was spotless, bed extremely comfortable and staff was very helpful and courteous. Would DEFINITELY stay there again. "
United States
Tim
The price is ￥12,357
￥13,840 total
includes taxes & fees
Jan 15 - Jan 16, 2026
Quality Inn & Suites Florence Civic Center
Premium bedding, pillowtop beds, desk, laptop workspace
Clarion Pointe Rock Hill Near University

Clarion Pointe Rock Hill Near University

Clarion Pointe Rock Hill Near University
2.5 star property
Rock Hill
9.0 out of 10, Wonderful, (1038)
"Room spotless, breakfast great, workers friendly, will encourage others to stay"
United States
Sandra
The price is ￥11,086
￥12,307 total
includes taxes & fees
Dec 21 - Dec 22
Clarion Pointe Rock Hill Near University
Fitness facility
Hotel Trundle

Hotel Trundle

Hotel Trundle
3.0 star property
Downtown Columbia
9.8 out of 10, Exceptional, (986)
"Very clean. Staff very nice and friendly. I would definitely stay there again"
United States
Leslie
The price is ￥21,658
￥24,258 total
includes taxes & fees
Dec 21 - Dec 22
Hotel Trundle
Free daily buffet breakfast
Hampton Inn & Suites Lexington Columbia

Hampton Inn & Suites Lexington Columbia

Hampton Inn & Suites Lexington Columbia
2.5 star property
Lexington
9.8 out of 10, Exceptional, (592)
"Clean and comfortable room, friendly staff, great location."
United States
Allison
The price is ￥16,079
￥17,848 total
includes taxes & fees
Dec 21 - Dec 22
Hampton Inn & Suites Lexington Columbia
Property amenity
Springhill Suites by Marriott Columbia near Fort Jackson

Springhill Suites by Marriott Columbia near Fort Jackson

Springhill Suites by Marriott Columbia near Fort Jackson
2.0 star property
Columbia
9.4 out of 10, Exceptional, (552)
"Clean, quiet and nice breakfast included."
United States
Darcy
The price is ￥15,269
￥17,103 total
includes taxes & fees
Dec 22 - Dec 23
Springhill Suites by Marriott Columbia near Fort Jackson
Exterior
Hampton Inn & Suites Florence-North-I-95

Hampton Inn & Suites Florence-North-I-95

Hampton Inn & Suites Florence-North-I-95
2.5 star property
Florence
9.0 out of 10, Wonderful, (813)
"The hotel was excellent. In fact we stayed 2 different nights on our travel up and down Rt 95. Breakfast was great and hotel very clean and quiet. "
United States
Cynthia
The price is ￥16,827
￥18,846 total
includes taxes & fees
Jan 15 - Jan 16, 2026
Hampton Inn & Suites Florence-North-I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Vacation Rentals in South Carolina Midlands

Cabin
Land view from property
Long Cove Resort near Charlotte Airport

Long Cove Resort near Charlotte Airport

Long Cove Resort near Charlotte Airport
3.0 star property
Steele Creek
8.6 out of 10, Excellent, (231)
"Beautiful beach"
Long Cove Resort near Charlotte Airport
See all vacation rentals
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular Southeastern United States attractions

Charlotte_CarowindsThemePark_6035117_08.jpg

Carowinds Theme Park

4.3/5 (702 reviews)
Choose from 13 roller coasters, chase your friends in a bumper car, enjoy the water slides and beaches of Boomerang Bay, and walk with dinosaurs.
See properties
Animals in the zoo. Wild African animals in a summer forest on a sunny day. Outdoor activities with children. Riverbanks Zoo and Garden, Columbia, South Carolina, USA. American flamingos in the zoo

Riverbanks Zoo and Garden

4.4/5 (613 reviews)
Why not meet the animals who call Riverbanks Zoo and Garden home during your trip to Columbia? You can attend a sporting event while in the area.
See properties

Learn more about South Carolina Midlands

With Revolutionary War sites, a charming capital city and lots of kayaking opportunities, this southern region is sure to delight.

See all hotels in South Carolina Midlands
South Carolina State House

Top South Carolina Midlands Hotel Reviews

Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

10/10 Excellent
"Excellent value for price."
Ronald 1-night trip
Posted 5 days ago
Howard Johnson by Wyndham Florence

More cheap stays in South Carolina Midlands

Motel 6 Fort Mill, SC - Charlotte

Motel 6 Fort Mill, SC - Charlotte

3541 Foothills Way Fort Mill SC
The price is ￥8,693 per night from Dec 16 to Dec 17
￥8,693
￥9,961 total
Dec 16 - Dec 17
includes taxes & fees
6.4/10 (1,000 reviews)

Hotels in South Carolina Midlands with star-rating

Explore a world of travel with Expedia