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Our top choices for Santa Ana hotels

Hostal La Cigarra

Hostal La Cigarra
2.0 star property
Santa Ana
7.6 out of 10, Good, (64 reviews)
"Excelente "
Mexico
David
Hostal La Cigarra

ART CASCO The Hotel

ART CASCO The Hotel
2.0 star property
Santa Ana
6.0 out of 10, (11 reviews)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
ART CASCO The Hotel

Casco View Apartments

Casco View Apartments
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (78 reviews)
"The space was very nice. "
United States
William
Casco View Apartments

Hotel República

Hotel República
2.0 star property
Santa Ana
6.6 out of 10, (187 reviews)
"It's meant for a short stay, close to Casco Viejo and coast line. Clean bed and bathroom. Needs some maintenance. Beware, there's no hot water if that's a deal breaker for you."
United States
Mario
Hotel República

La Manzana by Wynwood House

La Manzana by Wynwood House
3.0 star property
Santa Ana
7.2 out of 10, Good, (15 reviews)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
The price is ¥10,578
¥16,017 total
includes taxes & fees
Mar 24 - Mar 25
La Manzana by Wynwood House

Room-sofa Bed Stay Rooftop Pool & Gym, A

Room-sofa Bed Stay Rooftop Pool & Gym, A
2.0 star property
Santa Ana
2.0 out of 10, (1 review)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
The price is ¥10,448
¥11,493 total
includes taxes & fees
Mar 14 - Mar 15
Room-sofa Bed Stay Rooftop Pool & Gym, A

Taboga Palace Spa Hotel

Taboga Palace Spa Hotel
3.5 star property
17.7 km from Santa Ana
9.4 out of 10, Exceptional, (48 reviews)
"My room was perfect just steps from the pool with a great view of the ocean. Dave was a great host and help make my stay truly enjoyable. "
United States
James
The price is ¥20,666
¥22,733 total
includes taxes & fees
Mar 18 - Mar 19
Taboga Palace Spa Hotel

Villa Caprichosa

Villa Caprichosa
3.0 star property
18.3 km from Santa Ana
9.8 out of 10, Exceptional, (55 reviews)
"Nice view of the beach "
United States
Lourdes
The price is ¥35,843
¥39,427 total
includes taxes & fees
Apr 6 - Apr 7
Villa Caprichosa

Panama House Bed & Breakfast

Panama House Bed & Breakfast
2.5 star property
Bella Vista, 4.6 km from Santa Ana
9.0 out of 10, Wonderful, (196 reviews)
"Amenities, staff, cleanliness, price all excellent!"
United States
Christopher
Panama House Bed & Breakfast

La Résidence Panamá

La Résidence Panamá
2.5 star property
Campo Alegre, 3.4 km from Santa Ana
9.2 out of 10, Wonderful, (7 reviews)
"EL hotel es nuevo, todo muy lindo. La habitación que me tocó era muy cómoda, pero con solo una pequeña ventana a una zona de servicios... no muy lindo... unica observación El personal sumamente amable"
Mexico
JOAQUIN
The price is ¥17,964
¥19,760 total
includes taxes & fees
Apr 3 - Apr 4
La Résidence Panamá

Hotel Montreal

Hotel Montreal
3.5 star property
Bella Vista, 2.7 km from Santa Ana
6.0 out of 10, (411 reviews)
"The room was in good condition; the staff was very helpful."
United States
VELVETT
Hotel Montreal

Hotel Plaza Herrera

Hotel Plaza Herrera
4.0 star property
San Felipe, 0.7 km from Santa Ana
9.8 out of 10, Exceptional, (27 reviews)
"Great location in walkable area of Casco Viejo. Helpful staff."
United States
Sharon
The price is ¥37,719
¥41,621 total
includes taxes & fees
Mar 18 - Mar 19
Hotel Plaza Herrera

Ramada Panama Centro Via Argentina

Ramada Panama Centro Via Argentina
3.0 star property
El Cangrejo, 3.8 km from Santa Ana
7.4 out of 10, Good, (312 reviews)
"nice central access to the whole Panama City and convenient price"
United States
Jose
The price is ¥12,161
¥13,377 total
includes taxes & fees
Apr 5 - Apr 6
Ramada Panama Centro Via Argentina

Toscana Inn

Toscana Inn
3.5 star property
El Cangrejo, 3.7 km from Santa Ana
8.8 out of 10, Excellent, (742 reviews)
"Room was clean, bed comfortable but minimal amenities provided. Breakfast was basic however it served the need and price was good. Location perfect for convenience to transport, restaurants and shopping. "
United States
Merle
The price is ¥14,557
¥16,013 total
includes taxes & fees
Mar 16 - Mar 17
Toscana Inn

Hotel y Casino Central Park Panama

Hotel y Casino Central Park Panama
3.0 star property
Bethania, 5.6 km from Santa Ana
7.6 out of 10, Good, (442 reviews)
"Great service, clean, great location "
United States
EDGAR
The price is ¥4,129
¥4,542 total
includes taxes & fees
Apr 13 - Apr 14
Hotel y Casino Central Park Panama

Crowne Plaza Panama by IHG

Crowne Plaza Panama by IHG
4.0 star property
Bella Vista, 3.2 km from Santa Ana
8.0 out of 10, Very Good, (226 reviews)
"Staff were amazing . Great breakfast and convenient area close to the train station "
United States
Darius
The price is ¥15,293
¥16,822 total
includes taxes & fees
Apr 11 - Apr 12
Crowne Plaza Panama by IHG

Hilton Garden Inn Panama City Downtown, Panama

Hilton Garden Inn Panama City Downtown, Panama
3.5 star property
El Cangrejo, 3.4 km from Santa Ana
8.6 out of 10, Excellent, (1,001 reviews)
"Staff very friendly. Good breakfast. "
Canada
Liam
The price is ¥13,716
¥15,088 total
includes taxes & fees
Apr 12 - Apr 13
Hilton Garden Inn Panama City Downtown, Panama

MARINN PLACE Financial District

MARINN PLACE Financial District
3.5 star property
Campo Alegre, 3.3 km from Santa Ana
9.0 out of 10, Wonderful, (321 reviews)
"Yes"
United States
gerardo
MARINN PLACE Financial District

Gran Evenia Panama

Gran Evenia Panama
4.5 star property
El Cangrejo, 3.8 km from Santa Ana
9.2 out of 10, Wonderful, (222 reviews)
"room was clean, staff was great, the wi-Fi works good and the breakfast was a little fresh but nothing that a little salt cant fix"
United States
Shantel
Gran Evenia Panama

Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites
3.5 star property
El Cangrejo, 3.4 km from Santa Ana
8.8 out of 10, Excellent, (519 reviews)
"Very clean and amazing stay "
United States
Reinaldo
Torres de Alba Hotel & Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

San Felipe

If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?
Santa Ana is a neighborhood that travelers like for its seafood restaurants, shopping, and parks. Are you looking for Santa Ana travel tips? Be sure to check out Cinta Costera and Avenida Balboa while you're in the neighborhood.
Where is the best hotel for a stay in Santa Ana?
Based on Expedia customer reviews, Hotel República is the highest ranked property in Santa Ana. This hotel is a short 4-minute walk from Avenida Balboa, and it offers a rooftop terrace and free WiFi.
How many hotels can I expect to find in Santa Ana?
Expedia has 113 hotels and other accommodations in Santa Ana to choose from, making this an ideal home base for exploring the greater Panama City area.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! Most hotel room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Add dates, click "Search", then use the "fully refundable" filter to get top deals in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about picking new dates or cancelling your trip to Santa Ana, head over to our customer service page.
What is there to do in this Panama City neighborhood?
If you're looking forward to a day of shopping in Santa Ana, consider Avenida Central or Avenida Balboa, and pick out the perfect souvenir. A visit to Cinta Costera is also worth the trip while you're discovering the neighborhood. Amador Theater, Museum of Contemporary Art Panama, and Mi Pueblito are just a few of the places to visit in and around Santa Ana. When you're sightseeing in Panama City, Iglesia de la Merced and Mola Museum are also worth a stop.

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