The Best Resorts & Hotels with Spas in Panama City from ￥15,177 in 2026

A coastal cityscape with high-rise buildings, a marina, and a clear blue sky.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check availability on Panama City Resorts & Hotels with Spas

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Panama City hotels with a spa

A modern spa area with a hot tub, seating, and a city view.

A high-rise building with a modern architectural design, featuring a grid of windows and balconies.

An escalator in a hotel lobby with a patterned wall and framed artwork.

A rooftop lounge with modern seating and a panoramic city view.

1. Megapolis Hotel Panamá

San Francisco

Immerse in therapeutic bliss with 2 spa rooms, steam, and sauna at this full-service wellness hotel.

￥20,941

￥23,035 total

includes taxes & fees

Nov 7 - Nov 8

A covered outdoor seating area with a view of a city skyline and water.

A cityscape with high-rise buildings, a waterfront, and a modern sculpture.

A nighttime view of a high-rise building complex with illuminated windows and a prominent red-lit structure.

A restaurant with large windows offering a view of a city skyline and palm trees.

2. Plaza Paitilla Inn Hotel

San Francisco

Unwind with hot stone massages and facials at this hotel spa with pool views and plush treatment rooms.

￥19,463

￥21,578 total

includes taxes & fees

Nov 25 - Nov 26

A hotel room with a checkered floor, a window with white curtains, and a lounge area with chairs and tables.

A balcony with a city view, a table with a drink, chairs, and a potted orchid.

A spacious lobby with a round coffee table, seating areas, and a large wall clock.

A balcony with a table, chairs, and a view of a city skyline across a body of water.

3. Sofitel Legend Casco Viejo, Panama City

Casco Viejo

Indulge in a waterfront spa retreat with outdoor treatment areas and hot stone massages at this beautifully restored Colonial hotel.

￥66,356

￥72,992 total

includes taxes & fees

Nov 1 - Nov 2

A spacious lobby with a wooden staircase, multiple seating areas, and a reception desk.

A multi-level atrium with wooden staircases, seating areas, and a decorative ceiling.

A rooftop swimming pool with lounge chairs, potted plants, and a view of a city skyline including a prominent building with a dome.

4. Central Hotel Panama Casco Viejo

Casco Viejo

Discover revitalizing massages and soothing facials at this historic hotel with a rooftop pool and steam room in Panama's vibrant center.

￥25,719

￥28,292 total

includes taxes & fees

Oct 31 - Nov 1

A modern building facade with large glass windows and a visible sign for 'AQUA SPA'.

An outdoor dining area with clear glass tables and chairs, surrounded by palm trees and modern buildings.

A modern hotel room with a large bed, a TV, a desk, and a view of the city.

A rooftop lounge area with clear glass tables and chairs, a pool, and potted plants.

5. Decapolis Hotel Panama City

San Francisco

Revive in Panama's premier hotel spa with Turkish hammam, hydrotherapy, and multiple treatment rooms for total rejuvenation.

￥13,797

￥15,177 total

includes taxes & fees

Oct 31 - Nov 1

A rooftop pool with sun loungers and a city skyline in the background.

A modern hotel room with a large bed, a desk, a chair, and a wardrobe.

A long, narrow hallway with a wooden floor and light-colored walls.

A bar area with a curved counter, multiple screens, and a patterned carpet.

6. Waymore Hotel Spa & Casino

Bella Vista

Immerse in a full-service spa retreat with 4 treatment rooms, sauna, and steam room at this modern bed & breakfast.

￥13,671

￥23,782 total

includes taxes & fees

Oct 30 - Oct 31

A massage therapy session in a dimly lit room with a bedside table, candles, and a potted plant.

A modern hotel lobby with beige sofas, marble flooring, and a reception desk.

A dimly lit restaurant with wooden decor, tables, and chairs arranged for dining.

A hotel with a covered entrance, multiple windows, and a balcony with plants.

7. Hotel San Felipe

Casco Viejo

Recharge with daily aromatherapy, couples massages, and a garden-view spa at this stylish Panama City retreat.

￥24,577

￥27,035 total

includes taxes & fees

Oct 27 - Oct 28

A modern bathroom with a large bathtub, two sinks, and a glass-enclosed shower area with a city view.

A modern building with a symmetrical facade, multiple balconies, and a central atrium with lighting.

A terrace with seating and a view of the ocean.

8. JW Marriott Panama

San Francisco

Immerse in waterfront tranquility with bay views, rejuvenating in-room massages, and four outdoor pools for a complete spa getaway.

￥46,308

￥50,939 total

includes taxes & fees

Nov 21 - Nov 22

View all properties

Choose what matters most at spa hotels in Panama City

Pool

Breakfast included

Hot tub

5 stars

Gym

Spa hotels with pools in Panama City

A rooftop pool area with purple lounge chairs and a city skyline in the background.

Megapolis Hotel Panamá

San Francisco

￥20,941

￥23,035 total

includes taxes & fees

Nov 7 - Nov 8

Plaza Paitilla Inn Hotel

San Francisco

￥19,463

￥21,578 total

includes taxes & fees

Nov 25 - Nov 26

A modern building with a glass facade, a curved structure, and a flat roof.

A spacious lobby with red and blue seating, a large circular wall feature, and a modern design with concrete elements.

A modern hotel room with a large bed, a desk with a flat-screen TV, a city view, and a large painting on the wall.

Decapolis Hotel Panama City

San Francisco

￥13,797

￥15,177 total

includes taxes & fees

Oct 31 - Nov 1

A spacious living room with a high ceiling, large windows, and a decorative ceiling fan.

A hotel with a rooftop pool, lounge chairs, and a view of the sea.

Sofitel Legend Casco Viejo, Panama City

Casco Viejo

￥66,356

￥72,992 total

includes taxes & fees

Nov 1 - Nov 2

Waymore Hotel Spa & Casino

Bella Vista

￥13,671

￥23,782 total

includes taxes & fees

Oct 30 - Oct 31

A multi-story building with balconies, arched windows, and decorative railings.

A building with a balcony and a street view.

Central Hotel Panama Casco Viejo

Casco Viejo

￥25,719

￥28,292 total

includes taxes & fees

Oct 31 - Nov 1

A modern lobby with a glass railing, a central staircase, and a view of the cityscape through large windows.

A modern hotel room with a large window offering a city view, a chandelier, and a cozy seating area.

An indoor swimming pool with lounge chairs and a modern interior design.

A spacious lobby with a staircase, seating area, and a bar.

Las Americas Golden Tower Panama

San Francisco

￥22,719

￥24,990 total

includes taxes & fees

Nov 8 - Nov 9

A modern hotel pool area with lounge chairs and a clear view of the ocean.

A modern interior with a spiral staircase, a large window, and a seating area.

A modern bar area with seating and a view of the city.

A marina with boats docked, a city skyline with illuminated buildings, and a visible moon in the sky.

Hilton Panama

Bella Vista

￥41,202

￥45,322 total

includes taxes & fees

Nov 20 - Nov 21

A restaurant with multiple dining tables, chairs, and a central water feature.

A bar area with multiple seating options, a bar counter, and a fireplace.

A historic building with ornate stonework and a balcony with plants.

A rooftop terrace with tables and chairs, a view of two white towers, and a building with a large window.

Hotel La Compañía Casco Antiguo

Casco Viejo

￥43,868

￥48,255 total

includes taxes & fees

Oct 26 - Oct 27

A poolside area with lounge chairs and a view of the ocean.

A modern hotel room with a large bed, a chair, a nightstand with a lamp, and a view of the cityscape at dusk.

JW Marriott Panama

San Francisco

￥46,308

￥50,939 total

includes taxes & fees

Nov 21 - Nov 22

View all properties