
Panama City Vacations
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to ¥45,448 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Where to stay in Panama City
Find the best Panama City areas and neighborhoods for the activities you enjoy most. Learn more about Panama City

Casco Viejo
4.5/5(178 area reviews)
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.
Find the Best Panama City Vacation Packages
Panama City Hotel Deals

Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is ¥18,348 per night from Nov 18 to Nov 19
¥18,348
¥20,183 total
Nov 18 - Nov 19
includes taxes & fees
9/10 Wonderful! (4,500 reviews)
Great breakfast, big rooms and view from them
Reviewed on Nov 13, 2025

Waldorf Astoria Panama
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is ¥26,500 per night from Dec 1 to Dec 2
¥26,500
¥29,150 total
Dec 1 - Dec 2
includes taxes & fees
8.8/10 Excellent! (1,004 reviews)
Very beautiful room was spotless, and staff was very good with customer service
Reviewed on Nov 7, 2025

Megapolis Hotel Panamá
Avenida Balboa Panama City
Fully refundableReserve now, pay when you stay
8.4/10 Very Good! (1,182 reviews)
Was all clean , the staff gave good service.
Reviewed on Nov 8, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Panama City

Avenida Balboa
4/5(554 reviews)
You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.

Panama Canal Railway
4/5(10 reviews)
Enjoy an outing to Panama Canal Railway during your stay in Ancon. Stroll along the seaside or visit the shops in this vibrant area.
Albrook Shopping Mall
4/5(605 reviews)
You can enjoy some retail therapy with a trip to Albrook Shopping Mall, a favorite shopping spot in Ancon. Amble around this culturally rich area's seaside and enjoy its top-notch restaurants.
What to do in Panama City

Panama City: Zip Line Experience Over The City
¥6,106
per adult
90% of travellers recommend

The Panama Barcrawl - The OG Crawl (Panama City, Panama)
¥9,923
per adult
96% of travellers recommend

Panama City Visit an Indian town Embera and waterfall with lunch
¥6,717
per adult
96% of travellers recommend
Other vacations you might like
Expedia's Latest Trends
Hotels
Flights
- Flights from Sepang (KUL) to Tioman Island (TOD)
- Flights from Naha (OKA) to Indianapolis (IND)
- Flights from Narita (NRT) to Ulaanbaatar (ULN)
- Flights from Mashiki (KMJ) to Osaka (KIX)
- Flights from Osaka (KIX) to Incheon (ICN)
- Flights from Narita (NRT) to Cali (CLO)
- Flights to Japan
- Flights from Fukuoka to CHI-All Airports
- Flights from Osaka (KIX) to Laguindingan (CGY)
- Flights from Chiang Mai (CNX) to Tokyo (HND)
- Flights from Naha (OKA) to Rome (FCO)
- Flights from Ho Chi Minh City (SGN) to Manila (MNL)
Activities
Packages
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.

