Panama Vacations & Trips

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    Save up to ￥45,448 when you book a flight and hotel together*
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    With over 300,000 hotels worldwide, it's easy to create a perfect package
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Top destinations in Panama

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Panama City

Panama City
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David

David

Panama Vacation

While Panama is perhaps best known for its mighty canal, there’s so much more to this Central American country. Visitors will also be wowed by lush rainforests, idyllic beaches, rich indigenous culture and a unique colonial history.

Panama Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is ￥16,927 per night from Aug 25 to Aug 26
￥16,927
￥18,620 total
Aug 25 - Aug 26
includes taxes & fees
9/10 Wonderful! (4,148 reviews)
"The hotel is very clean, courteous staff and the location is central."

Reviewed on Aug 14, 2025

Hotel Riu Plaza Panama
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is ￥18,641 per night from Aug 31 to Sep 1
￥18,641
￥20,505 total
Aug 31 - Sep 1
includes taxes & fees
8.4/10 Very Good! (925 reviews)
"El hotel es super lindo y el desayuno es muy bueno. La atención también excelente."

Reviewed on Aug 6, 2025

Sheraton Grand Panama
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi, Panama City
Fully refundableReserve now, pay when you stay
The price is ￥11,921 per night from Aug 17 to Aug 18
￥11,921
￥13,113 total
Aug 17 - Aug 18
includes taxes & fees
9/10 Wonderful! (412 reviews)
"Nice hotel, lively lots of tourists/ music movement. convenient 24/7 coffee shop. walking distance from other restaurants/shops and night life"

Reviewed on Aug 15, 2025

Waymore Hotel Spa & Casino
See all 3,278 properties in Panama
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Panama vacation package cost?
Custom build your Panama vacation package from a low . Choose from any combination of rental cars, flights and hotels to pull together the trip you've been dreaming about. Remember to add on some activities and experiences!
How do I get a cheap travel package to Panama?
One of the easiest ways to save cash (and time) is to combine your bookings with Expedia. Hotels, flights, rental cars and activities — we've got them all. Select the combination that suits you and watch your savings stack up. Of course, a package deal is never one-size-fits-all. That's why we offer over 550 airlines and 1,000,000 hotels worldwide, which lets you customize your Panama vacation.
Where should I stay in Panama?
Panama City is a great place to visit. It draws in many visitors who come to check out its biggest sights, such as Bridge of the Americas and Miraflores Locks.
What are the top hotels in Panama?
When it comes to hotels in Panama City, Hotel Riu Plaza Panama and Crowne Plaza Panama Airport, an IHG Hotel are two terrific options. If you're also visiting Bocas del Toro, Playa Tortuga Hotel Beach And Resort and Azul Paradise will make you feel at home.
How far in advance should I book my Panama vacation?
It's difficult to pick the ideal time for airfares, but we usually say the earlier, the better. Most international journeys on Expedia become available up to 12 months in advance. If you're booking last minute, fear not. Discounted prices appear from time to time just weeks before departure dates.
What does an Expedia Panama travel package include?
Hotels, rental cars and flights, or any combination of them — it's up to you! Whether you're venturing to Panama with the kids or traveling solo, there's a package to fit your budget and style. Once you've made your booking, why not add on one or two tours or activities?
What should I know before booking a Panama travel package?
A travel package can be customized for your budget and is a terrific way to make your hard-earned dollars stretch further. How much you include is up to you. Rental cars, hotels and flights — come up with a combination that suits your plans.
Can I choose my airline with a Panama Expedia vacation package?
Yes — and it's simple too. Expedia has access to more than 550 partner airlines all over the world. Our packages give you the flexibility to pick from available flights, hotels and activities that fit your needs.
If I'm not able to travel, can I cancel my Panama vacation package?
Because we know life is full of surprises, the answer is yes. For further information, head to our Customer Service Portal. But generally speaking, if you've made your booking in the last 24 hours, you may be able to change or cancel it for free. Your airline, hotel or car rental company may impose a fee if you made your booking a while ago.

Discover the most popular places to visit in Panama

Cinta Costera a wonderful pedestrian walkway with a separate lane for bicyclists and skateboarders #OrbitzTravel

Avenida Balboa

4/5(554 reviews)

You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa
Jungle Land Adventures - you may choose to kayak, swim or go fishing after you spend some time exploring the rain forest for wild life! www.panamaroadrunner.com

Gamboa Rainforest Resort

4/5(299 reviews)

Explore the great outdoors at Gamboa Rainforest Resort, a lovely green space in Gamboa. While you're here, you can savor the top-notch restaurants.

Gamboa Rainforest Resort

Albrook Shopping Mall

4/5(605 reviews)

You can enjoy some retail therapy with a trip to Albrook Shopping Mall, a favorite shopping spot in Ancon. Amble around this vibrant area's seaside and enjoy its top-notch restaurants.

Albrook Shopping Mall

What to do in Panama

Slingshot Tour Panama

Slingshot Tour Panama

￥17,245
per adult
76% of travellers recommend
Slingshot Tour Panama
Day Tour

Day Tour in San Blas Islands All Included Visiting 4 Islands

￥22,006
per adult
94% of travellers recommend
Day Tour in San Blas Islands All Included Visiting 4 Islands
Panama City: Poin Glass Observation Deck Ticket with VR Tour

Panama City: Poin Glass Observation Deck Ticket with VR Tour

￥4,741
per adult
100% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
See all activities in Panama
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.