Santa Ana Vacations from ￥255,322

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    Save up to ￥45,448 when you book a flight and hotel together*

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The Latest Santa Ana Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
San Francisco
Price was ￥263,752, price is now ￥255,322 per person
￥255,322
per person
Apr 2 - Apr 3
found 1 day ago
Roundtrip flight included
Osaka (KIX) to Panama City (PTY)
9/10 Wonderful! (1,005 reviews)
Clean wonderful room, great staff, big breakfast

Reviewed on Jan 25, 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was ￥288,487, price is now ￥266,572 per person
￥266,572
per person
Apr 2 - Apr 3
found 1 day ago
Roundtrip flight included
Osaka (KIX) to Panama City (PTY)
9/10 Wonderful! (1,002 reviews)
Staff was excellent. Location great. Room was good.

Reviewed on Jan 27, 2026

Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
Price was ￥295,067, price is now ￥277,528 per person
￥277,528
per person
Apr 2 - Apr 3
found 1 day ago
Roundtrip flight included
Osaka (KIX) to Panama City (PTY)
7.4/10 Good! (1,002 reviews)
Edwin and the other bartenders inside were awesome and friendly. Rooms were clean. House keeping was great.

Reviewed on Jan 24, 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was ￥278,310, price is now ￥263,284 per person
￥263,284
per person
Apr 2 - Apr 3
found 1 day ago
Roundtrip flight included
Osaka (KIX) to Panama City (PTY)
8.4/10 Very Good! (1,204 reviews)
Clean room,helpful staff around the hotel,good food options

Reviewed on Jan 20, 2026

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was ￥265,060, price is now ￥256,216 per person
￥256,216
per person
Apr 2 - Apr 3
found 1 day ago
Roundtrip flight included
Osaka (KIX) to Panama City (PTY)
9/10 Wonderful! (4,515 reviews)
The first room was clean but the window has moisture in between the panel so you can’t see outside. The next day I told the front desk and they rectified it by moving us to a different room with no hustle

Reviewed on Jan 28, 2026

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
View of the Panama City Old Town

Casco Viejo

4.5/5(178 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or Palacio de las Garzas while you're exploring the area.

Find hotels in Casco Viejo

Santa Ana Hotel Deals

Casco View Apartments

Casco View Apartments

3.5 out of 5
C. 16 Oeste Panama City Provincia de Panamá
9/10 Wonderful! (65 reviews)
Buenas ! Me gustaría decirle que el lugar estaba bien limpio , el único problema fue es que el agua no estaba muy caliente , para poder tirar la basura en el piso 8 no había un tanque de basura y el inodoro se dañó así que el agua se salió pero me arreglaron tan pronto pudieron , gracias por todo ...

Reviewed on Jan 24, 2026

Get rates
Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is ￥19,056 per night from Feb 23 to Feb 24
￥19,056
￥20,962 total
Feb 23 - Feb 24
includes taxes & fees
9/10 Wonderful! (4,901 reviews)
Everything

Reviewed on Jan 27, 2026

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
The price is ￥16,779 per night from Feb 23 to Feb 24
￥16,779
￥18,457 total
Feb 23 - Feb 24
includes taxes & fees
8.4/10 Very Good! (2,409 reviews)
Ok

Reviewed on Jan 28, 2026

Crowne Plaza Panama Airport by IHG
See all 1,695 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Ana vacation package cost?
From as little as ￥255,322. Yes, you read that correctly. Our Santa Ana vacation packages are an easy way to stretch your budget further. Combine your favorite hotels, flights and rental car and explore this destination your way.
How do I get a cheap travel package to Santa Ana?
One of the easiest ways to save cash (and time) is to combine your bookings with Expedia. Flights, hotels, activities and rental cars — we've got it all. Pick and choose the combination that best fits you and see your savings grow. We know a package deal is never a one-size-fits-all. That's why Expedia offers over 550 air carriers and 1,000,000 hotels throughout the world, which lets you customize your Santa Ana vacation.
Where should I stay in Santa Ana?
Most who travel to Santa Ana include both Miraflores Locks and Metropolitan Cathedral of Panama on their bucket lists. Why not go for a hotel right near these great attractions?
What are the top hotels in Santa Ana?
If it's your first time in Santa Ana, make a reservation at Hotel Riazor or Hotel Doral. Both hotels will make you feel at home and are favorites among lots of travelers.
How far in advance should I book my Santa Ana vacation?
While prices change from time to time, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to a year in advance. If circumstances have left you booking late, you might still be in luck. Low prices to Santa Ana sometimes occur only weeks before departure.
What does an Expedia Santa Ana travel package include?
That mostly depends on you. You can select from a range of Santa Ana packages, such as a rental car, flight and hotel. You can also book a hotel and a flight, or a rental car and a flight. Once you've made your booking, you can add on the fun stuff like tours and activities. Whatever your perfect Santa Ana break looks like, get set to save!
What should I know before booking a Santa Ana travel package?
Discover deals to suit your budget with an Expedia package. Hotels, airfares, rental cars — we've got everything you need to plan your getaway. You'll save big dollars just for bundling your bookings. Whether you're taking off on a ski trip or getting some sun on a warm beach, your ideal getaway is only clicks away.
Can I choose my airline with a Santa Ana Expedia vacation package?
Definitely. Expedia has more than 550 airline partners to pick from globally. With all that choice at your fingertips, finding the right carrier to get you to Santa Ana shouldn't be hard.
If I'm not able to travel, can I cancel my Santa Ana vacation package?
We totally get it — life can throw you the odd curveball. If you've booked a Santa Ana vacation package and have to amend or cancel it, we're here to help. It's always worth visiting our Customer Service Portal first for information. But generally, if you've booked your package in the last 24 hours, you may be able to amend or cancel your itinerary at no cost. If it's been longer than 24 hours, your hotel, airline or car rental company may charge a fee.

Discover the most popular places to visit in Santa Ana

Panama City night skyline

Avenida Balboa

4/5(554 reviews)

You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa

Albrook Shopping Mall

4/5(605 reviews)

You can enjoy some retail therapy with a trip to Albrook Shopping Mall, a favorite shopping spot in Ancon. Amble around this vibrant area's seaside and enjoy its top-notch restaurants.

Albrook Shopping Mall

Panama Canal Railway

4/5(10 reviews)

Enjoy an outing to Panama Canal Railway during your stay in Ancon. Stroll along the seaside or visit the shops in this vibrant area.

Panama Canal Railway

Things to do

Panama City: Zip Line Experience Over The City & a Cocktail

Panama City: Zip Line Experience Over The City

￥6,325
per adult
90% of travellers recommend
Panama City: Zip Line Experience Over The City
From Panama City: Monkey Islands Tour on Gatun Lake

From Panama City: Monkey Islands Tour on Gatun Lake

￥9,487
per adult
90% of travellers recommend
From Panama City: Monkey Islands Tour on Gatun Lake
Great to do it alone or accompanied.

Zipline in Panama City.

￥5,922
per adult
100% of travellers recommend
Zipline in Panama City.
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.