Santa Ana Vacations from ￥240,538

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The Latest Santa Ana Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was ￥248,231, price is now ￥240,538 per person
￥240,538
per person
Oct 23 - Oct 24
found 17 hours ago
Roundtrip flight included
Tokyo (TYO) to Panama City (PTY)
9/10 Wonderful! (4,208 reviews)
Just don’t miss the BREAKFAST. It’s amazing.

Reviewed on Sep 4, 2025

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was ￥271,888, price is now ￥253,192 per person
￥253,192
per person
Oct 23 - Oct 24
found 17 hours ago
Roundtrip flight included
Tokyo (TYO) to Panama City (PTY)
9/10 Wonderful! (976 reviews)
The hotel is so beautiful, the people are very friendly and helpful!

Reviewed on Sep 2, 2025

American Trade Hotel

American Trade Hotel

4.5 out of 5
Casco Viejo
Price was ￥254,788, price is now ￥246,890 per person
￥246,890
per person
Oct 23 - Oct 24
found 17 hours ago
Roundtrip flight included
Tokyo (TYO) to Panama City (PTY)
9.4/10 Exceptional! (555 reviews)
Great hotel in Oldtown Panama City

Reviewed on Aug 27, 2025

Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
Price was ￥256,625, price is now ￥249,258 per person
￥249,258
per person
Oct 23 - Oct 24
found 17 hours ago
Roundtrip flight included
Tokyo (TYO) to Panama City (PTY)
7.4/10 Good! (1,019 reviews)
Property was in need of renovations especially in the pool areas and walkways throughout the property. Restaurants needed more variety on menus. Resort has a beautiful view and the staff is very friendly.

Reviewed on Sep 3, 2025

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Punta Paitilla
Price was ￥248,884, price is now ￥242,204 per person
￥242,204
per person
Oct 23 - Oct 24
found 17 hours ago
Roundtrip flight included
Tokyo (TYO) to Panama City (PTY)
8.8/10 Excellent! (1,003 reviews)
The view and our Jr. suite were amazing. Good value for what we paid. We had to rush out to catch a flight so we missed our included breakfast. Only took 20 minutes to get to the airport at 6:30 am.

Reviewed on Sep 3, 2025

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
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Casco Viejo

4.5/5(178 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Find hotels in Casco Viejo

Santa Ana Hotel Deals

Casco View Apartments

Casco View Apartments

3.5 out of 5
C. 16 Oeste, Panama City, Provincia de Panamá
Get rates
Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is ￥16,191 per night from Sep 5 to Sep 6
￥16,191
￥17,810 total
Sep 5 - Sep 6
includes taxes & fees
Hotel Riu Plaza Panama
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz, Veracruz, Panama
Fully refundableReserve now, pay when you stay
The price is ￥32,102 per night from Sep 28 to Sep 29
￥32,102
￥32,102 total
Sep 28 - Sep 29
includes taxes & fees
Dreams Playa Bonita Panama - All Inclusive
See all 1,522 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Ana vacation package cost?
From as little as ￥240,538. Yes, you read that correctly. Our Santa Ana vacation packages are an easy way to stretch your budget further. Combine your favorite hotels, flights and rental car and explore this destination your way.
How do I get a cheap travel package to Santa Ana?
One of the easiest ways to save cash (and time) is to combine your bookings with Expedia. Flights, hotels, activities and rental cars — we've got it all. Pick and choose the combination that best fits you and see your savings grow. We know a package deal is never a one-size-fits-all. That's why Expedia offers over 550 air carriers and 1,000,000 hotels throughout the world, which lets you customize your Santa Ana vacation.
Where should I stay in Santa Ana?
Most who travel to Santa Ana include both Miraflores Locks and Metropolitan Cathedral of Panama on their bucket lists. Why not go for a hotel right near these great attractions?
What are the top hotels in Santa Ana?
If it's your first time in Santa Ana, make a reservation at Hotel Riazor or Hotel Doral. Both hotels will make you feel at home and are favorites among lots of travelers.
How far in advance should I book my Santa Ana vacation?
While prices change from time to time, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to a year in advance. If circumstances have left you booking late, you might still be in luck. Low prices to Santa Ana sometimes occur only weeks before departure.
What does an Expedia Santa Ana travel package include?
That mostly depends on you. You can select from a range of Santa Ana packages, such as a rental car, flight and hotel. You can also book a hotel and a flight, or a rental car and a flight. Once you've made your booking, you can add on the fun stuff like tours and activities. Whatever your perfect Santa Ana break looks like, get set to save!
What should I know before booking a Santa Ana travel package?
Discover deals to suit your budget with an Expedia package. Hotels, airfares, rental cars — we've got everything you need to plan your getaway. You'll save big dollars just for bundling your bookings. Whether you're taking off on a ski trip or getting some sun on a warm beach, your ideal getaway is only clicks away.
Can I choose my airline with a Santa Ana Expedia vacation package?
Definitely. Expedia has more than 550 airline partners to pick from globally. With all that choice at your fingertips, finding the right carrier to get you to Santa Ana shouldn't be hard.
If I'm not able to travel, can I cancel my Santa Ana vacation package?
We totally get it — life can throw you the odd curveball. If you've booked a Santa Ana vacation package and have to amend or cancel it, we're here to help. It's always worth visiting our Customer Service Portal first for information. But generally, if you've booked your package in the last 24 hours, you may be able to amend or cancel your itinerary at no cost. If it's been longer than 24 hours, your hotel, airline or car rental company may charge a fee.

Discover the most popular places to visit in Santa Ana

Cinta Costera a wonderful pedestrian walkway with a separate lane for bicyclists and skateboarders #OrbitzTravel

Avenida Balboa

You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa
The famous Panama Canal Railways; nowadays tourists take the train from the Pacific coast to Caribbean coast or vice versa;US$25 per trip, about an hour ride

Panama Canal Railway

Enjoy an outing to Panama Canal Railway during your stay in Ancon. Stroll along the seaside or visit the shops in this culturally rich area.

Panama Canal Railway

Albrook Shopping Mall

You can enjoy some retail therapy with a trip to Albrook Shopping Mall, a favorite shopping spot in Ancon. Amble around this vibrant area's seaside and enjoy its top-notch restaurants.

Albrook Shopping Mall

Things to do

Slingshot Tour Panama

Slingshot Tour Panama

￥17,653
per adult
80% of travellers recommend
Slingshot Tour Panama
Day Tour

Day Tour in San Blas Islands All Included Visiting 4 Islands

￥22,022
per adult
94% of travellers recommend
Day Tour in San Blas Islands All Included Visiting 4 Islands
Panama City Visit an Indian town Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

￥7,390
per adult
96% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.