
Santa Ana Vacations
Book a Hotel + Flight or Car together to unlock savings
Photo by Isa
Better together
Save up to ¥45,448 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Where to stay in Santa Ana
Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana

Casco Viejo
4.5/5(178 area reviews)
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.
Santa Ana Hotel Deals

Casco View Apartments
C. 16 Oeste, Panama City, Provincia de Panamá
9.4/10 Exceptional! (38 reviews)
"I liked the buildings quietness and modern style."
Reviewed on Jun 23, 2025

Hotel Riu Plaza Panama
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is ¥16,816 per night from Jul 30 to Jul 31
¥16,816
¥18,498 total
Jul 30 - Jul 31
includes taxes & fees
9/10 Wonderful! (4,095 reviews)
"I really love it there it reminds me of home"
Reviewed on Jul 12, 2025

Dreams Playa Bonita Panama - All Inclusive
KM 7, Road to Veracruz, Veracruz, Panama
Fully refundableReserve now, pay when you stay
The price is ¥36,120 per night from Aug 1 to Aug 2
¥36,120
¥36,120 total
Aug 1 - Aug 2
includes taxes & fees
7.2/10 Good! (1,003 reviews)
"Un hotel muy acogedor!! Muy bonitas instalaciones"
Reviewed on Jul 11, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Discover the most popular places to visit in Santa Ana

Avenida Balboa
4/5(554 reviews)
You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.

Panama Canal Railway
4/5(10 reviews)
Enjoy an outing to Panama Canal Railway during your stay in Ancon. Stroll along the seaside or visit the shops in this vibrant area.
Albrook Shopping Mall
4/5(605 reviews)
You can enjoy some retail therapy with a trip to Albrook Shopping Mall, a favorite shopping spot in Ancon. Amble around this culturally rich area's seaside and enjoy its top-notch restaurants.
Things to do

Half day of Panama city and canal tour: shared and private
¥9,644
per adult
98% of travellers recommend

Day Tour in San Blas Islands All Included Visiting 4 Islands
¥21,553
per adult
94% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.