Serra Mesa, CA
San Diego
Visit Serra Mesa
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
San Diego Convention Center
During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's entertainment choices and fascinating museums.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Port of San Diego
Explore the waterfront in San Diego with a trip to Port of San Diego. Wander the seaside and beautiful beaches in the area.
Things to do
City Cruises San Diego: Premier Bottomless Mimosa Brunch Cruise
San Diego: Museum of Illusions Entry Ticket
San Diego Old Town Trolley Hop-On Hop-Off Tour
San Diego Whale Watching & Dolphin Cruise
San Diego City Lights Night Tour
Speed Boat Adventure Tour: Thrills on the San Diego Bay
Serra Mesa Hotel Deals
Paradise Point Resort & Spa
Spotless
Reviewed on Feb 11, 2026
Hard Rock Hotel San Diego
Beautiful stay
Reviewed on Feb 10, 2026
The DEXTRO Little Italy, BW Premier Collection
Everything was good
Reviewed on Feb 11, 2026
The Sofia Hotel
Location is close to Gaslamp district howvever seapoint village was cleaner and had nice restaurants and shops. The conference centre is a nice 15 to 20 minute walk from the hotel. The hotel manager Amy turned our stay around by listening issue with the AC and the fluff coming from it.We moved to ...
Reviewed on Feb 12, 2026
Manchester Grand Hyatt San Diego
great
Reviewed on Feb 8, 2026
Wyndham San Diego Bayside
Staff was very helpful and friendly
Reviewed on Feb 11, 2026
Other neighborhoods around Serra Mesa
Mission Valley
Boasting major shopping malls like Fashion Valley Mall and Westfield Mission Valley, this area offers entertainment and historic sites such as Mission San Diego de Alcalá and Presidio Park. Easily accessible via the San Diego Trolley system's Green Line.
North Park
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Del Cerro
Del Cerro might not have many top sights, but Cal Coast Credit Union Open Air Theater and Viejas Arena are two attractions nearby that you can check out.
Old Town San Diego
The ample dining options and beautiful seaside views are top of the list for many visitors to Old Town San Diego. A stop by Old Town San Diego State Park or Whaley House Museum might round out your trip.
Mission Bay
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
Serra Mesa, CA
Explore a world of travel with Expedia
- Aparthotels in Central San Diego
- Hotels near SDSU Transit Center Station
- Hotels with smoking rooms in San Diego
- Cheap Hotels in City Heights
- Inns in Gaslamp Quarter Station
- Chalets in San Diego
- North Park Hotels
- Ski Hotels in North Park
- Rv Parks in San Diego County
- Cheap Hotels in North Park
- Rv Parks in Mission San Diego Station
- All-Inclusive Hotel Hotels in Mission Valley
- Hillcrest Hotels
- Hotels near Qualcomm Stadium Station
- Clairemont Mesa East Hotels
- Hotels near Japanese Friendship Garden
- Town Houses in Seaport Village Station
- Old Town San Diego Hotels
- Hotels near University of San Diego
- Family Hotels in Linda Vista
- Hotels with an Indoor Pool in San Diego
- Hotels near Fashion Valley Transit Center Station
- Winery Hotels in Central San Diego
- Cheap Hotels in Hillcrest
- Apartments in Fenton Parkway Station
- Adventure Hotels in Liberty Station
- Pet-Friendly Hotels in San Carlos
- Little Italy Hotels
- Ski Hotels in Mission Valley
- Cheap Hotels in Central San Diego
- Hotels near Hotel Circle
- Hotels near San Diego Museum of Art
- Hotels near Mission Bay Park
- Mission Valley Hotels
- Residences in Central San Diego
- Adults Only Resorts & in Gaslamp Quarter
- Farmstay in Fiesta Island
- Hotels near Marine Corps Air Station Miramar
- Business Hotels in Kearny Mesa
- Business Hotels in Gaslamp Quarter
- Cheap Hotels in Downtown San Diego
- Clairemont Mesa Hotels
- Hotels near Waterfront Park
- Adults Only Resorts & in San Diego County
- Capsule Hotels in San Diego County
- All-Inclusive Hotel Hotels in Bay Park
- Miramar Hotels
- Rv Parks in Central San Diego
- Pet-Friendly Hotels in Miramar
- Hotels near Old Town San Diego State Park
- Family Hotels in San Carlos
- All-Inclusive Hotel Hotels in Gaslamp Quarter
- Hotels near Cal Coast Credit Union Open Air Theater
- Beach Hotels in Old Town San Diego
- Hotels near Balboa Park
- Hotels with Free Parking in San Diego County
- Hotels near Balboa Park Carousel
- Hotels near Marine Corps Recruit Depot
- Resorts in Gaslamp Quarter Station
- Linda Vista Hotels
- Cheap Hotels in Old Town San Diego
- Business Hotels in Old Town San Diego
- Hotels near Mission San Diego Station
- Luxury Hotels in North Park
- Luxury Hotels in San Diego
- Pet-Friendly Hotels in Old Town San Diego
- Houseboats in San Diego
- Clairemont Hotels
- Resorts in Morena - Linda Vista Station
- Kearny Mesa Hotels
- Hotels near San Diego Zoo
- City Heights Hotels
- Hotels near Mission Valley Mall
- Luxury Hotels in Serra Mesa
- Condo Resorts in Central San Diego
- Shopping Hotels in Mission Valley
- Beach Hotels in San Diego
- Luxury Hotels in Kearny Mesa
- Pet-Friendly Hotels in Central San Diego
- Cheap Hotels in Kearny Mesa
- Hotels near San Diego State University
- Hotels with Early Check-in in San Diego
- Bankers Hill Hotels
- Beach Hotels in Mission Valley
- Pet-Friendly Hotels in Mission Valley
- Motels in San Diego
- Cheap Hotels in Liberty Station
- Hotels near Fashion Valley Mall
- Aparthotels in San Diego County
- Hotels near San Diego Natural History Museum
- Hotels near Convoy District
- East Village Hotels
- Hotels near Montgomery Field
