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Discover Serra Mesa hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4.0 star property
9.9 km from Serra Mesa
8.4 out of 10, Very Good, (6035)
"I enjoyed my stay."
United States
Kevin
The price is ￥20,887
￥28,700 total
includes taxes & fees
Nov 24 - Nov 25
Wyndham San Diego Bayside
Outdoor pool
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4.0 star property
Gaslamp Quarter, 10.8 km from Serra Mesa
9.0 out of 10, Wonderful, (3077)
"Our stay was great! Would stay here again"
United States
Carla
The price is ￥24,834
￥35,901 total
includes taxes & fees
Dec 12 - Dec 13
Hard Rock Hotel San Diego
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace
Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel

3.5 star property
16.1 km from Serra Mesa
9.2 out of 10, Wonderful, (3393)
"Clean, staff friendly, great place for a stay"
United States
Derrick
The price is ￥17,945
￥19,774 total
includes taxes & fees
Nov 30 - Dec 1
Best Western Plus Marina Gateway Hotel
Rooftop terrace
Palihotel San Diego Gaslamp Quarter

Palihotel San Diego Gaslamp Quarter

4.0 star property
Gaslamp Quarter, 10.1 km from Serra Mesa
8.6 out of 10, Excellent, (2028)
"Clean room, excellent staff and pleasant atmosphere "
United States
Estela
The price is ￥17,773
￥20,606 total
includes taxes & fees
Nov 23 - Nov 24
Palihotel San Diego Gaslamp Quarter
Exterior
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

3.0 star property
Gaslamp Quarter, 10.6 km from Serra Mesa
9.0 out of 10, Wonderful, (1208)
"Clean room ,friendly staff, great location "
United States
Jessica
The price is ￥20,887
￥24,218 total
includes taxes & fees
Nov 20 - Nov 21
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Serves dinner and happy hour
The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter

3.5 star property
10.5 km from Serra Mesa
9.0 out of 10, Wonderful, (2653)
"Very nice location and rooms. "
United States
David
The price is ￥18,980
￥26,189 total
includes taxes & fees
Dec 14 - Dec 15
The Horton Grand, Downtown/Gaslamp Quarter
Lobby
El Cordova Hotel on Coronado Island

El Cordova Hotel on Coronado Island

3.5 star property
13.9 km from Serra Mesa
8.8 out of 10, Excellent, (1004)
"Thank you - great spot! I will stay again ⭐️ "
United States
Donna
The price is ￥21,609
￥28,448 total
includes taxes & fees
Nov 30 - Dec 1
El Cordova Hotel on Coronado Island
Garden
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

4.0 star property
5.7 km from Serra Mesa
9.2 out of 10, Wonderful, (2930)
"Great hotel"
United States
Michael
The price is ￥26,849
￥30,861 total
includes taxes & fees
Nov 17 - Nov 18
Legacy Resort Hotel & Spa
Property entrance
The Bristol Hotel San Diego

The Bristol Hotel San Diego

3.5 star property
9.9 km from Serra Mesa
8.6 out of 10, Excellent, (1427)
"Nice staff, comfortable beds"
United States
Amber
The Bristol Hotel San Diego
Lobby
Gaslamp Plaza Suites

Gaslamp Plaza Suites

3.5 star property
Gaslamp Quarter, 10 km from Serra Mesa
8.8 out of 10, Excellent, (1005)
"Everything was amazing! Both of the hotel desk clerks at check-in in the afternoon were so helpful, kind, and knowledgeable. Plenty of places to walk to and eat around the hotel. Clean and felt safe!"
United States
Yadira
The price is ￥17,164
￥19,524 total
includes taxes & fees
Dec 9 - Dec 10
Gaslamp Plaza Suites
Front of property
The Sofia Hotel

The Sofia Hotel

3.5 star property
10 km from Serra Mesa
8.4 out of 10, Very Good, (1627)
"Excellent stay all-around!"
United States
Nalani
The price is ￥17,099
￥23,505 total
includes taxes & fees
Dec 16 - Dec 17
The Sofia Hotel
Outdoor pool, a heated pool
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3.0 star property
5.4 km from Serra Mesa
8.0 out of 10, Very Good, (2391)
"We loved our stay, great price, very clean and excellent location! "
United States
Brenda
The price is ￥13,252
￥15,233 total
includes taxes & fees
Nov 17 - Nov 18
Days Inn by Wyndham San Diego Hotel Circle
2 outdoor pools, a heated pool, sun loungers
The Dana on Mission Bay

The Dana on Mission Bay

3.5 star property
Mission Bay, 10.1 km from Serra Mesa
8.8 out of 10, Excellent, (3860)
"Overall, nice place to stay!"
United States
Jazmine
The price is ￥24,573
￥31,336 total
includes taxes & fees
Nov 24 - Nov 25
The Dana on Mission Bay
Premium bedding, pillowtop beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

3.0 star property
Gaslamp Quarter, 10.4 km from Serra Mesa
9.4 out of 10, Exceptional, (1003)
"The room was immaculate, the staff were helpful and friendly and our stay was so wonderful. "
United States
Samantha Erin
The price is ￥16,568
￥23,676 total
includes taxes & fees
Nov 24 - Nov 25
Staypineapple, Hotel Z, Gaslamp San Diego
2 outdoor pools, open 6 AM to 10:00 PM, cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4.0 star property
10.7 km from Serra Mesa
9.2 out of 10, Wonderful, (1910)
"Great hotel with a great walkable location…staff was very nice and friendly "
United States
Lisa
The price is ￥24,573
￥36,619 total
includes taxes & fees
Nov 22 - Nov 23
Marriott Marquis San Diego Marina
Check-in/check-out kiosk
Urban Boutique Hotel

Urban Boutique Hotel

3.0 star property
Little Italy, 9.3 km from Serra Mesa
8.6 out of 10, Excellent, (1272)
"Alwsys clean , great staff andvperfect location"
United States
Colleen
Urban Boutique Hotel
Exterior
La Pensione Hotel

La Pensione Hotel

3.0 star property
Little Italy, 9.3 km from Serra Mesa
8.6 out of 10, Excellent, (1890)
"Great place"
United States
ADRIANA
La Pensione Hotel
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillowtop beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3.0 star property
9.3 km from Serra Mesa
8.8 out of 10, Excellent, (653)
"Great staff, great location, great value. "
United States
Juan
The price is ￥14,713
￥17,059 total
includes taxes & fees
Dec 14 - Dec 15
The DEXTRO Little Italy, BW Premier Collection
City view from property
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

4.0 star property
Little Italy, 9.3 km from Serra Mesa
8.2 out of 10, Very Good, (1218)
"Beautiful hotel ."
United States
Emiliano
The price is ￥17,001
￥19,712 total
includes taxes & fees
Nov 24 - Nov 25
Courtyard by Marriott San Diego Downtown Little Italy
3 outdoor pools, cabanas (surcharge), pool umbrellas
Sycuan Casino Resort

Sycuan Casino Resort

4.0 star property
29.1 km from Serra Mesa
9.2 out of 10, Wonderful, (1609)
"Nice hotel and friendly staff. Will definitely stay again ."
United States
Lorna
Sycuan Casino Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Hotels in Serra Mesa with free breakfast

6 restaurants, breakfast, lunch, dinner served; seafood
Manchester Grand Hyatt San Diego
Manchester Grand Hyatt San Diego
4.0 star property
  • Breakfast included
9.0 out of 10, Wonderful, (2861)
The price is ￥24,829
￥37,196 total
includes taxes & fees
Nov 25 - Nov 26
Manchester Grand Hyatt San Diego
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Hotels in Serra Mesa with a pool

Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillowtop beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection
The DEXTRO Little Italy, BW Premier Collection
3.0 star property
  • Pool
8.8 out of 10, Excellent, (653)
The price is ￥14,713
￥17,059 total
includes taxes & fees
Dec 14 - Dec 15
The DEXTRO Little Italy, BW Premier Collection
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Top guest rated hotels in Serra Mesa

View from property
Moxy San Diego Downtown/Gaslamp Quarter
Moxy San Diego Downtown/Gaslamp Quarter
3.5 star property
    9.0 out of 10, Wonderful, (1005)
    The price is ￥15,161
    ￥17,579 total
    includes taxes & fees
    Nov 24 - Nov 25
    Moxy San Diego Downtown/Gaslamp Quarter
    See more properties

    Where to stay in Serra Mesa

    Find the best Serra Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Serra Mesa
    Learn more about Serra Mesa
    US Grant Hotel

    Downtown San Diego

    Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

    Gaslamp Quarter showing signage, night scenes and street scenes

    Gaslamp Quarter

    Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

    Pacific Beach Park showing a beach

    Pacific Beach

    Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

    Belmont Park showing rides and a garden

    Mission Beach

    Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

    Ocean Beach

    Ocean Beach

    Ocean Beach is known for its stunning beaches, and with sights like Ocean Beach Pier and Dog Beach, you won't get bored spending a day wandering around this part of San Diego.

    Top Serra Mesa Hotel Reviews

    Legacy Resort Hotel & Spa

    Legacy Resort Hotel & Spa

    10/10 Excellent
    "Weekend getaway at this beautiful property was just what i needed defiantly will recommend 10/10"
    Erica 3-night trip
    Posted 18 hours ago
    Legacy Resort Hotel & Spa

    Explore a world of travel with Expedia

    Frequently asked questions

    What's it like in Serra Mesa?
    Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighborhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.
    How many hotels will I be able to find in the Serra Mesa area?
    Expedia has 37 hotels and other accommodations in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
    If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?
    Yes, you'll find most hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Add your dates and click on "Search", then filter by "fully refundable" to view the top deals on offer in Serra Mesa.
    Where can I learn more about changing or cancelling my trip to Serra Mesa?
    For more information about picking new dates or cancelling your trip to Serra Mesa, click here.
    What can I see and do in this San Diego neighborhood?
    Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.