Serra Mesa, CA
San Diego
Visit Serra Mesa
Popular places to visit
San Diego Zoo
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's entertainment choices and acclaimed art scene.
Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Mission Beach
A favorite vacation spot for 100 years, this seaside village combines old-fashioned charm with modern amenities.
SeaWorld
Animal interaction, entertaining rides and informative exhibits are all on offer at this family favorite destination.
Things to do
San Diego City Lights Night Tour
San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway
San Diego Whale Watching Tour
San Diego Sunset Cruise from Mission Bay
Crossing Borders: Tijuana Day Trip from San Diego
Taste of Little Italy in San Diego
Serra Mesa Hotel Deals
Handlery Hotel
Reviewed on Aug 21, 2025
Bay Club Hotel & Marina
Reviewed on Aug 23, 2025
Wyndham San Diego Bayside
Reviewed on Aug 24, 2025
The DEXTRO Little Italy, BW Premier Collection
Reviewed on Aug 20, 2025
The Dana on Mission Bay
Reviewed on Aug 23, 2025
Hotel del Coronado, Curio Collection by Hilton
Reviewed on Aug 22, 2025
Other neighborhoods around Serra Mesa
Mission Valley
Boasting major shopping malls like Fashion Valley Mall and Westfield Mission Valley, this area offers entertainment and historic sites such as Mission San Diego de Alcalá and Presidio Park. Easily accessible via the San Diego Trolley system's Green Line.
North Park
North Park is well-liked for its restaurants. You can also take some time to explore sights in the surrounding area like San Diego Zoo and San Diego Natural History Museum.
Hillcrest
Visitors to Hillcrest enjoy its restaurants, and if you want to do some exploring, Marston House is worth a stop.
Del Cerro
Del Cerro might not have many top sights, but Cal Coast Credit Union Open Air Theater and Viejas Arena are two attractions nearby that you can check out.
Old Town San Diego
The ample dining options and beautiful seaside views are top of the list for many visitors to Old Town San Diego. A stop by Old Town San Diego State Park or Whaley House Museum might round out your trip.
Mid-City
If you're spending time in Mid-City, check out sights like Cal Coast Credit Union Open Air Theater or Viejas Arena and hop on the metro to see more the city at SDSU Transit Center Station or Alvarado Station.
- San Diego Zoo
- San Diego Convention Center
- Mission Bay
- Petco Park
- Mission Beach
- Balboa Park
- Hotel Circle
- Naval Base San Diego
- Port of San Diego
- USS Midway Museum
- Marine Corps Recruit Depot
- Hotel del Coronado
- La Jolla Cove
- Coronado Beach
- Naval Base Coronado
- Seaport Village
- University of California
- Torrey Pines Golf Course
- Old Town San Diego State Park
- Marine Corps Air Station Miramar
- Waterfront Park
Other Hotels near Serra Mesa, San Diego
Expedia's Latest Trends
- Visit Venice Canals
- Visit Gaslamp Quarter
- Visit Bel Air
- Visit Union Square
- Visit Hollywood Hills
- Visit Downtown San Diego
- Visit Boyle Heights
- Visit Mission Valley
- Visit Point Loma
- Visit Hollywood
- Visit Miramar
- Visit Japantown
- Visit Downtown Los Angeles
- Visit Lake Balboa
- Visit Koreatown
- Visit Chinatown
- Visit Downtown San Jose
- Visit Fashion District
- Visit Ocean Beach
- Visit Fisherman's Wharf
- Visit Downtown San Francisco
- Visit Downtown Oakland
- Visit Chinatown
- Visit Haight-Ashbury
- Visit Little Russia
- Visit Skid Row