Serra Mesa Vacations from ￥238,267

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The Latest Serra Mesa Vacation Packages

Price found within the past 48 hours. Click for updated prices.
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
per person
Sep 19 - Sep 22
found 1 day ago
Roundtrip flight included
Tokyo (HND) to San Diego (SAN)
8.4/10 Very Good! (1,510 reviews)
All was very good, only small issue was the sink, water was draining slow & the shower drain also was draining slow, the shower would flood.

Reviewed on Aug 15, 2025

Hotel del Coronado, Curio Collection by Hilton

Hotel del Coronado, Curio Collection by Hilton

4 out of 5
Historic Downtown Coronado
per person
Sep 19 - Sep 22
found 1 day ago
Roundtrip flight included
Tokyo (HND) to San Diego (SAN)
8/10 Very Good! (1,011 reviews)
Beautiful property, too expensive!!!!! plus you pay taxes, resort fees and the food was too expensive. We won't be doing this one again!!!!

Reviewed on Aug 16, 2025

Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark

4 out of 5
Downtown San Diego
per person
Sep 19 - Sep 22
found 1 day ago
Roundtrip flight included
Tokyo (HND) to San Diego (SAN)
9.2/10 Wonderful! (1,988 reviews)
Great staff Would stay again

Reviewed on Aug 11, 2025

Town and Country San Diego

Town and Country San Diego

4 out of 5
Mission Valley
per person
Sep 19 - Sep 22
found 1 day ago
Roundtrip flight included
Tokyo (HND) to San Diego (SAN)
8.6/10 Excellent! (1,243 reviews)
Clean and inviting ambiance throughout the resort. Family friendly dining and food options inside the resort for those who want to stay there with their families.

Reviewed on Aug 16, 2025

The Bristol Hotel San Diego

The Bristol Hotel San Diego

3.5 out of 5
Downtown San Diego
per person
Sep 19 - Sep 22
found 1 day ago
Roundtrip flight included
Tokyo (HND) to San Diego (SAN)
8.4/10 Very Good! (1,350 reviews)
NOT SOUNDPROOF. THE CLEANERS WERE ALWAYS LOUD, banging on their equipment doors that affect their guests early in the morning. The street noise wasn'tthat bad but because if the. At nightI was there waiting for my passport to fly out. I could have rebooked while waiting, but I had to check out for my sanity.

Reviewed on Aug 15, 2025

Where to stay in Serra Mesa

Find the best Serra Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Serra Mesa
US Grant Hotel

Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(8,497 area reviews)

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Find hotels in Downtown San Diego

Serra Mesa Hotel Deals

Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is ￥13,837 per night from Aug 25 to Aug 26
￥13,837
￥15,905 total
Aug 25 - Aug 26
includes taxes & fees
8/10 Very Good! (1,957 reviews)
2nd Stay.
"The staff is wonderful, polite, and professional. The food is delicious, and the overall food experience is great. We will be coming back a third and many more times. Thanks again"

Reviewed on Aug 16, 2025

Handlery Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is ￥24,875 per night from Aug 24 to Aug 25
￥24,875
￥28,593 total
Aug 24 - Aug 25
includes taxes & fees
8.8/10 Excellent! (3,625 reviews)
"We had a great time. Our room was on the very far park end which wasn't ideal. I would have loved to look out toward the bay. The room itself was big and spacious. It was very noisy every morning when the trash company came to collect the garbage right outside our window. Minor little inconvenience, ..."

Reviewed on Aug 14, 2025

The Dana on Mission Bay
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is ￥25,037 per night from Aug 31 to Sep 1
￥25,037
￥37,036 total
Aug 31 - Sep 1
includes taxes & fees
9/10 Wonderful! (2,787 reviews)
"Promise this a treat for anyone…..The rooms were clean and the staycation was welcoming."

Reviewed on Aug 15, 2025

Manchester Grand Hyatt San Diego
See all 8,845 properties in Serra Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Serra Mesa vacation package cost?
Be ready to book, because a trip to Serra Mesa starts from just ￥238,267. When you bundle your hotels, flights and car rentals into a package, you'll land the lowest prices.
How do I get a cheap travel package to Serra Mesa?
One of the simplest ways to save dollars (and time) is to bundle your bookings with Expedia. Flights, hotels, activities and rental cars — we've got everything you need. Pick the combination that best suits you and watch your savings pile up. Of course, a travel package is never one-size-fits-all. That's why we offer more than 550 partner airlines and 1,000,000 hotel options worldwide, which lets you customize your Serra Mesa vacation.
Where should I stay in Serra Mesa?
Most visitors to Serra Mesa put both San Diego Zoo and Balboa Park on their itineraries. Why not go for a hotel that's close to these fantastic attractions?
What are the top hotels in Serra Mesa?
Get your escape off to an excellent start by locking in a room at Central Location - 3br/2ba. Stay Weekly. Clean. It's one of most sought-after properties in Serra Mesa. Another comfortable option is Newly Remodeled Beautiful Beach Bound And Centrally Located San Diego Home.
How far in advance should I book my Serra Mesa vacation?
It's difficult to pick the best time for airfares, but we normally say the earlier, the better. Most international flights on Expedia become available up to 12 months in advance. If you're booking late, fear not. Budget prices appear from time to time just weeks before departure dates.
What does an Expedia Serra Mesa travel package include?
From flights and hotels to rental cars, Expedia can help you craft a Serra Mesa package that's perfect for you. Vacationing for a few weeks? Consider a flight, hotel and rental car bundle. If your break is short, a flight and hotel deal could be what you're after. Experiences can also be added once you've made your booking. Our travel packages make it a cinch to plan and save.
What should I know before booking a Serra Mesa travel package?
You can save a tidy sum by combining your hotels, airfares and rental cars. Once you've made your booking, you can add on things like day tours or experiences. Your next unforgettable vacation is only a few clicks away.
Can I choose my airline with a Serra Mesa Expedia vacation package?
With a vacation package, you're the one in charge. Whether you'd like to fly to Serra Mesa in economy or first class, simply choose from the available airline options. Expedia has access to over 550 partner airlines all over the world.
If I'm not able to travel, can I cancel my Serra Mesa vacation package?
Plans can change in the blink of an eye, so yes. You may be able to cancel or alter your Serra Mesa vacation package at no cost if you've booked in the last 24 hours. For bookings made more than 24 hours ago, you can still make the necessary changes, but your car rental company, hotel or airline may impose a charge. Want more information? Check out our Customer Service Portal. We'll help make sure your getaway goes off without a hitch.

Discover the most popular places to visit in Serra Mesa

San Diego Zoo featuring landscape views, zoo animals and a pond

San Diego Zoo

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's entertainment choices and acclaimed art scene.

San Diego Convention Center
Mission Bay featuring a sandy beach

Mission Bay

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay

Things to do

San Diego City Lights Night Tour

San Diego City Lights Night Tour

￥6,794
per adult
94% of travellers recommend
San Diego City Lights Night Tour
San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway

San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway

￥18,314
per adult
86% of travellers recommend
San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway
Great Scenery

San Diego Sunset Cruise from Mission Bay

￥5,908
per adult
78% of travellers recommend
San Diego Sunset Cruise from Mission Bay
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.