Serra Mesa Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to ￥109,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place
Price found within the past 48 hours. Click for updated prices.
  • Exterior
    Jun 28 - Jun 30

    The Sofia Hotel + Flight

    Downtown San Diego
    2 nights
    3.5 star property
    8.6/10 - Excellent (2,120 reviews)
    "Very nice place! Will come back"
    Reviewed May 26, 2026
    Roundtrip • Los Angeles (LAX) - San Diego (SAN)
    LAX - SAN • 1 stop SAN - LAX • 1 stop
    ￥108,885
    ￥84,361
    per traveler
    found 7 hours ago
    The Sofia Hotel
  • Lobby
    Jul 17 - Jul 22

    Margaritaville Hotel San Diego Gaslamp Quarter + Flight

    Downtown San Diego
    5 nights
    4.0 star property
    9.0/10 - Wonderful (1,367 reviews)
    "Worst hotel in San Diego. Has bed bugs, my wife was bitten multiple times. Also beware of resort fee it’s a hidden charge they have around $60 USD per day over and above the Expedia price. We checked out early because of the bed bugs."
    Reviewed May 24, 2026
    Roundtrip • Tokyo (HND) - San Diego (SAN)
    HND - SAN • 1 stop SAN - NRT • 1 stop
    ￥406,475
    ￥304,588
    per traveler
    found 1 day ago
    Margaritaville Hotel San Diego Gaslamp Quarter
  • Classic Studio | In-room dining
    Jul 18 - Jul 22

    The Artifact Inn + Flight

    Downtown San Diego
    4 nights
    2.0 star property
    9.2/10 - Wonderful (77 reviews)
    "A lovely and welcoming oasis. Exactly as advertised. Staff were very helpful. Would definitely stay here again."
    Reviewed May 24, 2026
    Roundtrip • Tokyo (HND) - San Diego (SAN)
    HND - SAN • 1 stop SAN - NRT • 1 stop
    ￥629,232
    ￥473,560
    per traveler
    found 1 day ago
    The Artifact Inn
  • Exterior
    Jun 28 - Jun 30

    The Westin San Diego Gaslamp Quarter + Flight

    Downtown San Diego
    2 nights
    4.0 star property
    9.0/10 - Wonderful (1,003 reviews)
    "Location of the Hotel is great for restaurants "
    Reviewed May 16, 2026
    Roundtrip • Los Angeles (LAX) - San Diego (SAN)
    LAX - SAN • 1 stop SAN - LAX • 1 stop
    ￥108,936
    ￥85,204
    per traveler
    found 7 hours ago
    The Westin San Diego Gaslamp Quarter
  • Couples treatment rooms, steam room, body treatments, aromatherapy
    Jul 20 - Jul 25

    Rancho Bernardo Inn + Flight

    Rancho Bernardo
    5 nights
    4.0 star property
    8.8/10 - Excellent (1,002 reviews)
    "Clean"
    Reviewed May 22, 2026
    Roundtrip • Tokyo (NRT) - San Diego (SAN)
    NRT - SAN • 1 stop SAN - NRT • 1 stop
    ￥475,331
    ￥377,722
    per traveler
    found 1 day ago
    Rancho Bernardo Inn

Where to stay in Serra Mesa

Find the best Serra Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Serra Mesa
Downtown San Diego

Downtown San Diego

4 out of top 10 points of interest in this area

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Find hotels in Downtown San Diego

Serra Mesa Hotel Deals

The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
The price is ￥17,203 per night from Jun 14 to Jun 15
￥17,203
￥24,390 total
Jun 14 - Jun 15
includes taxes & fees
8.6/10 Excellent! (2,120 reviews)
"Very nice place! Will come back"

Reviewed on May 26, 2026

The Sofia Hotel
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
The price is ￥32,152 per night from May 31 to Jun 1
￥32,152
￥45,367 total
May 31 - Jun 1
includes taxes & fees
8.8/10 Excellent! (2,611 reviews)
"Amazing getaway with our family!! The kiddos had a ton of fun enjoying watching a movie while being in the pool! Drinks were delicious for adults! And the beach was beautiful Very serene- definitely will come again Right by Sea World too!"

Reviewed on May 25, 2026

Paradise Point Resort & Spa
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
The price is ￥36,395 per night from Jun 14 to Jun 15
￥36,395
￥50,859 total
Jun 14 - Jun 15
includes taxes & fees
9/10 Wonderful! (2,834 reviews)
"The hotel is under construction and it shows. We have stayed there a few times and the quality has declined for the price. I would no longer recommend this hotel like before."

Reviewed on May 26, 2026

Manchester Grand Hyatt San Diego
See all 9,131 properties in Serra Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Serra Mesa vacation package cost?
Be ready to book, because a trip to Serra Mesa starts from just . When you bundle your hotels, flights and car rentals into a package, you'll land the lowest prices.
How do I get a cheap travel package to Serra Mesa?
One of the simplest ways to save dollars (and time) is to bundle your bookings with Expedia. Flights, hotels, activities and rental cars — we've got everything you need. Pick the combination that best suits you and watch your savings pile up. Of course, a travel package is never one-size-fits-all. That's why we offer more than 550 partner airlines and 1,000,000 hotel options worldwide, which lets you customize your Serra Mesa vacation.
Where should I stay in Serra Mesa?
Most visitors to Serra Mesa put both San Diego Zoo and Balboa Park on their itineraries. Why not go for a hotel that's close to these fantastic attractions?
What are the top hotels in Serra Mesa?
Get your escape off to an excellent start by locking in a room at Central Location - 3br/2ba. Stay Weekly. Clean. It's one of most sought-after properties in Serra Mesa. Another comfortable option is Newly Remodeled Beautiful Beach Bound And Centrally Located San Diego Home.
How far in advance should I book my Serra Mesa vacation?
It's difficult to pick the best time for airfares, but we normally say the earlier, the better. Most international flights on Expedia become available up to 12 months in advance. If you're booking late, fear not. Budget prices appear from time to time just weeks before departure dates.
What does an Expedia Serra Mesa travel package include?
From flights and hotels to rental cars, Expedia can help you craft a Serra Mesa package that's perfect for you. Vacationing for a few weeks? Consider a flight, hotel and rental car bundle. If your break is short, a flight and hotel deal could be what you're after. Experiences can also be added once you've made your booking. Our travel packages make it a cinch to plan and save.
What should I know before booking a Serra Mesa travel package?
You can save a tidy sum by combining your hotels, airfares and rental cars. Once you've made your booking, you can add on things like day tours or experiences. Your next unforgettable vacation is only a few clicks away.
Can I choose my airline with a Serra Mesa Expedia vacation package?
With a vacation package, you're the one in charge. Whether you'd like to fly to Serra Mesa in economy or first class, simply choose from the available airline options. Expedia has access to over 550 partner airlines all over the world.
If I'm not able to travel, can I cancel my Serra Mesa vacation package?
Plans can change in the blink of an eye, so yes. You may be able to cancel or alter your Serra Mesa vacation package at no cost if you've booked in the last 24 hours. For bookings made more than 24 hours ago, you can still make the necessary changes, but your car rental company, hotel or airline may impose a charge. Want more information? Check out our Customer Service Portal. We'll help make sure your getaway goes off without a hitch.

Discover the most popular places to visit in Serra Mesa

San Diego Zoo

San Diego Zoo

4.5/5(3,637 reviews)

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

4.5/5(1,324 reviews)

During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's fascinating museums and acclaimed art scene.

San Diego Convention Center
Mission Bay

Mission Bay

4.5/5(2,416 reviews)

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay

Things to do

LEGOLAND® California Resort

LEGOLAND® California Resort

￥11,611
per adult
84% of travellers recommend
LEGOLAND® California Resort
Oceanside Whale and Dolphin Watching Adventures

Oceanside Whale and Dolphin Watching Adventures

￥8,943
per adult
90% of travellers recommend
Oceanside Whale and Dolphin Watching Adventures
San Diego Whale Watching Tour

San Diego Whale Watching & Dolphin Cruise

￥11,140
per adult
86% of travellers recommend
San Diego Whale Watching & Dolphin Cruise
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.