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Our top choices for Otay Mesa hotels
7.2 out of 10, Good, (1005)
"Clean, convenient location "
Mary
The price is ￥15,769
￥17,937 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHGOtay Mesa
8.0 out of 10, Very Good, (1568)
"Great place to stay. Really clean and helpful staff "
Zulma
The price is ￥18,609
￥21,168 total
includes taxes & fees
Jan 11 - Jan 12, 2026
8.4 out of 10, Very Good, (1001)
"Great spot"
Alexandro
The price is ￥12,793
￥14,424 total
includes taxes & fees
Jan 4 - Jan 5, 2026
9.0 out of 10, Wonderful, (1001)
"Loved this stay, they were very accommodating "
Maurizio
The price is ￥25,056
￥34,477 total
includes taxes & fees
Jan 1 - Jan 2, 2026
8.6 out of 10, Excellent, (1010)
"Great stay"
Naomi
Courtyard by Marriott Old Town
Courtyard by Marriott Old TownOld Town San Diego, 29.7 km from Otay Mesa
8.6 out of 10, Excellent, (1004)
"Great stay!!! Will be staying again! "
Raven
The price is ￥18,592
￥21,370 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa
Downtown San Diego
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
Gaslamp Quarter
Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.
Pacific Beach
Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.
Mission Beach
Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.
Ocean Beach
Ocean Beach is known for its stunning beaches, and with sights like Dog Beach and Sunset Cliffs Natural Park, you won't get bored spending a day wandering around this part of San Diego.
Top Otay Mesa Hotel Reviews
Courtyard by Marriott San Diego Downtown Little Italy
10/10 Excellent
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