Find hotels in Otay Mesa, San Diego from ￥16,185

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Discover 4,826 Otay Mesa hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Exterior
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 star property
Otay Mesa
8.0 out of 10, Very Good, (1534)
"Good comfortable beds good breakfast "
United States
Andrey
The price is ￥19,937
￥22,678 total
includes taxes & fees
Nov 23 - Nov 24
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Desk, laptop workspace, blackout drapes, iron/ironing board
Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa

2.5 star property
Otay Mesa
7.0 out of 10, Good, (1000)
"Hotel was great the staff was very attentive. "
United States
Anibal
The price is ￥14,841
￥16,882 total
includes taxes & fees
Nov 17 - Nov 18
Quality Suites San Diego Otay Mesa
Exterior
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

3.0 star property
Gaslamp Quarter, 24.1 km from Otay Mesa
9.0 out of 10, Wonderful, (1208)
"Clean room ,friendly staff, great location "
United States
Jessica
The price is ￥20,887
￥24,218 total
includes taxes & fees
Nov 19 - Nov 20
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Serves dinner and happy hour
The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter

3.5 star property
24.3 km from Otay Mesa
9.0 out of 10, Wonderful, (2655)
"Very nice location and rooms. "
United States
David
The price is ￥18,980
￥26,189 total
includes taxes & fees
Dec 14 - Dec 15
The Horton Grand, Downtown/Gaslamp Quarter
Outdoor pool
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4.0 star property
Gaslamp Quarter, 24 km from Otay Mesa
9.0 out of 10, Wonderful, (3077)
"Our stay was great! Would stay here again"
United States
Carla
The price is ￥24,834
￥35,901 total
includes taxes & fees
Dec 8 - Dec 9
Hard Rock Hotel San Diego
Rooftop terrace
Palihotel San Diego Gaslamp Quarter

Palihotel San Diego Gaslamp Quarter

4.0 star property
Gaslamp Quarter, 24.5 km from Otay Mesa
8.6 out of 10, Excellent, (2029)
"Clean room, excellent staff and pleasant atmosphere "
United States
Estela
The price is ￥17,773
￥20,606 total
includes taxes & fees
Nov 23 - Nov 24
Palihotel San Diego Gaslamp Quarter
Exterior
AC Hotel by Marriott San Diego Downtown Gaslamp Quarter

AC Hotel by Marriott San Diego Downtown Gaslamp Quarter

4.0 star property
Gaslamp Quarter, 24.4 km from Otay Mesa
8.8 out of 10, Excellent, (949)
"Great spot in Gaslamp! "
United States
Cassie
The price is ￥18,546
￥21,503 total
includes taxes & fees
Nov 27 - Nov 28
AC Hotel by Marriott San Diego Downtown Gaslamp Quarter
Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4.0 star property
25.7 km from Otay Mesa
8.4 out of 10, Very Good, (6038)
"I enjoyed my stay."
United States
Kevin
The price is ￥20,887
￥28,700 total
includes taxes & fees
Nov 23 - Nov 24
Wyndham San Diego Bayside
Lobby
El Cordova Hotel on Coronado Island

El Cordova Hotel on Coronado Island

3.5 star property
23.5 km from Otay Mesa
8.8 out of 10, Excellent, (1004)
"Thank you - great spot! I will stay again ⭐️ "
United States
Donna
The price is ￥19,490
￥26,115 total
includes taxes & fees
Nov 30 - Dec 1
El Cordova Hotel on Coronado Island
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace
Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel

3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3397)
"Clean, staff friendly, great place for a stay"
United States
Derrick
The price is ￥17,945
￥19,774 total
includes taxes & fees
Nov 23 - Nov 24
Best Western Plus Marina Gateway Hotel
Lobby
Gaslamp Plaza Suites

Gaslamp Plaza Suites

3.5 star property
Gaslamp Quarter, 24.6 km from Otay Mesa
8.8 out of 10, Excellent, (1005)
"An extremely clean and well kept vintage property. I loved the traditional hotel qualities, mended with modern amenities. A repeat stay is probable. "
United States
Paul
The price is ￥17,155
￥19,514 total
includes taxes & fees
Dec 9 - Dec 10
Gaslamp Plaza Suites
Premium bedding, pillowtop beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

3.0 star property
Gaslamp Quarter, 24.2 km from Otay Mesa
9.4 out of 10, Exceptional, (1003)
"The room was immaculate, the staff were helpful and friendly and our stay was so wonderful. "
United States
Samantha Erin
The price is ￥16,568
￥23,676 total
includes taxes & fees
Nov 24 - Nov 25
Staypineapple, Hotel Z, Gaslamp San Diego
Outdoor pool, sun loungers
Best Western Plus Suites Hotel Coronado Island

Best Western Plus Suites Hotel Coronado Island

2.5 star property
24.1 km from Otay Mesa
8.8 out of 10, Excellent, (1003)
"Great staff and breakfast "
United States
Samantha
The price is ￥23,603
￥25,963 total
includes taxes & fees
Nov 30 - Dec 1
Best Western Plus Suites Hotel Coronado Island
Front of property
The Sofia Hotel

The Sofia Hotel

3.5 star property
24.9 km from Otay Mesa
8.4 out of 10, Very Good, (1628)
"Excellent stay all-around!"
United States
Nalani
The Sofia Hotel
Property entrance
The Bristol Hotel San Diego

The Bristol Hotel San Diego

3.5 star property
24.9 km from Otay Mesa
8.6 out of 10, Excellent, (1428)
"Nice staff, comfortable beds"
United States
Amber
The Bristol Hotel San Diego
Pillowtop beds, in-room safe, desk, blackout drapes
Holiday Inn Express San Diego Downtown by IHG

Holiday Inn Express San Diego Downtown by IHG

2.5 star property
24.9 km from Otay Mesa
8.4 out of 10, Very Good, (1528)
"Very nice hotel. "
United States
James
The price is ￥15,919
￥18,457 total
includes taxes & fees
Dec 15 - Dec 16
Holiday Inn Express San Diego Downtown by IHG
View from property
Courtyard by Marriott San Diego Downtown

Courtyard by Marriott San Diego Downtown

4.0 star property
24.6 km from Otay Mesa
8.8 out of 10, Excellent, (1002)
"It was a good stay, the room seemed clean and "
United States
Soraya Lizbeth
The price is ￥20,401
￥23,654 total
includes taxes & fees
Nov 23 - Nov 24
Courtyard by Marriott San Diego Downtown
Lobby
Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego

2.5 star property
24.5 km from Otay Mesa
8.2 out of 10, Very Good, (1005)
"Great place "
United States
Fadi
The price is ￥14,713
￥16,185 total
includes taxes & fees
Dec 11 - Dec 12
Best Western Plus La Mesa San Diego
Presidential Suite, 2 Bedrooms, Non Smoking | Living room | 36-inch LCD TV with digital channels, TV, pay movies
Alma San Diego Downtown, a Tribute Portfolio Hotel

Alma San Diego Downtown, a Tribute Portfolio Hotel

4.0 star property
24.7 km from Otay Mesa
9.0 out of 10, Wonderful, (845)
"Lovely hotel. Really enjoyed the complimentary bottle of wine as well as how convenient it was to walk to restaurants & bars . "
United States
Gisselle
The price is ￥19,628
￥29,030 total
includes taxes & fees
Nov 23 - Nov 24
Alma San Diego Downtown, a Tribute Portfolio Hotel
Exterior
Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4.0 star property
Gaslamp Quarter, 24.1 km from Otay Mesa
9.0 out of 10, Wonderful, (1128)
"Great Hotel - good position and very helpful staff. "
United Kingdom
James
The price is ￥24,341
￥34,494 total
includes taxes & fees
Nov 23 - Nov 24
Margaritaville Hotel San Diego Gaslamp Quarter
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Hotels in Otay Mesa with free breakfast

Outdoor pool
Crowne Plaza San Diego - Mission Valley by IHG
Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
  • Breakfast included
7.8 out of 10, Good, (1005)
The price is ￥13,910
￥16,054 total
includes taxes & fees
Nov 30 - Dec 1
Crowne Plaza San Diego - Mission Valley by IHG
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Hotels in Otay Mesa with a pool

Outdoor pool, sun loungers
Hilton San Diego Bayfront
Hilton San Diego Bayfront
4.0 star property
  • Pool
8.6 out of 10, Excellent, (1811)
The price is ￥18,123
￥28,590 total
includes taxes & fees
Dec 14 - Dec 15
Hilton San Diego Bayfront
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Top guest rated hotels in Otay Mesa

Exterior
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
    8.0 out of 10, Very Good, (1534)
    The price is ￥19,937
    ￥22,678 total
    includes taxes & fees
    Nov 23 - Nov 24
    Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
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    Where to stay in Otay Mesa

    Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
    Learn more about Otay Mesa
    US Grant Hotel

    Downtown San Diego

    Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

    Gaslamp Quarter showing signage, night scenes and street scenes

    Gaslamp Quarter

    Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

    Pacific Beach Park showing a beach

    Pacific Beach

    Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

    Belmont Park showing rides and a garden

    Mission Beach

    Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

    Ocean Beach

    Ocean Beach

    Ocean Beach is known for its stunning beaches, and with sights like Ocean Beach Pier and Dog Beach, you won't get bored spending a day wandering around this part of San Diego.

    Top Otay Mesa Hotel Reviews

    Sheraton San Diego Resort

    Sheraton San Diego Resort

    10/10 Excellent
    "Excellent…. People were available. Room was extremely comfortable. Pools and hot tub were perfect!"
    Elizabeth 1-night trip
    Posted 20 hours ago
    Sheraton San Diego Resort

    Explore a world of travel with Expedia

    Frequently asked questions

    What's it like in Otay Mesa?
    Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.
    Where is the best hotel for a stay in Otay Mesa?
    Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
    If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
    Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.
    Where can I learn more about changing or cancelling my trip to Otay Mesa?
    To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/.
    What is there to do in this San Diego neighborhood?
    A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.