What's it like in Otay Mesa?

Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on our traveler data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.

Where can I learn more about changing or cancelling my trip to Otay Mesa?

To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/ .

What is there to do in this San Diego neighborhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

Top Otay Mesa Hotels

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Our top choices for Otay Mesa hotels

A modern interior with a long table and blue chairs, large windows with a view of palm trees and parked vehicles outside.

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Otay Mesa

Michael

￥25,884 total

includes taxes & fees

Oct 25 - Oct 26

A breakfast station with bread, bagels, waffles, and a coffee machine.

2. Quality Suites San Diego Otay Mesa

Otay Mesa

Anonymous traveler

￥18,478 total

includes taxes & fees

Nov 8 - Nov 9

A modern kitchen area with a self-serve station, including a waffle maker, coffee machine, and various food items.

3. Best Western Chula Vista/Otay Valley Hotel

7.1 km from Otay Mesa

Eric

￥19,094 total

includes taxes & fees

Oct 25 - Oct 26

An outdoor patio area with seating and a bar.

4. Ayres Hotel San Diego South - Chula Vista

6.5 km from Otay Mesa

Rosemary

￥33,538 total

includes taxes & fees

Nov 11 - Nov 12

A hotel room with two beds, a wooden headboard, a bedside table with a phone, and a wall-mounted light fixture.

5. Rodeway Inn San Diego South San Ysidro Border

5.8 km from Otay Mesa

Guadalupe

￥13,589 total

includes taxes & fees

Oct 25 - Oct 26

A hotel lobby with a patterned carpet, a reception desk, a sofa with cushions, and potted plants.

6. Comfort Inn Chula Vista San Diego South

13 km from Otay Mesa

Xochitl

￥18,095 total

includes taxes & fees

Nov 8 - Nov 9

A Holiday Inn Express building with a prominent entrance, palm trees, and a clear sky.

7. Holiday Inn Express San Diego South - Chula Vista by IHG

14.5 km from Otay Mesa

Taylor

￥27,463 total

includes taxes & fees

Nov 1 - Nov 2

A breakfast bar with La Quinta branding, a coffee machine, and a waffle display.

8. La Quinta Inn by Wyndham San Diego Chula Vista

12.9 km from Otay Mesa

Nuwan

￥18,469 total

includes taxes & fees

Nov 8 - Nov 9

A neatly arranged hotel room with a large bed, a desk, a chair, and a bedside table.

9. Valli Hi Motel

7.9 km from Otay Mesa

Christian

￥14,423 total

includes taxes & fees

Nov 19 - Nov 20

10. SpringHill Suites by Marriott Chula Vista Eastlake

10.5 km from Otay Mesa

Joey

￥31,298 total

includes taxes & fees

Nov 1 - Nov 2

A modern hotel with a prominent 'Hercor Hotel' sign, multiple balconies, and a 'Urban Boutique' label.

11. Hercor Hotel - Urban Boutique

13.6 km from Otay Mesa

fannie

￥18,092 total

includes taxes & fees

Nov 9 - Nov 10

A room with two teal armchairs, a small round table with a lamp, and a large cityscape painting on the wall.

12. SureStay Hotel by Best Western Chula Vista San Diego Bay

14.7 km from Otay Mesa

Frances

￥13,323 total

includes taxes & fees

Oct 25 - Oct 26

A spacious lobby with a fireplace, wooden furniture, and a chandelier.

13. Best Western Americana Inn

8 km from Otay Mesa

Rene

￥18,823 total

includes taxes & fees

Nov 8 - Nov 9

A retro-themed arcade with classic games, a foosball table, and a long communal table with stools.

14. The Rambler Hotel

14.8 km from Otay Mesa

Neal

￥20,821 total

includes taxes & fees

Nov 17 - Nov 18

A hotel room with a large bed, a desk, a chair, a painting, and a view of the city.

15. Best Western Plus Marina Gateway Hotel

16.9 km from Otay Mesa

Nicholas Ray

￥26,487 total

includes taxes & fees

Oct 25 - Oct 26

A swimming pool with palm trees and a mountain in the background.

16. Sycuan Casino Resort

28.5 km from Otay Mesa

Sarah

￥19,034 total

includes taxes & fees

Nov 16 - Nov 17

A spacious hotel lobby with a dining area, seating arrangements, and modern decor.

17. Holiday Inn Express San Diego South - National City by IHG

16.9 km from Otay Mesa

JUAN

￥24,204 total

includes taxes & fees

Nov 16 - Nov 17

A hotel room with a bed, a desk with a chair, a nightstand, and a wall-mounted TV displaying a sunset scene.

18. Hotel Palmeras Chula Vista

14.4 km from Otay Mesa

AHMAD

￥12,473 total

includes taxes & fees

Nov 19 - Nov 20

A hotel room with two beds, a desk, and a chair.

19. Howard Johnson by Wyndham National City/San Diego South

18.3 km from Otay Mesa

Michelle

￥14,100 total

includes taxes & fees

Nov 1 - Nov 2

An aerial view of a coastal resort with multiple buildings, marina, and a pier.

20. Loews Coronado Bay Resort

17.1 km from Otay Mesa

Pauline

￥46,370 total

includes taxes & fees

Nov 8 - Nov 9

View all properties

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa

A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

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A pier extending into the ocean with buildings at the end, under a partly cloudy sky.

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

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Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

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A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

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An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

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Top Otay Mesa Hotel Reviews

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

10/10 Excellent

"Staff was amazing and beds were sooo comfy"

Legacy Resort Hotel & Spa

10/10 Excellent

"We loved the stay although around the hotel were a ton of homeless ppl ( I kno the hotel has nothing to do with that) but we did notice they didn’t care who came in and out! Also the ppl area was very dirty leaves and dirty all over the pool area left over drinks from other guests I definitely would have someone come up once in awhile and idk maybe power wash it!"

Find hotels in Otay Mesa, San Diego

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Our top choices for Otay Mesa hotels

1. Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2. Quality Suites San Diego Otay Mesa

3. Best Western Chula Vista/Otay Valley Hotel

4. Ayres Hotel San Diego South - Chula Vista

5. Rodeway Inn San Diego South San Ysidro Border

6. Comfort Inn Chula Vista San Diego South

7. Holiday Inn Express San Diego South - Chula Vista by IHG

8. La Quinta Inn by Wyndham San Diego Chula Vista

9. Valli Hi Motel

10. SpringHill Suites by Marriott Chula Vista Eastlake

11. Hercor Hotel - Urban Boutique

12. SureStay Hotel by Best Western Chula Vista San Diego Bay

13. Best Western Americana Inn

14. The Rambler Hotel

15. Best Western Plus Marina Gateway Hotel

16. Sycuan Casino Resort

17. Holiday Inn Express San Diego South - National City by IHG

18. Hotel Palmeras Chula Vista

19. Howard Johnson by Wyndham National City/San Diego South

20. Loews Coronado Bay Resort

Where to stay in Otay Mesa

Downtown San Diego

Pacific Beach

Gaslamp Quarter

Mission Beach

Mission Bay

Top Otay Mesa Hotel Reviews

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

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