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Our top choices for Otay Mesa hotels

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.2 out of 10, Good, (1005)
"Clean, convenient location "
United States
Mary
The price is ¥15,769
¥17,937 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Quality Suites San Diego Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.0 out of 10, Very Good, (1568)
"Great place to stay. Really clean and helpful staff "
United States
Zulma
The price is ¥18,609
¥21,168 total
includes taxes & fees
Jan 11 - Jan 12, 2026
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Berkshire Motor Hotel

Berkshire Motor Hotel
2.5 star property
North Park, 26.7 km from Otay Mesa
8.4 out of 10, Very Good, (1001)
"Great spot"
United States
Alexandro
The price is ¥12,793
¥14,424 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Berkshire Motor Hotel

Westgate Hotel

Westgate Hotel
4.5 star property
24.9 km from Otay Mesa
9.0 out of 10, Wonderful, (1001)
"Loved this stay, they were very accommodating "
United States
Maurizio
The price is ¥25,056
¥34,477 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Westgate Hotel

Sea Harbor Hotel

Sea Harbor Hotel
2.0 star property
30.1 km from Otay Mesa
8.6 out of 10, Excellent, (1010)
"Great stay"
United States
Naomi
Sea Harbor Hotel

Courtyard by Marriott Old Town

Courtyard by Marriott Old Town
3.0 star property
Old Town San Diego, 29.7 km from Otay Mesa
8.6 out of 10, Excellent, (1004)
"Great stay!!! Will be staying again! "
United States
Raven
The price is ¥18,592
¥21,370 total
includes taxes & fees
Jan 8 - Jan 9, 2026
Courtyard by Marriott Old Town

Springhill Suites San Diego Mission Valley

Springhill Suites San Diego Mission Valley
3.5 star property
28.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1002)
"Clean, convenient, great property "
United States
Dana
The price is ¥17,547
¥20,170 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Springhill Suites San Diego Mission Valley

Ocean Villa Inn

Ocean Villa Inn
2.5 star property
Ocean Beach, 33.7 km from Otay Mesa
8.0 out of 10, Very Good, (1131)
"Fantastic location!"
United States
Lydia
Ocean Villa Inn

Heritage Inn San Diego

Heritage Inn San Diego
2.0 star property
31.8 km from Otay Mesa
7.4 out of 10, Good, (1187)
"Clean room, great location "
United States
Benjamin
The price is ¥9,366
¥10,765 total
includes taxes & fees
Jan 7 - Jan 8, 2026
Heritage Inn San Diego

Best Western Plus Bayside Inn

Best Western Plus Bayside Inn
3.0 star property
25.5 km from Otay Mesa
9.0 out of 10, Wonderful, (1002)
"Great area, staff was attentive and the balcony was an unexpected surprise! Great hotel! "
United States
Armando
The price is ¥19,056
¥22,057 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Best Western Plus Bayside Inn

La Pensione Hotel

La Pensione Hotel
3.0 star property
Little Italy, 25.8 km from Otay Mesa
8.6 out of 10, Excellent, (1891)
"Great check-in experience, convenient parking, the room was clean and bed was comfortable. The city view option was exceptionally pleasant. Will stay again! "
United States
Mike
La Pensione Hotel

Old Town Western Inn & Suites

Old Town Western Inn & Suites
2.5 star property
Old Town San Diego, 29.6 km from Otay Mesa
7.6 out of 10, Good, (1006)
"Clean, good staff, quiet, good location "
United States
Raul
Old Town Western Inn & Suites

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 24.2 km from Otay Mesa
9.4 out of 10, Exceptional, (1001)
"Great location "
United States
Mohammad
The price is ¥15,935
¥22,984 total
includes taxes & fees
Jan 19 - Jan 20, 2026
Staypineapple, Hotel Z, Gaslamp San Diego

Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld
3.0 star property
30.8 km from Otay Mesa
9.2 out of 10, Wonderful, (458)
"Clean room, helpful staff, convenient location "
United States
David
The price is ¥18,428
¥21,181 total
includes taxes & fees
Jan 9 - Jan 10, 2026
Hampton Inn & Suites by Hilton San Diego SeaWorld

Ocean Beach Hotel

Ocean Beach Hotel
3.0 star property
Ocean Beach, 33.5 km from Otay Mesa
8.8 out of 10, Excellent, (1273)
"Great location."
United States
Maryna
Ocean Beach Hotel

The Beau Downtown San Diego Gaslamp Quar

The Beau Downtown San Diego Gaslamp Quar
3.0 star property
Gaslamp Quarter, 24.5 km from Otay Mesa
8.8 out of 10, Excellent, (563)
"beautiful hotel, well maintained facilities, convenient location, very kind staff"
United States
Sergio
The price is ¥19,289
¥21,941 total
includes taxes & fees
Jan 7 - Jan 8, 2026
The Beau Downtown San Diego Gaslamp Quar

Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hilton Garden Inn San Diego Old Town/SeaWorld Area
3.0 star property
Old Town San Diego, 30.5 km from Otay Mesa
8.6 out of 10, Excellent, (1313)
"Clean room and friendly staff. Close to old town and family friendly!"
United States
Daisy
The price is ¥19,107
¥21,962 total
includes taxes & fees
Jan 18 - Jan 19, 2026
Hilton Garden Inn San Diego Old Town/SeaWorld Area

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
29.2 km from Otay Mesa
9.2 out of 10, Wonderful, (1716)
"Staff was friendly, room was clean, breakfast very good."
United States
Robert
The price is ¥23,723
¥27,269 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Hampton Inn & Suites San Diego Airport Liberty Station

Best Western Yacht Harbor Hotel

Best Western Yacht Harbor Hotel
2.5 star property
29.9 km from Otay Mesa
8.6 out of 10, Excellent, (1652)
"Enjoyed our stay. Very nice staff!"
United States
Julia
The price is ¥17,469
¥20,046 total
includes taxes & fees
Jan 6 - Jan 7, 2026
Best Western Yacht Harbor Hotel

AC Hotel by Marriott San Diego Downtown Gaslamp Quarter

AC Hotel by Marriott San Diego Downtown Gaslamp Quarter
4.0 star property
Gaslamp Quarter, 24.4 km from Otay Mesa
8.8 out of 10, Excellent, (981)
"Wonderful stay, wonderful staff!"
United States
Vanessa
The price is ¥22,928
¥26,584 total
includes taxes & fees
Jan 6 - Jan 7, 2026
AC Hotel by Marriott San Diego Downtown Gaslamp Quarter
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Learn more about Otay Mesa

Downtown San Diego

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

Ocean Beach

Ocean Beach is known for its stunning beaches, and with sights like Dog Beach and Sunset Cliffs Natural Park, you won't get bored spending a day wandering around this part of San Diego.

Top Otay Mesa Hotel Reviews

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.
Where can I learn more about changing or cancelling my trip to Otay Mesa?
To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/.
What is there to do in this San Diego neighborhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

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